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Protective effects of different anti‑inflammatory drugs on tracheal stenosis following injury and potential mechanisms

  • Authors:
    • Zhenjie Huang
    • Peng Wei
    • Luoman Gan
    • Wentao Li
    • Tonghua Zeng
    • Caicheng Qin
    • Zhiyu Chen
    • Guangnan Liu
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory Medicine, Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530007, P.R. China, School of Medicine, Qinghai University, Xining, Qinghai 810000, P.R. China, Department of Respiratory Medicine, Beihai People's Hospital, Beihai, Guangxi 536000, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 314
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    Published online on: March 2, 2021
       https://doi.org/10.3892/mmr.2021.11953
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Abstract

Tracheal stenosis following injury cannot be effectively treated. The current study compared the protective effects of different anti‑inflammatory drugs on tracheal stenosis and investigated their possible mechanisms. Rabbit tracheal stenosis models following injury were constructed and confirmed using hematoxylin and eosin (H&E) staining. A total of 30 rabbits were divided into the control (CON), penicillin (PEN), erythromycin (ERY), budesonide (BUD) and PEN + ERY + BUD groups (n=6). Stenotic tracheal tissue, serum and bronchoalveolar lavage fluid (BALF) were collected 10 days after continuous treatment. Pathological changes in the tracheas were observed by H&E staining. Histone deacetylase 2 (HDAC2) expression in tracheal tissues was detected by immunofluorescence. Immunohistochemistry was performed to detect collagen I (Col‑I) and collagen III (Col‑III) levels in tracheal tissues. Transforming growth factor β1 (TGF‑β1), vascular endothelial growth factor (VEGF) and interleukin 8 (IL‑8) levels in serum and BALF samples were determined using ELISA kits. Western blotting detected HDAC2, IL‑8, TGF‑β1 and VEGF levels in tracheal tissues. H&E staining demonstrated that tracheal epithelial hyperplasia and fibroblast proliferation in the ERY and PEN + ERY + BUD groups markedly improved compared with the CON group. Furthermore, in tracheal tissues, HDAC2 expression was significantly increased and IL‑8, TGF‑β1, VEGF, Col‑I and Col‑III levels were significantly decreased in the ERY and PEN + ERY + BUD groups compared with the CON group. Additionally, the results for the PEN + ERY + BUD were more significant compared with the ERY group. In serum and BALF samples, IL‑8, TGF‑β1 and VEGF levels in the ERY and PEN + ERY + BUD groups were significantly lower compared with the CON group, with the results of the PEN + ERY + BUD group being more significant compared with the ERY group. There were no significant differences between the PEN, BUD and CON groups. ERY inhibited tracheal granulation tissue proliferation and improved tracheal stenosis following injury and synergistic effects with PEN and BUD further enhanced these protective effects. The mechanism may involve HDAC2 upregulation and inhibition of local airway and systemic inflammatory responses.
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1 

Su ZQ, Wei XQ, Zhong CH, Chen XB, Luo WZ, Guo WL, Wang YZ and Li SY: The cause and efficacy of benign tracheal stenosis. Zhonghua Jie He He Hu Xi Za Zhi. 36:651–654. 2013.(In Chinese). PubMed/NCBI

2 

Zhang J, Wang T, Wang J, Pei YH, Xu M, Wang YL, Zhang X and Wang C: Effect of three interventional bronchoscopic methods on tracheal stenosis and the formation of granulation tissues in dogs. Chin Med J (Engl). 123:621–627. 2010.PubMed/NCBI

3 

Puyo CA and Dahms TE: Innate immunity mediating inflammation secondary to endotracheal intubation. Arch Otolaryngol Head Neck Surg. 138:854–858. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Lawrence DA, Branson B, Oliva I and Rubinowitz A: The wonderful world of the windpipe: A review of central airway anatomy and pathology. Can Assoc Radiol J. 66:30–43. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Li LH, Xu MP, Gan LM, Li Y, Liang YL, Li WT, Qin EY, Gan JH and Liu GN: Effect of low dose erythromycin on the proliferation of granulation tissue after tracheal injury. Zhonghua Yi Xue Za Zhi. 97:777–781. 2017.(In Chinese). PubMed/NCBI

