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Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease

  • Authors:
    • Bin Zhang
    • Dong Li
    • Gexiu Liu
    • Wenfeng Tan
    • Gaoxing Zhang
    • Jinli Liao
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Disease, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat‑Sen University, Jiangmen, Guangdong 529030, P.R. China, Clinical Experimental Center, Jiangmen Central Hospital, Affiliated Jiangmen Hospital of Sun Yat‑Sen University, Jiangmen, Guangdong 529030, P.R. China, Institute of Hematology, Medical College, Jinan University, Guangzhou, Guangdong 510632, P.R. China, Division of Emergency Medicine, Department of General Internal Medicine, Department of Emergency Intensive Care Unit, The First Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510080, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 321
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    Published online on: March 5, 2021
       https://doi.org/10.3892/mmr.2021.11960
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Abstract

It has previously been shown that the number of endothelial progenitor cells (EPCs) is negatively correlated with Syntax score in patients with coronary artery disease (CAD). However, the association between alterations in EPC function and Syntax score is still unknown. The present study evaluated the association between the activity of EPCs as well as endothelial function and Syntax score in patients with CAD and investigated the underlying mechanisms. A total of 60 patients with CAD were enrolled in 3 groups according to Syntax score, and 20 healthy subjects were recruited as the control group. The number and migratory, proliferative and adhesive activities of circulating EPCs were studied. The endothelial function was measured by flow‑mediated dilatation (FMD) and the levels of nitric oxide (NO) in plasma or secreted by EPCs were detected. The number and activity of circulating EPCs were lower in patients with a high Syntax score, which was similar to the alteration in FMD. The level of NO in plasma or secreted by EPCs also decreased as Syntax score increased. There was a negative association between FMD or circulating EPCs and Syntax score. A similar association was observed between the levels of NO in plasma or secreted by EPCs and Syntax score. Patients with CAD who had a higher Syntax score exhibited lower EPC numbers or activity and weaker endothelial function, which may be associated with attenuated NO production. These findings provide novel surrogate parameters for evaluation of the severity and complexity of CAD.
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View References

1 

He Y, Kothari V and Bornfeldt KE: High-density lipoprotein function in cardiovascular disease and diabetes mellitus. Arterioscler Thromb Vasc Biol. 38:e10–e16. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Piccolo R, Giustino G, Mehran R and Windecker S: Stable coronary artery disease: Revascularisation and invasive strategies. Lancet. 386:702–713. 2015. View Article : Google Scholar : PubMed/NCBI

3 

Calderón-Gerstein WS, López-Peña A, Macha-Ramírez R, Bruno-Huamán A, Espejo-Ramos R, Vílchez-Bravo S, Ramírez-Breña M, Damián-Mucha M and Matos-Mucha A: Endothelial dysfunction assessment by flow-mediated dilation in a high-altitude population. Vasc Health Risk Manag. 13:421–426. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Aicher A, Zeiher AM and Dimmeler S: Mobilizing endothelial progenitor cells. Hypertension. 45:321–325. 2005. View Article : Google Scholar : PubMed/NCBI

5 

Hill JM, Zalos G, Halcox JP, Schenke WH, Waclawiw MA, Quyyumi AA and Finkel T: Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 348:593–600. 2003. View Article : Google Scholar : PubMed/NCBI

6 

Ghem C, Dias LD, Sant'Anna RT, Kalil RAK, Markoski M and Nardi NB: Combined analysis of endothelial, hematopoietic, and mesenchymal stem cell compartments shows simultaneous but independent effects of age and heart disease. Stem Cells Int. 2017:52376342017. View Article : Google Scholar : PubMed/NCBI

7 

Chi J, Hong X, Wang Y, Zhao J and Yang W: Inverse correlation between circulating endothelial progenitor cells with CD34+CD133+ and the severity of coronary atherosclerosis assessed by Syntax score. Am J Med Sci. 347:457–462. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Kolh P and Windecker S: ESC/EACTS myocardial revascularization guidelines 2014. Eur Heart J. 35:3235–3236. 2014.PubMed/NCBI

9 

Sianos G, Morel MA, Kappetein AP, Morice MC, Colombo A, Dawkins K, van den Brand M, Van Dyck N, Russell ME, Mohr FW and Serruys PW: The Syntax score: An angiographic tool grading the complexity of coronary artery disease. EuroIntervention. 1:219–227. 2005.PubMed/NCBI

