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Long non‑coding RNA NEAT1 promotes pulmonary fibrosis by regulating the microRNA‑455‑3p/SMAD3 axis

  • Authors:
    • Yuan Liu
    • Fu-Ai Lu
    • Le Wang
    • Yong-Fu Wang
    • Chun-Feng Wu
  • View Affiliations / Copyright

    Affiliations: Department of Rheumatology, Liuzhou People's Hospital, Liuzhou, Guangxi Autonomous Region 545006, P.R. China, Department of Rheumatology, First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia 014010, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 218
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    Published online on: January 20, 2021
       https://doi.org/10.3892/mmr.2021.11857
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Abstract

Pulmonary fibrosis is an excessive repair response to tissue damage, triggering hyperplasia of fibrotic connective tissues; however, there is no effective treatment in a clinical setting. The purpose of the present study was to investigate the roles of long non‑coding RNA nuclear enriched abundant transcript 1 (NEAT1) and microRNA‑455‑3p (miR‑455‑3p) were investigated in pulmonary fibrosis. In this study, the mRNA expression levels of NEAT1, miR‑455‑3p and SMAD3 in the HPAEpiC alveolar and BEAS‑2B bronchial epithelial cell lines were determined using reverse transcription‑quantitative PCR, while the markers of epithelial‑mesenchymal transformation (EMT) and collagen production were determined using western blot analysis. A wound healing assay was performed to evaluate the migratory ability of the HPAEpiC and BEAS‑2B cell lines. The interactions between NEAT1 and miR‑455‑3p or SMAD3 and miR‑455‑3p were validated using a luciferase reporter gene assay. The results showed that the mRNA expression levels of NEAT1 and SMAD3 were upregulated in the TGF‑β1‑treated HPAEpiC and BEAS‑2B cell lines, while the mRNA expression level of miR‑455‑3p was significantly decreased. In addition, silencing NEAT1 effectively alleviated the migratory ability, EMT and collagen generation of the epithelial cells. Following these experiments, NEAT1 was identified as a sponge for miR‑455‑3p, and SMAD3 was a target gene of miR‑455‑3p. NEAT1 downregulation or miR‑455‑3p mimic inhibited the migratory ability, EMT and collagen production of the epithelial cells; however, the effects were reversed by the overexpression of SMAD3. Furthermore, NEAT1 knockdown reduced the expression level of SMAD3 by increasing the expression level of miR‑455‑3p to further inhibit the migratory ability, EMT and collagen production of epithelial cells.
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View References

1 

Ley B, Collard HR and King TE Jr: Clinical course and prediction of survival in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 183:431–440. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Povedano JM, Martinez P, Flores JM, Mulero F and Blasco MA: Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction. Cell Rep. 12:286–299. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Selman M and Pardo A: Role of epithelial cells in idiopathic pulmonary fibrosis: From innocent targets to serial killers. Proc Am Thorac Soc. 3:364–372. 2006. View Article : Google Scholar : PubMed/NCBI

4 

Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, du Bois RM and Borok Z: Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: Potential role in idiopathic pulmonary fibrosis. Am J Pathol. 166:1321–1332. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Hou J, Shi J, Chen L, Lv Z, Chen X, Cao H, Xiang Z and Han X: M2 macrophages promote myofibroblast differentiation of LR-MSCs and are associated with pulmonary fibrogenesis. Cell Commun Signal. 16:892018. View Article : Google Scholar : PubMed/NCBI

6 

Saito S, Zhuang Y, Shan B, Danchuk S, Luo F, Korfei M, Guenther A and Lasky JA: Tubastatin ameliorates pulmonary fibrosis by targeting the TGFβ-PI3K-Akt pathway. PLoS One. 12:e01866152017. View Article : Google Scholar : PubMed/NCBI

7 

Esteller M: Non-coding RNAs in human disease. Nat Rev Genet. 12:861–874. 2011. View Article : Google Scholar : PubMed/NCBI

8 

Fabian MR, Sonenberg N and Filipowicz W: Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem. 79:351–379. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Li S, Geng J, Xu X, Huang X, Leng D, Jiang D, Liang J, Wang C, Jiang D and Dai H: miR-130b-3p Modulates Epithelial-Mesenchymal Crosstalk in Lung Fibrosis by Targeting IGF-1. PLoS One. 11:e01504182016. View Article : Google Scholar : PubMed/NCBI

10 

Wei S, Wang Q, Zhou H, Qiu J, Li C, Shi C, Zhou S, Liu R and Lu L: miR-455-3p Alleviates Hepatic Stellate Cell Activation and Liver Fibrosis by Suppressing HSF1 Expression. Mol Ther Nucleic Acids. 16:758–769. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Zhu XJ, Gong Z, Li SJ, Jia HP and Li DL: Long non-coding RNA Hottip modulates high-glucose-induced inflammation and ECM accumulation through miR-455-3p/WNT2B in mouse mesangial cells. Int J Clin Exp Pathol. 12:2435–2445. 2019.PubMed/NCBI