6 

Yao H and Rahman I: Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicol Appl Pharmacol. 254:72–85. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Ito K, Lim S, Caramori G, Chung KF, Barnes PJ and Adcock IM: Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages. FASEB J. 15:1110–1112. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Barnes PJ: Role of HDAC2 in the pathophysiology of COPD. Annu Rev Physiol. 71:451–464. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Croft CB, Zub K and Borowiecki B: Therapy of iatrogenic subglottic stenosis: A steroid/antibiotic regimen. Laryngoscope. 89:482–489. 1979. View Article : Google Scholar : PubMed/NCBI

10 

Zhou L, Li Y, Gan LM, Qin EY, Meng XY, Gan JH, Li WT, Qin CC and Liu GN: Effects of different drugs on bronchial stenosis by TGF-β/mTOR signaling pathway in rabbit model. Zhonghua Yi Xue Za Zhi. 99:1898–1903. 2019.(In Chinese). PubMed/NCBI

11 

Thompson SR III: Treatment of syphilis in pregnancy. J Am Vener Dis Assoc. 3:158–167. 1976.PubMed/NCBI

12 

Giamarellos-Bourboulis EJ: Macrolides beyond the conventional antimicrobials: A class of potent immunomodulators. Int J Antimicrob Agents. 31:12–20. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Stern A, Skalsky K, Avni T, Carrara E, Leibovici L and Paul M: Corticosteroids for pneumonia. Cochrane Database Syst Rev. 12:CD0077202017.PubMed/NCBI

14 

Kilkenny C, Browne WJ, Cuthill IC, Emerson M and Altman DG: Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research. J Pharmacol Pharmacother. 1:94–99. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Nakagishi Y, Morimoto Y, Fujita M, Ozeki Y, Maehara T and Kikuchi M: Rabbit model of airway stenosis induced by scraping of the tracheal mucosa. Laryngoscope. 115:1087–1092. 2005. View Article : Google Scholar : PubMed/NCBI

16 

White WJ and Field KJ: Anesthesia and surgery of laboratory animals. Vet Clin North Am Small Anim Pract. 17:989–1017. 1987. View Article : Google Scholar : PubMed/NCBI

17 

Harken AH, Lillo RS and Haut MJ: The depressant influence of extracellular fluid hyperoxia on liver slice oxygen uptake. J Lab Clin Med. 89:1269–1277. 1977.PubMed/NCBI

18 

Spiers DE and Candas V: Relationship of skin surface area to body mass in the immature rat: A reexamination. J Appl Physiol Respir Environ Exerc Physiol. 56:240–243. 1984.PubMed/NCBI

19 

Lei H, Qian GS, Wu GM and Huang GJ: Transfection of human beta defensin 2 gene into the lung by aerosol inhalation: Experiment with rats. Zhonghua Yi Xue Za Zhi. 88:1425–1428. 2008.(In Chinese). PubMed/NCBI

20 

Lin JT, Zhang YM, Zhou X, Wang CZ, Huang M, Liu CT, Wu CG, Wan HY, Yu WC and Dai YR: Chinese expert consensus for non-antiinfective effects and clinical use of macrolides. Zhonghua Nei Ke Za Zhi. 56:546–557. 2017.(In Chinese). PubMed/NCBI

21 

Ushida K, Asai N, Uchiyama K, Enomoto A and Takahashi M: Development of a method to preliminarily embed tissue samples using low melting temperature fish gelatin before sectioning: A technical note. Pathol Int. 68:241–245. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Stauffer JL, Olson DE and Petty TL: Complications and consequences of endotracheal intubation and tracheotomy. A prospective study of 150 critically ill adult patients. Am J Med. 70:65–76. 1981. View Article : Google Scholar : PubMed/NCBI

