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1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 in silico

  • Authors:
    • Chutima Jansakun
    • Wanatsanan Chulrik
    • Waraluck Chaichompoo
    • Pathumwadee Yotmanee
    • Kanokporn Lehboon
    • Wilanee Chunglok
    • Apsorn Sattayakhom
    • Poonsit Hiransai
    • Kornyok Kamdee
    • Tanyarath Utaipan
    • Apichart Suksamrarn
    • Warangkana Chunglok
  • View Affiliations / Copyright

    Affiliations: School of Allied Health Sciences, Walailak University, Nakhon Si Thammarat 80161, Thailand, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Ramkhamhaeng University, Bangkok 10240, Thailand, Department of Microbiology, Faculty of Science, Prince of Songkla University, Songkhla 90110, Thailand, Department of Pre‑Clinic, Faculty of Science and Technology, Prince of Songkla University, Pattani Campus, Pattani 94000, Thailand
  • Article Number: 209
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    Published online on: January 18, 2021
       https://doi.org/10.3892/mmr.2021.11848
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Abstract

Trienones are curcuminoid analogues and are minor constituents in the rhizomes of numerous Curcuma plant species. Studies investigating the biological activities of trienones, particularly their anti‑inflammatory activities, are limited. In the present study, the trienone 1,7‑bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one (HMPH) was structurally modified from curcumin using a novel and concise method. HMPH was shown to exhibit potential anti‑inflammatory effects on lipopolysaccharide (LPS)‑activated RAW264.7 macrophages. Furthermore, LPS‑induced nitric oxide secretion in RAW264.7 cells was markedly and dose‑dependently inhibited by HMPH; in addition, HMPH had a greater efficacy compared with curcumin. This inhibition was accompanied by the suppression of inducible nitric oxide synthase and cyclooxygenase‑2 expression, as well as pro‑inflammatory cytokine secretion. To elucidate the molecular mechanism underlying the anti‑inflammatory effects of HMPH, the effects of this compound on nuclear factor‑κB (NF‑κB) translocation were assessed. HMPH significantly inhibited the translocation of p65 NF‑κB into the nucleus to a greater extent than curcumin, thus indicating that HMPH has more potent anti‑inflammatory activity than curcumin. In addition, an in silico modelling study revealed that HMPH possessed stronger binding energy to myeloid differentiation factor 2 (MD2) compared with that of curcumin, and indicated that the anti‑inflammatory effects of HMPH may be through upstream inhibition of the inflammatory pathway. In conclusion, HMPH may be considered a promising compound for reducing inflammation via targeting p65 NF‑κB translocation and interfering with MD2 binding.
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1 

Karakike E, Adami ME, Lada M, Gkavogianni T, Koutelidakis IM, Bauer M, Giamarellos-Bourboulis EJ and Tsangaris I: Late peaks of HMGB1 and sepsis outcome evidence for synergy with chronic inflammatory disorders. Shock. 52:334–339. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Stengel S, Quickert S, Lutz P, Ibidapo-Obe O, Steube A, Köse-Vogel N, Yarbakht M, Reuken PA, Busch M, Brandt A, et al: Peritoneal level of CD206 associates with mortality and an inflammatory macrophage phenotype in patients with decompensated cirrhosis and spontaneous bacterial peritonitis. Gastroenterology. 158:1745–1761. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Rajaiah R, Perkins DJ, Ireland DD and Vogel SN: CD14 dependence of TLR4 endocytosis and TRIF signaling displays ligand specificity and is dissociable in endotoxin tolerance. Proc Natl Acad Sci USA. 112:8391–8396. 2015. View Article : Google Scholar : PubMed/NCBI