10 

Tanaka T, Seto S, Yamamoto K, Kondo M and Otomo T: An assessment of risk factors for the complexity of coronary artery disease using the Syntax score. Cardiovasc Interv Ther. 28:16–21. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Wykrzykowska JJ, Garg S, Girasis C, de Vries T, Morel MA, van Es GA, Buszman P, Linke A, Ischinger T, Klauss V, et al: Value of the Syntax score for risk assessment in the all-comers population of the randomized multicenter LEADERS (limus eluted from A durable versus ERodable stent coating) trial. J Am Coll Cardiol. 56:272–277. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Mohr FW, Morice MC, Kappetein AP, Feldman TE, Ståhle E, Colombo A, Mack MJ, Holmes DR Jr, Morel MA, Van Dyck N, et al: Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical Syntax trial. Lancet. 381:629–638. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Mohr FW, Rastan AJ, Serruys PW, Kappetein AP, Holmes DR, Pomar JL, Westaby S, Leadley K, Dawkins KD and Mack MJ: Complex coronary anatomy in coronary artery bypass graft surgery: Impact of complex coronary anatomy in modern bypass surgery? Lessons learned from the Syntax trial after two years. J Thorac Cardiovasc Surg. 141:130–140. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Aicher A, Heeschen C, Mildner-Rihm C, Urbich C, Ihling C, Technau-Ihling K, Zeiher AM and Dimmeler S: Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med. 9:1370–1376. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Duda DG, Fukumura D and Jain RK: Role of eNOS in neovascularization: NO for endothelial progenitor cells. Trends Mol Med. 10:143–145. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Urbich C and Dimmeler S: Endothelial progenitor cells: characterization and role in vascular biology. Circ Res. 95:343–353. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Zhen Y, Xiao S, Ren Z, Shen HW, Su H, Tang YB and Zeng H: Increased endothelial progenitor cells and nitric oxide in young prehypertensive women. J Clin Hypertens (Greenwich). 17:298–305. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Zeng H, Jiang Y, Tang H, Ren Z, Zeng G and Yang Z: Abnormal phosphorylation of Tie2/Akt/eNOS signaling pathway and decreased number or function of circulating endothelial progenitor cells in prehypertensive premenopausal women with diabetes mellitus. BMC Endocr Disord. 16:132016. View Article : Google Scholar : PubMed/NCBI

19 

Yang Z, Chen L, Su C, Xia WH, Wang Y, Wang JM, Chen F, Zhang YY, Wu F, Xu SY, et al: Impaired endothelial progenitor cell activity is associated with reduced arterial elasticity in patients with essential hypertension. Clin Exp Hypertens. 32:444–452. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Yang Z, Wang JM, Chen L, Luo CF, Tang AL and Tao J: Acute exercise-induced nitric oxide production contributes to upregulation of circulating endothelial progenitor cells in healthy subjects. J Hum Hypertens. 21:452–460. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, Zeiher AM and Dimmeler S: Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res. 89:E1–E7. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Yang Z, Xia WH, Su C, Wu F, Zhang YY, Xu SY, Liu X, Zhang XY, Ou ZJ, Lai GH, et al: Regular exercise-induced increased number and activity of circulating endothelial progenitor cells attenuates age-related decline in arterial elasticity in healthy men. Int J Cardiol. 165:247–254. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Yang Z, Xia WH, Zhang YY, Xu SY, Liu X, Zhang XY, Yu BB, Qiu YX and Tao J: Shear stress-induced activation of Tie2-dependent signaling pathway enhances reendothelialization capacity of early endothelial progenitor cells. J Mol Cell Cardiol. 52:1155–1163. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Yang Z, Tao J, Wang JM, Tu C, Xu MG, Wang Y and Pan SR: Shear stress contributes to t-PA mRNA expression in human endothelial progenitor cells and nonthrombogenic potential of small diameter artificial vessels. Biochem Biophys Res Commun. 342:577–584. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Hirschi KK, Ingram DA and Yoder MC: Assessing identity, phenotype, and fate of endothelial progenitor cells. Arterioscler Thromb Vasc Biol. 28:1584–1595. 2008. View Article : Google Scholar : PubMed/NCBI

26 

Walther C, Gaede L, Adams V, Gelbrich G, Leichtle A, Erbs S, Sonnabend M, Fikenzer K, Korner A, Kiess W, et al: Effect of increased exercise in school children on physical fitness and endothelial progenitor cells: A prospective randomized trial. Circulation. 120:2251–2259. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Zeng W, Yuan W, Li L, Mi J, Xu S, Wen C, Zhou Z, Xiong J, Sun J, Ying D, et al: The promotion of endothelial progenitor cells recruitment by nerve growth factors in tissue-engineered blood vessels. Biomaterials. 31:1636–1645. 2010. View Article : Google Scholar : PubMed/NCBI