12 

Yu F, Jiang Z, Chen B, Dong P and Zheng J: NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6. J Mol Med (Berl). 95:1191–1202. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Huang S, Xu Y, Ge X, Xu B, Peng W, Jiang X, Shen L and Xia L: Long noncoding RNA NEAT1 accelerates the proliferation and fibrosis in diabetic nephropathy through activating Akt/mTOR signaling pathway. J Cell Physiol. 234:11200–11207. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Yao W, Li Y, Han L, Ji X, Pan H, Liu Y, Yuan J, Yan W and Ni C: The CDR1as/miR-7/TGFBR2 Axis Modulates EMT in Silica-Induced Pulmonary Fibrosis. Toxicol Sci. 166:465–478. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Zhao X, Sun J, Chen Y, Su W, Shan H, Li Y, Wang Y, Zheng N, Shan H and Liang H: lncRNA PFAR Promotes Lung Fibroblast Activation and Fibrosis by Targeting miR-138 to Regulate the YAP1-Twist Axis. Mol Ther. 26:2206–2217. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

17 

Wang X, Cheng Z, Dai L, Jiang T, Jia L, Jing X, An L, Wang H and Liu M: Knockdown of Long Noncoding RNA H19 Represses the Progress of Pulmonary Fibrosis through the Transforming Growth Factor β/Smad3 Pathway by Regulating MicroRNA 140. Mol Cell Biol. 39:e00143–19. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Wu Q, Han L, Yan W, Ji X, Han R, Yang J, Yuan J and Ni C: miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF. Sci Rep. 6:309212016. View Article : Google Scholar : PubMed/NCBI

19 

Sun J, Su W, Zhao X, Shan T, Jin T, Guo Y, Li C, Li R, Zhou Y, Shan H, et al: lncRNA PFAR contributes to fibrogenesis in lung fibroblasts through competitively binding to miR-15a. Biosci Rep. 39:BSR201902802019. View Article : Google Scholar : PubMed/NCBI

20 

Zhao X, Sun J, Chen Y, Su W, Shan H, Li Y, Wang Y, Zheng N, Shan H and Liang H: lncRNA PFAR Promotes Lung Fibroblast Activation and Fibrosis by Targeting miR-138 to Regulate the YAP1-Twist Axis. Mol Ther. 26:2206–2217. 2018. View Article : Google Scholar : PubMed/NCBI

21 

Hao X, Du Y, Qian L, Li D and Liu X: Upregulation of long noncoding RNA AP003419.16 predicts high risk of aging associated idiopathic pulmonary fibrosis. Mol Med Rep. 16:8085–8091. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Li JH, Zhang SQ, Qiu XG, Zhang SJ, Zheng SH and Zhang DH: Long non-coding RNA NEAT1 promotes malignant progression of thyroid carcinoma by regulating miRNA-214. Int J Oncol. 50:708–716. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Li X, Wang S, Li Z, Long X, Guo Z, Zhang G, Zu J, Chen Y and Wen L: Retracted: NEAT1 induces epithelial-mesenchymal transition and 5-FU resistance through the miR-129/ZEB2 axis in breast cancer. FEBS Lett. Nov 1–2016.(Epub ahead of print). doi: 10.1002/1873-3468.12474.

24 

Liu T, Zhang Y, Liu W and Zhao J: lncRNA NEAT1 Regulates the Development of Parkinson's Disease by Targeting AXIN1 Via Sponging miR-212-3p. Neurochem Res. Nov 26–2020.(Epub ahead of print). doi: 10.1007/s11064-020-03157-1. View Article : Google Scholar

25 

Liu L, Liu F, Sun Z, Peng Z, You T and Yu Z: lncRNA NEAT1 promotes apoptosis and inflammation in LPS-induced sepsis models by targeting miR-590-3p. Exp Ther Med. 20:3290–3300. 2020.PubMed/NCBI

26 

Dong C, Gongora R, Sosulski ML, Luo F and Sanchez CG: Regulation of transforming growth factor-beta1 (TGF-β1)-induced pro-fibrotic activities by circadian clock gene BMAL1. Respir Res. 17:42016. View Article : Google Scholar : PubMed/NCBI

27 

Yoshida M, Romberger DJ, Illig MG, Takizawa H, Sacco O, Spurzem JR, Sisson JH, Rennard SI and Beckmann JD: Transforming growth factor-beta stimulates the expression of desmosomal proteins in bronchial epithelial cells. Am J Respir Cell Mol Biol. 6:439–445. 1992. View Article : Google Scholar : PubMed/NCBI

28 

Ma J, Zhao N, Du L and Wang Y: Downregulation of lncRNA NEAT1 inhibits mouse mesangial cell proliferation, fibrosis, and inflammation but promotes apoptosis in diabetic nephropathy. Int J Clin Exp Pathol. 12:1174–1183. 2019.PubMed/NCBI

