1
|
Tan SY, Mei Wong JL, Sim YJ, Wong SS,
Mohamed Elhassan SA, Tan SH, Ling Lim GP, Rong Tay NW, Annan NC,
Bhattamisra SK and Candasamy M: Type 1 and 2 diabetes mellitus: A
review on current treatment approach and gene therapy as potential
intervention. Diabetes Metab Syndr. 13:364–372. 2019. View Article : Google Scholar : PubMed/NCBI
|
2
|
Zheng Y, Ley SH and Hu FB: Global
aetiology and epidemiology of type 2 diabetes mellitus and its
complications. Nat Rev Endocrinol. 14:88–98. 2018. View Article : Google Scholar : PubMed/NCBI
|
3
|
Shima T, Uto H, Ueki K, Takamura T, Kohgo
Y, Kawata S, Yasui K, Park H, Nakamura N, Nakatou T, et al:
Clinicopathological features of liver injury in patients with type
2 diabetes mellitus and comparative study of histologically proven
nonalcoholic fatty liver diseases with or without type 2 diabetes
mellitus. J Gastroenterol. 48:515–525. 2013. View Article : Google Scholar : PubMed/NCBI
|
4
|
Hsiang JC, Gane EJ, Bai WW and Gerred SJ:
Type 2 diabetes: A risk factor for liver mortality and
complications in hepatitis B cirrhosis patients. J Gastroenterol
Hepatol. 30:591–599. 2015. View Article : Google Scholar : PubMed/NCBI
|
5
|
Bedi O, Aggarwal S, Trehanpati N,
Ramakrishna G and Krishan P: Molecular and pathological events
involved in the pathogenesis of diabetes-associated nonalcoholic
fatty liver disease. J Clin Exp Hepatol. 9:607–618. 2019.
View Article : Google Scholar : PubMed/NCBI
|
6
|
Akash MS, Rehman K and Chen S: Role of
inflammatory mechanisms in pathogenesis of type 2 diabetes
mellitus. J Cell Biochem. 114:525–531. 2013. View Article : Google Scholar : PubMed/NCBI
|
7
|
Mizushima N and Komatsu M: Autophagy:
Renovation of cells and tissues. Cell. 147:728–741. 2011.
View Article : Google Scholar : PubMed/NCBI
|
8
|
Liu H, Javaheri A, Godar RJ, Murphy J, Ma
X, Rohatgi N, Mahadevan J, Hyrc K, Saftig P, Marshall C, et al:
Intermittent fasting preserves beta-cell mass in obesity-induced
diabetes via the autophagy-lysosome pathway. Autophagy.
13:1952–1968. 2017. View Article : Google Scholar : PubMed/NCBI
|
9
|
Chatterjee T, Pattanayak R, Ukil A,
Chowdhury S and Bhattacharyya M: Autophagy protects peripheral
blood mononuclear cells against inflammation, oxidative and
nitrosative stress in diabetic dyslipidemia. Free Radic Biol Med.
143:309–323. 2019. View Article : Google Scholar : PubMed/NCBI
|
10
|
Fan W, Han D, Sun Z, Ma S, Gao L, Chen J,
Li X, Li X, Fan M, Li C, et al: Endothelial deletion of mTORC1
protects against hindlimb ischemia in diabetic mice via activation
of autophagy, attenuation of oxidative stress and alleviation of
inflammation. Free Radic Biol Med. 108:725–740. 2017. View Article : Google Scholar : PubMed/NCBI
|
11
|
Martinez-Lopez N and Singh R: Autophagy
and lipid droplets in the liver. Annu Rev Nutr. 35:215–237. 2015.
View Article : Google Scholar : PubMed/NCBI
|
12
|
Zhang BB, Zhou G and Li C: AMPK: An
emerging drug target for diabetes and the metabolic syndrome. Cell
Metab. 9:407–416. 2009. View Article : Google Scholar : PubMed/NCBI
|
13
|
Kim J, Kundu M, Viollet B and Guan KL:
AMPK and mTOR regulate autophagy through direct phosphorylation of
Ulk1. Nat Cell Biol. 13:132–141. 2011. View Article : Google Scholar : PubMed/NCBI
|
14
|
Liu TY, Xiong XQ, Ren XS, Zhao MX, Shi CX,
Wang JJ, Zhou YB, Zhang F, Han Y, Gao XY, et al: FNDC5 alleviates
hepatosteatosis by restoring AMPK/mTOR-mediated autophagy, fatty
acid oxidation, and lipogenesis in mice. Diabetes. 65:3262–3275.
