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Article

Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels

  • Authors:
    • Shu Zhang
    • Juanli Xing
    • Yulin Gong
    • Ping Li
    • Boqian Wang
    • Ling Xu
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China, Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710048, P.R. China, Department of Rheumatic Immunology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 010110, P.R. China, Department of Obstetrics, Yongkang Maternal and Child Health Care Hospital, Yongkang, Zhejiang 321300, P.R. China
  • Article Number: 591
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    Published online on: June 17, 2021
       https://doi.org/10.3892/mmr.2021.12230
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Abstract

Benign paroxysmal positional vertigo (BPPV) is the most common peripheral vertigo‑associated disease. Vitamin D (VD) helps maintain normal otolith function and may be associated with BPPV. VD exerts its biological functions primarily via the VD receptor (VDR). The present study demonstrated that serum VD levels were significantly decreased in patients with BPPV compared with in controls. VDR, otolith‑associated protein otoconin‑90 (OC90) and NADPH oxidase 3 (NOX3) expression levels were also significantly decreased in patients with BPPV compared with in controls. Furthermore, a positive correlation was observed between VD levels and VDR expression. Receiver operating characteristic curve analysis identified VDR expression levels as a potential diagnostic marker for BPPV. OC90 and NOX3 expression levels were notably lower in the inner ear tissue of VDR knockout mice compared with in those of wild‑type mice. In mice overexpressing VDR, OC90 and NOX3 were also overexpressed. Following intravenous injection of VD in VDR knockout mice, expression levels of OC90 and NOX3 were not significantly different from those in VDR knockout mice injected with saline. This indicated that VDR may be underexpressed in patients with BPPV and was associated with the expression levels of otolith‑associated proteins. Moreover, VDR mediated VD activation, leading to otolith protein formation. The present study provided a novel theoretical basis for BPPV onset that may facilitate the development of more effective diagnostic and treatment options.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang S, Xing J, Gong Y, Li P, Wang B and Xu L: Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels. Mol Med Rep 24: 591, 2021.
APA
Zhang, S., Xing, J., Gong, Y., Li, P., Wang, B., & Xu, L. (2021). Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels. Molecular Medicine Reports, 24, 591. https://doi.org/10.3892/mmr.2021.12230
MLA
Zhang, S., Xing, J., Gong, Y., Li, P., Wang, B., Xu, L."Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels". Molecular Medicine Reports 24.2 (2021): 591.
Chicago
Zhang, S., Xing, J., Gong, Y., Li, P., Wang, B., Xu, L."Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels". Molecular Medicine Reports 24, no. 2 (2021): 591. https://doi.org/10.3892/mmr.2021.12230
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang S, Xing J, Gong Y, Li P, Wang B and Xu L: Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels. Mol Med Rep 24: 591, 2021.
APA
Zhang, S., Xing, J., Gong, Y., Li, P., Wang, B., & Xu, L. (2021). Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels. Molecular Medicine Reports, 24, 591. https://doi.org/10.3892/mmr.2021.12230
MLA
Zhang, S., Xing, J., Gong, Y., Li, P., Wang, B., Xu, L."Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels". Molecular Medicine Reports 24.2 (2021): 591.
Chicago
Zhang, S., Xing, J., Gong, Y., Li, P., Wang, B., Xu, L."Downregulation of VDR in benign paroxysmal positional vertigo patients inhibits otolith‑associated protein expression levels". Molecular Medicine Reports 24, no. 2 (2021): 591. https://doi.org/10.3892/mmr.2021.12230
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