23 

Plojoux J, Laroumagne S, Vandemoortele T, Astoul PJ, Thomas PA and Dutau H: Management of benign dynamic ‘A-shape’ tracheal stenosis: A retrospective study of 60 patients. Ann Thorac Surg. 99:447–453. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Barros CD, Fernandez-Bussy S, Folch E, Flandes AJ and Majid A: Non-malignant central airway obstruction. Arch Bronconeumol. 50:345–354. 2014.(In English, Spanish). View Article : Google Scholar : PubMed/NCBI

25 

Zhang J, Wang J, Wang T, Xu M, Dang BW, Pei YH and Zhang CY: A pilot study on interventional bronchoscopy in the management of airway stenosis with benign hyperplasia. Zhonghua Jie He He Hu Xi Za Zhi. 34:334–338. 2011.(In Chinese). PubMed/NCBI

26 

Ferreira S, Nogueira C, Oliveira A, Neves S, Almeida J and Moura e Sá J: Bronchoscopic dilation techniques and topical application of mitomycin-C in the treatment of tracheal stenosis post intubation-two case reports. Rev Port Pneumol. 16:149–156. 2010.(In Portuguese). View Article : Google Scholar : PubMed/NCBI

27 

Simpson CB and James JC: The efficacy of mitomycin-C in the treatment of laryngotracheal stenosis. Laryngoscope. 116:1923–1925. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Tendulkar RD, Fleming PA, Reddy CA, Gildea TR, Machuzak M and Mehta AC: High-dose-rate endobronchial brachytherapy for recurrent airway obstruction from hyperplastic granulation tissue. Int J Radiat Oncol Biol Phys. 70:701–706. 2008. View Article : Google Scholar : PubMed/NCBI

29 

Zhu GH, Ng AH, Venkatraman SS, Boey FYC, Wee ALY, Trasti SL and Lim LHY: A novel bioabsorbable drug-eluting tracheal stent. Laryngoscope. 121:2234–2239. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Shin JH, Song HY, Seo TS, Yuk SH, Kim YH, Cho YM, Choi GB, Kim TH and Suh JY: Influence of a dexamethasone-eluting covered stent on tissue reaction: An experimental study in a canine bronchial model. Eur Radiol. 15:1241–1249. 2005. View Article : Google Scholar : PubMed/NCBI

31 

Venhaus M, Behn C, Freitag L and Zimmermann K: Simulations and experiments of the balloon dilatation of airway stenoses. Biomed Tech (Berl). 54:187–195. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Erelel M, Yakar F and Yakar A: Endobronchial tuberculosis with lobar obstruction successfully treated by argon plasma coagulation. South Med J. 102:1078–1081. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Krimsky WS, Rodrigues MP, Malayaman N and Sarkar S: Spray cryotherapy for the treatment of glottic and subglottic stenosis. Laryngoscope. 120:473–477. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Brown MT and Montgomery WW: Microbiology of tracheal granulation tissue associated with silicone airway prostheses. Ann Otol Rhinol Laryngol. 105:624–627. 1996. View Article : Google Scholar : PubMed/NCBI

35 

Simoni P and Wiatrak BJ: Microbiology of stents in laryngotracheal reconstruction. Laryngoscope. 114:364–367. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Matt BH, Myer CR III, Harrison CJ, Reising SF and Cotton RT: Tracheal granulation tissue. A study of bacteriology. Arch Otolaryngol Head Neck Surg. 117:538–541. 1991. View Article : Google Scholar : PubMed/NCBI

37 

Barnes PJ: How corticosteroids control inflammation: Quintiles Prize Lecture 2005. Br J Pharmacol. 148:245–254. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Yokoi A, Nakao M, Bitoh Y, Arai H, Oshima Y and Nishijima E: Treatment of postoperative tracheal granulation tissue with inhaled budesonide in congenital tracheal stenosis. J Pediatr Surg. 49:293–295, 295. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Toren K, Blanc PD, Qvarfordt I, Aspevall O and Schioler L: Inhaled corticosteroids use and risk of invasive pneumococcal disease risk in a population-based study. Ann Am Thorac Soc. 17:1570–1575. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Amsden GW: Anti-inflammatory effects of macrolides-an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions? J Antimicrob Chemother. 55:10–21. 2005. View Article : Google Scholar : PubMed/NCBI

