Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2021 Volume 23 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2021 Volume 23 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation

  • Authors:
    • Ting Cai
    • Wenquan Wu
    • Longhua Guo
    • Yongwu Xia
    • Xiaoxin Jiang
    • Limei Zhang
    • Feiding Peng
    • Pinghong Ming
  • View Affiliations / Copyright

    Affiliations: Department of Acupuncture and Moxibustion, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518055, P.R. China, Department of Clinical Laboratory, The People's Hospital of Longhua, Shenzhen, Guangdong 518109, P.R. China
    Copyright: © Cai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 242
    |
    Published online on: February 1, 2021
       https://doi.org/10.3892/mmr.2021.11881
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Notoginsenoside R1 (NGR1), a monomer of Traditional Chinese medicine, is from the Panax notoginsenoside complex, and has been reported to inhibit the proliferation of various types of cancer. However the mechanism underlying NGR1‑mediated inhibition of cervical carcinoma cell proliferation remains unclear. Therefore, the current study aimed to investigate the antitumor effects of NGR1 on cervical carcinoma cell lines (CaSki and HeLa cells) in vitro. The Cell Counting Kit‑8 and soft agar cell colony formation assay results revealed that NGR1 suppressed the viability and the number colonies of CaSki and HeLa cells, respectively. Furthermore, the DAPI staining, flow cytometry and western blotting results revealed that NGR1 induced cervical carcinoma cell apoptosis, cell cycle arrest in the S phase, upregulation of cyclin A2 and CDK2 expression levels, and downregulation of cyclin D1 expression levels. To further investigate the mechanisms of NGR1, DNA‑damage‑related proteins, including H2A.X variant histone (H2AX), ATR serine/threonine kinase (ATR) and p53, and the nucleolus protein, plant homeodomain finger protein 6 (PHF6) were analyzed. The results indicated that NGR1 triggered the phosphorylation of H2AX and ATR in a dose‑ and time‑dependent manner, and downregulated the expression level of PHF6 and upregulated the expression level of p53 in a dose‑ and time‑dependent manner. In conclusion, the findings of the present indicated that NGR1 may inhibit the viability of cervical carcinoma cells and induce cell apoptosis via DNA damage, which may be activated by the downregulation of PHF6 expression levels, and the subsequent triggering of the phosphorylation of H2AX and ATR. In addition, NGR1 may exert an ability to arrest cervical carcinoma cells in the S phase and upregulate the expression levels of cyclin A2 and CDK2. Therefore, NGR1 may serve as a novel chemotherapeutic agent for cervical carcinoma.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Pineros M, Znaor A, Soerjomataram I and Bray F: Global Cancer Observatory: Cancer Today. International Agency for Research on Cancer; Lyon: 2018

2 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Silver MI and Kobrin S: Exacerbating disparities? Cervical cancer screening and HPV vaccination. Prev Med. 130:1059022020. View Article : Google Scholar : PubMed/NCBI

4 

Cervical cancer analysis reveals new mutations. Cancer Discov. 7:3442017.

5 

Kailash U, Soundararajan CC, Lakshmy R, Arora R, Vivekanandhan S and Das BC: Telomerase activity as an adjunct to high-risk human papillomavirus types 16 and 18 and cytology screening in cervical cancer. Br J Cancer. 95:1250–1257. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Sharma A, Rajappa M, Saxena A and Sharma M: Telomerase activity as a tumor marker in Indian women with cervical intraepithelial neoplasia and cervical cancer. Mol Diagn Ther. 11:193–201. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Li C, Ma C, Zhang W and Wang J: The immune function differences and high-risk human papillomavirus infection in the progress of cervical cancer. Eur J Gynaecol Oncol. 35:557–561. 2014.PubMed/NCBI

8 

Lindström AK and Hellberg D: Immunohistochemical LRIG3 expression in cervical intraepithelial neoplasia and invasive squamous cell cervical cancer: Association with expression of tumor markers, hormones, high-risk HPV-infection, smoking and patient outcome. Eur J Histochem. 58:22272014. View Article : Google Scholar : PubMed/NCBI

