Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
September-2021 Volume 24 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2021 Volume 24 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells

  • Authors:
    • Jie Liu
    • Siya Xu
    • Shixin Liu
    • Bingguan Chen
  • View Affiliations / Copyright

    Affiliations: Department of Intensive Care Unit, Hefei Boe Hospital Co., Ltd., Hefei, Anhui 230011, P.R. China, Department of Emergency, Central Theater General Hospital of The People's Liberation Army of China, Wuhan, Hubei 430070, P.R. China, Department of General Surgery, Hefei Boe Hospital Co., Ltd., Hefei, Anhui 230011, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 633
    |
    Published online on: July 6, 2021
       https://doi.org/10.3892/mmr.2021.12272
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Previous studies have identified microRNA (miRNA/miR)‑3613‑3p as a heat stress (HS)‑related miRNA in endothelial cells that can lead to apoptosis. However, the mechanism underlying the miR‑3613‑3p‑mediated apoptosis of HS‑exposed endothelial cells remains unclear. In the present study, western blot analysis and reverse transcription‑quantitative PCR were used to determine protein and miRNA expression levels, respectively. Annexin V‑fluorescein isothiocyanate/propidium iodide staining, caspase‑3 activity measurements and DNA fragmentation assays were performed to detect apoptosis. To evaluate whether mitogen‑activated protein kinase kinase kinase 2 (MAP3K2) was a direct target of miR‑3613‑3p, a luciferase reporter assay was performed. In addition, transient transfection was used to carry out loss‑ and gain‑of‑function experiments. The results revealed that miR‑3613‑3p expression was reduced in human umbilical vein endothelial cells (HUVECs) following HS, which led to apoptosis. Mechanistically, following HS, a decrease in miR‑3613‑3p binding to the 3'‑untranslated region of MAP3K2 directly upregulated its expression, and the downstream p38 and caspase‑3 pathways, thereby leading to apoptosis. Taken together, the results of the present study demonstrated that HS suppressed miR‑3613‑3p expression, which activated the MAP3K2/p38/caspase‑3 pathway, leading to the apoptosis of HUVECs. In conclusion, the miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway may serve an indispensable role in regulating the progression of apoptosis, indicating a regulatory role of miR‑3613‑3p in the pathophysiology of HS‑exposed endothelial cells.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Jin H, Chen Y, Ding C, Lin Y, Chen Y, Jiang D and Su L: Microcirculatory disorders and protective role of Xuebijing in severe heat stroke. Sci Rep. 8:45532018. View Article : Google Scholar : PubMed/NCBI

2 

Bouchama A and Knochel JP: Heat stroke. N Engl J Med. 346:1978–1988. 2002. View Article : Google Scholar : PubMed/NCBI

3 

Roberts GT, Ghebeh H, Chishti MA, Al-Mohanna F, El-Sayed R, Al-Mohanna F and Bouchama A: Microvascular injury, thrombosis, inflammation, and apoptosis in the pathogenesis of heatstroke: A study in baboon model. Arterioscler Thromb Vasc Biol. 28:1130–1136. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Lam NN, Hung TD and Hung DK: Acute respiratory distress syndrome among severe burn patients in a developing country: Application result of the berlin definition. Ann Burns Fire Disasters. 31:9–12. 2018.PubMed/NCBI

5 

Haines RJ, Wang CY, Yang CGY, Eitnier RA, Wang F and Wu MH: Targeting palmitoyl acyltransferase ZDHHC21 improves gut epithelial barrier dysfunction resulting from burn-induced systemic inflammation. Am J Physiol Gastrointest Liver Physiol. 313:G549–G557. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Bouchama A, Hammami MM, Haq A, Jackson J and al-Sedairy S: Evidence for endothelial cell activation/injury in heatstroke. Crit Care Med. 24:1173–1178. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Oshima K, Han X, Ouyang Y, El Masri R, Yang Y, Haeger SM, McMurtry SA, Lane TC, Davizon-Castillo P, Zhang F, et al: Loss of endothelial sulfatase-1 after experimental sepsis attenuates subsequent pulmonary inflammatory responses. Am J Physiol Lung Cell Mol Physiol. 317:L667–L677. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Colbert JF and Schmidt EP: Endothelial and microcirculatory function and dysfunction in sepsis. Clin Chest Med. 37:263–275. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Bombeli T, Mueller M and Haeberli A: Anticoagulant properties of the vascular endothelium. Thromb Haemost. 77:408–423. 1997. View Article : Google Scholar : PubMed/NCBI

