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miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1

  • Authors:
    • Jin Wang
    • Ruixin Yao
    • Qiulin Luo
    • Lirong Tan
    • Beibei Jia
    • Nan Ouyang
    • Yezhou Li
    • Jian Tong
    • Jianxiang Li
  • View Affiliations / Copyright

    Affiliations: Department of Toxicology, School of Public Health, Medical College of Soochow University, Suzhou, Jiangsu 215123, P.R. China, School of Medicine, University of Manchester, M13 9PL Manchester, UK
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 562
    |
    Published online on: June 6, 2021
       https://doi.org/10.3892/mmr.2021.12201
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Abstract

Cigarette smoking is the leading cause of all histological types of lung cancer, and the role that microRNAs (miRNAs) serve in its pathogenesis is being increasingly recognized. The aim of the present study was to investigate the role of miR‑200b on migration in cigarette smoke‑induced malignant transformed cells. In the present study, miR‑200b expression was found to be increased in cigarette smoke (CS)‑exposed BEAS‑2B cells, lung cancer cell lines and tumor tissue samples. Using wound healing and Transwell migration assays, the migratory ability was shown to be increased in miR‑200b‑overexpressing cells, whereas miR‑200b knockdown resulted in reduced migration. Additionally, the expression of E‑Cadherin was downregulated, whereas that of N‑Cadherin was upregulated in miR‑200b mimic‑transfected cells, suggesting an increase in epithelial‑mesenchymal transition. Downstream, using four target gene prediction tools, six target genes of miR‑200b were predicted, amongst which, ETS proto‑oncogene 1 transcription factor (ETS1) was shown to be significantly associated with tumor invasion depth and negatively associated with miR‑200b expression. The interaction between miR‑200b and ETS1 was confirmed using a dual‑luciferase reporter assay. Using rescue experiments, the increased migratory ability of the miR‑200b‑overexpressing cells was reversed by ETS1 overexpression. In summary, this study showed that miR‑200b overexpression serves a carcinogenic role and promotes the migration of BEAS‑2B cells following long‑term exposure to CS by targeting ETS1.
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1 

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D and Bray F: Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136:E359–E386. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Hirsch FR, Scagliotti GV, Mulshine JL, Kwon R, Curran WJ Jr, Wu YL and Paz-Ares L: Lung cancer: Current therapies and new targeted treatments. Lancet. 389:299–311. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Goebel C, Louden CL, McKenna R Jr, Onugha O, Wachtel A and Long T: Diagnosis of non-small cell lung cancer for early stage asymptomatic patients. Cancer Genomics Proteomics. 16:229–244. 2019. View Article : Google Scholar : PubMed/NCBI

4 

Hay ED: An overview of epithelio-mesenchymal transformation. Acta Anat (Basel). 154:8–20. 1995. View Article : Google Scholar : PubMed/NCBI

5 

Kalluri R and Weinberg RA: The basics of epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Du H, Sun J, Chen Z, Nie J, Tong J and Li J: Cigarette smoke-induced failure of apoptosis resulting in enhanced neoplastic transformation in human bronchial epithelial cells. J Toxicol Environ Health A. 75:707–720. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Huang H, Ji Y, Zhang J, Su Z, Liu M, Tong J, Ge C, Chen T and Li J: Aberrant DNA methylation in radon and/or cigarette smoke-induced malignant transformation in BEAS-2B human lung cell line. J Toxicol Environ Health A. 80:1321–1330. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Wang J, Yu XF, Ouyang N, Zhao S, Yao H, Guan X, Tong J, Chen T and Li JX: MicroRNA and mRNA Interaction network regulates the malignant transformation of human bronchial epithelial cells induced by Cigarette smoke. Front Oncol. 9:10292019. View Article : Google Scholar : PubMed/NCBI

10 

Zaravinos A: The regulatory role of MicroRNAs in EMT and cancer. J Oncol. 2015:8658162015. View Article : Google Scholar : PubMed/NCBI

11 

Gros J and Tabin CJ: Vertebrate limb bud formation is initiated by localized epithelial-to-mesenchymal transition. Science. 343:1253–1256. 2014. View Article : Google Scholar : PubMed/NCBI

12 

Correa-Costa M, Andrade-Oliveira V, Braga TT, Castoldi A, Aguiar CF, Origassa CS, Rodas AC, Hiyane MI, Malheiros DM, Rios FJ, et al: Activation of platelet-activating factor receptor exacerbates renal inflammation and promotes fibrosis. Lab Invest. 94:455–466. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Grande MT, Sánchez-Laorden B, López-Blau C, De Frutos CA, Boutet A, Arévalo M, Rowe RG, Weiss SJ, López-Novoa JM and Nieto MA: Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease. Nat Med. 21:989–997. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Dhayat SA, Mardin WA, Köhler G, Bahde R, Vowinkel T, Wolters H, Senninger N, Haier J and Mees ST: The microRNA-200 family - a potential diagnostic marker in hepatocellular carcinoma? J Surg Oncol. 110:430–438. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Hur K, Toiyama Y, Takahashi M, Balaguer F, Nagasaka T, Koike J, Hemmi H, Koi M, Boland CR and Goel A: MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut. 62:1315–1326. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Bojmar L, Karlsson E, Ellegård S, Olsson H, Björnsson B, Hallböök O, Larsson M, Stål O and Sandström P: The role of microRNA-200 in progression of human colorectal and breast cancer. PLoS One. 8:e848152013. View Article : Google Scholar : PubMed/NCBI

