Open Access

Circular RNA: A novel type of biomarker for glioma (Review)

  • Authors:
    • Wei Sun
    • Huandi Zhou
    • Xuetao Han
    • Liubing Hou
    • Xiaoying Xue
  • View Affiliations

  • Published online on: June 24, 2021     https://doi.org/10.3892/mmr.2021.12240
  • Article Number: 602
  • Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

With the rapid development of sequencing technologies, the characteristics and functions of circular RNAs (circRNAs) in different tissues, and their underlying pathophysiological mechanisms, have been identified. circRNAs are significantly enriched in the brain and are continually expressed from the embryonic stage to the adult stage in rats. Previous studies have reported that certain circRNAs are differentially expressed in glioma and regulate a number of biological processes, such as cell proliferation, metastasis and oncogenesis of glioma. Furthermore, certain circRNAs have been associated with tumor size, World Health Organization tumor grade and poor prognosis in patients with glioma. It has been hypothesized that circRNAs may be involved in the onset and progression of glioma through transcriptional regulation, protein translation and binding to microRNAs. These properties and functions suggest the potential of circRNAs as prognostic biomarkers and therapeutic targets for glioma. For the present review, published studies were examined from PubMed, Embase, Cochrane Central and the reference lists of the retrieved articles. The aim of the present review was to summarize the progress of circRNA research in glioma, discuss the potential diagnostic and prognostic values, and the roles of circRNAs in glioma, and provide a novel theoretical basis and research concepts for the prediction, diagnosis and treatment of glioma.
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August-2021
Volume 24 Issue 2

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Sun W, Zhou H, Han X, Hou L and Xue X: Circular RNA: A novel type of biomarker for glioma (Review). Mol Med Rep 24: 602, 2021
APA
Sun, W., Zhou, H., Han, X., Hou, L., & Xue, X. (2021). Circular RNA: A novel type of biomarker for glioma (Review). Molecular Medicine Reports, 24, 602. https://doi.org/10.3892/mmr.2021.12240
MLA
Sun, W., Zhou, H., Han, X., Hou, L., Xue, X."Circular RNA: A novel type of biomarker for glioma (Review)". Molecular Medicine Reports 24.2 (2021): 602.
Chicago
Sun, W., Zhou, H., Han, X., Hou, L., Xue, X."Circular RNA: A novel type of biomarker for glioma (Review)". Molecular Medicine Reports 24, no. 2 (2021): 602. https://doi.org/10.3892/mmr.2021.12240