Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
July-2021 Volume 24 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2021 Volume 24 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Guan Xin Dan Shen formulation protects db/db mice against diabetic cardiomyopathy via activation of Nrf2 signaling

  • Authors:
    • Bin Zhang
    • Chen-Yang Zhang
    • Xue-Lian Zhang
    • Gui-Bo Sun
    • Xiao-Bo Sun
  • View Affiliations / Copyright

    Affiliations: Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 531
    |
    Published online on: May 25, 2021
       https://doi.org/10.3892/mmr.2021.12170
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Guan Xin Dan Shen formulation (GXDSF) is a widely used treatment for the management of coronary heart disease in China and is composed of three primary components: Dalbergiae odoriferae Lignum, Salviae miltiorrhizae Radix et Rhizoma and Panax notoginseng Radix et Rhizoma. However, the potential use of GXDSF for the management of diabetic cardiomyopathy (DCM) has not been previously assessed. The present study aimed to assess the effects of GXDSF on DCM, as well as the underlying mechanism. In the present study, db/db mice were used. Following treatment with GXDSF for 10 weeks, fasting blood glucose, insulin sensitivity, serum lipid levels and cardiac enzyme levels were detected. Cardiac pathological alterations and cardiac function were assessed by performing hematoxylin and eosin staining and echocardiograms, respectively. TUNEL assays were conducted to assess cardiomyocyte apoptosis. Additionally, reverse transcription‑quantitative PCR and western blotting were performed to evaluate the expression of apoptosis‑associated genes and proteins, respectively. In the model group, the db/db mice displayed obesity, hyperlipidemia and hyperglycemia, accompanied by noticeable myocardial hypertrophy and diastolic dysfunction. Following treatment with GXDSF for 10 weeks, serum triglyceride levels were lower and insulin sensitivity was enhanced in db/db mice compared with the model group, which indicated improvement in condition. Cardiac hypertrophy and dysfunction were also improved in db/db mice following treatment with GXDSF, resulting in significantly increased left ventricular ejection fraction and fractional shortening compared with the model group. Following treatment with metformin or GXDSF, model‑induced increases in levels of myocardial enzymes were decreased in the moderate and high dose groups. Moreover, the results indicated that, compared with the model group, GXDSF significantly inhibited cardiomyocyte apoptosis in diabetic heart tissues by increasing Bcl‑2 expression and decreasing the expression levels of Bax, cleaved caspase‑3 and cleaved caspase‑9. Mechanistically, GXDSF enhanced Akt phosphorylation, which upregulated antioxidant enzymes mediated by nuclear factor erythroid 2‑related factor 2 (Nrf2) signaling. Collectively, the results of the present study indicated that GXDSF attenuated cardiac dysfunction and inhibited cardiomyocyte apoptosis in diabetic mice via activation of Akt/Nrf2 signaling. Therefore, GXDSF may serve as a potential therapeutic agent for the management of DCM.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Barooti A, Kamran M, Kharazmi F, Eftakhar E, Malekzadeh K, Talebi A and Soltani N: Effect of oral magnesium sulfate administration on blood glucose hemostasis via inhibition of gluconeogenesis and FOXO1 gene expression in liver and muscle in diabetic rats. Biomed Pharmacother. 109:1819–1825. 2019. View Article : Google Scholar : PubMed/NCBI

2 

Perry BD, Caldow MK, Brennan-Speranza TC, Sbaraglia M, Jerums G, Garnham A, Wong C, Levinger P, Asrar Ul Haq M, Hare DL, et al: Muscle atrophy in patients with type 2 diabetes mellitus: Roles of inflammatory pathways, physical activity and exercise. Exerc Immunol Rev. 22:94–109. 2016.PubMed/NCBI

3 

Papatheodorou K, Banach M, Bekiari E, Rizzo M and Edmonds M: Complications of diabetes 2017. J Diabetes Res. 2018:30861672018. View Article : Google Scholar : PubMed/NCBI

4 

Tsai TH, Lin CJ, Chua S, Chung SY, Chen SM, Lee CH and Hang CL: Deletion of RasGRF1 attenuated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy in mice through affecting inflammation and oxidative stress. Int J Mol Sci. 19:30942018. View Article : Google Scholar : PubMed/NCBI

5 

Lam CS: Diabetic cardiomyopathy: An expression of stage B heart failure with preserved ejection fraction. Diab Vasc Dis Res. 12:234–238. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Dai B, Li H, Fan J, Zhao Y, Yin Z, Nie X, Wang DW and Chen C: MiR-21 protected against diabetic cardiomyopathy induced diastolic dysfunction by targeting gelsolin. Cardiovasc Diabetol. 17:1232018. View Article : Google Scholar : PubMed/NCBI

