Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2021 Volume 23 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2021 Volume 23 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Total flavonoids of Rhizoma drynariae ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway

  • Authors:
    • Wenxue Lv
    • Mingxiu Yu
    • Qingyi Yang
    • Peng Kong
    • Bing Yan
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Lixia, Jinan, Shandong 250014, P.R. China, Department of Special Inspection, The Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Lixia, Jinan, Shandong 250014, P.R. China
    Copyright: © Lv et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 345
    |
    Published online on: March 9, 2021
       https://doi.org/10.3892/mmr.2021.11984
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Steroid‑induced avascular necrosis of the femoral head (SANFH) is a common orthopaedic disease that is difficult to treat. The present study investigated the effects of total flavonoids of Rhizoma drynariae (TFRD) on SANFH and explored its underlying mechanisms. The SANFH rat model was induced by intramuscular injection of lipopolysaccharides and methylprednisolone. Osteoblasts were isolated from the calvariae of neonatal rats and then cultured with dexamethasone (Dex). TFRD was used in vitro and in vivo, respectively. Haematoxylin and eosin staining was used to assess the pathological changes in the femoral head. Terminal deoxynucleotidyl transferase‑mediated deoxyuridine triphosphate nick end labelling assay and flow cytometry were conducted to detect apoptosis of osteoblasts. The 2',7'‑dichlorofluorescein‑diacetate staining method was used to detect reactive oxygen species (ROS) levels in osteoblasts and the 3‑(4,5‑dimethylthiazol‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay was used to detect osteoblast proliferation. The expression of caspase‑3, Bax, Bcl‑2, VEGF, runt‑related transcription factor 2 (RUNX2), osteoprotegerin (OPG), osteocalcin (OCN), receptor activator of nuclear factor κB ligand (RANKL) and phosphoinositide 3‑kinase (PI3K)/AKT pathway related‑proteins were detected via western blotting. It was found that TFRD reduced the pathological changes, inhibited apoptosis, increased the expression of VEGF, RUNX2, OPG and OCN, decreased RANKL expression and activated the PI3K/AKT pathway in SANFH rats. TFRD promoted proliferation, inhibited apoptosis and reduced ROS levels by activating the PI3K/AKT pathway in osteoblasts. In conclusion, TFRD protected against SANFH in a rat model. In addition, TFRD protected osteoblasts from Dex‑induced damage through the PI3K/AKT pathway. The findings of the present study may contribute to find an effective treatment for the management of SANFH.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Xiang S, Li Z and Weng X: The role of lncRNA RP11-154D6 in steroid-induced osteonecrosis of the femoral head through BMSC regulation. J Cell Biochem. 120:18435–18445. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Yan YQ, Pang QJ and Xu RJ: Effects of erythropoietin for precaution of steroid-induced femoral head necrosis in rats. BMC Musculoskelet Disord. 19:2822018. View Article : Google Scholar : PubMed/NCBI

3 

Xue XH, Feng ZH, Li ZX and Pan XY: Salidroside inhibits steroid-induced avascular necrosis of the femoral head via the PI3K/Akt signaling pathway: In vitro and in vivo studies. Mol Med Rep. 17:3751–3757. 2018.PubMed/NCBI

4 

Ren X, Fan W, Shao Z, Chen K, Yu X and Liang Q: A metabolomic study on early detection of steroid-induced avascular necrosis of the femoral head. Oncotarget. 9:7984–7995. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Wong GKC, Poon WS and Chiu KH: Steroid-induced avascular necrosis of the hip in neurosurgical patients: Epidemiological study. ANZ J Surg. 75:409–410. 2015. View Article : Google Scholar

6 

Bae WY, Kim HY, Choi KS, Chang KH, Hong YH, Eun J, Lee NK and Paik HD: Investigation of Brassica juncea, Forsythia suspensa, and Inula britannica: Phytochemical properties, antiviral effects, and safety. BMC Complement Altern Med. 19:2532019. View Article : Google Scholar : PubMed/NCBI

