Open Access

Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review)

  • Authors:
    • Qingtao Zhang
    • Jian Yu
    • Qiuqiu Chen
    • Honghai Yan
    • Hongjiang Du
    • Wenjing Luo
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  • Published online on: July 13, 2021     https://doi.org/10.3892/mmr.2021.12287
  • Article Number: 648
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tissues have remarkable natural capabilities to regenerate for the purpose of physiological turnover and repair of damage. Adult mesenchymal stem cells (MSCs) are well known for their unique self‑renewal ability, pluripotency, homing potential, paracrine effects and immunomodulation. Advanced research of the unique properties of MSCs have opened up new horizons for tissue regenerative therapies. However, certain drawbacks of the application of MSCs, such as the low survival rate of transplanted MSCs, unsatisfactory efficiency and even failure to regenerate under an unbalanced microenvironment, are concerning with regards to their wider therapeutic applications. The activity of stem cells is mainly regulated by the anatomical niche; where they are placed during their clinical and therapeutic applications. Crosstalk between various niche signals maintains MSCs in homeostasis, in which the WNT signaling pathway plays vital roles. Several external or internal stimuli have been reported to interrupt the normal bioactivity of stem cells. The irreversible tissue loss that occurs during infection at the site of tissue grafting suggests an inhibitory effect mediated by microbial infections within MSC niches. In addition, MSC‑seeded tissue engineering success is difficult in various tissues, when sites of injury are under the effects of a severe infection despite the immunomodulatory properties of MSCs. In the present review, the current understanding of the way in which WNT signaling regulates MSC activity modification under physiological and pathological conditions was summarized. An effort was also made to illustrate parts of the underlying mechanism, including the inflammatory factors and their interactions with the regulatory WNT signaling pathway, aiming to promote the clinical translation of MSC‑based therapy.
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September-2021
Volume 24 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Q, Yu J, Chen Q, Yan H, Du H and Luo W: Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review). Mol Med Rep 24: 648, 2021
APA
Zhang, Q., Yu, J., Chen, Q., Yan, H., Du, H., & Luo, W. (2021). Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review). Molecular Medicine Reports, 24, 648. https://doi.org/10.3892/mmr.2021.12287
MLA
Zhang, Q., Yu, J., Chen, Q., Yan, H., Du, H., Luo, W."Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review)". Molecular Medicine Reports 24.3 (2021): 648.
Chicago
Zhang, Q., Yu, J., Chen, Q., Yan, H., Du, H., Luo, W."Regulation of pathophysiological and tissue regenerative functions of MSCs mediated via the WNT signaling pathway (Review)". Molecular Medicine Reports 24, no. 3 (2021): 648. https://doi.org/10.3892/mmr.2021.12287