7 

Ni R, Cao T, Xiong S, Ma J, Fan GC, Lacefield JC, Lu Y, Le Tissier S and Peng T: Therapeutic inhibition of mitochondrial reactive oxygen species with mito-TEMPO reduces diabetic cardiomyopathy. Free Radic Biol Med. 90:12–23. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Luo W, Jin Y, Wu G, Zhu W, Qian Y, Zhang Y, Li J, Zhu A and Liang G: Blockage of ROS and MAPKs-mediated inflammation via restoring SIRT1 by a new compound LF10 prevents type 1 diabetic cardiomyopathy. Toxicol Appl Pharmacol. 370:24–35. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Kayama Y, Raaz U, Jagger A, Adam M, Schellinger IN, Sakamoto M, Suzuki H, Toyama K, Spin JM and Tsao PS: Diabetic cardiovascular disease induced by oxidative stress. Int J Mol Sci. 16:25234–25263. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Wang J, Song Y, Elsherif L, Song Z, Zhou G, Prabhu SD, Saari JT and Cai L: Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation. Circulation. 113:544–554. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Wu MS, Liang JT, Lin YD, Wu ET, Tseng YZ and Chang KC: Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes. Br J Pharmacol. 154:758–764. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Lu J, Pontré B, Pickup S, Choong SY, Li M, Xu H, Gamble GD, Phillips AR, Cowan BR, Young AA and Cooper GJ: Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment. Cardiovasc Diabetol. 12:282013. View Article : Google Scholar : PubMed/NCBI

13 

Forcheron F, Basset A, Abdallah P, Del Carmine P, Gadot N and Beylot M: Diabetic cardiomyopathy: Effects of fenofibrate and metformin in an experimental model-the Zucker diabetic rat. Cardiovasc Diabetol. 8:162009. View Article : Google Scholar : PubMed/NCBI

14 

Xie Z, Lau K, Eby B, Lozano P, He C, Pennington B, Li H, Rathi S, Dong Y, Tian R, et al: Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes. 60:1770–1778. 2011. View Article : Google Scholar : PubMed/NCBI

15 

Rösen R, Rump AF and Rösen P: The ACE-inhibitor captopril improves myocardial perfusion in spontaneously diabetic (BB) rats. Diabetologia. 38:509–517. 1995. View Article : Google Scholar

16 

Al-Shafei AI, Wise RG, Gresham GA, Bronns G, Carpenter TA, Hall LD and Huang CL: Non-invasive magnetic resonance imaging assessment of myocardial changes and the effects of angiotensin-converting enzyme inhibition in diabetic rats. J Physiol. 538:541–553. 2002. View Article : Google Scholar : PubMed/NCBI

17 

Turan B: A comparative summary on antioxidant-like actions of timolol with other antioxidants in diabetic cardiomyopathy. Curr Drug Deliv. 13:418–423. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Savarese G, D'Amore C, Federici M, De Martino F, Dellegrottaglie S, Marciano C, Ferrazzano F, Losco T, Lund LH, Trimarco B, et al: Effects of dipeptidyl peptidase 4 inhibitors and sodium-glucose linked coTransporter-2 inhibitors on cardiovascular events in patients with type 2 diabetes mellitus: A meta-analysis. Int J Cardiol. 220:595–601. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Suzuki T and Yamamoto M: Molecular basis of the Keap1-Nrf2 system. Free Radic Biol Med. 88:93–100. 2015. View Article : Google Scholar : PubMed/NCBI

20 

Ge ZD, Lian Q, Mao X and Xia Z: Current status and challenges of NRF2 as a potential therapeutic target for diabetic cardiomyopathy. Int Heart J. 60:512–520. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Luo J, Yan D, Li S, Liu S, Zeng F, Cheung CW, Liu H, Irwin MG, Huang H and Xia Z: Allopurinol reduces oxidative stress and activates Nrf2/p62 to attenuate diabetic cardiomyopathy in rats. J Cell Mol Med. 24:1760–1773. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Deng X, Xing X, Sun G, Xu X, Wu H, Li G and Sun X: Guanxin danshen formulation protects against myocardial ischemia reperfusion injury-induced left ventricular remodeling by upregulating estrogen receptor β. Front Pharmacol. 8:7772017. View Article : Google Scholar : PubMed/NCBI

23 

Li J, Han L, Zhu, Wang D and Shang Z: Guanxin Danshen Pills in Treatment of 200 Cases of Patients with Coronary Heart Disease Angina Pectoris. China &Foreign Medical Treatment. 24:126–128. 2017.