4 

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X and Zhao L: Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 9:7204–7218. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Pizzuto M, Lonez C, Baroja-Mazo A, Martínez-Banaclocha H, Tourlomousis P, Gangloff M, Pelegrin P, Ruysschaert JM, Gay NJ and Bryant CE: Saturation of acyl chains converts cardiolipin from an antagonist to an activator of Toll-like receptor-4. Cell Mol Life Sci. 76:3667–3678. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Taniguchi K and Karin M: NF-κB, inflammation, immunity and cancer: Coming of age. Nat Rev Immunol. 18:309–324. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Obaid M, Udden SMN, Deb P, Shihabeddin N, Zaki MH and Mandal SS: LncRNA HOTAIR regulates lipopolysaccharide-induced cytokine expression and inflammatory response in macrophages. Sci Rep. 8:156702018. View Article : Google Scholar : PubMed/NCBI

8 

Aoki T, Frȍsen J, Fukuda M, Bando K, Shioi G, Tsuji K, Ollikainen E, Nozaki K, Laakkonen J and Narumiya S: Prostaglandin E2-EP2-NF-κB signaling in macrophages as a potential therapeutic target for intracranial aneurysms. Sci Signal. 10:eaah60372017. View Article : Google Scholar : PubMed/NCBI

9 

Manček-Keber M, Gradišar H, Iñigo Pestaña M, Martinez de Tejada G and Jerala R: Free thiol group of MD-2 as the target for inhibition of the lipopolysaccharide-induced cell activation. J Biol Chem. 284:19493–19500. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Wang Y, Shan X, Dai Y, Jiang L, Chen G, Zhang Y, Wang Z, Dong L, Wu J, Guo G, et al: Curcumin analog L48H37 prevents lipopolysaccharide-induced TLR4 signaling pathway activation and sepsis via targeting MD2. J Pharmacol Exp Ther. 353:539–550. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Kocaadam B and Şanlier N: Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr. 57:2889–2895. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Akter J, Hossain MA, Takara K, Islam MZ and Hou DX: Antioxidant activity of different species and varieties of turmeric (Curcuma spp): Isolation of active compounds. Comp Biochem Physiol C Toxicol Pharmacol. 215:9–17. 2019. View Article : Google Scholar : PubMed/NCBI

13 

Park SY and Kim DS: Discovery of natural products from Curcuma longa that protect cells from beta-amyloid insult: A drug discovery effort against Alzheimer's disease. J Nat Prod. 65:1227–1231. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Chuprajob T, Changtam C, Chokchaisiri R, Chunglok W, Sornkaew N and Suksamrarn A: Synthesis, cytotoxicity against human oral cancer KB cells and structure-activity relationship studies of trienone analogues of curcuminoids. Bioorg Med Chem Lett. 24:2839–2844. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Wang R, Zhang X, Chen C, Chen G, Zhong Q, Zhang Q, Zheng S, Wang G and Chen QH: Synthesis and evaluation of 1,7-diheteroarylhepta-1,4,6-trien-3-ones as curcumin-based anticancer agents. Eur J Med Chem. 110:164–180. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Utaipan T, Boonyanuphong P, Chuprajob T, Suksamrarn A and Chunglok W: A trienone analog of curcumin, 1,7-bis (3-hydroxyphenyl)-1,4,6-heptatrien-3-one, possesses ROS- and caspase-mediated apoptosis in human oral squamous cell carcinoma cells in vitro. Appl Biol Chem. 63:72020. View Article : Google Scholar

17 

Srivilai J, Rabgay K, Khorana N, Waranuch N, Nuengchamnong N, Wisuitiprot W, Chuprajob T, Changtam C, Suksamrarn A, Chavasiri W, et al: Anti-androgenic curcumin analogues as steroid 5-alpha reductase inhibitors. Med Chem Res. 26:1550–1556. 2017. View Article : Google Scholar

