Open Access

Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis

  • Authors:
    • Haoyu Wu
    • Wanying Zhang
    • Yunbo Zhang
    • Zhen Kang
    • Xinxiunan Miao
    • Xiaolin Na
  • View Affiliations

  • Published online on: February 22, 2021     https://doi.org/10.3892/mmr.2021.11930
  • Article Number: 290
  • Copyright: © Wu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Di (2‑ethylhexyl) phthalate (DEHP), an environmental pollutant, is widely used as a plasticizer and causes serious pollution in the ecological environment. As previously reported, exposure to DEHP may cause thyroid dysfunction of the hypothalamic‑pituitary‑thyroid (HPT) axis. However, the underlying role of DEHP remains to be elucidated. The present study performed intragastrical administration of DEHP (150, 300 and 600 mg/kg) once a day for 90 consecutive days. DEHP‑stimulated oxidative stress increased the thyroid follicular cavity diameter and caused thyrocyte oedema. Furthermore, DEHP exposure altered mRNA and protein levels. Thus, DEHP may perturb TH homeostasis by affecting biosynthesis, biotransformation, bio‑transportation, receptor levels and metabolism through disruption of the HPT axis and activation of the thyroid‑stimulating hormone (TSH)/TSH receptor signaling pathway. These results identified the formerly unappreciated endocrine‑disrupting activities of phthalates and the molecular mechanisms of DEHP‑induced thyrotoxicity.
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April-2021
Volume 23 Issue 4

Print ISSN: 1791-2997
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Spandidos Publications style
Wu H, Zhang W, Zhang Y, Kang Z, Miao X and Na X: Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis. Mol Med Rep 23: 290, 2021
APA
Wu, H., Zhang, W., Zhang, Y., Kang, Z., Miao, X., & Na, X. (2021). Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis. Molecular Medicine Reports, 23, 290. https://doi.org/10.3892/mmr.2021.11930
MLA
Wu, H., Zhang, W., Zhang, Y., Kang, Z., Miao, X., Na, X."Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis". Molecular Medicine Reports 23.4 (2021): 290.
Chicago
Wu, H., Zhang, W., Zhang, Y., Kang, Z., Miao, X., Na, X."Novel insights into di‑(2‑ethylhexyl)phthalate activation: Implications for the hypothalamus‑pituitary‑thyroid axis". Molecular Medicine Reports 23, no. 4 (2021): 290. https://doi.org/10.3892/mmr.2021.11930