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Article

Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis

  • Authors:
    • Yong Zhang
    • Haibo Zhang
    • Muqun Wang
    • Shan Gao
    • Lei Hong
    • Tingting Hou
    • Yaoyao Zhang
    • Yuling Zhu
    • Feng Qian
  • View Affiliations / Copyright

    Affiliations: Department of Pulmonary and Critical Care Medicine, First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, Anhui 233004, P.R. China, Engineering Research Center of Cell and Therapeutic Antibody, Ministry of Education, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, P.R. China
  • Article Number: 133
    |
    Published online on: December 13, 2020
       https://doi.org/10.3892/mmr.2020.11772
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Abstract

Shikonin is the major active component in Lithospermum erythrorhizon and has pharmacological effects including reducing inflammation, aiding resistance to bacteria and promoting wound healing. However, the effect of shikonin on lipoteichoic acid (LTA)‑induced acute lung injury (ALI) remains to be elucidated. ALI is a serious illness resulting from significant pulmonary inflammation caused by various diseases, such as sepsis, acid aspiration and trauma. The present study found that shikonin significantly attenuated LTA‑induced ALI. Following shikonin treatment, the accumulation of pulmonary neutrophils and expression of TNFα, IL‑1β and IL‑6 were decreased in mice with LTA‑induced ALI. Furthermore, Shikonin promoted neutrophil apoptosis by increasing the activation of caspase‑3 and reducing the expression of the antiapoptotic myeloid cell leukemia‑1 (Mcl‑1) protein. However, shikonin treatment did not influence the expression of B‑cell lymphoma‑2. The findings of the present study demonstrated that shikonin protected against LTA‑induced ALI by promoting caspase-3 and Mcl‑1‑related neutrophil apoptosis, suggesting that shikonin is a potential agent that can be used in the treatment of sepsis‑mediated lung injury.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Zhang H, Wang M, Gao S, Hong L, Hou T, Zhang Y, Zhu Y and Qian F: Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis. Mol Med Rep 23: 133, 2021.
APA
Zhang, Y., Zhang, H., Wang, M., Gao, S., Hong, L., Hou, T. ... Qian, F. (2021). Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis. Molecular Medicine Reports, 23, 133. https://doi.org/10.3892/mmr.2020.11772
MLA
Zhang, Y., Zhang, H., Wang, M., Gao, S., Hong, L., Hou, T., Zhang, Y., Zhu, Y., Qian, F."Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis". Molecular Medicine Reports 23.2 (2021): 133.
Chicago
Zhang, Y., Zhang, H., Wang, M., Gao, S., Hong, L., Hou, T., Zhang, Y., Zhu, Y., Qian, F."Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis". Molecular Medicine Reports 23, no. 2 (2021): 133. https://doi.org/10.3892/mmr.2020.11772
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Zhang H, Wang M, Gao S, Hong L, Hou T, Zhang Y, Zhu Y and Qian F: Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis. Mol Med Rep 23: 133, 2021.
APA
Zhang, Y., Zhang, H., Wang, M., Gao, S., Hong, L., Hou, T. ... Qian, F. (2021). Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis. Molecular Medicine Reports, 23, 133. https://doi.org/10.3892/mmr.2020.11772
MLA
Zhang, Y., Zhang, H., Wang, M., Gao, S., Hong, L., Hou, T., Zhang, Y., Zhu, Y., Qian, F."Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis". Molecular Medicine Reports 23.2 (2021): 133.
Chicago
Zhang, Y., Zhang, H., Wang, M., Gao, S., Hong, L., Hou, T., Zhang, Y., Zhu, Y., Qian, F."Shikonin ameliorates lipoteichoic acid‑induced acute lung injury via promotion of neutrophil apoptosis". Molecular Medicine Reports 23, no. 2 (2021): 133. https://doi.org/10.3892/mmr.2020.11772
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