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Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia

  • Authors:
    • Caiyan Hu
    • Yupeng Yan
    • Chengbing Fu
    • Jin Ding
    • Tiantian Li
    • Shuqiong Wang
    • Liu Fang
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, Qing Hai University Medical College, Xining, Qinghai 810000, P.R. China
    Copyright: © Hu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 563
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    Published online on: June 7, 2021
       https://doi.org/10.3892/mmr.2021.12202
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Abstract

GATA binding protein 1 (GATA‑1) is one of the most important hematopoietic transcription factors in the production of blood cells, such as platelets, eosinophils, mast cells and erythrocytes. GATA‑1 regulates the participation of microRNA (miRNAs/miRs) in erythroid differentiation under normoxia. However, GATA‑1 expression and the regulation of miR‑210‑3p in the context of erythroid differentiation under hypoxia remain unknown. The present study examined the expression levels of GATA‑1 and miR‑210‑3p in the model of erythroid differentiation in K562 cells under hypoxia, and determined the effects of GATA‑1, miR‑210‑3p and SMAD2 on erythroid differentiation through lentivirus transfection experiments. The present study detected increased GATA‑1 expression under hypoxia. Moreover, miR‑210‑3p was identified as a positive regulator of erythroid differentiation, which was upregulated both during erythroid differentiation and in GATA‑1 overexpression experiments under hypoxia. Importantly, in the K562 cell model of erythroid differentiation under hypoxia, miR‑210‑3p was upregulated in a GATA‑1‑dependent manner. Using a double luciferase reporter assay, miR‑210‑3p was identified as a downstream target of GATA‑1‑mediated regulation of erythropoiesis. Gain‑ or loss‑of‑function analysis of miR‑210‑3p identified its importance in erythroid differentiation. Furthermore, it was found that SMAD2 may be a downstream target gene for miR‑210‑3p. Bioinformatics predictions suggested that SMAD2 mediated miR‑210‑3p‑induced regulation of erythroid differentiation. Collectively, the present study provides novel insights into the miRNA regulation of erythroid differentiation.
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View References

1 

Kerenyi MA and Orkin SH: Networking erythropoiesis. J Exp Med. 207:2537–2541. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Haase VH: Hypoxic regulation of erythropoiesis and iron metabolism. Am J Physiol Ren Physiol. 299:F1–F13. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Narayan AD, Ersek A, Campbell TA, Colón DM, Pixley JS and Zanjani ED: The effect of hypoxia and stem cell source on haemoglobin switching. Br J Haematol. 128:562–570. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Rogers HM, Yu X, Wen J, Smith R, Fibach E and Noguchi CT: Hypoxia alters progression of the erythroid program. Exp Hematol. 36:17–27. 2008. View Article : Google Scholar : PubMed/NCBI

5 

Vlaski M, Lafarge X, Chevaleyre J, Duchez P, Boiron JM and Ivanovic Z: Low oxygen concentration as a general physiologic regulator of erythropoiesis beyond the EPO-related downstream tuning and a tool for the optimization of red blood cell production ex vivo. Exp Hematol. 37:573–584. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Ferreira R, Ohneda K, Yamamoto M and Philipsen S: GATA1 Function, a paradigm for transcription factors in hematopoiesis. Mol Cell Biol. 25:1215–1227. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Yu M, Riva L, Xie H, Schindler Y, Moran TB, Cheng Y, Yu D, Hardison R, Weiss MJ, Orkin SH, et al: Insights into GATA-1-mediated gene activation versus repression via genome-wide chromatin occupancy analysis. Mol Cell. 36:682–695. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Scherzer CR, Grass JA, Liao Z, Pepivani I, Zheng B, Eklund AC, Ney PA, Ng J, McGoldrick M, Mollenhauer B, et al: GATA transcription factors directly regulate the Parkinson's disease-linked gene alpha-synuclein. Proc Natl Acad Sci USA. 105:10907–10912. 2008. View Article : Google Scholar : PubMed/NCBI