18 

Jang MK, Sohn DH and Ryu JH: A curcuminoid and sesquiterpenes as inhibitors of macrophage TNF-α release from Curcuma zedoaria. Planta Med. 67:550–552. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Tan RZ, Liu J, Zhang YY, Wang HL, Li JC, Liu YH, Zhong X, Zhang YW, Yan Y, Lan HY, et al: Curcumin relieved cisplatin-induced kidney inflammation through inhibiting Mincle-maintained M1 macrophage phenotype. Phytomedicine. 52:284–294. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Zhao F, Gong Y, Hu Y, Lu M, Wang J, Dong J, Chen D, Chen L, Fu F and Qiu F: Curcumin and its major metabolites inhibit the inflammatory response induced by lipopolysaccharide: Translocation of nuclear factor-κB as potential target. Mol Med Rep. 11:3087–3093. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Gradišar H, Keber MM, Pristovšek P and Jerala R: MD-2 as the target of curcumin in the inhibition of response to LPS. J Leukoc Biol. 82:968–974. 2007. View Article : Google Scholar : PubMed/NCBI

22 

Mirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z and Sahebkar A: Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother. 85:102–112. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Koeberle A, Muñoz E, Appendino GB, Minassi A, Pace S, Rossi A, Weinigel C, Barz D, Sautebin L, Caprioglio D, et al: SAR studies on curcumin's pro-inflammatory targets: Discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase. J Med Chem. 57:5638–5648. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Changtam C, de Koning HP, Ibrahim H, Sajid MS, Gould MK and Suksamrarn A: Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. Eur J Med Chem. 45:941–956. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Sun J, Zhang X, Broderick M and Fein H: Measurement of nitric oxide production in biological systems by using Griess reaction assay. Sensors (Basel). 3:276–284. 2003. View Article : Google Scholar

26 

Morris GM, Huey R, Lindstrom W, Sanner MF, Belew RK, Goodsell DS and Olson AJ: AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J Comput Chem. 30:2785–2791. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Morris G, Goodsell D, Halliday R, Huey R, Hart W, Belew R and Olson A: Automated docking using a lamarckian genetic algorithm and an empirical binding free energy function. J Comput Chem. 19:1639–1662. 1998. View Article : Google Scholar

28 

Case DA, Betz RM, Cerutti DS, Cheatham TE, Darden TA, Duke RE, Giese TJ, Gohlke H, Goetz AW, Homeyer N, et al: AMBER 2016. University of California; San Francisco: 2016

29 

Liang G, Li X, Chen L, Yang S, Wu X, Studer E, Gurley E, Hylemon PB, Ye F, Li Y, et al: Synthesis and anti-inflammatory activities of mono-carbonyl analogues of curcumin. Bioorg Med Chem Lett. 18:1525–1529. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Zhao C, Zhang Y, Zou P, Wang J, He W, Shi D, Li H, Liang G and Yang S: Synthesis and biological evaluation of a novel class of curcumin analogs as anti-inflammatory agents for prevention and treatment of sepsis in mouse model. Drug Des Devel Ther. 9:1663–1678. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Ullah MO, Sweet MJ, Mansell A, Kellie S and Kobe B: TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target. J Leukoc Biol. 100:27–45. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Wang Z, Chen G, Chen L, Liu X, Fu W, Zhang Y, Li C, Liang G and Cai Y: Insights into the binding mode of curcumin to MD-2: Studies from molecular docking, molecular dynamics simulations and experimental assessments. Mol Biosyst. 11:1933–1938. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Wang Y, Shan X, Chen G, Jiang L, Wang Z, Fang Q, Liu X, Wang J, Zhang Y, Wu W, et al: MD-2 as the target of a novel small molecule, L6H21, in the attenuation of LPS-induced inflammatory response and sepsis. Br J Pharmacol. 172:4391–4405. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Zhang Y, Liu Z, Wu J, Bai B, Chen H, Xiao Z, Chen L, Zhao Y, Lum H, Wang Y, et al: New MD2 inhibitors derived from curcumin with improved anti-inflammatory activity. Eur J Med Chem. 148:291–305. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Li B, Hu Y, Zhao Y, Cheng M, Qin H, Cheng T, Wang Q, Peng X and Zhang X: Curcumin attenuates titanium particle-induced inflammation by regulating macrophage polarization in vitro and in vivo. Front Immunol. 8:552017.PubMed/NCBI