28 

Heiss C, Keymel S, Niesler U, Ziemann J, Kelm M and Kalka C: Impaired progenitor cell activity in age-related endothelial dysfunction. J Am Coll Cardiol. 45:1441–1448. 2005. View Article : Google Scholar : PubMed/NCBI

29 

Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, et al: Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the international brachial artery reactivity task force. J Am Coll Cardiol. 39:257–265. 2002. View Article : Google Scholar : PubMed/NCBI

30 

Sibal L, Aldibbiat A, Agarwal SC, Mitchell G, Oates C, Razvi S, Weaver JU, Shaw JA and Home PD: Circulating endothelial progenitor cells, endothelial function, carotid intima-media thickness and circulating markers of endothelial dysfunction in people with type 1 diabetes without macrovascular disease or microalbuminuria. Diabetologia. 52:1464–1473. 2009. View Article : Google Scholar : PubMed/NCBI

31 

Farooq V, Head SJ, Kappetein AP and Serruys PW: Widening clinical applications of the Syntax score. Heart. 100:276–287. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Chen SL, Chen JP, Mintz G, Xu B, Kan J, Ye F, Zhang J, Sun X, Xu Y, Jiang Q, et al: Comparison between the NERS (new risk stratification) score and the Syntax (synergy between percutaneous coronary intervention with taxus and cardiac surgery) score in outcome prediction for unprotected left main stenting. JACC Cardiovasc Interv. 3:632–641. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Yadav M, Palmerini T, Caixeta A, Madhavan MV, Sanidas E, Kirtane AJ, Stone GW and Généreux P: Prediction of coronary risk by Syntax and derived scores: Synergy between percutaneous coronary intervention with taxus and cardiac surgery. J Am Coll Cardiol. 62:1219–1230. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Cuenza L, Collado MP and Ho Khe Sui J: Global risk score and clinical Syntax score as predictors of clinical outcomes of patients undergoing unprotected left main percutaneous catheter intervention. Cardiol Res. 8:312–318. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Bentzon JF, Otsuka F, Virmani R and Falk E: Mechanisms of plaque formation and rupture. Circ Res. 114:1852–1866. 2014. View Article : Google Scholar : PubMed/NCBI

36 

Flammer AJ, Anderson T, Celermajer DS, Creager MA, Deanfield J, Ganz P, Hamburg NM, Lüscher TF, Shechter M, Taddei S, et al: The assessment of endothelial function: From research into clinical practice. Circulation. 126:753–767. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Shyu KG: Enhancement of new vessel formation by angiopoietin-2/Tie2 signaling in endothelial progenitor cells: A new hope for future therapy? Cardiovasc Res. 72:359–360. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A and Sessa WC: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 399:597–601. 1999. View Article : Google Scholar : PubMed/NCBI

39 

Thum T, Fraccarollo D, Schultheiss M, Froese S, Galuppo P, Widder JD, Tsikas D, Ertl G and Bauersachs J: Endothelial nitric oxide synthase uncoupling impairs endothelial progenitor cell mobilization and function in diabetes. Diabetes. 56:666–674. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang B, Li D, Liu G, Tan W, Zhang G and Liao J: Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease. Mol Med Rep 23: 321, 2021.
APA
Zhang, B., Li, D., Liu, G., Tan, W., Zhang, G., & Liao, J. (2021). Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease. Molecular Medicine Reports, 23, 321. https://doi.org/10.3892/mmr.2021.11960
MLA
Zhang, B., Li, D., Liu, G., Tan, W., Zhang, G., Liao, J."Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease". Molecular Medicine Reports 23.5 (2021): 321.
Chicago
Zhang, B., Li, D., Liu, G., Tan, W., Zhang, G., Liao, J."Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease". Molecular Medicine Reports 23, no. 5 (2021): 321. https://doi.org/10.3892/mmr.2021.11960
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang B, Li D, Liu G, Tan W, Zhang G and Liao J: Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease. Mol Med Rep 23: 321, 2021.
APA
Zhang, B., Li, D., Liu, G., Tan, W., Zhang, G., & Liao, J. (2021). Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease. Molecular Medicine Reports, 23, 321. https://doi.org/10.3892/mmr.2021.11960
MLA
Zhang, B., Li, D., Liu, G., Tan, W., Zhang, G., Liao, J."Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease". Molecular Medicine Reports 23.5 (2021): 321.
Chicago
Zhang, B., Li, D., Liu, G., Tan, W., Zhang, G., Liao, J."Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease". Molecular Medicine Reports 23, no. 5 (2021): 321. https://doi.org/10.3892/mmr.2021.11960
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