9 

Crispino JD: GATA1 in normal and malignant hematopoiesis. Semin Cell Dev Biol. 16:137–147. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Cantor AB and Orkin SH: Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene. 21:3368–3376. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Dore LC, Amigo JD, Dos Santos CO, Zhang Z, Gai X, Tobias JW, Yu D, Klein AM, Dorman C, Wu W, et al: A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci USA. 105:3333–3338. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Nilsen TW: Mechanisms of microRNA-mediated gene regulation in animal cells. Trends Genet. 5:243–249. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Bianchi N, Zuccato C, Finotti A, Lampronti I, Borgatti M and Gambari R: Involvement of miRNA in erythroid differentiation. Epigenomics. 4:51–65. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Huang X, Le QT and Giaccia AJ: MiR-210-micromanager of the hypoxia pathway. Trends Mol Med. 16:230–237. 2010. View Article : Google Scholar : PubMed/NCBI

15 

Kosaka N, Sugiura K, Yamamoto Y, Yoshioka Y, Miyazaki H, Komatsu N, Ochiya T and Kato T: Identification of erythropoietin-induced microRNAs in haematopoietic cells during erythroid differentiation. Br J Haematol. 142:293–300. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Rowley PT, Ohlsson-Wilhelm BM, Farley BA and LaBella S: Inducers of erythroid differentiation in K562 human leukemia cells. Exp Hematol. 9:32–37. 1981.PubMed/NCBI

17 

Gahmberg CG and Andersson LC: K562-a human leukemia cell line with erythroid features. Semin Hematol. 18:72–77. 1981.PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2002. View Article : Google Scholar : PubMed/NCBI

19 

Mazan-Mamczarz K and Gartenhaus RB: Role of microRNA deregulation in the pathogenesis of diffuse large B-cell lymphoma (DLBCL). Leuk Res. 37:1420–1428. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, Ivey KN, Bruneau BG, Stainier DY and Srivastava D: miR-126 regulates angiogenic signaling and vascular integrity. Dev Cell. 15:272–284. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Abend JR, Uldrick T and Ziegelbauer JM: Regulation of tumor necrosis factor-like weak inducer of apoptosis receptor protein (TWEAKR) expression by kaposi's sarcoma-associated herpesvirus MicroRNA prevents tweak-induced apoptosis and inflammatory cytokine expression. J Virol. 84:12139–12151. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Shivdasani RA: MicroRNAs: Regulators of gene expression and cell differentiation. Blood. 108:3646–3653. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Bapat A, Schippel N, Shi X, Jasbi P, Gu H, Kala M, Sertil A and Sharma S: Hypoxia promotes erythroid differentiation through the development of progenitors and proerythroblasts. Exp Hematol. 97:32–46.e35. 2021. View Article : Google Scholar : PubMed/NCBI

24 

Kaelin WG Jr and Ratcliffe PJ: Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway. Mol Cell. 30:393–402. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Windsor JS and Rodway GW: Heights and haematology: The story of haemoglobin at altitude. Postgrad Med J. 83:148–151. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Noguchi CT and Rogers H: Hypoxia alters progression of the erythroid program. Exp Hematol. 2:163. 2007.

27 

Welch JJ, Watts JA, Vakoc CR, Yao Y, Wang H, Hardison RC, Blobel GA, Chodosh LA and Weiss MJ: Global regulation of erythroid gene expression by transcription factor GATA-1. Blood. 10:3136–3147. 2004. View Article : Google Scholar : PubMed/NCBI

28 

Wu J, Zhou LQ, Yu W, Zhao ZG, Xie XM, Wang WT, Xiong J, Li M, Xue Z, Wang X, et al: PML4 facilitates erythroid differentiation by enhancing the transcriptional activity of GATA-1. Blood. 123:261–270. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Doss JF, Corcoran DL, Jima D, Telen MJ, Dave SS and Chi JT: A comprehensive joint analysis of the long and short RNA transcriptomes of human erythrocytes. BMC Genomics. 16:952. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Rasmussen KD, Simmini S, Abreugoodger C, Bartonicek N, Di Giacomo M, Bilbao-Cortes D, Horos R, Von Lindern M, Enright AJ and O'Carroll D: The miR-144/451 locus is required for erythroid homeostasis. J Exp Med. 207:1351–1358. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Undi RB, Kandi R and Gutti RK: MicroRNAs as haematopoiesis regulators. Adv Hematol. 2013:6957542013. View Article : Google Scholar : PubMed/NCBI

