Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2021 Volume 23 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2021 Volume 23 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging

  • Authors:
    • Lihua Zhuang
    • Yingnan Kong
    • Shuohui Yang
    • Fang Lu
    • Zhigang Gong
    • Songhua Zhan
    • Mengxiao Liu
  • View Affiliations / Copyright

    Affiliations: Department of Radiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, P.R. China, MR Scientific Marketing, Siemens Healthcare, Shanghai 201318, P.R. China
    Copyright: © Zhuang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 282
    |
    Published online on: February 18, 2021
       https://doi.org/10.3892/mmr.2021.11921
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The inflammatory response and apoptosis are key factors in cerebral ischemia‑reperfusion injury. The severity of the inflammatory reaction and apoptosis has an important impact on the prognosis of stroke. The ultrasmall superparamagnetic iron oxide particle has provided an effective magnetic resonance molecular imaging method for dynamic observation of the cell infiltration process in vivo. The aims of the present study were to investigate the inflammatory response of cerebral ischemia‑reperfusion injury in mice using ferumoxytol‑enhanced magnetic resonance imaging, and to observe the dynamic changes of inflammatory response and apoptosis. In the present study a C57BL/6n mouse cerebral ischemia‑reperfusion model was established by blocking the right middle cerebral artery with an occluding suture. Subsequently, the mice were injected with ferumoxytol via the tail vein, and magnetic resonance scanning was performed at corresponding time points to observe the signal changes. Furthermore, blood samples were used to measure the level of serum inflammatory factors, and histological staining was performed to assess the number of iron‑swallowing microglial cells and apoptotic cells. The present results suggested that there was no significant difference in the serum inflammatory factors tumor necrosis factor‑α and interleukin 1β between the middle cerebral artery occlusion (MCAO) and MCAO + ferumoxytol groups injected with ferumoxytol and physiological saline. The lowest signal ratio in the negative enhancement region was decreased 24 h after reperfusion in mice injected with ferumoxytol. The proportion of iron‑swallowing microglial cells and TUNEL‑positive cells were the highest at 24 h after reperfusion, and decreased gradually at 48 and 72 h after reperfusion. Therefore, the present results indicated that ferumoxytol injection of 18 mg Fe/kg does not affect the inflammatory response in the acute phase of cerebral ischemia and reperfusion. Ferumoxytol‑enhanced magnetic resonance imaging can be used as an effective means to monitor the inflammatory response in the acute phase of cerebral ischemia‑reperfusion injury. Furthermore, it was found that activation of the inflammatory response and apoptosis in the acute stage of cerebral ischemia‑reperfusion injury is consistent.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Guzik A and Bushnell C: Stroke epidemiology and risk factor management. Continuum (Minneapolis, Minn.). 23:15–39. 2017.PubMed/NCBI

2 

Wang Y, Cui L, Ji X, Dong Q, Zeng J, Wang Y, Zhou Y, Zhao X, Wang C, Liu L, et al: The China national stroke registry for patients with acute cerebrovascular events: Design, rationale, and baseline patient characteristics. Int J Stroke. 6:355–361. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Duris K and Jurajda M: Evolutionary concept of inflammatory response and stroke. J Neurosci Res. 98:98–104. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Radak D, Katsiki N, Resanovic I, Jovanovic A, Sudar-Milovanovic E, Zafirovic S, Mousad SA and Isenovic ER: Apoptosis and acute brain ischemia in ischemic stroke. Curr Vasc Pharmacol. 15:115–122. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Kim E and Cho S: Microglia and monocyte-derived macrophages in stroke. Neurotherapeutics. 13:702–718. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Jin R, Yang G and Li G: Inflammatory mechanisms in ischemic stroke: Role of inflammatory cells. J Leukoc Biol. 87:779–789. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Duris K, Splichal Z and Jurajda M: The role of inflammatory response in stroke associated programmed cell death. Curr Neuropharmacol. 16:1365–1374. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Chauveau F, Cho TH, Berthezene Y, Nighoghossian N and Wiart M: Imaging inflammation in stroke using magnetic resonance imaging. Int J Clin Pharmacol Ther. 48:718–728. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Antonucci MU and Yazdani M: A helpful tool in diagnosing stroke mimics: Arterial spin labeled perfusion magnetic resonanceimaging. J Emerg Med. Mar 18–2020.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