2016. View Article : Google Scholar : PubMed/NCBI
|
15
|
Yang Y, Gao J, Zhang Y, Xu W, Hao Y, Xu Z
and Tao L: Natural pyrethrins induce autophagy of HepG2 cells
through the activation of AMPK/mTOR pathway. Environ Pollut.
241:1091–1097. 2018. View Article : Google Scholar : PubMed/NCBI
|
16
|
Wang E, Wang L, Ding R, Zhai M, Ge R, Zhou
P, Wang T, Fang H, Wang J and Huang J: Astragaloside IV acts
through multi-scale mechanisms to effectively reduce diabetic
nephropathy. Pharmacol Res. 157:1048312020. View Article : Google Scholar : PubMed/NCBI
|
17
|
Song MT, Ruan J, Zhang RY, Deng J, Ma ZQ
and Ma SP: Astragaloside IV ameliorates neuroinflammation-induced
depressive-like behaviors in mice via the PPARγ/NF-κB/NLRP3
inflammasome axis. Acta Pharmacol Sin. 39:1559–1570. 2018.
View Article : Google Scholar : PubMed/NCBI
|
18
|
Ju Y, Su Y, Chen Q, Ma K, Ji T, Wang Z and
Li W and Li W: Protective effects of Astragaloside IV on
endoplasmic reticulum stress-induced renal tubular epithelial cells
apoptosis in type 2 diabetic nephropathy rats. Biomed Pharmacother.
109:84–92. 2019. View Article : Google Scholar : PubMed/NCBI
|
19
|
Wang Z, Zhu Y, Zhang Y, Zhang J, Ji T and
Li W and Li W: Protective effects of AS-IV on diabetic
cardiomyopathy by improving myocardial lipid metabolism in rat
models of T2DM. Biomed Pharmacother. 127:1100812020. View Article : Google Scholar : PubMed/NCBI
|
20
|
Antuna-Puente B, Disse E, Rabasa-Lhoret R,
Laville M, Capeau J and Bastard JP: How can we measure insulin
sensitivity/resistance? Diabetes Metab. 37:179–188. 2011.
View Article : Google Scholar : PubMed/NCBI
|
21
|
Xu L, Yu Y, Sang R, Li J, Ge B and Zhang
X: Protective effects of taraxasterol against ethanol-induced liver
injury by regulating CYP2E1/Nrf2/HO-1 and NF-κB signaling pathways
in mice. Oxid Med Cell Longev. 2018:82841072018. View Article : Google Scholar : PubMed/NCBI
|
22
|
Michalopoulos GK: Hepatostat: Liver
regeneration and normal liver tissue maintenance. Hepatology.
65:1384–1392. 2017. View Article : Google Scholar : PubMed/NCBI
|
23
|
Bao L, Li J, Zha D, Zhang L, Gao P, Yao T
and Wu X: Chlorogenic acid prevents diabetic nephropathy by
inhibiting oxidative stress and inflammation through modulation of
the Nrf2/HO-1 and NF-κB pathways. Int Immunopharmacol. 54:245–253.
2018. View Article : Google Scholar : PubMed/NCBI
|
24
|
Guo M, Lu H, Qin J, Qu S, Wang W, Guo Y,
Liao W, Song M, Chen J and Wang Y: Biochanin A provides
neuroprotection against cerebral Ischemia/Reperfusion Injury by
Nrf2-mediated inhibition of oxidative stress and inflammation
signaling pathway in rats. Med Sci Monit. 25:8975–8983. 2019.
View Article : Google Scholar : PubMed/NCBI
|
25
|
Ding GB, Sun J, Wu G, Li B, Yang P, Li Z
and Nie G: Robust anticancer efficacy of a biologically synthesized
tumor acidity-responsive and Autophagy-Inducing functional beclin
1. ACS Appl Mater Interfaces. 10:5227–5239. 2018. View Article : Google Scholar : PubMed/NCBI
|
26
|
Hanada T, Noda NN, Satomi Y, Ichimura Y,
Fujioka Y, Takao T, Inagaki F and Ohsumi Y: The Atg12-Atg5
conjugate has a novel E3-like activity for protein lipidation in
autophagy. J Biol Chem. 282:37298–37302. 2007. View Article : Google Scholar : PubMed/NCBI
|
27
|
Bardag-Gorce F, Francis T, Nan L, Li J, He
Lue Y, French BA and French SW: Modifications in P62 occur due to
proteasome inhibition in alcoholic liver disease. Life Sci.
