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A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review)

  • Authors:
    • Lan-Lan Mi
    • Yue Zhu
    • Hong-Yan Lu
  • View Affiliations

  • Published online on: March 26, 2021     https://doi.org/10.3892/mmr.2021.12042
  • Article Number: 403
  • Copyright: © Mi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Type 2 innate lymphoid cells (ILC2s) are important innate immune cells that are involved in type 2 inflammation, in both mice and humans. ILC2s are stimulated by factors, including interleukin (IL)‑33 and IL‑25, and activated ILC2s secrete several cytokines that mediate type 2 immunity by inducing profound changes in physiology, including activation of alternative (M2) macrophages. M2 macrophages possess immune modulatory, phagocytic, tissue repair and remodeling properties, and can regulate ILC2s under infection. The present review summarizes the role of ILC2s as innate cells and M2 macrophages as anti‑inflammatory cells, and discusses current literature on their important biological significance. The present review also highlights how the crosstalk between ILC2s and M2 macrophages contributes to lung development, induces pulmonary parasitic expulsion, exacerbates pulmonary viral and fungal infections and allergic airway diseases, and promotes the development of lung diseases, such as pulmonary fibrosis, chronic obstructive pulmonary disease and carcinoma of the lungs.
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June-2021
Volume 23 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Mi L, Zhu Y and Lu H: A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review). Mol Med Rep 23: 403, 2021
APA
Mi, L., Zhu, Y., & Lu, H. (2021). A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review). Molecular Medicine Reports, 23, 403. https://doi.org/10.3892/mmr.2021.12042
MLA
Mi, L., Zhu, Y., Lu, H."A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review)". Molecular Medicine Reports 23.6 (2021): 403.
Chicago
Mi, L., Zhu, Y., Lu, H."A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases (Review)". Molecular Medicine Reports 23, no. 6 (2021): 403. https://doi.org/10.3892/mmr.2021.12042