11 

Rausch M, Sauter A, Fröhlich J, Neubacher U, Radü EW and Rudin M: Dynamic patterns of USPIO enhancement canbe observed in macrophages after ischemic braindamage. Magn Reson Med. 46:1018–1022. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Weissleder R, Stark DD, Engelstad BL, Bacon BR, Compton CC, White DL, Jacobs P and Lewis J: Superparamagnetic iron oxide: Pharmacokinetics and toxicity. AJR Am J Roentgenol. 152:167–173. 1989. View Article : Google Scholar : PubMed/NCBI

13 

Hedgire S, Krebill C, Wojtkiewicz GR, Oliveira I, Ghoshhajra BB, Hoffmann U and Harisinghani MG: Ultrasmall superparamagnetic iron oxide nanoparticle uptake as noninvasive marker of aortic wall inflammation on MRI: Proof of concept study. Br J Radiol. 91:201804612018. View Article : Google Scholar : PubMed/NCBI

14 

Duan X, Wang Y, Zhang F, Lu L, Cao M, Lin B, Zhang X, Mao J, Shuai X and Shen J: Superparamagnetic Iron Oxide-loaded cationic polymersomes for cellular MR imaging of therapeutic stem cells in stroke. J Biomed Nanotechnol. 12:2112–2124. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Debats OA, Fortuin AS, Meijer HJ, Hambrock T, Litjens GJ, Barentsz JO and Huisman HJ: Intranodal signal suppression in pelvic MR lymphography of prostate cancer patients: A quantitative comparison of ferumoxtran-10 and ferumoxytol. PeerJ. 4:e24712016. View Article : Google Scholar : PubMed/NCBI

16 

Farr TD, Lai CH, Grünstein D, Orts-Gil G, Wang CC, Boehm-Sturm P, Seeberger PH and Harms C: Imaging early endothelial inflammation following stroke by core shell silica superparamagnetic glyconanoparticles that target selectin. Nano Lett. 14:2130–2134. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Beckmann N, Cannet C, Babin AL, Blé FX, Zurbruegg S, Kneuer R and Dousset V: In vivo visualization of macrophage infiltration and activity in inflammation using magnetic resonance imaging. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 1:272–298. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Brochet B, Deloire MS, Touil T, Anne O, Caillé JM, Dousset V and Petry KG: Early macrophage MRI of inflammatory lesions predicts lesion severity and disease development in relapsing EAE. Neuroimage. 32:266–274. 2006. View Article : Google Scholar : PubMed/NCBI

19 

Marinescu M, Chauveau F, Durand A, Riou A, Cho TH, Dencausse A, Ballet S, Nighoghossian N, Berthezène Y and Wiart M: Monitoring therapeutic effects in experimental stroke by serial USPIO-enhanced MRI. Eur Radiol. 23:37–47. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Luther EM, Petters C, Bulcke F, Kaltz A, Thiel K, Bickmeyer U and Dringen R: Endocytotic uptake of iron oxide nanoparticles by cultured brain microglial cells. Acta Biomater. 9:8454–8465. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Gkagkanasiou M, Ploussi A, Gazouli M and Efstathopoulos EP: USPIO-Enhanced MRI Neuroimaging: A Review. J Neuroimaging. 26:161–168. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Strobel K, Hoerr V, Schmid F, Wachsmuth L, Löffler B and Faber C: Early detection of lung inflammation: Exploiting T1-effects of iron oxide particles using UTE MRI. Magn Reson Med. 68:1924–1931. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Belayev L, Alonso OF, Busto R, Zhao W and Ginsberg MD: Middle cerebral artery occlusion in the rat by intraluminal suture. Neurological and pathological evaluation of an improved model. Stroke. 27:1616–1623. 1996. View Article : Google Scholar : PubMed/NCBI