9 

Falletta P, Sanchez-del-Campo L, Chauhan J, Effern M, Kenyon A, Kershaw CJ, Siddaway R, Lisle R, Freter R, Daniels MJ, et al: Translation reprogramming is an evolutionarily conserved driver of phenotypic plasticity and therapeutic resistance in melanoma. Genes Deve. 31:18–33. 2017. View Article : Google Scholar

10 

Wang F, Li L, Liu B, Chen Z and Li C: Hyaluronic acid decorated pluronic P85 solid lipid nanoparticles as a potential carrier to overcome multidrug resistance in cervical and breast cancer. Biomed Pharmacother. 86:595–604. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Yang BR, Cheung KK, Zhou X, Xie RF, Cheng PP, Wu S, Zhou ZY, Tang JY, Hoi PM, Wang YH and Lee SM: Amelioration of acute myocardial infarction by saponins from flower buds of Panax notoginseng via pro-angiogenesis and anti-apoptosis. J Ethnopharmacol. 181:50–58. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Wang P, Zhang L, Yao J, Shi Y, Li P and Ding K: An arabinogalactan from flowers of Panax notoginseng inhibits angiogenesis by BMP2/Smad/Id1 signaling. Carbohydr Polym. 121:328–335. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Su P, Wang L, Du SJ, Xin WF and Zhang WS: Advance in studies of Panax notoginseng saponins on pharmacological mechanism of nervous system disease. Zhongguo Zhong Yao Za Zhi. 39:4516–4521. 2014.(In Chinese). PubMed/NCBI

14 

Xia W, Sun C, Zhao Y and Wu L: Hypolipidemic and antioxidant activities of sanchi (Radix notoginseng) in rats fed with a high fat diet. Phytomedicine. 18:516–520. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Zhao Y, Sun X, Yu X, Gao R and Yin L: Saponins from Panax notoginseng leaves improve the symptoms of aplastic anemia and aberrant immunity in mice. Biomed Pharmacother. 102:959–965. 2018. View Article : Google Scholar : PubMed/NCBI

16 

He NW, Zhao Y, Guo L, Shang J and Yang XB: Antioxidant, antiproliferative, and Pro-apoptotic activities of a Saponin extract derived from the roots of Panax notoginseng (Burk.) F.H. Chen. J Med Food. 15:350–359. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Yan Z, Zhu ZL, Wang HQ, Li W, Mi YX and Liu CX: Pharmacokinetics of panaxatrol disuccinate sodium, a novel anti-cancer drug from Panax notoginseng, in healthy volunteers and patients with advanced solid tumors. Acta Pharmacol Sin. 31:1515–1522. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Wan CZ, Xie JT, Fishbein A, Aung HH, He H, Mehendale SR, He TC, Du W and Yuan CS: Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells. Phytother Res. 23:6–13. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Cong S, Xiang L, Yuan X, Bai D and Zhang X: Notoginsenoside R1 up-regulates microRNA-132 to protect human lung fibroblast MRC-5 cells from lipopolysaccharide-caused injury. Int Immunopharmacol. 68:137–144. 2019. View Article : Google Scholar : PubMed/NCBI

20 

Ming P, Cai T, Li J, Ning Y, Xie S, Tao T and Tang F: A novel arylbenzofuran induces cervical cancer cell apoptosis and G1/S arrest through ERK-mediated Cdk2/cyclin-A signaling pathway. Oncotarget. 7:41843–41856. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Chen DL, Engle JT, Griffin EA, Miller JP, Chu W, Zhou D and Mach RH: Imaging Caspase-3 activation as a marker of apoptosis-targeted treatment response in cancer. Mol Imaging Biol. 17:384–393. 2014. View Article : Google Scholar

22 

Wang Y, Luo W and Wang Y: PARP-1 and its associated nucleases in DNA damage response. DNA Repair (Amst). 81:1026512019. View Article : Google Scholar : PubMed/NCBI

23 

Caron MC, Sharma AK, O'Sullivan J, Myler LR, Ferreira MT, Rodrigue A, Coulombe Y, Ethier C, Gagné JP, Langelier MF, et al: Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks. Nat Commun. 10:29542019. View Article : Google Scholar : PubMed/NCBI