41 

Li M, Zhong X, He Z, Wen M, Li J, Peng X, Liu G, Deng J, Zhang J and Bai J: Effect of erythromycin on cigarette-induced histone deacetylase protein expression and nuclear factor-kB activity in human macrophages in vitro. Int Immunopharmacol. 12:643–650. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Seemungal TA, Wilkinson TM, Hurst JR, Perera WR, Sapsford RJ and Wedzicha JA: Long-term erythromycin therapy is associated with decreased chronic obstructive pulmonary disease exacerbations. Am J Respir Crit Care Med. 178:1139–1147. 2008. View Article : Google Scholar : PubMed/NCBI

43 

Zhang Q, Zhao K, Shen Q, Han Y, Gu Y, Li X, Zhao D, Liu Y, Wang C, Zhang X, et al: Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6. Nature. 525:389–393. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Ito K, Yamamura S, Essilfie-Quaye S, Cosio B, Ito M, Barnes PJ and Adcock IM: Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med. 203:7–13. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Adenuga D, Yao H, March TH, Seagrave J and Rahman I: Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am J Respir Cell Mol Biol. 40:464–473. 2009. View Article : Google Scholar : PubMed/NCBI

46 

Barnes PJ: Immunology of asthma and chronic obstructive pulmonary disease. Nat Rev Immunol. 8:183–192. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Ito K, Caramori G, Lim S, Oates T, Chung KF, Barnes PJ and Adcock IM: Expression and activity of histone deacetylases in human asthmatic airways. Am J Respir Crit Care Med. 166:392–396. 2002. View Article : Google Scholar : PubMed/NCBI

48 

Cosio BG, Tsaprouni L, Ito K, Jazrawi E, Adcock IM and Barnes PJ: Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. J Exp Med. 200:689–695. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Zhang Y, He Z, Sun X, Li Z, Zhao L, Mao C, Huang D, Zhang J and Zhong X: Erythromycin restores oxidative stress-induced corticosteroid responsiveness of human THP-1 cells by up-regulating the expression of histone deacetylase 2. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 30:384–387. 2014.(In Chinese). PubMed/NCBI

50 

Cui Y, Luo L, Li C, Chen P and Chen Y: Long-term macrolide treatment for the prevention of acute exacerbations in COPD: A systematic review and meta-analysis. Int J Chron Obstruct Pulmon Dis. 13:3813–3829. 2018. View Article : Google Scholar : PubMed/NCBI

51 

Miao L, Gao Z, Huang F, Huang S, Zhang R, Ma D, Wu Q, Li F, Chen H and Wang J: Erythromycin enhances the anti-inflammatory activity of budesonide in COPD rat model. Int J Clin Exp Med. 8:22217–22226. 2015.PubMed/NCBI

52 

Ellis S, Lin EJ and Tartar D: Immunology of wound healing. Curr Dermatol Rep. 7:350–358. 2018. View Article : Google Scholar : PubMed/NCBI

53 

Arellano-Orden E, Serrano C, Montes-Worboys A, Sánchez-López V, Laborda A, Lostalé F, Lahuerta C, Rodríguez-Panadero F and de Gregorio MA: Stent-induced tracheal stenosis can be predicted by IL-8 expression in rabbits. Eur J Clin Invest. 47:84–92. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Song Y, Yu P, Lu JJ, Lu HZ, Zhu L, Yu ZH, Chen HZ and Cui YY: A mucoactive drug carbocisteine ameliorates steroid resistance in rat COPD model. Pulm Pharmacol Ther. 39:38–47. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Hannigan M, Zhan L, Ai Y and Huang CK: The role of p38 MAP kinase in TGF-beta1-induced signal transduction in human neutrophils. Biochem Biophys Res Commun. 246:55–58. 1998. View Article : Google Scholar : PubMed/NCBI