24 

Liu W, Wang X, Zheng Y, Shang G, Huang J, Tao J and Chen L: Electroacupuncture inhibits inflammatory injury by targeting the miR-9-mediated NF-κB signaling pathway following ischemic stroke. Mol Med Rep. 13:1618–1626. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Sage JE, Samii VF, Abramson CJ, Green EM, Smith M and Dingus C: Comparison of conventional spin-echo and fast spin-echo magnetic resonance imaging in the canine brain. Vet Radiol Ultrasound. 47:249–253. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Attenberger UI, Runge VM, Stemmer A, Williams KD, Naul LG, Michaely HJ, Schoenberg SO, Reiser MF and Wintersperger BJ: Diffusion weighted imaging: A comprehensive evaluation of a fast spin echo DWI sequence with BLADE (PROPELLER) k-space sampling at 3T, using a 32-channel head coil in acute brain ischemia. Invest Radiol. 44:656–661. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Ohsawa K, Imai Y, Sasaki Y and Kohsaka S: Microglia/macrophage-specific Protein Iba1 Binds to Fimbrin and Enhances Its Actin-bundling activity. J Neurochem. 88:844–856. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Annovazzi L, Mellai M, Bovio E, Mazzetti S, Pollo B and Schiffer D: Microglia immunophenotyping in gliomas. Oncol Lett. 15:998–1006. 2018.PubMed/NCBI

29 

Konishi H, Kobayashi M, Kunisawa T, Imai K, Sayo A, Malissen B, Crocker PR, Sato K and Kiyama H: Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes. Glia. 65:1927–1943. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Castaneda RT, Khurana A, Khan R and Daldrup-Link HE: Labeling stem cells with ferumoxytol, an FDA-approved iron oxide nanoparticle. J Vis Exp. e34822011.PubMed/NCBI

31 

Cui L, Hu J, Li CC, Wang CM and Zhang CY: An electrochemical biosensor based on the enhanced quasi-reversible redox signal of prussian blue generated by self-sacrificial label of iron metal-organic framework. Biosens Bioelectron. 122:168–174. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Ma Y, Ma L, Guo Q and Zhang S: Expression of bone morphogenetic protein-2 and its receptors in epithelial ovarian cancer and their influence on the prognosis of ovarian cancer patients. J Exp Clin Cancer Res. 29:852010. View Article : Google Scholar : PubMed/NCBI

33 

Anrather J and Iadecola C: Inflammation and stroke: An overview. Neurotherapeutics. 13:661–670. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Petrovic-Djergovic D, Goonewardena SN and Pinsky DJ: Inflammatory disequilibrium in stroke. Circ Res. 119:142–158. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Longa EZ, Weinstein PR, Carlson S and Cummins R: Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 20:84–91. 1989. View Article : Google Scholar : PubMed/NCBI

36 

Benedek A, Móricz K, Jurányi Z, Gigler G, Lévay G, Hársing LG Jr, Mátyus P, Szénási G and Albert M: Use of TTC staining for the evaluation of tissue injury in the early phases of reperfusion after focal cerebral ischemia in rats. Brain Res. 1116:159–165. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Moraga A, Gómez-Vallejo V, Cuartero MI, Szczupak B, San Sebastián E, Markuerkiaga I, Pradillo JM, Higuchi M, Llop J, Moro MÁ, et al: Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography. J Cereb Blood Flow Metab. 36:702–708. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Weinstein JS, Varallyay CG, Dosa E, Gahramanov S, Hamilton B, Rooney WD, Muldoon LL and Neuwelt EA: Superparamagnetic iron oxide nanoparticles: Diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review. J Cereb Blood Flow Metab. 30:15–35. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Shah A and Dobrovolskaia MA: Immunological effects of iron oxide nanoparticles and iron-based complex drug formulations: Therapeutic benefits, toxicity, mechanistic insights, and translational considerations. Nanomedicine. 14:977–990. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Weissleder R, Elizondo G, Wittenberg J, Rabito CA, Bengele HH and Josephson L: Ultrasmall superparamagnetic iron oxide: Characterization of a new class of contrast agents for MR imaging. Radiology. 175:489–493. 1990. View Article : Google Scholar : PubMed/NCBI

