Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2021 Volume 23 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2021 Volume 23 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis

  • Authors:
    • Bin Wang
    • Xi-Han Li
    • Zhang Song
    • Min-Li Li
    • Xiao-Wei Wu
    • Mei-Xia Guo
    • Xiao-Hua Zhang
    • Xiao-Ping Zou
  • View Affiliations / Copyright

    Affiliations: Nanjing Drum Tower Hospital Clinical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210008, P.R. China, Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University, Nanjing, Jiangsu 210008, P.R. China, Department of Gastroenterology, Jinling Hospital, Nanjing, Jiangsu 210002, P.R. China
  • Article Number: 287
    |
    Published online on: February 19, 2021
       https://doi.org/10.3892/mmr.2021.11926
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Severe acute pancreatitis (SAP) is a common acute abdominal disease accompanied by systemic inflammatory response syndrome, which may be complicated by acute kidney injury (AKI). Isoacteoside (ISO) is the active ingredient of Monochasma savatieri Franch. ex Maxim and has been reported to have anti‑inflammatory activities. The present study detected the effects of ISO on AKI induced by SAP in rat models, and the underlying mechanism. The optimum dose of ISO for treatment of AKI induced by SAP was determined. The serum levels of TNF‑α and IL‑6 were estimated using an ELISA. Kidney injury was evaluated by histopathological examination, and the expression levels of nitric oxide were also detected. The expression levels of Toll‑like receptor 4 (TLR4) and NF‑κB p65 were measured by immunohistochemistry and western blotting. The results revealed that ISO may serve a critical role in ameliorating AKI induced by SAP. These effects may be associated with the TLR4/NF‑κB signaling pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG and Vege SS; Acute Pancreatitis Classification Working Group, : Classification of acute pancreatitis-2012: Revision of the Atlanta classification and definitions by international consensus. Gut. 62:102–111. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Wu BU, Batech M, Quezada M, Lew D, Fujikawa K, Kung J, Jamil LH, Chen W, Afghani E, Reicher S, et al: Dynamic measurement of disease activity in acute pancreatitis: The pancreatitis activity scoring system. Am J Gastroenterol. 112:1144–1152. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Buxbaum J, Quezada M, Chong B, Gupta N, Yu CY, Lane C, Da B, Leung K, Shulman I, Pandol S and Wu B: The pancreatitis activity scoring system predicts clinical outcomes in acute pancreatitis: Findings from a prospective cohort study. Am J Gastroenterol. 113:755–764. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Devani K, Charilaou P, Radadiya D, Brahmbhatt B, Young M and Reddy C: Acute pancreatitis: Trends in outcomes and the role of acute kidney injury in mortality-A propensity-matched analysis. Pancreatology. 18:870–877. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Petejova N and Martinek A: Acute kidney injury following acute pancreatitis: A review. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 157:105–113. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Chai X, Huang HB, Feng G, Cao YH, Cheng QS, Li SH, He CY, Lu WH and Qin MM: Baseline serum cystatin C is a potential predictor for acute kidney injury in patients with acute pancreatitis. Dis Markers. 19:84312192018.

7 

Mao W, Wu J, Zhang H, Zhou J, Ye B, Li G, Gao L, Li X, Ke L, Tong Z, et al: Increase in serum chloride and chloride exposure are associated with acute kidney injury in moderately severe and severe acute pancreatitis patients. Pancreatology. 19:136–142. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Liu YL, He WJ, Mo L, Shi MF, Zhu YY, Pan S, Li XR, Xu QM and Yang SL: Antimicrobial, anti-inflammatory activities and toxicology of phenylethanoid glycosides from Monochasma savatieri Franch. ex Maxim. J Ethnopharmacol. 149:431–437. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Nam SY, Kim HY, Yoou MS, Kim AH, Park BJ, Jeong HJ and Kim HM: Anti-inflammatory effects of isoacteoside from abeliophyllum distichum. Immunopharmacol Immunotoxicol. 37:258–264. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Gao H, Cui Y, Kang N, Liu X, Liu Y, Zou Y, Zhang Z, Li X, Yang S, Li J, et al: Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization. Br J Pharmacol. 174:2880–2896. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Jaworek J, Szklarczyk J, Kot M, Góralska M, Jaworek A, Bonior J, Leja-Szpak A, Nawrot-Porąbka K, Link-Lenczowski P, Ceranowicz P, et al: Chemerin alleviates acute pancreatitis in the rat thorough modulation of NF-κB signal. Pancreatology. 19:401–408. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Korkmaz FT, Elsasser TH and Kerr DE: Variation in fibroblast expression of toll-like receptor 4 and lipopolysaccharide-induced cytokine production between animals predicts control of bacterial growth but not severity of Escherichia coli mastitis. J Dairy Sci. 101:10098–10115. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Zhu GQ, Jeon SH, Lee KW, Tian WJ, Cho HJ, Ha US, Hong SH, Lee JY, Moon MK, Moon SH, et al: Electric stimulation hyperthermia relieves inflammation via the suppressor of cytokine signaling 3-toll like receptor 4 pathway in a prostatitis rat model. World J Mens Health. 38:359–369. 2020. View Article : Google Scholar : PubMed/NCBI