17 

Kan CW, Hahn MA, Gard GB, Maidens J, Huh JY, Marsh DJ and Howell VM: Elevated levels of circulating microRNA-200 family members correlate with serous epithelial ovarian cancer. BMC Cancer. 12:6272012. View Article : Google Scholar : PubMed/NCBI

18 

Pacurari M, Addison JB, Bondalapati N, Wan YW, Luo D, Qian Y, Castranova V, Ivanov AV and Guo NL: The microRNA-200 family targets multiple non-small cell lung cancer prognostic markers in H1299 cells and BEAS-2B cells. Int J Oncol. 43:548–560. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Feng B, Wang R and Chen LB: Review of miR-200b and cancer chemosensitivity. Biomed Pharmacother. 66:397–402. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Liu K, Zhang W, Tan J, Ma J and Zhao J: miR-200b-3p functions as an oncogene by targeting ABCA1 in lung adenocarcinoma. Technol Cancer Res Treat. 18:15330338198925902019. View Article : Google Scholar : PubMed/NCBI

21 

Goldman MJ, Craft B, Hastie M, Repečka K, McDade F, Kamath A, Banerjee A, Luo Y, Rogers D, Brooks AN, et al: Visualizing and interpreting cancer genomics data via the Xena platform. Nat Biotechnol. 38:675–678. 2020. View Article : Google Scholar : PubMed/NCBI

22 

Vucic EA, Thu KL, Pikor LA, Enfield KS, Yee J, English JC, MacAulay CE, Lam S, Jurisica I and Lam WL: Smoking status impacts microRNA mediated prognosis and lung adenocarcinoma biology. BMC Cancer. 14:7782014. View Article : Google Scholar : PubMed/NCBI

23 

Huang W, Jin Y, Yuan Y, Bai C, Wu Y, Zhu H and Lu S: Validation and target gene screening of hsa-miR-205 in lung squamous cell carcinoma. Chin Med J (Engl). 127:272–278. 2014.PubMed/NCBI

24 

Arima C, Kajino T, Tamada Y, Imoto S, Shimada Y, Nakatochi M, Suzuki M, Isomura H, Yatabe Y, Yamaguchi T, et al: Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features. Carcinogenesis. 35:2224–2231. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Bjaanaes MM, Halvorsen AR, Solberg S, Jørgensen L, Dragani TA, Galvan A, Colombo F, Anderlini M, Pastorino U, Kure E, et al: Unique microRNA-profiles in EGFR-mutated lung adenocarcinomas. Int J Cancer. 135:1812–1821. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Lu TP, Tsai MH, Lee JM, Hsu CP, Chen PC, Lin CW, Shih JY, Yang PC, Hsiao CK, Lai LC, et al: Identification of a novel biomarker, SEMA5A, for non-small cell lung carcinoma in nonsmoking women. Cancer Epidemiol Biomarkers Prev. 19:2590–2597. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Wei TY, Juan CC, Hisa JY, Su LJ, Lee YC, Chou HY, Chen JM, Wu YC, Chiu SC, Hsu CP, et al: Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade. Cancer Sci. 103:1640–1650. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Whiteaker JR, Halusa GN, Hoofnagle AN, Sharma V, MacLean B, Yan P, Wrobel JA, Kennedy J, Mani DR, Zimmerman LJ, et al Clinical proteomic tumor analysis consortium (CPTAC), : CPTAC assay portal: A repository of targeted proteomic assays. Nat Methods. 11:703–704. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Yao Y, Hu J, Shen Z, Yao R, Liu S, Li Y, Cong H, Wang X, Qiu W and Yue L: MiR-200b expression in breast cancer: A prognostic marker and act on cell proliferation and apoptosis by targeting Sp1. J Cell Mol Med. 19:760–769. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Shinozaki A, Sakatani T, Ushiku T, Hino R, Isogai M, Ishikawa S, Uozaki H, Takada K and Fukayama M: Downregulation of microRNA-200 in EBV-associated gastric carcinoma. Cancer Res. 70:4719–4727. 2010. View Article : Google Scholar : PubMed/NCBI