41 

Clemente-Casares X and Santamaria P: Nanomedicine in autoimmunity. Immunol Lett. 158:167–174. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Toyota T, Ohguri N, Maruyama K, Fujinami M, Saga T and Aoki I: Giant vesicles containing superparamagnetic iron oxide as biodegradable cell-tracking MRI probes. Anal Chem. 84:3952–3957. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Himmelreich U and Dresselaers T: Cell labeling and tracking for experimental models using magnetic resonance imaging. Methods. 48:112–124. 2009. View Article : Google Scholar : PubMed/NCBI

44 

von Zur Muhlen C, von Elverfeldt D, Bassler N, Neudorfer I, Steitz B, Petri-Fink A, Hofmann H, Bode C and Peter K: Superparamagnetic iron oxide binding and uptake as imaged by magnetic resonance is mediated by the integrin receptor Mac-1 (CD11b/CD18): Implications on imaging of atherosclerotic plaques. Atherosclerosis. 193:102–111. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Stoll G and Bendszus M: New approaches to neuroimaging of central nervous system inflammation. Curr Opin Neurol. 23:282–286. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Yang YM, Feng X, Yin le K, Li CC, Jia J and Du ZG: Comparison of USPIO-enhanced MRI and Gd-DTPA enhancement during the subacute stage of focal cerebral ischemia in rats. Acta Radiol. 55:864–873. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Nighoghossian N, Wiart M, Cakmak S, Berthezène Y, Derex L, Cho TH, Nemoz C, Chapuis F, Tisserand GL, Pialat JB, et al: Inflammatory response after ischemic stroke: A USPIO-enhanced MRI study in patients. Stroke. 38:303–307. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Balakrishnan VS, Rao M, Kausz AT, Brenner L, Pereira BJ, Frigo TB and Lewis JM: Physicochemical properties of ferumoxytol, a new intravenous iron preparation. Eur J Clin Invest. 39:489–496. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Toth GB, Varallyay CG, Horvath A, Bashir MR, Choyke PL, Daldrup-Link HE, Dosa E, Finn JP, Gahramanov S, Harisinghani M, et al: Current and potential imaging applications of ferumoxytol for magnetic resonance imaging. Kidney Int. 92:47–66. 2017. View Article : Google Scholar : PubMed/NCBI

50 

Bashir MR, Bhatti L, Marin D and Nelson RC: Emerging applications for ferumoxytol as a contrast agent in MRI. J Magn Reson Imaging. 41:884–898. 2015. View Article : Google Scholar : PubMed/NCBI

51 

Wiart M, Davoust N, Pialat JB, Desestret V, Moucharrafie S, Cho TH, Mutin M, Langlois JB, Beuf O, Honnorat J, et al: MRI monitoring of neuroinflammation in mouse focal ischemia. Stroke. 38:131–137. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Sekerdag E, Solaroglu I and Gursoy-Ozdemir Y: Cell death mechanisms in stroke and novel molecular and cellular treatment options. Curr Neuropharmacol. 16:1396–1415. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Kuschinsky W and Gillardon F: Apoptosis and cerebral ischemia. Cerebrovasc Dis. 10:165–169. 2000. View Article : Google Scholar : PubMed/NCBI