24 

Yu Y, Sun G, Luo Y, Wang M, Chen R, Zhang J, Ai Q, Xing N and Sun X: Cardioprotective effects of Notoginsenoside R1 against ischemia/reperfusion injuries by regulating oxidative stress- and endoplasmic reticulum stress- related signaling pathways. Sci Rep. 6:217302016. View Article : Google Scholar : PubMed/NCBI

25 

Xiao J, Zhu T, Yin YZ and Sun B: Notoginsenoside R1, a unique constituent of Panax notoginseng, blinds proinflammatory monocytes to protect against cardiac hypertrophy in ApoE−/− mice. Eur J Pharmacol. 833:441–450. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Fan C, Qiao Y and Tang M: Notoginsenoside R1 attenuates high glucose-induced endothelial damage in rat retinal capillary endothelial cells by modulating the intracellular redox state. Drug Des Devel Ther. 11:3343–3354. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Yu LJ, Zhang KJ, Zhu JZ, Zheng Q, Bao XY, Thapa S, Wang Y and Chu MP: Salvianolic acid exerts cardioprotection through promoting angiogenesis in animal models of acute myocardial infarction: Preclinical evidence. Oxid Med Cell Longev. 2017:81923832017. View Article : Google Scholar : PubMed/NCBI

28 

Yu H, Zhen J, Yang Y, Gu J, Wu S and Liu Q: Ginsenoside Rg1 ameliorates diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress-induced apoptosis in a streptozotocin-induced diabetes rat model. J Cell Mol Med. 20:623–631. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Paolillo S, Marsico F, Prastaro M, Renga F, Esposito L, De Martino F, Di Napoli P, Esposito I, Ambrosio A, Ianniruberto M, et al: Diabetic cardiomyopathy: Definition, diagnosis, and therapeutic implications. Heart Fail Clin. 15:341–347. 2019. View Article : Google Scholar : PubMed/NCBI

30 

National Research Council (US) Institute for Laboratory Animal Research, . Guide for the Care and Use of Laboratory Animals. National Academies Press; Washington, DC: 1996

31 

Xie W, Meng X, Zhai Y, Ye T, Zhou P, Nan F, Sun G and Sun X: Antidepressant-like effects of the Guanxin Danshen formula via mediation of the CaMK II-CREB-BDNF signalling pathway in chronic unpredictable mild stress-induced depressive rats. Ann Transl Med. 7:5642019. View Article : Google Scholar : PubMed/NCBI

32 

Shan T, Liang X, Bi P and Kuang S: Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle. FASEB J. 27:1981–1989. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Zhang C, Wang F, Zhang Y, Kang Y, Wang H, Si M, Su L, Xin X, Xue F, Hao F, et al: Celecoxib prevents pressure overload-induced cardiac hypertrophy and dysfunction by inhibiting inflammation, apoptosis and oxidative stress. J Cell Mol Med. 20:116–127. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Chai C, Song LJ, Han SY, Li XQ and Li M: MicroRNA-21 promotes glioma cell proliferation and inhibits senescence and apoptosis by targeting SPRY1 via the PTEN/PI3K/AKT signaling pathway. CNS Neurosci Ther. 24:369–380. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Wang S, Zhang T, Yang Z, Lin J, Cai B, Ke Q, Lan W, Shi J, Wu S and Lin W: Heme oxygenase-1 protects spinal cord neurons from hydrogen peroxide-induced apoptosis via suppression of Cdc42/MLK3/MKK7/JNK3 signaling. Apoptosis. 22:449–462. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Huynh K, Bernardo BC, McMullen JR and Ritchie RH: Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways. Pharmacol Ther. 142:375–415. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, et al: Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart. Circulation. 119:1272–1283. 2009. View Article : Google Scholar : PubMed/NCBI

39 

Dludla PV, Joubert E, Muller CJF, Louw J and Johnson R: Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside. Nutr Metab (Lond). 14:452017. View Article : Google Scholar : PubMed/NCBI

