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Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes

  • Authors:
    • Xu-Lan Wang
    • Wei Zhang
    • Zhe Li
    • Wen-Qi Han
    • Hao-Yu Wu
    • Qun-Rang Wang
    • Xin-Hong Liu
    • Kun Xing
    • Gong Cheng
    • Feng-Jun Chang
  • View Affiliations / Copyright

    Affiliations: Department of Nursing, Xian'yang Vocational and Technical College, Fengxi New Town United Avenue, Xi'an, Shaanxi 712000, P.R. China, Department of Cardiology, Shaanxi Provincial People's Hospital and The Third Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710068, P.R. China, Department of Cardiology, Affiliated Hospital of Shaanxi Traditional Chinese Medicine University, Xianyang, Shaanxi 712000, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 474
    |
    Published online on: April 21, 2021
       https://doi.org/10.3892/mmr.2021.12113
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Abstract

As a common factor of both type 2 diabetes mellitus (T2DM) and acute coronary syndrome (ACS), circulating microparticles (MPs) may provide a link between these two diseases. The present study compared the content and function of MPs from patients with ACS with or without T2DM. MPs from healthy subjects (n=20), patients with ACS (n=24), patients with T2DM (n=20) and patients with combined ACS and T2DM (n=24) were obtained. After incubating rat thoracic tissue with MPs, the effect of MPs on endothelial‑dependent vasodilatation, expression of caveolin‑1 and endothelial nitric oxide synthase (eNOS), phosphorylation of eNOS at the S1177 and T495 sites and its association with heat shock protein 90 (Hsp90), and the generation of NO and superoxide anion (O2˙‑) were determined. MP concentrations were higher in patients with T2DM and patients with ACS with or without T2DM than in healthy subjects. Moreover, MPs from patients with T2DM or ACS led to impairment in endothelial‑dependent vasodilatation, decreased expression of NO, as well as eNOS and its phosphorylation at Ser1177 and association with Hsp90, but increased eNOS phosphorylation at T495, caveolin‑1 expression and O2˙‑ generation. These effects were strengthened by MPs from patients with ACS combined with T2DM. T2DM not only increased MP content but also resulted in greater vascular impairment effects in ACS. These results may provide novel insight into the treatment of patients with ACS and T2DM.
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1 

Gach O, El HZ and Lancellotti P: Acute coronary syndrome. Rev Med Liege. 73:243–250. 2018.(In French). PubMed/NCBI

2 

Wang R, Wang M, Ye J, Sun G and Sun X: Mechanism overview and target mining of atherosclerosis: Endothelial cell injury in atherosclerosis is regulated by glycolysis (Review). Int J Mol Med. 47:65–76. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Libby P, Ridker PM and Maseri A: Inflammation and atherosclerosis. Circulation. 105:1135–1143. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Kristensen SD, Ravn HB and Falk E: Insights into the pathophysiology of unstable coronary artery disease. Am J Cardiol. 80:5E–9E. 1997. View Article : Google Scholar : PubMed/NCBI

5 

Freedman JE and Loscalzo J: Nitric oxide and its relationship to thrombotic disorders. J Thromb Haemost. 1:1183–1188. 2003. View Article : Google Scholar : PubMed/NCBI

6 

McGuire DK, Emanuelsson H, Granger CB, E Magnus Ohman, D J Moliterno, H D White, D Ardissino, J W Box, R M Califf and E J Topol: Influence of diabetes mellitus on clinical outcomes across the spectrum of acute coronary syndromes. Findings from the GUSTO-IIb study. GUSTO IIb Investigators. Eur Heart J. 21:1750–1758. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Hildebrandt P: Diabetic patients and acute coronary syndromes. Eur Heart J. 22:887–888. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Han D, Rozanski A, Gransar H, Sharir T, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, et al: Myocardial ischemic burden and differences in prognosis among patients with and without diabetes: Results from the multicenter international REFINE SPECT registry. Diabetes Care. 43:453–459. 2020. View Article : Google Scholar : PubMed/NCBI

9 

Wackers FJ, Young LH, Inzucchi SE, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Heller GV, Filipchuk N, et al: Detection of silent myocardial ischemia in asymptomatic diabetic subjects: The DIAD study. Diabetes Care. 27:1954–1961. 2004. View Article : Google Scholar : PubMed/NCBI