56 

Postlethwaite AE, Keski-Oja J, Moses HL and Kang AH: Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor beta. J Exp Med. 165:251–256. 1987. View Article : Google Scholar : PubMed/NCBI

57 

Perng DW, Wu YC, Chang KT, Wu MT, Chiou YC, Su KC, Perng RP and Lee YC: Leukotriene C4 induces TGF-beta1 production in airway epithelium via p38 kinase pathway. Am J Respir Cell Mol Biol. 34:101–107. 2006. View Article : Google Scholar : PubMed/NCBI

58 

Ferrara N: Vascular endothelial growth factor and the regulation of angiogenesis. Recent Prog Horm Res. 55:15–35, 35–36. 2000.PubMed/NCBI

59 

Leung DW, Cachianes G, Kuang WJ, Goeddel DV and Ferrara N: Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 246:1306–1309. 1989. View Article : Google Scholar : PubMed/NCBI

60 

Zhang J, Li Q, Bai C, Han Y and Huang Y: Inhalation of TGF-beta1 antibody: A new method to inhibit the airway stenosis induced by the endobronchial tuberculosis. Med Hypotheses. 73:1065–1066. 2009. View Article : Google Scholar : PubMed/NCBI

61 

Lee YC, Hung MH, Liu LY, Chang KT, Chou TY, Wang YC, Wu YC, Lai CL, Tsai CC, Su KC and Perng DW: The roles of transforming growth factor-beta(1) and vascular endothelial growth factor in the tracheal granulation formation. Pulm Pharmacol Ther. 24:23–31. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang Z, Wei P, Gan L, Li W, Zeng T, Qin C, Chen Z and Liu G: Protective effects of different anti‑inflammatory drugs on tracheal stenosis following injury and potential mechanisms. Mol Med Rep 23: 314, 2021.
APA
Huang, Z., Wei, P., Gan, L., Li, W., Zeng, T., Qin, C. ... Liu, G. (2021). Protective effects of different anti‑inflammatory drugs on tracheal stenosis following injury and potential mechanisms. Molecular Medicine Reports, 23, 314. https://doi.org/10.3892/mmr.2021.11953
MLA
Huang, Z., Wei, P., Gan, L., Li, W., Zeng, T., Qin, C., Chen, Z., Liu, G."Protective effects of different anti‑inflammatory drugs on tracheal stenosis following injury and potential mechanisms". Molecular Medicine Reports 23.5 (2021): 314.
Chicago
Huang, Z., Wei, P., Gan, L., Li, W., Zeng, T., Qin, C., Chen, Z., Liu, G."Protective effects of different anti‑inflammatory drugs on tracheal stenosis following injury and potential mechanisms". Molecular Medicine Reports 23, no. 5 (2021): 314. https://doi.org/10.3892/mmr.2021.11953
Copy and paste a formatted citation
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Spandidos Publications style
Huang Z, Wei P, Gan L, Li W, Zeng T, Qin C, Chen Z and Liu G: Protective effects of different anti‑inflammatory drugs on tracheal stenosis following injury and potential mechanisms. Mol Med Rep 23: 314, 2021.
APA
Huang, Z., Wei, P., Gan, L., Li, W., Zeng, T., Qin, C. ... Liu, G. (2021). Protective effects of different anti‑inflammatory drugs on tracheal stenosis following injury and potential mechanisms. Molecular Medicine Reports, 23, 314. https://doi.org/10.3892/mmr.2021.11953
MLA
Huang, Z., Wei, P., Gan, L., Li, W., Zeng, T., Qin, C., Chen, Z., Liu, G."Protective effects of different anti‑inflammatory drugs on tracheal stenosis following injury and potential mechanisms". Molecular Medicine Reports 23.5 (2021): 314.
Chicago
Huang, Z., Wei, P., Gan, L., Li, W., Zeng, T., Qin, C., Chen, Z., Liu, G."Protective effects of different anti‑inflammatory drugs on tracheal stenosis following injury and potential mechanisms". Molecular Medicine Reports 23, no. 5 (2021): 314. https://doi.org/10.3892/mmr.2021.11953
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