7 

Li L, Hou X, Xu R, Liu C and Tu M: Research review on the pharmacological effects of astragaloside IV. Fundam Clin Pharmacol. 31:17–36. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Zhang Y, Jiang J, Shen H, Chai Y, Wei X and Xie Y: Total flavonoids from Rhizoma Drynariae (Gusuibu) for treating osteoporotic fractures: Implication in clinical practice. Drug Des Devel Ther. 11:1881–1890. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Lin FX, Du SX, Liu DZ, Hu QX, Yu GY, Wu CC, Zheng GZ, Xie D, Li XD and Chang B: Naringin promotes osteogenic differentiation of bone marrow stromal cells by up-regulating Foxc2 expression via the IHH signaling pathway. Am J Transl Res. 8:5098–5107. 2016.PubMed/NCBI

10 

Wong RW, Rabie B, Bendeus M and Hägg U: The effects of rhizoma curculiginis and rhizoma drynariae extracts on bones. Chin Med. 2:132007. View Article : Google Scholar : PubMed/NCBI

11 

Kuang MJ, Zhang WH, He WW, Sun L, Ma JX, Wang D and Ma XL: Naringin regulates bone metabolism in glucocorticoid-induced osteonecrosis of the femoral head via the Akt/Bad signal cascades. Chem Biol Interact. 304:97–105. 2019. View Article : Google Scholar : PubMed/NCBI

12 

Guntur AR and Rosen CJ: The skeleton: A multi-functional complex organ. New insights into osteoblasts and their role in bone formation: The central role of PI3Kinase. J Endocrinol. 211:123–130. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Gu Y, Du J, Si M, Mo J, Qiao S and Lai H: The roles of PI3K/Akt signaling pathway in regulating MC3T3-E1 preosteoblast proliferation and differentiation on SLA and SLActive titanium surfaces. J Biomed Mater Res A. 101:748–754. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Ma J, Sawai H, Ochi N, Matsuo Y, Xu D, Yasuda A, Takahashi H, Wakasugi T and Takeyama H: PTEN regulates angiogenesis through PI3K/Akt/VEGF signaling pathway in human pancreatic cancer cells. Mol Cell Biochem. 331:161–171. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Zhang J, Liu X, Li H, Chen C, Hu B, Niu X, Li Q, Zhao B, Xie Z and Wang Y: Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway. Stem Cell Res Ther. 7:1362016. View Article : Google Scholar : PubMed/NCBI

16 

Hu J, Gu Y and Fan W: Rg1 protects rat bone marrow stem cells against hydrogen peroxide-induced cell apoptosis through the PI3K/Akt pathway. Mol Med Rep. 14:406–412. 2016. View Article : Google Scholar : PubMed/NCBI

17 

National Research Council: Guide for the Care and Use of Laboratory Animals: Eighth edition. The National Academies Press; Washington, DC: 2011

18 

Spiers DE and Candas V: Relationship of skin surface area to body mass in the immature rat: A reexamination. J Appl Physiol Respir Environ Exerc Physiol. 56:240–243. 1984.PubMed/NCBI

19 

Lu X, Xiong Z, Li J, Zheng S, Huo T and Li F: Metabonomic study on ‘Kidney-Yang Deficiency syndrome’ and intervention effects of Rhizoma Drynariae extracts in rats using ultra performance liquid chromatography coupled with mass spectrometry. Talanta. 83:700–708. 2011. View Article : Google Scholar : PubMed/NCBI