54 

Müller K, Skepper JN, Posfai M, Trivedi R, Howarth S, Corot C, Lancelot E, Thompson PW, Brown AP and Gillard JH: Effect of ultrasmall superparamagnetic iron oxide nanoparticles (Ferumoxtran-10) on human monocyte-macrophages in vitro. Biomaterials. 28:1629–1642. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Hsiao JK, Chu HH, Wang YH, Lai CW, Chou PT, Hsieh ST, Wang JL and Liu HM: Macrophage physiological function after superparamagnetic iron oxide labeling. NMR Biomed. 21:820–829. 2008. View Article : Google Scholar : PubMed/NCBI

56 

Siglienti I, Bendszus M, Kleinschnitz C and Stoll G: Cytokine profile of iron-laden macrophages: Implications for cellular magnetic resonance imaging. J Neuroimmunol. 173:166–173. 2006. View Article : Google Scholar : PubMed/NCBI

57 

Oude Engberink RD, van der Pol SM, Döpp EA, de Vries HE and Blezer EL: Comparison of SPIO and USPIO for in vitro labeling of human monocytes: MR detection and cell function. Radiology. 243:467–474. 2007. View Article : Google Scholar : PubMed/NCBI

58 

Eamegdool SS, Weible MW II, Pham BT, Hawkett BS, Grieve SM and Chan-Ling T: Ultrasmall superparamagnetic iron oxide nanoparticle prelabelling of human neural precursor cells. Biomaterials. 35:5549–5564. 2014. View Article : Google Scholar : PubMed/NCBI

59 

Doyle KP, Quach LN, Arceuil HE and Buckwalter MS: Ferumoxytol administration does not alter infarct volume or the inflammatory response to stroke in mice. Neurosci Lett. 584:236–240. 2015. View Article : Google Scholar : PubMed/NCBI

60 

Saleh A, Schroeter M, Ringelstein A, Hartung HP, Siebler M, Mödder U and Jander S: Iron oxide particle-enhanced MRI suggests variability of brain inflammation at early stages after ischemic stroke. Stroke. 38:2733–2737. 2007. View Article : Google Scholar : PubMed/NCBI

61 

Wang Y, Wang B, Zhu MT, Li M, Wang HJ, Wang M, Ouyang H, Chai ZF, Feng WY and Zhao YL: Microglial activation, recruitment and phagocytosis as linked phenomena in ferric oxide nanoparticle exposure. Toxicol Lett. 205:26–37. 2011. View Article : Google Scholar : PubMed/NCBI

62 

Pohland M, Glumm R, Wiekhorst F, Kiwit J and Glumm J: Biocompatibility of very small superparamagnetic iron oxide nanoparticles in murine organotypic hippocampal slice cultures and the role of microglia. Int J Nanomedicine. 12:1577–1591. 2017. View Article : Google Scholar : PubMed/NCBI

63 

Christen T, Ni W, Qiu D, Schmiedeskamp H, Bammer R, Moseley M and Zaharchuk G: High-resolution cerebral blood volume imaging in humans using the blood pool contrast agent ferumoxytol. Magn Reson Med. 70:705–710. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Desestret V, Brisset JC, Moucharrafie S, Devillard E, Nataf S, Honnorat J, Nighoghossian N, Berthezène Y and Wiart M: Early-stage investigations of ultrasmall superparamagnetic iron oxide-induced signal change after permanent middle cerebral artery occlusion in mice. Stroke. 40:1834–1841. 2009. View Article : Google Scholar : PubMed/NCBI

65 

van der Zijden JP, van der Toorn A, van der Marel K and Dijkhuizen RM: Longitudinal in vivo MRI of alterations in perilesional tissue after transient ischemic stroke in rats. Exp Neuro. 212:207–212. 2008. View Article : Google Scholar

