Open Access

miR‑34c‑5p targets Notch1 and suppresses the metastasis and invasion of cervical cancer

  • Authors:
    • Huali Wei
    • Xiaolan Wang
    • Xiumin Niu
    • Ruili Jiao
    • Xiaojuan Li
    • Sumei Wang
  • View Affiliations

  • Published online on: December 7, 2020     https://doi.org/10.3892/mmr.2020.11759
  • Article Number: 120
  • Copyright: © Wei et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Micro (mi)RNAs are crucial participants in the progression of cervical cancer (CC). Growing evidence indicates that miRNA (miR)‑34c‑5p is a pivotal tumor suppressor in numerous types of cancer and its functions in CC require further investigating. The present study demonstrated that there was a decreased level of miR‑34c‑5p in CC‑associated cell lines compared with healthy control samples. It also demonstrated that miR‑34c‑5p targeted Notch1 and suppressed CC progression. Dual‑luciferase reporter assays verified the targeted relationship of miR‑34c‑5p and Notch1. The expression of Notch1 in HeLa cells was markedly reduced following miR‑34c‑5p overexpression and the proliferation, migration and invasion of HeLa cells were reduced although apoptosis was accelerated. However, overexpression of miR‑34c‑5p was reversed following the addition of Notch1, which supported the finding of the targeted relationship between miR‑34c‑5p and Notch1. Flow cytometry demonstrated that miR‑34c‑5p inhibited the proliferation of HeLa cells while accelerating apoptosis. The present study concluded that miR‑34c‑5p was a tumor suppressor in CC and may be a novel measure for the future treatment of CC.
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February-2021
Volume 23 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Wei H, Wang X, Niu X, Jiao R, Li X and Wang S: miR‑34c‑5p targets Notch1 and suppresses the metastasis and invasion of cervical cancer. Mol Med Rep 23: 120, 2021
APA
Wei, H., Wang, X., Niu, X., Jiao, R., Li, X., & Wang, S. (2021). miR‑34c‑5p targets Notch1 and suppresses the metastasis and invasion of cervical cancer. Molecular Medicine Reports, 23, 120. https://doi.org/10.3892/mmr.2020.11759
MLA
Wei, H., Wang, X., Niu, X., Jiao, R., Li, X., Wang, S."miR‑34c‑5p targets Notch1 and suppresses the metastasis and invasion of cervical cancer". Molecular Medicine Reports 23.2 (2021): 120.
Chicago
Wei, H., Wang, X., Niu, X., Jiao, R., Li, X., Wang, S."miR‑34c‑5p targets Notch1 and suppresses the metastasis and invasion of cervical cancer". Molecular Medicine Reports 23, no. 2 (2021): 120. https://doi.org/10.3892/mmr.2020.11759