24 

Siddiqui WA, Ahad A and Ahsan H: The mystery of BCL2 family: Bcl-2 proteins and apoptosis: An update. Arch Toxicol. 89:289–317. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Todd MA, Huh MS and Picketts DJ: The sub-nucleolar localization of PHF6 defines its role in rDNA transcription and early processing events. Eur J Human Genet. 10:1453–1459. 2016. View Article : Google Scholar

26 

Todd MA and Picketts DJ: PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex. J Proteome Res. 11:4326–4337. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Wang J, Leung JWC, Gong Z, Feng L, Shi X and Chen J: PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem. 288:3174–3183. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Zhao J, Cui L, Sun J, Xie Z, Zhang L, Ding Z and Quan X: Notoginsenoside R1 alleviates oxidized low-density lipoprotein-induced apoptosis, inflammatory response, and oxidative stress in HUVECS through modulation of XIST/miR-221-3p/TRAF6 axis. Cell Signall. 76:1097812020. View Article : Google Scholar

29 

Zhong L, Zhou XL, Liu YS, Wang YM, Ma F, Guo BL, Yan ZQ and Zhang QY: Estrogen receptor α mediates the effects of notoginsenoside R1 on endotoxin-induced inflammatory and apoptotic responses in H9c2 cardiomyocytes. Mol Med Rep. 12:119–126. 2015. View Article : Google Scholar : PubMed/NCBI

30 

He K, Yan L, Pan CS, Liu YY, Cui YC, Hu BH, Chang X, Li Q, Sun K, Mao XW, et al: ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury. Am J Physiol Heart Circ Physiol. 307:H1764–H1776. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Yu Y, Sun G, Luo Y, Wang M, Chen R, Zhang J, Ai Q, Xing N and Sun X: Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress-related signaling pathways. Sci Rep. 6:217302016. View Article : Google Scholar : PubMed/NCBI

32 

Peng Y, Li SN, Pei X and Hao K: The multivariate regression statistics strategy to investigate content-effect correlation of multiple components in Traditional Chinese Medicine based on a partial least squares method. Molecules. 23:5452018. View Article : Google Scholar

33 

Li Y, Li Z, Jia Y, Ding B and Yu J: In vitro Anti-hepatoma activities of Notoginsenoside R1 through downregulation of tumor promoter miR-21. Dig Dis Sci. 65:1364–1375. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Lee CY, Hsieh SL, Hsieh S, Tsai CC, Hsieh LC, Kuo YH and Wu CC: Inhibition of human colorectal cancer metastasis by notoginsenoside R1, an important compound from Panax notoginseng. Oncol Rep. 37:399–407. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Limsuwanchote S, Wungsintaweekul J, Yusakul G, Han JY, Sasaki-Tabata K, Tanaka H, Shoyama Y and Morimoto S: Preparation of a monoclonal antibody against Notoginsenoside R1, a distinctive saponin from Panax notoginseng, and its application to indirect competitive ELISA. Planta Medica. 80:337–342. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Sun HX, Chen Y and Ye Y: Ginsenoside Re and notoginsenoside R1: Immunologic adjuvants with low haemolytic effect. Chem Biodivers. 3:718–726. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Dwyer DJ, Camacho DM, Kohanski MA, Callura JM and Collins JJ: Antibiotic-induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis. Mol Cell. 46:561–572. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Li Y, Zhou M, Hu Q, Bai XC, Huang W, Scheres SH and Shi Y: Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme. Proc Natl Acad Sci USA. 114:1542–1547. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Funk K, Czauderna C, Klesse R, Becker D, Hajduk J, Oelgeklaus A, Reichenbach F, Fimm-Todt F, Lauterwasser J, Galle PR, et al: BAX redistribution induces apoptosis resistance and selective stress sensitivity in human HCC. Cancers (Basel). 12:14372020. View Article : Google Scholar

40 

Kulkarni S, Micci MA, Leser J, Shin C, Tang SC, Fu YY, Liu L, Li Q, Saha M, Li C, et al: Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis. Proc Natl Acad Sci USA. 114:E3709–E3718. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Marchi S, Patergnani S, Missiroli S, Morciano G, Rimessi A, Wieckowski MR, Giorgi C and Pinton P: Mitochondrial and endoplasmic reticulum calcium homeostasis and cell death. Cell Calcium. 69:62–72. 2018. View Article : Google Scholar : PubMed/NCBI