32 

Xie Y, Li W, Feng J, Wu T and Li J: MicroRNA-363 and GATA-1 are regulated by HIF-1α in K562 cells under hypoxia. Mol Med Rep. 14:2503–2510. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Raghuwanshi S, Karnati HK, Sarvothaman S, Gutti U, Saladi RGV, Tummala PR and Gutti RK: microRNAs: Key players in hematopoiesis. Adv Exp Med Bio. 887:171–211. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Sarakul O, Vattanaviboon P, Tanaka Y, Fucharoen S, Abe Y, Svasti S and Umemura T: Enhanced erythroid cell differentiation in hypoxic condition is in part contributed by miR-210. Blood Cells Mol Dis. 51:98–103. 2013. View Article : Google Scholar : PubMed/NCBI

35 

Zhu Y, Wang D, Wang F, Li T, Dong L, Liu H, Ma Y, Jiang F, Yin H, Yan W, et al: A comprehensive analysis of GATA-1-regulated miRNAs reveals miR-23a to be a positive modulator of erythropoiesis. Nucleic Acids Res. 41:4129–4143. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Liu B, Sun J, Lei X, Zhu Z, Pei C and Qin L: MicroRNA-486-5p suppresses TGF-β2-induced proliferation, invasion and epithelial-mesenchymal transition of lens epithelial cells by targeting Smad2. J Biosci. 42:575–584. 2017. View Article : Google Scholar : PubMed/NCBI

37 

AlMegbel AM and Shuler CF: SMAD2 overexpression rescues the TGF-β3 null mutant mice cleft palate by increased apoptosis. Differentiation. 111:60–69. 2020. View Article : Google Scholar : PubMed/NCBI

38 

Cheung KS, Sposito N, Stumpf PS, Wilson DI, Sanchez-Elsner T and Oreffo ROC: MicroRNA-146a regulates human foetal femur derived skeletal stem cell differentiation by down-regulating SMAD2 and SMAD3. PLoS One. 9:e980632014. View Article : Google Scholar : PubMed/NCBI

39 

Söderberg SS, Karlsson G and Karlsson S: Complex and context dependent regulation of hematopoiesis by TGF-β superfamily signaling. Ann N Y Acad Sci. 1176:55–69. 2009. View Article : Google Scholar

40 

Blank U and Karlsson S: The role of Smad signaling in hematopoiesis and translational hematology. Leukemia. 25:1379–1388. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Shav-Tal Y and Zipori D: The role of activin A in regulation of hemopoiesis. Stem Cells. 20:493–500. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Shiozaki M, Sakai R, Tabuchi M, Nakamura T, Sugino K, Sugino H and Eto Y: Evidence for the participation of endogenous activin A/erythroid differentiation factor in the regulation of erythropoiesis. Proc Natl Acad Sci USA. 89:1553–1556. 1992. View Article : Google Scholar : PubMed/NCBI

43 

Zhou L, Nguyen AN, Sohal D, Ma JY, Pahanish P, Gundabolu K, Hayman J, Chubak A, Mo Y, Bhagat TD, et al: Inhibition of the TGF-β receptor I kinase promotes hematopoiesis in MDS. Blood. 112:3434–3443. 2008. View Article : Google Scholar : PubMed/NCBI

44 

Dussiot M, Maciel TT, Fricot A, Chartier C, Negre O, Veiga J, Grapton D, Paubelle E, Payen E, Beuzard Y, et al: An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia. Nat Med. 20:398–407. 2014. View Article : Google Scholar : PubMed/NCBI