14 

Luo L, Bokil NJ, Wall AA, Kapetanovic R, Lansdaal NM, Marceline F, Burgess BJ, Tong SJ, Guo Z, Alexandrov K, et al: SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nat Commun. 8:141332017. View Article : Google Scholar : PubMed/NCBI

15 

Kawasaki T and Kawai T: Toll-like receptor signaling pathways. Front Immunol. 5:4612014. View Article : Google Scholar : PubMed/NCBI

16 

Cen Y, Liu C, Li X, Yan Z, Kuang M, Su Y, Pan X, Qin R, Liu X, Zheng J and Zhou H: Artesunate ameliorates severe acute pancreatitis (SAP) in rats by inhibiting expression of pro-inflammatory cytokines and Toll-like receptor 4. Int Immunopharmacol. 38:252–260. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Johnson GB, Brunn GJ and Platt JL: Cutting edge: An endogenous pathway to systemic inflammatory response syndrome (SIRS)-like reactions through Toll-like receptor 4. J Immunol. 172:20–24. 2004. View Article : Google Scholar : PubMed/NCBI

18 

Wang B, Xu XB, Jin XX, Wu XW, Li ML, Guo MX and Zhang XH: Effects of ω-3 fatty acids on toll-like receptor 4 and nuclear factor-κB p65 in the pancreas of rats with severe acute pancreatitis. Pancreas. 46:1267–1274. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Aho HJ, Koskensalo SM and Nevalainen TJ: Experimental pancreatitis in the rat. Sodium taurocholate-induced acute haemorrhagic pancreatitis. Scand J Gastroenterol. 15:411–416. 1980. View Article : Google Scholar : PubMed/NCBI

20 

Schmidt J, Rattner DW, Lewandrowski K, Compton CC, Mandavilli U, Knoefel WT and Warshaw AL: A better model of acute pancreatitis for evaluating therapy. Ann Surg. 215:44–56. 1992. View Article : Google Scholar : PubMed/NCBI

21 

Paller MS, Hoidal JR and Ferris TF: Oxygen free radicals in ischemic acute renal failure in the rat. J Clin Invest. 74:1156–1164. 1984. View Article : Google Scholar : PubMed/NCBI

22 

Shiao YJ, Su MH, Lin HC and Wu CR: Acteoside and isoacteoside protect amyloid β peptide induced cytotoxicity, cognitive deficit and neurochemical disturbances in vitro and in vivo. Int J Mol Sci. 18:8952017. View Article : Google Scholar

23 

Zhao K, Chen C, Shi Q, Deng W, Zuo T, He X, Liu T, Zhao L and Wang W: Inhibition of glycogen synthase kinase-3β attenuates acute kidney injury in sodium taurocholate-induced severeacute pancreatitis in rats. Mol Med Rep. 10:3185–3192. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Naqvi R: Acute kidney injury in association with acute pancreatitis. Pak J Med Sci. 34:606–609. 2018. View Article : Google Scholar : PubMed/NCBI