36 

Zhang J, Zheng Y, Luo Y, Du Y, Zhang X and Fu J: Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/TLR4/NF-κB pathways in BV2 cells. Mol Immunol. 116:29–37. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Oh SW, Cha JY, Jung JE, Chang BC, Kwon HJ, Lee BR and Kim DY: Curcumin attenuates allergic airway inflammation and hyper-responsiveness in mice through NF-κB inhibition. J Ethnopharmacol. 136:414–421. 2011. View Article : Google Scholar : PubMed/NCBI

38 

Chen Q, Chen T, Li W, Zhang W, Zhu J, Li Y, Huang Y, Shen Y and Yu C: Mycoepoxydiene inhibits lipopolysaccharide-induced inflammatory responses through the of TRAF6 polyubiquitination. PLoS One. 7:e448902012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Jansakun C, Chulrik W, Chaichompoo W, Yotmanee P, Lehboon K, Chunglok W, Sattayakhom A, Hiransai P, Kamdee K, Utaipan T, Utaipan T, et al: 1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 <em>in silico</em>. Mol Med Rep 23: 209, 2021.
APA
Jansakun, C., Chulrik, W., Chaichompoo, W., Yotmanee, P., Lehboon, K., Chunglok, W. ... Chunglok, W. (2021). 1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 <em>in silico</em>. Molecular Medicine Reports, 23, 209. https://doi.org/10.3892/mmr.2021.11848
MLA
Jansakun, C., Chulrik, W., Chaichompoo, W., Yotmanee, P., Lehboon, K., Chunglok, W., Sattayakhom, A., Hiransai, P., Kamdee, K., Utaipan, T., Suksamrarn, A., Chunglok, W."1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 <em>in silico</em>". Molecular Medicine Reports 23.3 (2021): 209.
Chicago
Jansakun, C., Chulrik, W., Chaichompoo, W., Yotmanee, P., Lehboon, K., Chunglok, W., Sattayakhom, A., Hiransai, P., Kamdee, K., Utaipan, T., Suksamrarn, A., Chunglok, W."1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 <em>in silico</em>". Molecular Medicine Reports 23, no. 3 (2021): 209. https://doi.org/10.3892/mmr.2021.11848
Copy and paste a formatted citation
x
Spandidos Publications style
Jansakun C, Chulrik W, Chaichompoo W, Yotmanee P, Lehboon K, Chunglok W, Sattayakhom A, Hiransai P, Kamdee K, Utaipan T, Utaipan T, et al: 1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 <em>in silico</em>. Mol Med Rep 23: 209, 2021.
APA
Jansakun, C., Chulrik, W., Chaichompoo, W., Yotmanee, P., Lehboon, K., Chunglok, W. ... Chunglok, W. (2021). 1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 <em>in silico</em>. Molecular Medicine Reports, 23, 209. https://doi.org/10.3892/mmr.2021.11848
MLA
Jansakun, C., Chulrik, W., Chaichompoo, W., Yotmanee, P., Lehboon, K., Chunglok, W., Sattayakhom, A., Hiransai, P., Kamdee, K., Utaipan, T., Suksamrarn, A., Chunglok, W."1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 <em>in silico</em>". Molecular Medicine Reports 23.3 (2021): 209.
Chicago
Jansakun, C., Chulrik, W., Chaichompoo, W., Yotmanee, P., Lehboon, K., Chunglok, W., Sattayakhom, A., Hiransai, P., Kamdee, K., Utaipan, T., Suksamrarn, A., Chunglok, W."1,7‑Bis(4‑hydroxy‑3‑methoxyphenyl)‑1,4,6‑heptatrien‑3‑one alleviates lipopolysaccharide‑induced inflammation by targeting NF‑κB translocation in murine macrophages and it interacts with MD2 <em>in silico</em>". Molecular Medicine Reports 23, no. 3 (2021): 209. https://doi.org/10.3892/mmr.2021.11848
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