20 

Feng Z, Zheng W, Tang Q, Cheng L, Li H, Ni W and Pan X: Fludarabine inhibits STAT1-mediated up-regulation of caspase-3 expression in dexamethasone-induced osteoblasts apoptosis and slows the progression of steroid-induced avascular necrosis of the femoral head in rats. Apoptosis. 22:1001–1012. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Wang A, Ren M and Wang J: The pathogenesis of steroid-induced osteonecrosis of the femoral head: A systematic review of the literature. Gene. 671:103–109. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Song HM, Wei YC, Li N, Wu B, Xie N, Zhang KM, Wang SZ and Wang HM: Effects of Wenyangbushen formula on the expression of VEGF, OPG, RANK and RANKL in rabbits with steroid-induced femoral head avascular necrosis. Mol Med Rep. 12:8155–8161. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Xu L, Huang G, Guo X, Zhou Q and He S: Total flavonoids, extracted from Polygonum knotweed L, exert beneficial hepatoprotection against liver injury. J Cell Biochem. 120:12677–12683. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Cheng Y, Yang Z, Shi J, Yang J, Zhao J, He Y and Qi M: Total flavonoids of Epimedium ameliorates testicular damage in streptozotocin-induced diabetic rats by suppressing inflammation and oxidative stress. Environ Toxicol. 35:268–276. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Guo Y, Xing L, Chen N, Gao C, Ding Z and Jin B: Total flavonoids from the Carya cathayensis Sarg. leaves inhibit HUVEC senescence through the miR-34a/SIRT1 pathway. J Cell Biochem. 120:17240–17249. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Kang SN, Lee JS, Park JH, Cho JH, Park JH, Cho KK, Lee OH and Kim IS: In vitro anti-osteoporosis properties of diverse Korean Drynariae rhizoma phenolic extracts. Nutrients. 6:1737–1751. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Weinstein RS: Glucocorticoid-induced osteonecrosis. Endocrine. 41:183–190. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Assouline-Dayan Y, Chang C, Greenspan A, Shoenfeld Y and Gershwin ME: Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum. 32:94–124. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Inoue A and Ono K: A histological study of idiopathic avascular necrosis of the head of the femur. J Bone Joint Surg Br. 61-B:138–143. 1979. View Article : Google Scholar : PubMed/NCBI

30 

Ichiseki T, Ueda S, Ueda Y, Tuchiya M, Kaneuji A and Kawahara N: Involvement of necroptosis, a newly recognized cell death type, in steroid-induced osteonecrosis in a rabbit model. Int J Med Sci. 14:110–114. 2017. View Article : Google Scholar : PubMed/NCBI

31 

Varoga D, Drescher W, Pufe M, Groth G and Pufe T: Differential expression of vascular endothelial growth factor in glucocorticoid-related osteonecrosis of the femoral head. Clin Orthop Relat Res. 467:3273–3282. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Carlevaro MF, Cermelli S, Cancedda R and Cancedda FD: Vascular endothelial growth factor (VEGF) in cartilage neovascularization and chondrocyte differentiation: Auto-paracrine role during endochondral bone formation. J Cell Sci. 113:59–69. 2000.PubMed/NCBI

33 

Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, Fahrig M, Vandenhoeck A, Harpal K, Eberhardt C, et al: Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 380:435–439. 1996. View Article : Google Scholar : PubMed/NCBI

34 

Zheng LZ, Cao HJ, Chen SH, Tang T, Fu WM, Huang L, Chow DHK, Wang YX, Griffith JF, He W, et al: Blockage of src by specific siRNA as a novel therapeutic strategy to prevent destructive repair in steroid-associated osteonecrosis in rabbits. J Bone Miner Res. 30:2044–2057. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Piuzzi NS, Anis HK and Muschler GF: Osteonecrosis of the femoral head with subchondral collapse. Cleve Clin J Med. 86:511–512. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Zhu C, Lv Y, Qian C, Qian H, Jiao T, Wang L and Zhang F: Proliferation and osteogenic differentiation of rat BMSCs on a novel Ti/SiC metal matrix nanocomposite modified by friction stir processing. Sci Rep. 6:388752016. View Article : Google Scholar : PubMed/NCBI

37 

Qian C, Zhu C, Yu W, Jiang X and Zhang F: High-fat diet/low-dose streptozotocin-induced type 2 diabetes in rats impacts osteogenesis and wnt signaling in bone marrow stromal cells. PLoS One. 10:e01363902015. View Article : Google Scholar : PubMed/NCBI

