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miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6

  • Authors:
    • Mei Zhang
    • Hongwei Wang
    • Xiaomei Zhang
    • Fengping Liu
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy Technology, Linyi Cancer Hospital, Linyi, Shandong 276000, P.R China, Department of Operating Theatre, Linyi Cancer Hospital, Linyi, Shandong 276000, P.R China, Department of Gynaecology, Linyi Cancer Hospital, Linyi, Shandong 276000, P.R China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 200
    |
    Published online on: January 12, 2021
       https://doi.org/10.3892/mmr.2021.11839
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Abstract

Breast cancer is the worldwide leading cause of cancer‑related deaths among women. Increasing evidence has demonstrated that microRNAs (miRNAs) play critical roles in the carcinogenesis and progression of breast cancer. miR‑653‑5p was previously reported to be involved in cell proliferation and apoptosis. However, the role of miR‑653‑5p in the progression of breast cancer has not been studied. In the present study, it was found that overexpression of miR‑653‑5p significantly inhibited the proliferation, migration and invasion of breast cancer cells in vitro. Moreover, overexpression of miR‑653‑5p promoted cell apoptosis in breast cancer by regulating the Bcl‑2/Bax axis and caspase‑9 activation. Additionally, the epithelial‑mesenchymal transition and activation of the Akt/mammalian target of rapamycin signaling pathway were also inhibited by miR‑653‑5p. Furthermore, the data demonstrated that miR‑653‑5p directly targeted mitogen‑activated protein kinase 6 (MAPK6) and negatively regulated its expression in breast cancer cells. Upregulation of MAPK6 could overcome the inhibitory effects of miR‑653‑5p on cell proliferation and migration in breast cancer. In conclusion, this study suggested that miR‑653‑5p functions as a tumor suppressor by targeting MAPK6 in the progression of breast cancer, and it may be a potential target for breast cancer therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang M, Wang H, Zhang X and Liu F: miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6. Mol Med Rep 23: 200, 2021.
APA
Zhang, M., Wang, H., Zhang, X., & Liu, F. (2021). miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6. Molecular Medicine Reports, 23, 200. https://doi.org/10.3892/mmr.2021.11839
MLA
Zhang, M., Wang, H., Zhang, X., Liu, F."miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6". Molecular Medicine Reports 23.3 (2021): 200.
Chicago
Zhang, M., Wang, H., Zhang, X., Liu, F."miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6". Molecular Medicine Reports 23, no. 3 (2021): 200. https://doi.org/10.3892/mmr.2021.11839
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang M, Wang H, Zhang X and Liu F: miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6. Mol Med Rep 23: 200, 2021.
APA
Zhang, M., Wang, H., Zhang, X., & Liu, F. (2021). miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6. Molecular Medicine Reports, 23, 200. https://doi.org/10.3892/mmr.2021.11839
MLA
Zhang, M., Wang, H., Zhang, X., Liu, F."miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6". Molecular Medicine Reports 23.3 (2021): 200.
Chicago
Zhang, M., Wang, H., Zhang, X., Liu, F."miR‑653‑5p suppresses the growth and migration of breast cancer cells by targeting MAPK6". Molecular Medicine Reports 23, no. 3 (2021): 200. https://doi.org/10.3892/mmr.2021.11839
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