10 

Donadello K, Piagnerelli M, Reggiori G, Gottin L, Scolletta S, Occhipinti G, Zouaoui Boudjeltia K and Vincent JL: Reduced red blood cell deformability over time is associated with a poor outcome in septic patients. Microvasc Res. 101:8–14. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Bartel DP: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell. 116:281–297. 2004. View Article : Google Scholar : PubMed/NCBI

12 

Liu J, Zhu G, Xu S, Liu S, Lu Q and Tang Z: Analysis of miRNA expression profiling in human umbilical vein endothelial cells affected by heat stress. Int J Mol Med. 40:1719–1730. 2017.PubMed/NCBI

13 

Corre I, Paris F and Huot J: The p38 pathway, a major pleiotropic cascade that transduces stress and metastatic signals in endothelial cells. Oncotarget. 8:55684–55714. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Li M, van Esch BCAM, Wagenaar GTM, Garssen J, Folkerts G and Henricks PAJ: Pro- and anti-inflammatory effects of short chain fatty acids on immune and endothelial cells. Eur J Pharmacol. 831:52–59. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Huang W, Xie W, Gong J, Wang W, Cai S, Huang Q, Chen Z and Liu Y: Heat stress induces RIP1/RIP3-dependent necroptosis through the MAPK, NF-κB, and c-Jun signaling pathways in pulmonary vascular endothelial cells. Biochem Biophys Res Commun. 528:206–212. 2020. View Article : Google Scholar : PubMed/NCBI

16 

Yong YX, Yang H, Lian J, Xu XW, Han K, Hu MY, Wang HC and Zhou LM: Up-regulated microRNA-199b-3p represses the apoptosis of cerebral microvascular endothelial cells in ischemic stroke through down-regulation of MAPK/ERK/EGR1 axis. Cell Cycle. 18:1868–1881. 2019. View Article : Google Scholar : PubMed/NCBI

17 

Zhou Z, Chen Y, Zhang D, Wu S, Liu T, Cai G and Qin S: MicroRNA-30-3p suppresses inflammatory factor-induced endothelial cell injury by targeting TCF21. Mediators Inflamm. 2019:13421902019. View Article : Google Scholar : PubMed/NCBI

18 

Yi J and Gao ZF: MicroRNA-9-5p promotes angiogenesis but inhibits apoptosis and inflammation of high glucose-induced injury in human umbilical vascular endothelial cells by targeting CXCR4. Int J Biol Macromol. 130:1–9. 2019. View Article : Google Scholar : PubMed/NCBI

19 

Liu J, Han X, Zhu G, Liu S, Lu Q and Tang Z: Analysis of potential functional significance of microRNA-3613-3p in human umbilical vein endothelial cells affected by heat stress. Mol Med Rep. 20:1846–1856. 2019.PubMed/NCBI

20 

Tang S, Allagadda V, Chibli H, Nadeau JL and Mayer GD: Comparison of cytotoxicity and expression of metal regulatory genes in zebrafish (Danio rerio) liver cells exposed to cadmium sulfate, zinc sulfate and quantum dots. Metallomics. 5:1411–1422. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Tang S, Cai Q, Chibli H, Allagadda V, Nadeau JL and Mayer GD: Cadmium sulfate and CdTe-quantum dots alter DNA repair in zebrafish (Danio rerio) liver cells. Toxicol Appl Pharmacol. 272:443–452. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Li X, Xue X, Sun Y, Chen L, Zhao T, Yang W, Chen Y and Zhang Z: MicroRNA-326-5p enhances therapeutic potential of endothelial progenitor cells for myocardial infarction. Stem Cell Res Ther. 10:3232019. View Article : Google Scholar : PubMed/NCBI

