Open Access

Major signaling pathways and key mediators of macrophages in acute kidney injury (Review)

  • Authors:
    • Ning Li
    • Jiale Chen
    • Pengtao Wang
    • Haojun Fan
    • Shike Hou
    • Yanhua Gong
  • View Affiliations

  • Published online on: April 16, 2021     https://doi.org/10.3892/mmr.2021.12094
  • Article Number: 455
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute kidney injury (AKI) has become a global public health problem with high morbidity and mortality rates, as well as high healthcare costs. Immune cells, particularly macrophages, which regulate tissue development, destroy pathogens, control homeostasis and repair wounds, play crucial and complex roles in AKI. In various types of AKI, numerous rapidly recruited monocytes and tissue‑resident macrophages act in a coordinated manner. Thus, elucidating the phenotypic and functional characteristics of macrophages in AKI is essential for identifying potential therapeutic targets. Macrophage‑sensing mediators and macrophage‑derived mediators participate in the major macrophage‑related signaling pathways in AKI, which regulate macrophage polarization and determine disease progression. In conclusion, macrophages change their roles and regulatory mechanisms during the occurrence and development of AKI. The aim of the present review was to contribute to an improved understanding of AKI and to the identification of novel therapeutic targets for this condition.
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June-2021
Volume 23 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Li N, Chen J, Wang P, Fan H, Hou S and Gong Y: Major signaling pathways and key mediators of macrophages in acute kidney injury (Review). Mol Med Rep 23: 455, 2021
APA
Li, N., Chen, J., Wang, P., Fan, H., Hou, S., & Gong, Y. (2021). Major signaling pathways and key mediators of macrophages in acute kidney injury (Review). Molecular Medicine Reports, 23, 455. https://doi.org/10.3892/mmr.2021.12094
MLA
Li, N., Chen, J., Wang, P., Fan, H., Hou, S., Gong, Y."Major signaling pathways and key mediators of macrophages in acute kidney injury (Review)". Molecular Medicine Reports 23.6 (2021): 455.
Chicago
Li, N., Chen, J., Wang, P., Fan, H., Hou, S., Gong, Y."Major signaling pathways and key mediators of macrophages in acute kidney injury (Review)". Molecular Medicine Reports 23, no. 6 (2021): 455. https://doi.org/10.3892/mmr.2021.12094