25 

Malmstrøm ML, Hansen MB, Andersen AM, Ersbøll AK, Nielsen OH, Jørgensen LN and Novovicet S: Cytokines and organ failure in acute pancreatitis: Inflammatory response in acute pancreatitis. Pancreas. 41:271–277. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Zhang XP, Wang L and Zhou YF: The pathogenic mechanism of severe acute pancreatitis complicated with renal injury: A review of current knowledge. Dig Dis Sci. 53:297–306. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Yu J, Deng W, Wang W, Ding Y, Jin H, Chen C, Chen X, Xiong X and Xu S: Inhibition of poly (ADPRibose) polymerase attenuates acute kidney injury in sodium taurocholate-induced acute pancreatitis in rats. Pancreas. 41:1299–1305. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Okusa MD, Linden J, Huang L, Rieger JM, Macdonald TL and Huynh LP: A(2A) adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion. Am J Physiol Renal Physiol. 279:F809–F818. 2000. View Article : Google Scholar : PubMed/NCBI

29 

Mazzon E, Impellizzeri D, Di Paola R, Paterniti I, Esposito E, Cappellani A, Bramanti P and Cuzzocrea S: Effects of mitogen-activated protein kinase signaling pathway inhibition on the development of cerulean-induced acute pancreatitis in mice. Pancreas. 41:560–570. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Centorrino T, Ciccolo A, Van de Loo FAJ, Britti D, Caputi AP and Thiemermann C: Inducible nitric oxide synthase-deficient mice exhibit resistance to the acute pancreatitis induced by cerulein. Shock. 17:416–422. 2002. View Article : Google Scholar : PubMed/NCBI

31 

Li Z, Xia X, Zhang S, Zhang A, Bo W and Zhou R: Up-regulation of Toll-like receptor 4 was suppressed by emodin and baicalin in the setting of acute pancreatitis. Biomed Pharmacother. 63:120–128. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Hoque R, Farooq A, Ghani A, Gorelick F and Mehal WZ: Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Gastroenterology. 146:1763–1774. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Chen J, Hartono JR, John R, Bennett M, Zhou XJ, Wang Y, Wu Q, Winterberg PD, Nagami GT and Lu CY: Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4. Kidney Int. 80:504–515. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Kulkarni OP, Hartter I, Mulay SR, Hagemann J, Darisipudi MN, Vr SK, Romoli S, Thomasova D, Ryu M, Kobold S and Anders HJ: Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. J Am Soc Nephrol. 25:978–989. 2014. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang B, Li X, Song Z, Li M, Wu X, Guo M, Zhang X and Zou X: Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis. Mol Med Rep 23: 287, 2021.
APA
Wang, B., Li, X., Song, Z., Li, M., Wu, X., Guo, M. ... Zou, X. (2021). Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis. Molecular Medicine Reports, 23, 287. https://doi.org/10.3892/mmr.2021.11926
MLA
Wang, B., Li, X., Song, Z., Li, M., Wu, X., Guo, M., Zhang, X., Zou, X."Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis". Molecular Medicine Reports 23.4 (2021): 287.
Chicago
Wang, B., Li, X., Song, Z., Li, M., Wu, X., Guo, M., Zhang, X., Zou, X."Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis". Molecular Medicine Reports 23, no. 4 (2021): 287. https://doi.org/10.3892/mmr.2021.11926
Copy and paste a formatted citation
x
Spandidos Publications style
Wang B, Li X, Song Z, Li M, Wu X, Guo M, Zhang X and Zou X: Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis. Mol Med Rep 23: 287, 2021.
APA
Wang, B., Li, X., Song, Z., Li, M., Wu, X., Guo, M. ... Zou, X. (2021). Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis. Molecular Medicine Reports, 23, 287. https://doi.org/10.3892/mmr.2021.11926
MLA
Wang, B., Li, X., Song, Z., Li, M., Wu, X., Guo, M., Zhang, X., Zou, X."Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis". Molecular Medicine Reports 23.4 (2021): 287.
Chicago
Wang, B., Li, X., Song, Z., Li, M., Wu, X., Guo, M., Zhang, X., Zou, X."Isoacteoside attenuates acute kidney injury induced by severe acute pancreatitis". Molecular Medicine Reports 23, no. 4 (2021): 287. https://doi.org/10.3892/mmr.2021.11926
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team