24 

Xing X, Li Z, Yang X, Li M, Liu C, Pang Y, Zhang L, Li X, Liu G and Xiao Y: Adipose-derived mesenchymal stem cells-derived exosome-mediated microRNA-342-5p protects endothelial cells against atherosclerosis. Aging (Albany NY). 12:3880–3898. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Deng X, Chu X, Wang P, Ma X, Wei C, Sun C, Yang J and Li Y: MicroRNA-29a-3p reduces TNFα-induced endothelial dysfunction by targeting tumor necrosis factor receptor 1. Mol Ther Nucleic Acids. 18:903–915. 2019. View Article : Google Scholar : PubMed/NCBI

26 

Zehorai E and Seger R: Beta-like importins mediate the nuclear translocation of mitogen-activated protein kinases. Mol Cell Biol. 34:259–270. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Lee Y, Kim YJ, Kim MH and Kwak JM: MAPK cascades in guard cell signal transduction. Front Plant Sci. 7:802016. View Article : Google Scholar : PubMed/NCBI

28 

Zhu G, Qiu W, Li Y, Zhao C, He F, Zhou M, Wang L, Zhao D, Lu Y, Zhang J, et al: Sublytic C5b-9 induces glomerular mesangial cell apoptosis through the cascade pathway of MEKK2-p38 MAPK-IRF-1-TRADD-caspase 8 in rat Thy-1 nephritis. J Immunol. 198:1104–1118. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Chen Z, Zhu R and Zheng J, Chen C, Huang C, Ma J, Xu C, Zhai W and Zheng J: Cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing STAT3 signals in renal cell carcinoma. Oncotarget. 8:50023–50033. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Chang X, Liu F, Wang X, Lin A, Zhao H and Su B: The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation. Immunity. 34:201–212. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Li H, Liu Y, Wen M, Zhao F, Zhao Z, Liu Y, Lin X and Wang L: Hydroxysafflor yellow A (HSYA) alleviates apoptosis and autophagy of neural stem cells induced by heat stress via p38 MAPK/MK2/Hsp27-78 signaling pathway. Biomed Pharmacother. 114:1088152019. View Article : Google Scholar : PubMed/NCBI

32 

Zhuang Y, Xu H, Richard SA, Cao J, Li H, Shen H, Yu Z, Zhang J, Wang Z, Li X and Chen G: Inhibition of EPAC2 attenuates intracerebral hemorrhage-induced secondary brain injury via the p38/BIM/caspase-3 pathway. J Mol Neurosci. 67:353–363. 2019. View Article : Google Scholar : PubMed/NCBI

33 

Barata AG and Dick TP: A role for peroxiredoxins in H2O2- and MEKK-dependent activation of the p38 signaling pathway. Redox Biol. 28:1013402020. View Article : Google Scholar : PubMed/NCBI

34 

Deschodt-Lanckman M and Strosberg AD: In vitro degradation of the C-terminal octapeptide of cholecystokinin by ‘enkephalinase A’. FEBS Lett. 152:109–113. 1983. View Article : Google Scholar : PubMed/NCBI

35 

Dermott JM, Ha JH, Lee CH and Dhanasekaran N: Differential regulation of Jun N-terminal kinase and p38MAP kinase by Galpha12. Oncogene. 23:226–232. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Raviv Z, Kalie E and Seger R: MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation. J Cell Sci. 117:1773–1784. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Shen CT, Qiu ZL, Song HJ, Wei WJ and Luo QY: miRNA-106a directly targeting RARB associates with the expression of Na(+)/I(−) symporter in thyroid cancer by regulating MAPK signaling pathway. J Exp Clin Cancer Res. 35:1012016. View Article : Google Scholar : PubMed/NCBI

38 

Tsioumpekou M, Papadopoulos N, Burovic F, Heldin CH and Lennartsson J: Platelet-derived growth factor (PDGF)-induced activation of Erk5 MAP-kinase is dependent on Mekk2, Mek1/2, PKC and PI3-kinase, and affects BMP signaling. Cell Signal. 28:1422–1431. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Shi X, Liu TT, Yu XN, Balakrishnan A, Zhu HR, Guo HY, Zhang GC, Bilegsaikhan E, Sun JL, Song GQ, et al: microRNA-93-5p promotes hepatocellular carcinoma progression via a microRNA-93-5p/MAP3K2/c-Jun positive feedback circuit. Oncogene. 39:5768–5781. 2020. View Article : Google Scholar : PubMed/NCBI

