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Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy

  • Authors:
    • Yunfeng Zhu
    • Yong Su
    • Jie Zhang
    • Yanhua Zhang
    • Yan Li
    • Yuli Han
    • Xianan Dong
    • Weizu Li
    • Weiping Li
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Anti‑Inflammatory and Immunopharmacology, Ministry of Education, Department of Pharmacology, Basic Medicine College, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China
    Copyright: © Zhu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 437
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    Published online on: April 9, 2021
       https://doi.org/10.3892/mmr.2021.12076
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Abstract

Diabetic liver injury is a serious complication of type 2 diabetes mellitus (T2DM), which is often irreversible in the later stage, and affects the quality of life. Autophagy serves an important role in the occurrence and development of diabetic liver injury. For example, it can improve insulin resistance (IR), dyslipidaemia, oxidative stress and inflammation. Astragaloside IV (AS‑IV) is a natural saponin isolated from the plant Astragalus membranaceus, which has comprehensive pharmacological effects, such as anti‑oxidation, anti‑inflammation and anti‑apoptosis properties, as well as can enhance immunity. However, whether AS‑IV can alleviate diabetic liver injury in T2DM and its underlying mechanisms remain unknown. The present study used high‑fat diets combined with low‑dose streptozotocin to induce a diabetic liver injury model in T2DM rats to investigate whether AS‑IV could alleviate diabetic liver injury and to identify its underlying mechanisms. The results demonstrated that AS‑IV treatment could restore changes in food intake, water intake, urine volume and body weight, as well as improve liver function and glucose homeostasis in T2DM rats. Moreover, AS‑IV treatment promoted suppressed autophagy in the liver of T2DM rats and improved IR, dyslipidaemia, oxidative stress and inflammation. In addition, AS‑IV activated adenosine monophosphate‑activated protein kinase (AMPK), which inhibited mTOR. Taken together, the present study suggested that AS‑IV alleviated diabetic liver injury in T2DM rats, and its mechanism may be associated with the promotion of AMPK/mTOR‑mediated autophagy, which further improved IR, dyslipidaemia, oxidative stress and inflammation. Thus, the regulation of autophagy may be an effective strategy to treat diabetic liver injury in T2DM.
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Copy and paste a formatted citation
Spandidos Publications style
Zhu Y, Su Y, Zhang J, Zhang Y, Li Y, Han Y, Dong X, Li W and Li W: Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy. Mol Med Rep 23: 437, 2021.
APA
Zhu, Y., Su, Y., Zhang, J., Zhang, Y., Li, Y., Han, Y. ... Li, W. (2021). Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy. Molecular Medicine Reports, 23, 437. https://doi.org/10.3892/mmr.2021.12076
MLA
Zhu, Y., Su, Y., Zhang, J., Zhang, Y., Li, Y., Han, Y., Dong, X., Li, W., Li, W."Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy". Molecular Medicine Reports 23.6 (2021): 437.
Chicago
Zhu, Y., Su, Y., Zhang, J., Zhang, Y., Li, Y., Han, Y., Dong, X., Li, W., Li, W."Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy". Molecular Medicine Reports 23, no. 6 (2021): 437. https://doi.org/10.3892/mmr.2021.12076
Copy and paste a formatted citation
x
Spandidos Publications style
Zhu Y, Su Y, Zhang J, Zhang Y, Li Y, Han Y, Dong X, Li W and Li W: Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy. Mol Med Rep 23: 437, 2021.
APA
Zhu, Y., Su, Y., Zhang, J., Zhang, Y., Li, Y., Han, Y. ... Li, W. (2021). Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy. Molecular Medicine Reports, 23, 437. https://doi.org/10.3892/mmr.2021.12076
MLA
Zhu, Y., Su, Y., Zhang, J., Zhang, Y., Li, Y., Han, Y., Dong, X., Li, W., Li, W."Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy". Molecular Medicine Reports 23.6 (2021): 437.
Chicago
Zhu, Y., Su, Y., Zhang, J., Zhang, Y., Li, Y., Han, Y., Dong, X., Li, W., Li, W."Astragaloside IV alleviates liver injury in type 2 diabetes due to promotion of AMPK/mTOR‑mediated autophagy". Molecular Medicine Reports 23, no. 6 (2021): 437. https://doi.org/10.3892/mmr.2021.12076
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