32 

He M, Liu Y, Deng X, Qi S, Sun X, Liu G, Liu Y, Liu Y and Zhao M: Down-regulation of miR-200b-3p by low p73 contributes to the androgen-independence of prostate cancer cells. Prostate. 73:1048–1056. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Li Y, Guan B, Liu J, Zhang Z, He S, Zhan Y, Su B, Han H, Zhang X, Wang B, et al: MicroRNA-200b is downregulated and suppresses metastasis by targeting LAMA4 in renal cell carcinoma. EBioMedicine. 44:439–451. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Zhang HF, Alshareef A, Wu C, Jiao JW, Sorensen PH, Lai R, Xu LY and Li EM: miR-200b induces cell cycle arrest and represses cell growth in esophageal squamous cell carcinoma. Carcinogenesis. 37:858–869. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Zhang Z, Xing T, Chen Y and Xiao J: Exosome-mediated miR-200b promotes colorectal cancer proliferation upon TGF-β1 exposure. Biomed Pharmacother. 106:1135–1143. 2018. View Article : Google Scholar : PubMed/NCBI

36 

Zeng F, Xue M, Xiao T, Li Y, Xiao S, Jiang B and Ren C: MiR-200b promotes the cell proliferation and metastasis of cervical cancer by inhibiting FOXG1. Biomed Pharmacother. 79:294–301. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Fu Y, Liu X, Zhou N, Du L, Sun Y, Zhang X and Ge Y: MicroRNA-200b stimulates tumour growth in TGFBR2-null colorectal cancers by negatively regulating p27/kip1. J Cell Physiol. 229:772–782. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Vrijens K, Bollati V and Nawrot TS: MicroRNAs as potential signatures of environmental exposure or effect: A systematic review. Environ Health Perspect. 123:399–411. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Wang C, Kam RKT, Shi W, Xia Y, Chen X, Cao Y, Sun J, Du Y, Lu G, Chen Z, et al: The proto-oncogene transcription factor Ets1 regulates neural crest development through histone deacetylase 1 to mediate output of bone morphogenetic protein signaling. J Biol Chem. 290:21925–21938. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Shaikhibrahim Z and Wernert N: ETS transcription factors and prostate cancer: The role of the family prototype ETS-1 (Review). Int J Oncol. 40:1748–1754. 2012.PubMed/NCBI

41 

Dittmer J: The role of the transcription factor Ets1 in carcinoma. Semin Cancer Biol. 35:20–38. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Xu C, Liu S, Fu H, Li S, Tie Y, Zhu J, Xing R, Jin Y, Sun Z and Zheng X: MicroRNA-193b regulates proliferation, migration and invasion in human hepatocellular carcinoma cells. Eur J Cancer. 46:2828–2836. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Wei W, Hu Z, Fu H, Tie Y, Zhang H, Wu Y and Zheng X: MicroRNA-1 and microRNA-499 downregulate the expression of the ets1 proto-oncogene in HepG2 cells. Oncol Rep. 28:701–706. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Ma N, Chen F, Shen SL, Chen W, Chen LZ, Su Q, Zhang LJ, Bi J, Zeng WT, Li W, et al: MicroRNA-129-5p inhibits hepatocellular carcinoma cell metastasis and invasion via targeting ETS1. Biochem Biophys Res Commun. 461:618–623. 2015. View Article : Google Scholar : PubMed/NCBI

45 

Chan YC, Khanna S, Roy S and Sen CK: miR-200b targets Ets-1 and is down-regulated by hypoxia to induce angiogenic response of endothelial cells. J Biol Chem. 286:2047–2056. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang J, Yao R, Luo Q, Tan L, Jia B, Ouyang N, Li Y, Tong J and Li J: miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1. Mol Med Rep 24: 562, 2021.
APA
Wang, J., Yao, R., Luo, Q., Tan, L., Jia, B., Ouyang, N. ... Li, J. (2021). miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1. Molecular Medicine Reports, 24, 562. https://doi.org/10.3892/mmr.2021.12201
MLA
Wang, J., Yao, R., Luo, Q., Tan, L., Jia, B., Ouyang, N., Li, Y., Tong, J., Li, J."miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1". Molecular Medicine Reports 24.2 (2021): 562.
Chicago
Wang, J., Yao, R., Luo, Q., Tan, L., Jia, B., Ouyang, N., Li, Y., Tong, J., Li, J."miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1". Molecular Medicine Reports 24, no. 2 (2021): 562. https://doi.org/10.3892/mmr.2021.12201
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Yao R, Luo Q, Tan L, Jia B, Ouyang N, Li Y, Tong J and Li J: miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1. Mol Med Rep 24: 562, 2021.
APA
Wang, J., Yao, R., Luo, Q., Tan, L., Jia, B., Ouyang, N. ... Li, J. (2021). miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1. Molecular Medicine Reports, 24, 562. https://doi.org/10.3892/mmr.2021.12201
MLA
Wang, J., Yao, R., Luo, Q., Tan, L., Jia, B., Ouyang, N., Li, Y., Tong, J., Li, J."miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1". Molecular Medicine Reports 24.2 (2021): 562.
Chicago
Wang, J., Yao, R., Luo, Q., Tan, L., Jia, B., Ouyang, N., Li, Y., Tong, J., Li, J."miR‑200b upregulation promotes migration of BEAS‑2B cells following long‑term exposure to cigarette smoke by targeting ETS1". Molecular Medicine Reports 24, no. 2 (2021): 562. https://doi.org/10.3892/mmr.2021.12201
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