38 

Croucher PI, Mcdonald MM and Martin TJ: Bone metastasis: The importance of the neighbourhood. Nat Rev Cancer. 16:373–386. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Peng WX, Ye C, Dong WT, Yang LL, Wang CQ, Wei ZA, Wu JH, Li Q, Deng J and Zhang J: MicroRNA-34a alleviates steroid-induced avascular necrosis of femoral head by targeting Tgif2 through OPG/RANK/RANKL signaling pathway. Exp Biol Med (Maywood). 242:1234–1243. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Zhang H, Zhou F, Pan Z, Bu X, Wang Y and Chen F: 11β-hydroxysteroid dehydrogenases-2 decreases the apoptosis of MC3T3/MLO-Y4 cells induced by glucocorticoids. Biochem Biophys Res Commun. 490:1399–1406. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Xu X, Wen H, Hu Y, Yu H, Zhang Y, Chen C and Pan X: STAT1-caspase 3 pathway in the apoptotic process associated with steroid-induced necrosis of the femoral head. J Mol Histol. 45:473–485. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Li DW, Liu ZQ, Chen W, Yao M and Li GR: Association of glycogen synthase kinase-3β with Parkinson's disease (Review). Mol Med Rep. 9:2043–2050. 2014. View Article : Google Scholar : PubMed/NCBI

43 

Chao DT and Korsmeyer SJ: BCL-2 family: Regulators of cell death. Annu Rev Immunol. 16:395–419. 1998. View Article : Google Scholar : PubMed/NCBI

44 

Ravindran J, Gupta N, Agrawal M, Asb B and Rao PVL: Modulation of ROS/MAPK signaling pathways by okadaic acid leads to cell death via, mitochondrial mediated caspase-dependent mechanism. Apoptosis. 16:145–161. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Deng S, Zhou JL, Fang HS, Nie ZG, Chen S and Peng H: Sesamin protects the femoral head from osteonecrosis by inhibiting ROS-induced osteoblast apoptosis in rat model. Front Physiol. 9:17872018. View Article : Google Scholar : PubMed/NCBI

46 

Sato A, Tu X, McAndrews K, Plotkin L and Bellido T: Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice. Bone. 73:60–68. 2015. View Article : Google Scholar : PubMed/NCBI

47 

Li J, He C, Tong W, Zou Y, Li D, Zhang C and Xu W: Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production. Int J Clin Exp Pathol. 8:13695–13706. 2015.PubMed/NCBI

48 

Cakir E, Yilmaz A, Demirag F, Oguztuzun S, Sahin S, Yazici UE and Aydin M: Prognostic significance of micropapillary pattern in lung adenocarcinoma and expression of apoptosis-related markers: Caspase-3, bcl-2, and p53. APMIS. 119:574–580. 2011. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lv W, Yu M, Yang Q, Kong P and Yan B: Total flavonoids of <em>Rhizoma drynariae</em> ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway. Mol Med Rep 23: 345, 2021.
APA
Lv, W., Yu, M., Yang, Q., Kong, P., & Yan, B. (2021). Total flavonoids of <em>Rhizoma drynariae</em> ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway. Molecular Medicine Reports, 23, 345. https://doi.org/10.3892/mmr.2021.11984
MLA
Lv, W., Yu, M., Yang, Q., Kong, P., Yan, B."Total flavonoids of <em>Rhizoma drynariae</em> ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway". Molecular Medicine Reports 23.5 (2021): 345.
Chicago
Lv, W., Yu, M., Yang, Q., Kong, P., Yan, B."Total flavonoids of <em>Rhizoma drynariae</em> ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway". Molecular Medicine Reports 23, no. 5 (2021): 345. https://doi.org/10.3892/mmr.2021.11984
Copy and paste a formatted citation
x
Spandidos Publications style
Lv W, Yu M, Yang Q, Kong P and Yan B: Total flavonoids of <em>Rhizoma drynariae</em> ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway. Mol Med Rep 23: 345, 2021.
APA
Lv, W., Yu, M., Yang, Q., Kong, P., & Yan, B. (2021). Total flavonoids of <em>Rhizoma drynariae</em> ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway. Molecular Medicine Reports, 23, 345. https://doi.org/10.3892/mmr.2021.11984
MLA
Lv, W., Yu, M., Yang, Q., Kong, P., Yan, B."Total flavonoids of <em>Rhizoma drynariae</em> ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway". Molecular Medicine Reports 23.5 (2021): 345.
Chicago
Lv, W., Yu, M., Yang, Q., Kong, P., Yan, B."Total flavonoids of <em>Rhizoma drynariae</em> ameliorate steroid‑induced avascular necrosis of the femoral head via the PI3K/AKT pathway". Molecular Medicine Reports 23, no. 5 (2021): 345. https://doi.org/10.3892/mmr.2021.11984
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team