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Article

Upregulation of miR‑126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway

  • Authors:
    • Jianming Su
    • Limin Ding
  • View Affiliations / Copyright

    Affiliations: Department of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China
  • Article Number: 373
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    Published online on: March 16, 2021
       https://doi.org/10.3892/mmr.2021.12012
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Abstract

Sepsis‑induced cardiorenal syndrome is one of the multiple organ dysfunctions observed in sepsis. It is determined by a primary dysfunction in one organ that leads to secondary injury to another organ. Studies have shown the involvement of microRNAs (miRs) in the diagnosis and prognosis of several pathologies. However, the implication of miR‑126 in the podocyte damage associated with sepsis has not been evaluated until now. In the current study, the miR‑126 expression was downregulated in a podocyte injury model together with downregulation of nephrin expression. The transfection of podocytes from podocyte injury group with miR‑126 mimics demonstrated an increase in cell proliferation and a decrease in cell apoptosis. Bioinformatics analysis predicted that the target of miR‑126 was epidermal growth factor‑like domain multiple 6 (EGFL6) and dyskeratosis congenita 1 (DKC1) and these were confirmed by dual‑luciferase reporter assay. miR‑126 upregulation determined EGFL6 and DKC1 upregulation and prevented podocyte injury. The current study demonstrated that overexpression of miR‑126 could protect podocytes from sepsis‑induced injury through an EGFL6/DKC1 signaling pathway.
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Copy and paste a formatted citation
Spandidos Publications style
Su J and Ding L: Upregulation of miR‑126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway. Mol Med Rep 23: 373, 2021.
APA
Su, J., & Ding, L. (2021). Upregulation of miR‑126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway. Molecular Medicine Reports, 23, 373. https://doi.org/10.3892/mmr.2021.12012
MLA
Su, J., Ding, L."Upregulation of miR‑126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway". Molecular Medicine Reports 23.5 (2021): 373.
Chicago
Su, J., Ding, L."Upregulation of miR‑126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway". Molecular Medicine Reports 23, no. 5 (2021): 373. https://doi.org/10.3892/mmr.2021.12012
Copy and paste a formatted citation
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Spandidos Publications style
Su J and Ding L: Upregulation of miR‑126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway. Mol Med Rep 23: 373, 2021.
APA
Su, J., & Ding, L. (2021). Upregulation of miR‑126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway. Molecular Medicine Reports, 23, 373. https://doi.org/10.3892/mmr.2021.12012
MLA
Su, J., Ding, L."Upregulation of miR‑126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway". Molecular Medicine Reports 23.5 (2021): 373.
Chicago
Su, J., Ding, L."Upregulation of miR‑126 inhibits podocyte injury in sepsis via EGFL6/DKC1 signaling pathway". Molecular Medicine Reports 23, no. 5 (2021): 373. https://doi.org/10.3892/mmr.2021.12012
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