77:2594–2602. 2005. View Article : Google Scholar : PubMed/NCBI
|
28
|
Rao Z, Pan X, Zhang H, Sun J, Li J, Lu T,
Gao M, Liu S, Yu D and Ding Z: Isoflurane preconditioning
alleviated murine liver ischemia and reperfusion injury by
restoring AMPK/mTOR-mediated autophagy. Anesth Analg.
125:1355–1363. 2017. View Article : Google Scholar : PubMed/NCBI
|
29
|
Han D: Treatment with astragaloside IV
reduced blood glucose, regulated blood lipids, and protected liver
function in diabetic rats. J Int Med Res. 49:3000605198411652021.
View Article : Google Scholar : PubMed/NCBI
|
30
|
Zhang Y, Cao Y, Chen J, Qin H and Yang L:
A New possible mechanism by which punicalagin protects against
liver injury induced by type 2 diabetes mellitus: Upregulation of
autophagy via the Akt/FoxO3a signaling pathway. J Agric Food Chem.
67:13948–13959. 2019. View Article : Google Scholar : PubMed/NCBI
|
31
|
Liang W, Zhang D, Kang J, Meng X, Yang J,
Yang L, Xue N, Gao Q, Han S and Gou X: Protective effects of rutin
on liver injury in type 2 diabetic db/db mice. Biomed Pharmacother.
107:721–728. 2018. View Article : Google Scholar : PubMed/NCBI
|
32
|
Gao K, Yang R, Zhang J, Wang Z, Jia C,
Zhang F, Li S, Wang J, Murtaza G, Xie H, et al: Effects of Qijian
mixture on type 2 diabetes assessed by metabonomics, gut microbiota
and network pharmacology. Pharmacol Res. 130:93–109. 2018.
View Article : Google Scholar : PubMed/NCBI
|
33
|
Qu X, Gao H, Tao L, Zhang Y, Zhai J, Sun
J, Song Y and Zhang S: Astragaloside IV protects against
cisplatin-induced liver and kidney injury via autophagy-mediated
inhibition of NLRP3 in rats. J Toxicol Sci. 44:167–175. 2019.
View Article : Google Scholar : PubMed/NCBI
|
34
|
Liu W, Liu G and Liu J: Effects of
astragaloside IV on the pharmacokinetics of omeprazole in rats.
Pharm Biol. 57:449–452. 2019. View Article : Google Scholar : PubMed/NCBI
|
35
|
Zhang Q, Li Y, Liang T, Lu X, Zhang C, Liu
X, Jiang X, Martin RC, Cheng M and Cai L: ER stress and autophagy
dysfunction contribute to fatty liver in diabetic mice. Int J Biol
Sci. 11:559–568. 2015. View Article : Google Scholar : PubMed/NCBI
|
36
|
Lin CW, Zhang H, Li M, Xiong X, Chen X,
Chen X, Dong XC and Yin XM: Pharmacological promotion of autophagy
alleviates steatosis and injury in alcoholic and non-alcoholic
fatty liver conditions in mice. J Hepatol. 58:993–999. 2013.
View Article : Google Scholar : PubMed/NCBI
|
37
|
Zhang F, Zhao S, Yan W, Xia Y, Chen X,
Wang W, Zhang J, Gao C, Peng C, Yan F, et al: Branched chain amino
acids cause liver injury in obese/diabetic mice by promoting
adipocyte lipolysis and inhibiting hepatic autophagy. EBioMedicine.
13:157–167. 2016. View Article : Google Scholar : PubMed/NCBI
|
38
|
Yao Q, Ke ZQ, Guo S, Yang XS, Zhang FX,
Liu XF, Chen X, Chen HG, Ke HY and Liu C: Curcumin protects against
diabetic cardiomyopathy by promoting autophagy and alleviating
apoptosis. J Mol Cell Cardiol. 124:26–34. 2018. View Article : Google Scholar : PubMed/NCBI
|
39
|
Artunc F, Schleicher E, Weigert C,
Fritsche A, Stefan N and Häring HU: The impact of insulin
resistance on the kidney and vasculature. Nat Revi Nephrol.
12:721–737. 2016. View Article : Google Scholar
|
40
|
Jourdan T, Godlewski G and Kunos G:
Endocannabinoid regulation of β-cell functions: Implications for
glycaemic control and diabetes. Diabetes Obes Metab. 18:549–557.