45 

Suragani RN, Cawley SM, Li R, Wallner S, Alexander MJ, Mulivor AW, Gardenghi S, Rivella S, Grinberg AV, Pearsall RS and Kumar R: Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia. Blood. 123:3864–3872. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Suragani RN, Cadena SM, Cawley SM, Sako D, Mitchell D, Li R, Davies MV, Alexander MJ, Devine M, Loveday KS, et al: Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis. Nat Med. 20:408–414. 2014. View Article : Google Scholar : PubMed/NCBI

47 

Martinez PA, Li R, Ramanathan HN, Bhasin M, Persall RS, Kumar R and Suragani RNVS: Smad2/3-pathway ligand trap luspatercept enhances erythroid differentiation in murine β-thalassaemia by increasing GATA-1 availability. J Cell Mol Med. 24:6162–6177. 2020. View Article : Google Scholar : PubMed/NCBI

48 

Wu F, Weigel KJ, Zhou H and Wang XJ: Paradoxical roles of TGF-β signaling in suppressing and promoting squamous cell carcinoma. Acta Biochim Biophys Sin (Shanghai). 50:730. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Tannehill-Gregg SH, Kusewitt DF, Rosol TJ and Weinstein M: The roles of Smad2 and Smad3 in the development of chemically induced skin tumors in mice. Vet Pathol. 41:278–282. 2004. View Article : Google Scholar : PubMed/NCBI

50 

Phuah NH, Azmi MN, Awang K and Nagoor NH: Down-regulation of microRNA-210 confers sensitivity towards 1′s-1′-acetoxychavicol acetate (ACA) in cervical cancer cells by targeting SMAD4. Mol Cells. 40:291–298. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Mizuno Y, Tokuzawa Y, Ninomiya Y, Yagi K, Yatsuka-Kanesaki Y, Suda T, Fukuda T, Katagiri T, Kondoh Y, Amemiya T, et al: miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b. FEBS Lett. 583:2263–2268. 2009. View Article : Google Scholar : PubMed/NCBI

52 

Miyazono K, Maeda S and Imamura T: BMP receptor signaling: Transcriptional targets, regulation of signals, and signaling cross-talk. Cytokine Growth Factor Rev. 16:251–263. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Maeda S, Hayashi M, Komiya S, Imamura T and Miyazono K: Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J. 23:552–563. 2004. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Hu C, Yan Y, Fu C, Ding J, Li T, Wang S and Fang L: Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia. Mol Med Rep 24: 563, 2021.
APA
Hu, C., Yan, Y., Fu, C., Ding, J., Li, T., Wang, S., & Fang, L. (2021). Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia. Molecular Medicine Reports, 24, 563. https://doi.org/10.3892/mmr.2021.12202
MLA
Hu, C., Yan, Y., Fu, C., Ding, J., Li, T., Wang, S., Fang, L."Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia". Molecular Medicine Reports 24.2 (2021): 563.
Chicago
Hu, C., Yan, Y., Fu, C., Ding, J., Li, T., Wang, S., Fang, L."Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia". Molecular Medicine Reports 24, no. 2 (2021): 563. https://doi.org/10.3892/mmr.2021.12202
Copy and paste a formatted citation
x
Spandidos Publications style
Hu C, Yan Y, Fu C, Ding J, Li T, Wang S and Fang L: Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia. Mol Med Rep 24: 563, 2021.
APA
Hu, C., Yan, Y., Fu, C., Ding, J., Li, T., Wang, S., & Fang, L. (2021). Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia. Molecular Medicine Reports, 24, 563. https://doi.org/10.3892/mmr.2021.12202
MLA
Hu, C., Yan, Y., Fu, C., Ding, J., Li, T., Wang, S., Fang, L."Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia". Molecular Medicine Reports 24.2 (2021): 563.
Chicago
Hu, C., Yan, Y., Fu, C., Ding, J., Li, T., Wang, S., Fang, L."Effects of miR‑210‑3p on the erythroid differentiation of K562 cells under hypoxia". Molecular Medicine Reports 24, no. 2 (2021): 563. https://doi.org/10.3892/mmr.2021.12202
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