66 

Mishra SK, Kumar BS, Khushu S, Singh AK and Gangenahalli G: Early monitoring and quantitative evaluation of macrophage infiltration after experimental traumatic brain injury: A magnetic resonance imaging and flow cytometric analysis. Mol Cell Neurosci. 78:25–34. 2017. View Article : Google Scholar : PubMed/NCBI

67 

Perego C, Fumagalli S and De Simoni MG: Temporal pattern of expression and colocalization of microglia/macrophage phenotype markers following brain ischemic injury in mice. J Neuroinflammation. 8:1742011. View Article : Google Scholar : PubMed/NCBI

68 

Ortiz de Mendivil A, Alcalá-Galiano A, Ochoa M, Salvador E and Millán JM: Brainstem stroke: Anatomy, clinical and radiological findings. Semin Ultrasound CT MR. 34:131–141. 2013. View Article : Google Scholar : PubMed/NCBI

69 

Nakamura K and Shichita T: Cellular and molecular mechanisms of sterile inflammation in ischaemic stroke. J Biochem. 165:459–464. 2019. View Article : Google Scholar : PubMed/NCBI

70 

Hou K, Xu D, Li F, Chen S and Li Y: The progress of neuronal autophagy in cerebral ischemia stroke: Mechanisms, roles and research methods. J Neurol Sci. 400:72–82. 2019. View Article : Google Scholar : PubMed/NCBI

71 

Haacke EM, Ayaz M, Khan A, Manova ES, Krishnamurthy B, Gollapalli L, Ciulla C, Kim I, Petersen F and Kirsch W: Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain. J Magn Reson Imaging. 26:256–264. 2007. View Article : Google Scholar : PubMed/NCBI

72 

Schroeter M, Saleh A, Wiedermann D, Hoehn M and Jander S: Histochemical detection of ultrasmall superparamagnetic iron oxide (USPIO) contrast medium uptake in experimental brain ischemia. Magn Reson Med. 52:403–406. 2004. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhuang L, Kong Y, Yang S, Lu F, Gong Z, Zhan S and Liu M: Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging. Mol Med Rep 23: 282, 2021.
APA
Zhuang, L., Kong, Y., Yang, S., Lu, F., Gong, Z., Zhan, S., & Liu, M. (2021). Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging. Molecular Medicine Reports, 23, 282. https://doi.org/10.3892/mmr.2021.11921
MLA
Zhuang, L., Kong, Y., Yang, S., Lu, F., Gong, Z., Zhan, S., Liu, M."Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging". Molecular Medicine Reports 23.4 (2021): 282.
Chicago
Zhuang, L., Kong, Y., Yang, S., Lu, F., Gong, Z., Zhan, S., Liu, M."Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging". Molecular Medicine Reports 23, no. 4 (2021): 282. https://doi.org/10.3892/mmr.2021.11921
Copy and paste a formatted citation
x
Spandidos Publications style
Zhuang L, Kong Y, Yang S, Lu F, Gong Z, Zhan S and Liu M: Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging. Mol Med Rep 23: 282, 2021.
APA
Zhuang, L., Kong, Y., Yang, S., Lu, F., Gong, Z., Zhan, S., & Liu, M. (2021). Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging. Molecular Medicine Reports, 23, 282. https://doi.org/10.3892/mmr.2021.11921
MLA
Zhuang, L., Kong, Y., Yang, S., Lu, F., Gong, Z., Zhan, S., Liu, M."Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging". Molecular Medicine Reports 23.4 (2021): 282.
Chicago
Zhuang, L., Kong, Y., Yang, S., Lu, F., Gong, Z., Zhan, S., Liu, M."Dynamic changes of inflammation and apoptosis in cerebral ischemia‑reperfusion injury in mice investigated by ferumoxytol‑enhanced magnetic resonance imaging". Molecular Medicine Reports 23, no. 4 (2021): 282. https://doi.org/10.3892/mmr.2021.11921
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team