40 

Gencoglu H, Tuzcu M, Hayirli A and Sahin K: Protective effects of resveratrol against streptozotocin-induced diabetes in rats by modulation of visfatin/sirtuin-1 pathway and glucose transporters. Int J Food Sci Nutr. 66:314–320. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Zhu R, Sun H, Yu K, Zhong Y, Shi H, Wei Y, Su X, Xu W, Luo Q, Zhang F, et al: Interleukin-37 and dendritic cells treated with interleukin-37 plus troponin I ameliorate cardiac remodeling after myocardial infarction. J Am Heart Assoc. 5:e0044062016. View Article : Google Scholar : PubMed/NCBI

42 

Zhang WX, He BM, Wu Y, Qiao JF and Peng ZY: Melatonin protects against sepsis-induced cardiac dysfunction by regulating apoptosis and autophagy via activation of SIRT1 in mice. Life Sci. 217:8–15. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Yamada S, Ding Y, Tanimoto A, Wang KY, Guo X, Li Z, Tasaki T, Nabesima A, Murata Y, Shimajiri S, et al: Apoptosis signal-regulating kinase 1 deficiency accelerates hyperlipidemia-induced atheromatous plaques via suppression of macrophage apoptosis. Arterioscler Thromb Vasc Biol. 31:1555–1564. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Guo Y, Yin HJ and Shi DZ: Effect of xinnao shutong capsule on cardiac muscle cell apoptosis and protein expressions of Bcl-2 and Bax in hyperlipidemia rats after myocardial infarction. Zhongguo Zhong Xi Yi Jie He Za Zhi. 26:541–544. 2006.(In Chinese). PubMed/NCBI

45 

Wang Y, Xue J, Li Y, Zhou X, Qiao S and Han D: Telmisartan protects against high glucose/high lipid-induced apoptosis and insulin secretion by reducing the oxidative and ER stress. Cell Biochem Funct. 37:161–168. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Giacco F and Brownlee M: Oxidative stress and diabetic complications. Circ Res. 107:1058–1070. 2010. View Article : Google Scholar : PubMed/NCBI

47 

Vásquez-Trincado C, García-Carvajal I, Pennanen C, Parra V, Hill JA, Rothermel BA and Lavandero S: Mitochondrial dynamics, mitophagy and cardiovascular disease. J Physiol. 594:509–525. 2016. View Article : Google Scholar

48 

Cheng L, Shen ZF, Sun GB and Sun XB: Advances in diabetic animal models and its application in the traditional Chinese medicine research. Yao Xue Xue Bao. 50:951–958. 2015.(In Chinese). PubMed/NCBI

49 

Zhang X and Hao Y: Beneficial effects of echinacoside on diabetic cardiomyopathy in diabetic Db/Db mice. Drug Des Devel Ther. 14:5575–5587. 2020. View Article : Google Scholar : PubMed/NCBI

50 

Wang S, Wang B, Wang Y, Tong Q, Liu Q, Sun J, Zheng Y and Cai L: Zinc prevents the development of diabetic cardiomyopathy in db/db Mice. Int J Mol Sci. 18:5802017. View Article : Google Scholar : PubMed/NCBI

51 

Quan LH, Zhang C, Dong M, Jiang J, Xu H, Yan C, Liu X, Zhou H, Zhang H, Chen L, et al: Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. Gut. 69:1239–1247. 2020. View Article : Google Scholar : PubMed/NCBI

52 

Xu Y, Wang N, Tan HY, Li S, Zhang C, Zhang Z and Feng Y: Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstructionvia leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity. Theranostics. 10:11302–11323. 2020. View Article : Google Scholar : PubMed/NCBI

53 

Tan PP, Zhou BH, Zhao WP, Jia LS, Liu J and Wang HW: Mitochondria-mediated pathway regulates C2C12 cell apoptosis induced by fluoride. Biol Trace Elem Res. 185:440–447. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Lu Q and Hong W: Bcl2 enhances c-Myc-mediated MMP-2 expression of vascular smooth muscle cells. Cell Signal. 21:1054–1059. 2009. View Article : Google Scholar : PubMed/NCBI

55 

Zhang G, Zeng X, Zhang R, Liu J, Zhang W, Zhao Y, Zhang X, Wu Z, Tan Y, Wu Y and Du B: Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3. Phytomedicine. 23:1329–1336. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Birkinshaw RW and Czabotar PE: The BCL-2 family of proteins and mitochondrial outer membrane permeabilisation. Semin Cell Dev Biol. 72:152–162. 2017. View Article : Google Scholar : PubMed/NCBI

57 

Antonsson B and Martinou JC: The Bcl-2 protein family. Exp Cell Res. 256:50–57. 2000. View Article : Google Scholar : PubMed/NCBI

