Open Access

Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease

  • Authors:
    • Bin Zhang
    • Dong Li
    • Gexiu Liu
    • Wenfeng Tan
    • Gaoxing Zhang
    • Jinli Liao
  • View Affiliations

  • Published online on: March 5, 2021     https://doi.org/10.3892/mmr.2021.11960
  • Article Number: 321
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

It has previously been shown that the number of endothelial progenitor cells (EPCs) is negatively correlated with Syntax score in patients with coronary artery disease (CAD). However, the association between alterations in EPC function and Syntax score is still unknown. The present study evaluated the association between the activity of EPCs as well as endothelial function and Syntax score in patients with CAD and investigated the underlying mechanisms. A total of 60 patients with CAD were enrolled in 3 groups according to Syntax score, and 20 healthy subjects were recruited as the control group. The number and migratory, proliferative and adhesive activities of circulating EPCs were studied. The endothelial function was measured by flow‑mediated dilatation (FMD) and the levels of nitric oxide (NO) in plasma or secreted by EPCs were detected. The number and activity of circulating EPCs were lower in patients with a high Syntax score, which was similar to the alteration in FMD. The level of NO in plasma or secreted by EPCs also decreased as Syntax score increased. There was a negative association between FMD or circulating EPCs and Syntax score. A similar association was observed between the levels of NO in plasma or secreted by EPCs and Syntax score. Patients with CAD who had a higher Syntax score exhibited lower EPC numbers or activity and weaker endothelial function, which may be associated with attenuated NO production. These findings provide novel surrogate parameters for evaluation of the severity and complexity of CAD.
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May-2021
Volume 23 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Zhang B, Li D, Liu G, Tan W, Zhang G and Liao J: Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease. Mol Med Rep 23: 321, 2021
APA
Zhang, B., Li, D., Liu, G., Tan, W., Zhang, G., & Liao, J. (2021). Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease. Molecular Medicine Reports, 23, 321. https://doi.org/10.3892/mmr.2021.11960
MLA
Zhang, B., Li, D., Liu, G., Tan, W., Zhang, G., Liao, J."Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease". Molecular Medicine Reports 23.5 (2021): 321.
Chicago
Zhang, B., Li, D., Liu, G., Tan, W., Zhang, G., Liao, J."Impaired activity of circulating EPCs and endothelial function are associated with increased Syntax score in patients with coronary artery disease". Molecular Medicine Reports 23, no. 5 (2021): 321. https://doi.org/10.3892/mmr.2021.11960