40 

Liu Y, Zhou G, Wang Z, Guo X, Xu Q, Huang Q and Su L: NF-κB signaling is essential for resistance to heat stress-induced early stage apoptosis in human umbilical vein endothelial cells. Sci Rep. 5:135472015. View Article : Google Scholar : PubMed/NCBI

41 

Li L, Tan H, Yang H, Li F, He X, Gu Z, Zhao M and Su L: Reactive oxygen species mediate heat stress-induced apoptosis via ERK dephosphorylation and Bcl-2 ubiquitination in human umbilical vein endothelial cells. Oncotarget. 8:12902–12916. 2017. View Article : Google Scholar : PubMed/NCBI

42 

Li H, Liu Y, Gu Z, Li L, Liu Y, Wang L and Su L: p38 MAPK-MK2 pathway regulates the heat-stress-induced accumulation of reactive oxygen species that mediates apoptotic cell death in glial cells. Oncol Lett. 15:775–782. 2018.PubMed/NCBI

43 

Liu Y, Wang Z, Xie W, Gu Z, Xu Q and Su L: Oxidative stress regulates mitogen-activated protein kinases and c-Jun activation involved in heat stress and lipopolysaccharide-induced intestinal epithelial cell apoptosis. Mol Med Rep. 16:2579–2587. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Liu ZF, Ji JJ, Zheng D, Su L and Peng T: Calpain-2 protects against heat stress-induced cardiomyocyte apoptosis and heart dysfunction by blocking p38 mitogen-activated protein kinase activation. J Cell Physiol. 234:10761–10770. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Pu Y, Liu Z, Tian H and Bao Y: The immunomodulatory effect of Poria cocos polysaccharides is mediated by the Ca2+/PKC/p38/NF-κB signaling pathway in macrophages. Int Immunopharmacol. 72:252–257. 2019. View Article : Google Scholar : PubMed/NCBI

46 

Wang W, Weng J, Yu L, Huang Q, Jiang Y and Guo X: Role of TLR4-p38 MAPK-Hsp27 signal pathway in LPS-induced pulmonary epithelial hyperpermeability. BMC Pulm Med. 18:1782018. View Article : Google Scholar : PubMed/NCBI

47 

Zhang X, Chen Q, Song H, Jiang W, Xie S, Huang J and Kang G: MicroRNA-375 prevents TGF-β-dependent transdifferentiation of lung fibroblasts via the MAP2K6/P38 pathway. Mol Med Rep. 22:1803–1810. 2020. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu J, Xu S, Liu S and Chen B: miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells. Mol Med Rep 24: 633, 2021.
APA
Liu, J., Xu, S., Liu, S., & Chen, B. (2021). miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells. Molecular Medicine Reports, 24, 633. https://doi.org/10.3892/mmr.2021.12272
MLA
Liu, J., Xu, S., Liu, S., Chen, B."miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells". Molecular Medicine Reports 24.3 (2021): 633.
Chicago
Liu, J., Xu, S., Liu, S., Chen, B."miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells". Molecular Medicine Reports 24, no. 3 (2021): 633. https://doi.org/10.3892/mmr.2021.12272
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Xu S, Liu S and Chen B: miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells. Mol Med Rep 24: 633, 2021.
APA
Liu, J., Xu, S., Liu, S., & Chen, B. (2021). miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells. Molecular Medicine Reports, 24, 633. https://doi.org/10.3892/mmr.2021.12272
MLA
Liu, J., Xu, S., Liu, S., Chen, B."miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells". Molecular Medicine Reports 24.3 (2021): 633.
Chicago
Liu, J., Xu, S., Liu, S., Chen, B."miR‑3613‑3p/MAP3K2/p38/caspase‑3 pathway regulates the heat‑stress‑induced apoptosis of endothelial cells". Molecular Medicine Reports 24, no. 3 (2021): 633. https://doi.org/10.3892/mmr.2021.12272
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team