10 

Martinez MC, Tesse A, Zobairi F and Andriantsitohaina R: Shed membrane microparticles from circulating and vascular cells in regulating vascular function. Am J Physiol Heart Circ Physiol. 288:H1004–H1009. 2005. View Article : Google Scholar : PubMed/NCBI

11 

Zaldivia MTK, McFadyen JD, Lim B, Wang X and Peter K: Platelet-derived microvesicles in cardiovascular diseases. Front Cardiovasc Med. 4:742017. View Article : Google Scholar : PubMed/NCBI

12 

Han WQ, Chang FJ, Wang QR and Pan JQ: Microparticles from patients with acute coronary syndrome impair vasodilatation by inhibiting the Akt/eNOS-Hsp90 signaling pathway. Cardiology. 132:252–260. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Koga H, Sugiyama S, Kugiyama K, Watanabe K, Fukushima H, Tanaka T, Sakamoto T, Yoshimura M, Jinnouchi H and Ogawa H: Elevated levels of VE-cadherin-positive endothelial microparticles in patients with type 2 diabetes mellitus and coronary artery disease. J Am Coll Cardiol. 45:1622–1630. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Boulanger CM, Scoazec A, Ebrahimian T, Henry P, Mathieu E, Tedgui A and Mallat Z: Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction. Circulation. 104:2649–2652. 2001. View Article : Google Scholar : PubMed/NCBI

15 

Cheng G, Shan XF, Wang XL, Dong WW, Li Z, Liu XH, Zhang W, Xing K and Chang FJ: Endothelial damage effects of circulating microparticles from patients with stable angina are reduced by aspirin through ERK/p38 MAPKs pathways. Cardiovasc Ther. 35:2017. View Article : Google Scholar

16 

Ci HB, Ou ZJ, Chang FJ, Liu DH, He GW, Xu Z, Yuan HY, Wang ZP, Zhang X and Ou JS: Endothelial microparticles increase in mitral valve disease and impair mitral valve endothelial function. Am J Physiol Endocrinol Metab. 304:E695–E702. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Wen B, Combes V, Bonhoure A, Weksler BB, Couraud PO and Grau GE: Endotoxin-induced monocytic microparticles have contrasting effects on endothelial inflammatory responses. PLoS One. 9:e915972014. View Article : Google Scholar : PubMed/NCBI

18 

Colle IO, De Vriese AS, Van Vlierberghe HR, Lameire NH and De Vos MM: Vascular hyporesponsiveness in the mesenteric artery of anaesthetized rats with cirrhosis and portal hypertension: An in-vivo study. Eur J Gastroenterol Hepatol. 16:139–145. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Erol A and Koşay S: Effects of aminoguanidine administration on vascular hyporeactivity in thoracic aorta from endotoxaemic rats. Eur J Pharmacol. 408:175–181. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Martin S, Tesse A, Hugel B, Martínez MC, Morel O, Freyssinet JM and Andriantsitohaina R: Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression. Circulation. 109:1653–1659. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Biasucci LM, Porto I, Di Vito L, De Maria GL, Leone AM, Tinelli G, Tritarelli A, Di Rocco G, Snider F, Capogrossi MC and Crea F: Differences in microparticle release in patients with acute coronary syndrome and stable angina. Circ J. 76:2174–2182. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Bernal-Mizrachi L, Jy W, Fierro C, Macdonough R, Velazques HA, Purow J, Jimenez JJ, Horstman LL, Ferreira A, de Marchena E and Ahn YS: Endothelial microparticles correlate with high-risk angiographic lesions in acute coronary syndromes. Int J Cardiol. 97:439–446. 2004. View Article : Google Scholar : PubMed/NCBI

23 

Hu FB and Stampfer MJ: Is type 2 diabetes mellitus a vascular condition? Arterioscler Thromb Vasc Biol. 23:1715–1716. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Ceriello A and Motz E: Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol. 24:816–823. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Tang X, Luo YX, Chen HZ and Liu DP: Mitochondria, endothelial cell function, and vascular diseases. Front Physiol. 5:1752014. View Article : Google Scholar : PubMed/NCBI