58 

Matsui T and Rosenzweig A: Convergent signal transduction pathways controlling cardiomyocyte survival and function: The role of PI 3-kinase and akt. J Mol Cell Cardiol. 38:63–71. 2005. View Article : Google Scholar : PubMed/NCBI

59 

Hong HJ, Liu JC, Chen PY, Chen JJ, Chan P and Cheng TH: Tanshinone IIA prevents doxorubicin-induced cardiomyocyte apoptosis through Akt-dependent pathway. Int J Cardiol. 157:174–179. 2012. View Article : Google Scholar : PubMed/NCBI

60 

Su D, Zhou Y, Hu S, Guan L, Shi C, Wang Q, Chen Y, Lu C, Li Q and Ma X: Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis. Biomed Pharmacother. 93:1197–1204. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Zhang B, Chen Y, Shen Q, Liu G, Ye J, Sun G and Sun X: Myricitrin attenuates high glucose-induced apoptosis through activating Akt-Nrf2 signaling in H9c2 cardiomyocytes. Molecules. 21:8802016. View Article : Google Scholar : PubMed/NCBI

62 

Mahalanobish S, Saha S, Dutta S and Sil PC: Mangiferin alleviates arsenic induced oxidative lung injury via upregulation of the Nrf2-HO1 axis. Food Chem Toxicol. 126:41–55. 2019. View Article : Google Scholar : PubMed/NCBI

63 

Unnikrishnan R, Anjana RM and Mohan V: Diabetes mellitus and its complications in India. Nat Rev Endocrinol. 12:357–370. 2016. View Article : Google Scholar : PubMed/NCBI

64 

Athithan L, Gulsin GS, McCann GP and Levelt E: Diabetic cardiomyopathy: Pathophysiology, theories and evidence to date. World J Diabetes. 10:490–510. 2019. View Article : Google Scholar : PubMed/NCBI

65 

Hu X, Bai T, Xu Z, Liu Q, Zheng Y and Cai L: Pathophysiological fundamentals of diabetic cardiomyopathy. Compr Physiol. 7:693–711. 2017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang B, Zhang C, Zhang X, Sun G and Sun X: Guan Xin Dan Shen formulation protects <em>db/db</em> mice against diabetic cardiomyopathy via activation of Nrf2 signaling. Mol Med Rep 24: 531, 2021.
APA
Zhang, B., Zhang, C., Zhang, X., Sun, G., & Sun, X. (2021). Guan Xin Dan Shen formulation protects <em>db/db</em> mice against diabetic cardiomyopathy via activation of Nrf2 signaling. Molecular Medicine Reports, 24, 531. https://doi.org/10.3892/mmr.2021.12170
MLA
Zhang, B., Zhang, C., Zhang, X., Sun, G., Sun, X."Guan Xin Dan Shen formulation protects <em>db/db</em> mice against diabetic cardiomyopathy via activation of Nrf2 signaling". Molecular Medicine Reports 24.1 (2021): 531.
Chicago
Zhang, B., Zhang, C., Zhang, X., Sun, G., Sun, X."Guan Xin Dan Shen formulation protects <em>db/db</em> mice against diabetic cardiomyopathy via activation of Nrf2 signaling". Molecular Medicine Reports 24, no. 1 (2021): 531. https://doi.org/10.3892/mmr.2021.12170
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang B, Zhang C, Zhang X, Sun G and Sun X: Guan Xin Dan Shen formulation protects <em>db/db</em> mice against diabetic cardiomyopathy via activation of Nrf2 signaling. Mol Med Rep 24: 531, 2021.
APA
Zhang, B., Zhang, C., Zhang, X., Sun, G., & Sun, X. (2021). Guan Xin Dan Shen formulation protects <em>db/db</em> mice against diabetic cardiomyopathy via activation of Nrf2 signaling. Molecular Medicine Reports, 24, 531. https://doi.org/10.3892/mmr.2021.12170
MLA
Zhang, B., Zhang, C., Zhang, X., Sun, G., Sun, X."Guan Xin Dan Shen formulation protects <em>db/db</em> mice against diabetic cardiomyopathy via activation of Nrf2 signaling". Molecular Medicine Reports 24.1 (2021): 531.
Chicago
Zhang, B., Zhang, C., Zhang, X., Sun, G., Sun, X."Guan Xin Dan Shen formulation protects <em>db/db</em> mice against diabetic cardiomyopathy via activation of Nrf2 signaling". Molecular Medicine Reports 24, no. 1 (2021): 531. https://doi.org/10.3892/mmr.2021.12170
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team