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LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction

  • Authors:
    • Peng Wang
    • Wenbo Zhang
    • Zhen Feng
    • Jian Zhang
    • Ying Sun
    • Wei Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Feicheng Mining Center Hospital, Feicheng, Shandong 271600, P.R. China, Department of Gastroenterology, Feicheng Mining Center Hospital, Feicheng, Shandong 271600, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 526
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    Published online on: May 25, 2021
       https://doi.org/10.3892/mmr.2021.12165
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Abstract

Heart failure (HF) is a progressive myocardial disease that affects pulse rate. Notably, chronic inflammation serves a crucial role in cardiac dysfunction and HF. Appropriate cardiomyocyte‑fibroblast communication is essential for cardiac function. In addition, cardiac fibroblasts (CFs) are the main cellular population in the cardiac microenvironment; therefore, determining the role of CFs in HF progression and the associated molecular basis is important. In the present study, ELISAs were performed to detect inflammatory factors in the sera of patients with HF and their association with CF activation was analyzed using Pearson's correlation coefficient. The mechanism underlying the proinflammatory phenotype of CFs was investigated via western blotting. Notably, the levels of IL10 and TNF‑α were significantly increased in the sera of patients with HF. Further analysis revealed that CFs were extensively activated in the cardiac tissues of patients with HF and released excessive amounts of cytokines, which could impair the viability of cardiomyocytes. Moreover, low‑density lipoprotein (LDL)‑induced NLRC3 inflammasome was activated in CFs, which gave rise to proinflammatory phenotypes. Targeting LDL in CFs significantly improved the functioning of cardiomyocytes and inhibited apoptosis. These findings highlighted the critical role of LDL in inflammasome activation; to the best of our knowledge, the present study is the first to reveal that CF‑induced microenvironmental inflammation may suppress cardiomyocyte viability. The present study established the cellular basis for CF activation during HF progression and provided information on the cellular interactions important for HF treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Wang P, Zhang W, Feng Z, Zhang J, Sun Y and Zhang W: LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction. Mol Med Rep 24: 526, 2021.
APA
Wang, P., Zhang, W., Feng, Z., Zhang, J., Sun, Y., & Zhang, W. (2021). LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction. Molecular Medicine Reports, 24, 526. https://doi.org/10.3892/mmr.2021.12165
MLA
Wang, P., Zhang, W., Feng, Z., Zhang, J., Sun, Y., Zhang, W."LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction". Molecular Medicine Reports 24.1 (2021): 526.
Chicago
Wang, P., Zhang, W., Feng, Z., Zhang, J., Sun, Y., Zhang, W."LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction". Molecular Medicine Reports 24, no. 1 (2021): 526. https://doi.org/10.3892/mmr.2021.12165
Copy and paste a formatted citation
x
Spandidos Publications style
Wang P, Zhang W, Feng Z, Zhang J, Sun Y and Zhang W: LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction. Mol Med Rep 24: 526, 2021.
APA
Wang, P., Zhang, W., Feng, Z., Zhang, J., Sun, Y., & Zhang, W. (2021). LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction. Molecular Medicine Reports, 24, 526. https://doi.org/10.3892/mmr.2021.12165
MLA
Wang, P., Zhang, W., Feng, Z., Zhang, J., Sun, Y., Zhang, W."LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction". Molecular Medicine Reports 24.1 (2021): 526.
Chicago
Wang, P., Zhang, W., Feng, Z., Zhang, J., Sun, Y., Zhang, W."LDL‑induced NLRC3 inflammasome activation in cardiac fibroblasts contributes to cardiomyocytic dysfunction". Molecular Medicine Reports 24, no. 1 (2021): 526. https://doi.org/10.3892/mmr.2021.12165
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