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Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia

  • Authors:
    • Dongya Li
    • Jie Peng
    • Tiantian Li
    • Yichen Liu
    • Min Chen
    • Xiaofeng Shi
  • View Affiliations / Copyright

    Affiliations: Department of Hematology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 449
    |
    Published online on: April 13, 2021
       https://doi.org/10.3892/mmr.2021.12088
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Abstract

Itgb3‑integrin‑deficient (Itgb3‑/‑) mice have been reported as a Glanzmann thrombasthenia (GT) model and have been used for platelet research. However, it remains unclear whether this mouse model can fully simulate patients with GT or whether it has different characteristics from these patients. The present study aimed to answer this question. Itgb3‑/‑ mice were tested for platelet function, tail bleeding, whole‑blood count, bone marrow hematopoiesis and organ enlargement. Itgb3‑/‑ platelets showed impaired functions, including fibrinogen binding, aggregation, adhesion or spreading. Itgb3‑/‑ mice demonstrated decreased platelet count and microcytic hypochromic anemia. Reduced iron staining of bone marrow and decreased plasma ferritin level confirmed the diagnosis of iron deficiency anemia. Evident splenomegaly was observed in Itgb3‑/‑ mice. Immunohistochemical analysis of spleen biopsy revealed normal expression of CD3 and CD19, but elevated expression of CD71, which suggested that the splenomegaly in Itgb3‑/‑ mice may be associated with extramedullary hematopoiesis. In conclusion, Itgb3‑/‑ mice exhibited some unique characteristics that differed from those of human patients with GT and thus cannot completely simulate patients with GT.
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Copy and paste a formatted citation
Spandidos Publications style
Li D, Peng J, Li T, Liu Y, Chen M and Shi X: Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia. Mol Med Rep 23: 449, 2021.
APA
Li, D., Peng, J., Li, T., Liu, Y., Chen, M., & Shi, X. (2021). Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia. Molecular Medicine Reports, 23, 449. https://doi.org/10.3892/mmr.2021.12088
MLA
Li, D., Peng, J., Li, T., Liu, Y., Chen, M., Shi, X."Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia". Molecular Medicine Reports 23.6 (2021): 449.
Chicago
Li, D., Peng, J., Li, T., Liu, Y., Chen, M., Shi, X."Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia". Molecular Medicine Reports 23, no. 6 (2021): 449. https://doi.org/10.3892/mmr.2021.12088
Copy and paste a formatted citation
x
Spandidos Publications style
Li D, Peng J, Li T, Liu Y, Chen M and Shi X: Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia. Mol Med Rep 23: 449, 2021.
APA
Li, D., Peng, J., Li, T., Liu, Y., Chen, M., & Shi, X. (2021). Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia. Molecular Medicine Reports, 23, 449. https://doi.org/10.3892/mmr.2021.12088
MLA
Li, D., Peng, J., Li, T., Liu, Y., Chen, M., Shi, X."Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia". Molecular Medicine Reports 23.6 (2021): 449.
Chicago
Li, D., Peng, J., Li, T., Liu, Y., Chen, M., Shi, X."Itgb3-integrin-deficient mice may not be a sufficient model for patients with Glanzmann thrombasthenia". Molecular Medicine Reports 23, no. 6 (2021): 449. https://doi.org/10.3892/mmr.2021.12088
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