42 

Stadler J and Richly H: Regulation of DNA repair mechanisms: How the chromatin environment regulates the DNA damage response. Int J Mol Sci. 18:17152017. View Article : Google Scholar

43 

Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER III, Hurov KE, Luo J, Bakalarski CE, Zhao Z, Solimini N, Lerenthal Y, et al: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science. 316:1160–1166. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Zheng L, Dai H, Zhou M, Li X, Liu C, Guo Z, Wu X, Wu J, Wang C, Zhong J, et al: Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression. Nat Commun. 3:8152012. View Article : Google Scholar : PubMed/NCBI

45 

Lowndes NF and Toh GW: DNA repair: The importance of phosphorylating histone H2AX. Curr Biol. 15:R99–R102. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Jakob B, Splinter J, Conrad S, Voss KO, Zink D, Durante M, Löbrich M and Taucher-Scholz G: DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin. Nucleic Acids Res. 39:6489–6499. 2011. View Article : Google Scholar : PubMed/NCBI

47 

Müller B, Ellinwood NM, Lorenz B and Stieger K: Detection of DNA double strand breaks by γH2AX does not result in 53bp1 recruitment in mouse retinal tissues. Front Neurosci. 12:2862018. View Article : Google Scholar : PubMed/NCBI

48 

Zhang C, Mejia LA, Huang J, Valnegri P, Bennett EJ, Anckar J, Jahani-Asl A, Gallardo G, Ikeuchi Y, Yamada T, et al: The X-linked intellectual disability protein PHF6 associates with the PAF1 complex and regulates neuronal migration in the mammalian brain. Neuron. 78:986–993. 2013. View Article : Google Scholar : PubMed/NCBI

49 

Vallée D, Chevrier E, Graham GE, Lazzaro MA, Lavigne PA, Hunter AG and Picketts DJ: A novel PHF6 mutation results in enhanced exon skipping and mild Borjeson-Forssman-Lehmann syndrome. J Med Genet. 41:778–783. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Rocha CRR, Silva MM, Quinet A, Cabral-Neto JB and Menck CFM: DNA repair pathways and cisplatin resistance: An intimate relationship. Clinics (Sao Paulo). 73 (Suppl 1):e478s2018. View Article : Google Scholar : PubMed/NCBI

51 

Salehan MR and Morse HR: DNA damage repair and tolerance: A role in chemotherapeutic drug resistance. Br J Biomed Sci. 70:31–40. 2016. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Cai T, Wu W, Guo L, Xia Y, Jiang X, Zhang L, Peng F and Ming P: Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation. Mol Med Rep 23: 242, 2021.
APA
Cai, T., Wu, W., Guo, L., Xia, Y., Jiang, X., Zhang, L. ... Ming, P. (2021). Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation. Molecular Medicine Reports, 23, 242. https://doi.org/10.3892/mmr.2021.11881
MLA
Cai, T., Wu, W., Guo, L., Xia, Y., Jiang, X., Zhang, L., Peng, F., Ming, P."Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation". Molecular Medicine Reports 23.4 (2021): 242.
Chicago
Cai, T., Wu, W., Guo, L., Xia, Y., Jiang, X., Zhang, L., Peng, F., Ming, P."Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation". Molecular Medicine Reports 23, no. 4 (2021): 242. https://doi.org/10.3892/mmr.2021.11881
Copy and paste a formatted citation
x
Spandidos Publications style
Cai T, Wu W, Guo L, Xia Y, Jiang X, Zhang L, Peng F and Ming P: Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation. Mol Med Rep 23: 242, 2021.
APA
Cai, T., Wu, W., Guo, L., Xia, Y., Jiang, X., Zhang, L. ... Ming, P. (2021). Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation. Molecular Medicine Reports, 23, 242. https://doi.org/10.3892/mmr.2021.11881
MLA
Cai, T., Wu, W., Guo, L., Xia, Y., Jiang, X., Zhang, L., Peng, F., Ming, P."Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation". Molecular Medicine Reports 23.4 (2021): 242.
Chicago
Cai, T., Wu, W., Guo, L., Xia, Y., Jiang, X., Zhang, L., Peng, F., Ming, P."Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation". Molecular Medicine Reports 23, no. 4 (2021): 242. https://doi.org/10.3892/mmr.2021.11881
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team