29 

Jin SS, Lin XF, Zheng JZ, Wang Q and Guan HQ: lncRNA NEAT1 regulates fibrosis and inflammatory response induced by nonalcoholic fatty liver by regulating miR-506/GLI3. Eur Cytokine Netw. 30:98–106. 2019.PubMed/NCBI

30 

Li X, Ye S and Lu Y: Long non-coding RNA NEAT1 overexpression associates with increased exacerbation risk, severity, and inflammation, as well as decreased lung function through the interaction with microRNA-124 in asthma. J Clin Lab Anal. 34:e230232020.PubMed/NCBI

31 

Zhao Y, Yan M, Yun Y, Zhang J, Zhang R, Li Y, Wu X, Liu Q, Miao W and Jiang H: MicroRNA-455-3p functions as a tumor suppressor by targeting eIF4E in prostate cancer. Oncol Rep. 37:2449–2458. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Zheng J, Lin Z, Zhang L and Chen H: MicroRNA-455-3p Inhibits Tumor Cell Proliferation and Induces Apoptosis in HCT116 Human Colon Cancer Cells. Med Sci Monit. 22:4431–4437. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Zhan T, Huang X, Tian X, Chen X, Ding Y, Luo H and Zhang Y: Downregulation of MicroRNA-455-3p Links to Proliferation and Drug Resistance of Pancreatic Cancer Cells via Targeting TAZ. Mol Ther Nucleic Acids. 10:215–226. 2018. View Article : Google Scholar : PubMed/NCBI

34 

Guo J, Liu C, Wang W, Liu Y, He H, Chen C, Xiang R and Luo Y: Identification of serum miR-1915-3p and miR-455-3p as biomarkers for breast cancer. PLoS One. 13:e02007162018. View Article : Google Scholar : PubMed/NCBI

35 

Zhou Y and Chai X: Protective effect of bicyclol against pulmonary fibrosis via regulation of microRNA-455-3p in rats. J Cell Biochem. 121:651–660. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Wu J, Liu J, Ding Y, Zhu M, Lu K, Zhou J, Xie X, Xu Y, Shen X, Chen Y, et al: MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy. Biochem Biophys Res Commun. 503:977–983. 2018. View Article : Google Scholar : PubMed/NCBI

37 

Derynck R and Zhang YE: Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature. 425:577–584. 2003. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu Y, Lu F, Wang L, Wang Y and Wu C: Long non‑coding RNA NEAT1 promotes pulmonary fibrosis by regulating the microRNA‑455‑3p/SMAD3 axis. Mol Med Rep 23: 218, 2021.
APA
Liu, Y., Lu, F., Wang, L., Wang, Y., & Wu, C. (2021). Long non‑coding RNA NEAT1 promotes pulmonary fibrosis by regulating the microRNA‑455‑3p/SMAD3 axis. Molecular Medicine Reports, 23, 218. https://doi.org/10.3892/mmr.2021.11857
MLA
Liu, Y., Lu, F., Wang, L., Wang, Y., Wu, C."Long non‑coding RNA NEAT1 promotes pulmonary fibrosis by regulating the microRNA‑455‑3p/SMAD3 axis". Molecular Medicine Reports 23.3 (2021): 218.
Chicago
Liu, Y., Lu, F., Wang, L., Wang, Y., Wu, C."Long non‑coding RNA NEAT1 promotes pulmonary fibrosis by regulating the microRNA‑455‑3p/SMAD3 axis". Molecular Medicine Reports 23, no. 3 (2021): 218. https://doi.org/10.3892/mmr.2021.11857
Copy and paste a formatted citation
x
Spandidos Publications style
Liu Y, Lu F, Wang L, Wang Y and Wu C: Long non‑coding RNA NEAT1 promotes pulmonary fibrosis by regulating the microRNA‑455‑3p/SMAD3 axis. Mol Med Rep 23: 218, 2021.
APA
Liu, Y., Lu, F., Wang, L., Wang, Y., & Wu, C. (2021). Long non‑coding RNA NEAT1 promotes pulmonary fibrosis by regulating the microRNA‑455‑3p/SMAD3 axis. Molecular Medicine Reports, 23, 218. https://doi.org/10.3892/mmr.2021.11857
MLA
Liu, Y., Lu, F., Wang, L., Wang, Y., Wu, C."Long non‑coding RNA NEAT1 promotes pulmonary fibrosis by regulating the microRNA‑455‑3p/SMAD3 axis". Molecular Medicine Reports 23.3 (2021): 218.
Chicago
Liu, Y., Lu, F., Wang, L., Wang, Y., Wu, C."Long non‑coding RNA NEAT1 promotes pulmonary fibrosis by regulating the microRNA‑455‑3p/SMAD3 axis". Molecular Medicine Reports 23, no. 3 (2021): 218. https://doi.org/10.3892/mmr.2021.11857
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