2016. View Article : Google Scholar : PubMed/NCBI
|
41
|
Ahmadieh H and Azar ST: Liver disease and
diabetes: Association, pathophysiology, and management. Diabetes
Res Clin Pract. 104:53–62. 2014. View Article : Google Scholar : PubMed/NCBI
|
42
|
Liu HY, Han J, Cao SY, Hong T, Zhuo D, Shi
J, Liu Z and Cao W: Hepatic autophagy is suppressed in the presence
of insulin resistance and hyperinsulinemia: Inhibition of
FoxO1-dependent expression of key autophagy genes by insulin. J
Biol Chem. 284:31484–31492. 2009. View Article : Google Scholar : PubMed/NCBI
|
43
|
Codogno P and Meijer AJ: Autophagy: A
potential link between obesity and insulin resistance. Cell
Metabolism. 11:449–451. 2010. View Article : Google Scholar : PubMed/NCBI
|
44
|
Li R, Guo E, Yang J, Li A, Yang Y, Liu S,
Liu A and Jiang X: 1,25(OH)2 D3 attenuates
hepatic steatosis by inducing autophagy in mice. Obesity (Silver
Spring). 25:561–571. 2017. View Article : Google Scholar : PubMed/NCBI
|
45
|
Jung HS, Chung KW, Won Kim J, Kim J,
Komatsu M, Tanaka K, Nguyen YH, Kang TM, Yoon KH, Kim JW, et al:
Loss of autophagy diminishes pancreatic beta cell mass and function
with resultant hyperglycemia. Cell Metab. 8:318–324. 2008.
View Article : Google Scholar : PubMed/NCBI
|
46
|
Mir SU, George NM, Zahoor L, Harms R,
Guinn Z and Sarvetnick NE: Inhibition of autophagic turnover in
β-cells by fatty acids and glucose leads to apoptotic cell death. J
Biol Chem. 290:6071–6085. 2015. View Article : Google Scholar : PubMed/NCBI
|
47
|
Wang C, Li Y, Hao M and Li W:
Astragaloside IV inhibits triglyceride accumulation in
insulin-resistant HepG2 cells via AMPK-induced SREBP-1c
phosphorylation. Front Pharmacol. 9:3452018. View Article : Google Scholar : PubMed/NCBI
|
48
|
Wu MY, Yiang GT and Lai TT: The Oxidative
stress and mitochondrial dysfunction during the pathogenesis of
diabetic retinopathy. Oxid Med Cell Longev. 2018:34201872018.
View Article : Google Scholar : PubMed/NCBI
|
49
|
Zhang Y, Yuan D, Yao W, Zhu Q, Liu Y,
Huang F, Feng J, Chen X, Huang Y, Chi X and Hei Z: Hyperglycemia
aggravates hepatic ischemia reperfusion injury by inducing chronic
oxidative stress and inflammation. Oxid Med Cell Longev.
2016:39196272016. View Article : Google Scholar : PubMed/NCBI
|
50
|
Meng L, Zhao X and Zhang H: HIPK1
interference attenuates inflammation and oxidative stress of acute
lung injury via autophagy. Med Sci Monit. 25:827–835. 2019.
View Article : Google Scholar : PubMed/NCBI
|
51
|
He KQ, Li WZ, Chai XQ, Yin YY, Jiang Y and
Li WP: Astragaloside IV prevents kidney injury caused by iatrogenic
hyperinsulinemia in a streptozotocin-induced diabetic rat model.
Int J Mol Med. 41:1078–1088. 2018.PubMed/NCBI
|
52
|
Yang F, Zhang L, Gao Z, Sun X, Yu M, Dong
S, Wu J, Zhao Y, Xu C, Zhang W and Lu F: Exogenous H2S protects
against diabetic cardiomyopathy by activating autophagy via the
AMPK/mTOR pathway. Cell Physiol Biochem. 43:1168–1187. 2017.
View Article : Google Scholar : PubMed/NCBI
|
53
|
Guo H, Wang Y, Zhang X, Zang Y, Zhang Y,
Wang L, Wang H, Wang Y, Cao A and Peng W: Astragaloside IV protects
against podocyte injury via SERCA2-dependent ER stress reduction
and AMPKα-regulated autophagy induction in streptozotocin-induced
diabetic nephropathy. Sci Rep. 7:68522017. View Article : Google Scholar : PubMed/NCBI
|
54
|
Lin J, Pan X, Huang C, Gu M, Chen X, Zheng
X, Shao Z, Hu S, Wang B, Lin H, et al: Dual regulation of microglia
and neurons by Astragaloside IV-mediated mTORC1 suppression
promotes functional recovery after acute spinal cord injury. J Cell
Mol Med. 24:671–685. 2020. View Article : Google Scholar : PubMed/NCBI
|