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Review Open Access

HIF‑1α in myocardial ischemia‑reperfusion injury (Review)

  • Authors:
    • Jie Zheng
    • Peier Chen
    • Jianfeng Zhong
    • Yu Cheng
    • Hao Chen
    • Yuan He
    • Can Chen
  • View Affiliations / Copyright

    Affiliations: Laboratory of Cardiovascular Diseases, Guangdong Medical University, Zhanjiang, Guangdong 524000, P.R. China, Guangdong Key Laboratory of Age‑related Cardiac and Cerebral Diseases, The Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524001, P.R. China, Department of Cardiology, The Second Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong 524003, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 352
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    Published online on: March 12, 2021
       https://doi.org/10.3892/mmr.2021.11991
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Abstract

Myocardial ischemia‑reperfusion injury (MIRI) is a severe injury to the ischemic myocardium following the recovery of blood flow. Currently, there is no effective treatment for MIRI in clinical practice. Over the past two decades, biological studies of hypoxia and hypoxia‑inducible factor‑1α (HIF‑1α) have notably improved understanding of oxygen homeostasis. HIF‑1α is an oxygen‑sensitive transcription factor that mediates adaptive metabolic responses to hypoxia and serves a pivotal role in MIRI. In particular, previous studies have demonstrated that HIF‑1α improves mitochondrial function, decreases cellular oxidative stress, activates cardioprotective signaling pathways and downstream protective genes and interacts with non‑coding RNAs. The present review summarizes the roles and associated mechanisms of action of HIF‑1α in MIRI. In addition, HIF‑1α‑associated MIRI intervention, including natural compounds, exosomes, ischemic preconditioning and ischemic post‑processing are presented. The present review provides evidence for the roles of HIF‑1α activation in MIRI and supports its use as a therapeutic target.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng J, Chen P, Zhong J, Cheng Y, Chen H, He Y and Chen C: HIF‑1α in myocardial ischemia‑reperfusion injury (Review). Mol Med Rep 23: 352, 2021.
APA
Zheng, J., Chen, P., Zhong, J., Cheng, Y., Chen, H., He, Y., & Chen, C. (2021). HIF‑1α in myocardial ischemia‑reperfusion injury (Review). Molecular Medicine Reports, 23, 352. https://doi.org/10.3892/mmr.2021.11991
MLA
Zheng, J., Chen, P., Zhong, J., Cheng, Y., Chen, H., He, Y., Chen, C."HIF‑1α in myocardial ischemia‑reperfusion injury (Review)". Molecular Medicine Reports 23.5 (2021): 352.
Chicago
Zheng, J., Chen, P., Zhong, J., Cheng, Y., Chen, H., He, Y., Chen, C."HIF‑1α in myocardial ischemia‑reperfusion injury (Review)". Molecular Medicine Reports 23, no. 5 (2021): 352. https://doi.org/10.3892/mmr.2021.11991
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng J, Chen P, Zhong J, Cheng Y, Chen H, He Y and Chen C: HIF‑1α in myocardial ischemia‑reperfusion injury (Review). Mol Med Rep 23: 352, 2021.
APA
Zheng, J., Chen, P., Zhong, J., Cheng, Y., Chen, H., He, Y., & Chen, C. (2021). HIF‑1α in myocardial ischemia‑reperfusion injury (Review). Molecular Medicine Reports, 23, 352. https://doi.org/10.3892/mmr.2021.11991
MLA
Zheng, J., Chen, P., Zhong, J., Cheng, Y., Chen, H., He, Y., Chen, C."HIF‑1α in myocardial ischemia‑reperfusion injury (Review)". Molecular Medicine Reports 23.5 (2021): 352.
Chicago
Zheng, J., Chen, P., Zhong, J., Cheng, Y., Chen, H., He, Y., Chen, C."HIF‑1α in myocardial ischemia‑reperfusion injury (Review)". Molecular Medicine Reports 23, no. 5 (2021): 352. https://doi.org/10.3892/mmr.2021.11991
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