26 

Wong WT, Wong SL, Tian XY and Huang Y: Endothelial dysfunction: The common consequence in diabetes and hypertension. J Cardiovasc Pharmacol. 55:300–307. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Wang F, Guo X, Shen X, Kream RM, Mantione KJ and Stefano GB: Vascular dysfunction associated with type 2 diabetes and Alzheimer's disease: A potential etiological linkage. Med Sci Monit Basic Res. 20:118–129. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Münzel T: Endothelial dysfunction: Pathophysiology, diagnosis and prognosis. Dtsch Med Wochenschr. 133:2465–2470. 2008.(In German). View Article : Google Scholar

29 

Tejero J, Shiva S and Gladwin MT: Sources of vascular nitric oxide and reactive oxygen species and their regulation. Physiol Rev. 99:311–379. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Voldstedlund M, Vinten J and Tranum-Jensen J: Cav-p60 expression in rat muscle tissues. Distribution of caveolar proteins. Cell Tissue Res. 306:265–276. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Mineo C and Shaul PW: Regulation of eNOS in caveolae. Adv Exp Med Biol. 729:51–62. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Meye C, Schumann J, Wagner A and Gross P: Effects of homocysteine on the levels of caveolin-1 and eNOS in caveolae of human coronary artery endothelial cells. Atherosclerosis. 190:256–263. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Qin L, Zhu N, Ao BX, Liu C, Shi YN, Du K, Chen JX, Zheng XL and Liao DF: Caveolae and caveolin-1 integrate reverse cholesterol transport and inflammation in atherosclerosis. Int J Mol Sci. 17:4292016. View Article : Google Scholar : PubMed/NCBI

34 

Zhao YY, Liu Y, Stan RV, Fan L, Gu Y, Dalton N, Chu PH, Peterson K, Ross J Jr and Chien KR: Defects in caveolin-1 cause dilated cardiomyopathy and pulmonary hypertension in knockout mice. Proc Natl Acad Sci USA. 99:11375–11380. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Pechánová O and Simko F: The role of nitric oxide in the maintenance of vasoactive balance. Physiol Res. 2 (Suppl 56):S7–S16. 2007.

36 

Yetik-Anacak G and Catravas JD: Nitric oxide and the endothelium: History and impact on cardiovascular disease. Vascul Pharmacol. 45:268–276. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Zhang W, Li Z, Han W, Wu H, Wang Q, Liu X, Xing K, Cheng G, Chang F, Chang F, et al: Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes. Mol Med Rep 23: 474, 2021.
APA
Wang, X., Zhang, W., Li, Z., Han, W., Wu, H., Wang, Q. ... Chang, F. (2021). Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes. Molecular Medicine Reports, 23, 474. https://doi.org/10.3892/mmr.2021.12113
MLA
Wang, X., Zhang, W., Li, Z., Han, W., Wu, H., Wang, Q., Liu, X., Xing, K., Cheng, G., Chang, F."Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes". Molecular Medicine Reports 23.6 (2021): 474.
Chicago
Wang, X., Zhang, W., Li, Z., Han, W., Wu, H., Wang, Q., Liu, X., Xing, K., Cheng, G., Chang, F."Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes". Molecular Medicine Reports 23, no. 6 (2021): 474. https://doi.org/10.3892/mmr.2021.12113
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Zhang W, Li Z, Han W, Wu H, Wang Q, Liu X, Xing K, Cheng G, Chang F, Chang F, et al: Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes. Mol Med Rep 23: 474, 2021.
APA
Wang, X., Zhang, W., Li, Z., Han, W., Wu, H., Wang, Q. ... Chang, F. (2021). Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes. Molecular Medicine Reports, 23, 474. https://doi.org/10.3892/mmr.2021.12113
MLA
Wang, X., Zhang, W., Li, Z., Han, W., Wu, H., Wang, Q., Liu, X., Xing, K., Cheng, G., Chang, F."Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes". Molecular Medicine Reports 23.6 (2021): 474.
Chicago
Wang, X., Zhang, W., Li, Z., Han, W., Wu, H., Wang, Q., Liu, X., Xing, K., Cheng, G., Chang, F."Vascular damage effect of circulating microparticles in patients with ACS is aggravated by type 2 diabetes". Molecular Medicine Reports 23, no. 6 (2021): 474. https://doi.org/10.3892/mmr.2021.12113
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