Open Access

Functions of circular RNAs in bladder, prostate and renal cell cancer (Review)

  • Authors:
    • Longfei Yang
    • Xiaofeng Zou
    • Junrong Zou
    • Guoxi Zhang
  • View Affiliations

  • Published online on: February 26, 2021     https://doi.org/10.3892/mmr.2021.11946
  • Article Number: 307
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Circular RNAs (circRNAs) are a class of non‑coding RNAs formed by covalently closed loops through back‑splicing and exon‑skipping. circRNAs have been confirmed to play a vital role in various biological functions, acting as microRNA sponges and reservoirs, as well as combining with RNA‑binding proteins during the progression of multiple cancer types. Therefore, the present review evaluated recent research articles in PubMed that were published between November 2017 and September 2020. Key word search strings included: ‘Circular RNA (circRNA) AND bladder cancer (BC)’, ‘circular RNA (circRNA) AND prostate cancer (PCa)’ and ‘circular RNA (circRNA) AND renal cell cancer (RCC)’. In total, >58 circRNAs were found to be implicated in urological cancers, with several of the circRNAs targeting common carcinogenic pathways, such as the AKT, TGF‑β, MAPK, VEGF and even metabolic pathways. circRNAs are important modulators of BC, PCa and RCC. circRNAs are functionally implicated in the pathogenesis of these cancer types, and have been found to act as biomarkers for the diagnosis and prognosis of urological cancer. However, to the best of our knowledge, the functions of circRNAs in tumors of the urinary system remain largely unknown and require further research.
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May-2021
Volume 23 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Yang L, Zou X, Zou J and Zhang G: Functions of circular RNAs in bladder, prostate and renal cell cancer (Review). Mol Med Rep 23: 307, 2021
APA
Yang, L., Zou, X., Zou, J., & Zhang, G. (2021). Functions of circular RNAs in bladder, prostate and renal cell cancer (Review). Molecular Medicine Reports, 23, 307. https://doi.org/10.3892/mmr.2021.11946
MLA
Yang, L., Zou, X., Zou, J., Zhang, G."Functions of circular RNAs in bladder, prostate and renal cell cancer (Review)". Molecular Medicine Reports 23.5 (2021): 307.
Chicago
Yang, L., Zou, X., Zou, J., Zhang, G."Functions of circular RNAs in bladder, prostate and renal cell cancer (Review)". Molecular Medicine Reports 23, no. 5 (2021): 307. https://doi.org/10.3892/mmr.2021.11946