Open Access

Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin

  • Authors:
    • Zi-Rong Zhang
    • Zheng-Gen Yang
    • Yan-Mei Xu
    • Zhe-Yan Wang
    • Jian Wen
    • Bo-Hong Chen
    • Ping Wang
    • Wei Wei
    • Zhen Li
    • Wen-Qi Dong
  • View Affiliations

  • Published online on: February 22, 2021     https://doi.org/10.3892/mmr.2021.11929
  • Article Number: 289
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cytoglobin (Cygb) is a globin molecule that is ubiquitously expressed in all tissues and has a protective role under oxidative stress. It has also been demonstrated to be effective in the treatment of alcoholic fatty liver disease (AFLD). In order to study the molecular mechanisms underlying its beneficial effects for the treatment of alcoholic liver, two‑dimensional electrophoresis and mass spectrometric analysis were performed on serum and liver tissues from an in vivo rat model of AFLD. A total of 26 differentially expressed proteins were identified in the serum and 20 differentially expressed proteins were identified in liver specimens. Using online bioinformatics tools, it was indicated that these differentially expressed proteins were primarily associated with pathways including binding and uptake of ligands by scavenger receptors, response to corticosteroid, plasma lipoprotein remodeling, regulation of complement cascade, hydrogen peroxide catabolic process, as well as response to nutrient and monosaccharide. The present results suggested that recombinant human Cygb exerts its role in the treatment of AFLD primarily through affecting nutrient metabolism, monocarboxylic acid biosynthesis, regulation of glutathione expression, plasma lipoprotein remodeling and removal of metabolic waste from the blood.
View Figures
View References

Related Articles

Journal Cover

April-2021
Volume 23 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Z, Yang Z, Xu Y, Wang Z, Wen J, Chen B, Wang P, Wei W, Li Z, Dong W, Dong W, et al: Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin. Mol Med Rep 23: 289, 2021
APA
Zhang, Z., Yang, Z., Xu, Y., Wang, Z., Wen, J., Chen, B. ... Dong, W. (2021). Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin. Molecular Medicine Reports, 23, 289. https://doi.org/10.3892/mmr.2021.11929
MLA
Zhang, Z., Yang, Z., Xu, Y., Wang, Z., Wen, J., Chen, B., Wang, P., Wei, W., Li, Z., Dong, W."Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin". Molecular Medicine Reports 23.4 (2021): 289.
Chicago
Zhang, Z., Yang, Z., Xu, Y., Wang, Z., Wen, J., Chen, B., Wang, P., Wei, W., Li, Z., Dong, W."Bioinformatics analysis of differentially expressed proteins in alcoholic fatty liver disease treated with recombinant human cytoglobin". Molecular Medicine Reports 23, no. 4 (2021): 289. https://doi.org/10.3892/mmr.2021.11929