Open Access

GINS2 affects cell proliferation, apoptosis, migration and invasion in thyroid cancer via regulating MAPK signaling pathway

  • Authors:
    • Saifei He
    • Miao Zhang
    • Ying Ye
    • Yanan Song
    • Xing Ma
    • Guoyu Wang
    • Juhua Zhuang
    • Wei Xia
    • Bin Zhao
  • View Affiliations

  • Published online on: February 1, 2021     https://doi.org/10.3892/mmr.2021.11885
  • Article Number: 246
  • Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Globally, thyroid cancer (TC) is considered to be the commonest endocrine malignancy. GINS complex subunit 2 (GINS2) belongs to the GINS complex family and is associated with cellular migration, invasion and growth. The present study aimed to investigate the underlying mechanisms of GINS2 on cell viability, migration and invasion in TC cells. By using MTT, wound healing and Transwell assays, the cell viability, migration and invasion were determined. Apoptosis was examined by immunofluorescence. Western blotting was used to detect protein expression levels. In the present study, biological function analysis demonstrated that GINS2 interference attenuated cell viability, migration and invasion in TC cell lines (K1 and SW579). It was discovered that, compared with the control group, GINS2 silencing induced apoptosis in TC cells. Additionally, GINS2 interference inhibited key proteins in the MAPK signaling pathway, including JNK, ERK and p38. According to these comparative experiments, GINS2 was considered to act a pivotal part in cell viability, migration and invasion of TC by regulating the MAPK signaling pathway and might be a potential therapeutic target for treating TC.
View Figures
View References

Related Articles

Journal Cover

April-2021
Volume 23 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
He S, Zhang M, Ye Y, Song Y, Ma X, Wang G, Zhuang J, Xia W and Zhao B: GINS2 affects cell proliferation, apoptosis, migration and invasion in thyroid cancer via regulating MAPK signaling pathway. Mol Med Rep 23: 246, 2021
APA
He, S., Zhang, M., Ye, Y., Song, Y., Ma, X., Wang, G. ... Zhao, B. (2021). GINS2 affects cell proliferation, apoptosis, migration and invasion in thyroid cancer via regulating MAPK signaling pathway. Molecular Medicine Reports, 23, 246. https://doi.org/10.3892/mmr.2021.11885
MLA
He, S., Zhang, M., Ye, Y., Song, Y., Ma, X., Wang, G., Zhuang, J., Xia, W., Zhao, B."GINS2 affects cell proliferation, apoptosis, migration and invasion in thyroid cancer via regulating MAPK signaling pathway". Molecular Medicine Reports 23.4 (2021): 246.
Chicago
He, S., Zhang, M., Ye, Y., Song, Y., Ma, X., Wang, G., Zhuang, J., Xia, W., Zhao, B."GINS2 affects cell proliferation, apoptosis, migration and invasion in thyroid cancer via regulating MAPK signaling pathway". Molecular Medicine Reports 23, no. 4 (2021): 246. https://doi.org/10.3892/mmr.2021.11885