Open Access

Ghrelin and its role in gastrointestinal tract tumors (Review)

  • Authors:
    • Irene Alexandra Spiridon
    • Delia Gabriela Apostol Ciobanu
    • Simona Eliza Giușcă
    • Irina Draga Căruntu
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  • Published online on: July 19, 2021     https://doi.org/10.3892/mmr.2021.12302
  • Article Number: 663
  • Copyright: © Spiridon et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ghrelin, an orexigenic hormone, is a peptide that binds to the growth hormone secretagogue receptor; it is secreted mainly by enteroendocrine cells in the oxyntic glands of the stomach. Ghrelin serves a role in both local and systemic physiological processes, and is implicated in various pathologies, including neoplasia, with tissue expression in several types of malignancies in both in vitro and in vivo studies. However, the precise implications of the ghrelin axis in metastasis, invasion and cancer progression regulation has yet to be established. In the case of gastrointestinal (GI) tract malignancies, ghrelin has shown potential to become a prognostic factor or even a therapeutic target, although data in the literature are inconsistent and unsystematic, with reports untailored to a specific histological subtype of cancer or a particular localization. The evaluation of immunohistochemical expression shows a limited outlook owing to the low number of cases analyzed, and in vivo analyses have conflicting data regarding differences in ghrelin serum levels in patients with cancer. The aim of this review was to examine the relationship between ghrelin and GI tract malignancies to demonstrate the inconsistencies in current results and to highlight its clinical significance in the outcome of these patients.
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September-2021
Volume 24 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Spiridon IA, Ciobanu DG, Giușcă SE and Căruntu ID: Ghrelin and its role in gastrointestinal tract tumors (Review). Mol Med Rep 24: 663, 2021
APA
Spiridon, I.A., Ciobanu, D.G., Giușcă, S.E., & Căruntu, I.D. (2021). Ghrelin and its role in gastrointestinal tract tumors (Review). Molecular Medicine Reports, 24, 663. https://doi.org/10.3892/mmr.2021.12302
MLA
Spiridon, I. A., Ciobanu, D. G., Giușcă, S. E., Căruntu, I. D."Ghrelin and its role in gastrointestinal tract tumors (Review)". Molecular Medicine Reports 24.3 (2021): 663.
Chicago
Spiridon, I. A., Ciobanu, D. G., Giușcă, S. E., Căruntu, I. D."Ghrelin and its role in gastrointestinal tract tumors (Review)". Molecular Medicine Reports 24, no. 3 (2021): 663. https://doi.org/10.3892/mmr.2021.12302