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Article

CXCL16 may be a predisposing factor to atherosclerosis: An animal study

  • Authors:
    • Junbi Zhao
    • Menglin Yang
    • Jie Wu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China, Department of Burns, Plastic Surgery and Dermatology, No. 922 Hospital of Joint Support Unit of the People's Liberation Army, Hengyang, Hunan 421002, P.R. China
  • Article Number: 716
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    Published online on: August 10, 2021
       https://doi.org/10.3892/mmr.2021.12355
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Abstract

Atherosclerosis (AS) is a chronic inflammatory process initiated when lipoprotein is retained in the arterial wall. Leukocyte recruitment accelerates this process. CXC chemokine ligand 16 (CXCL16) acts as a chemokine to attract immune cells and also facilitates the phagocytosis process of modified low‑density lipoprotein. Whether CXCL16 promotes or inhibits the pathological process of AS remains to be elucidated. To clarify this, CXCL16 gene was introduced into C57BL/6J wild‑type mice to establish a stable CXCL16 overexpression mouse model. The initial changes of AS in mice were induced by high‑fat diet (HFD). To study how the interaction of HFD and CXCL16 affected fatty acid metabolism and deposition, body weight and plasma lipid profile were assessed. Soluble CXCL16, matrix metalloproteinase‑9, monocyte chemoattractant protein‑1 and intercellular adhesion molecule‑1 were detected by immunohistochemistry and ELISA to identify how CXCL16 affects AS lesion formation. The present study suggested that overexpression of CXCL16 combined with HFD lead to atherogenesis by upregulating the aforementioned inflammatory related genes at a protein level. The present study was the first, to the best of the authors' knowledge, to build a CXCL16 homozygous transgenic mice model to study how overexpressed CXCL16 is associated with AS for intervening in the occurrence and development of AS.
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Copy and paste a formatted citation
Spandidos Publications style
Zhao J, Yang M and Wu J: CXCL16 may be a predisposing factor to atherosclerosis: An animal study. Mol Med Rep 24: 716, 2021.
APA
Zhao, J., Yang, M., & Wu, J. (2021). CXCL16 may be a predisposing factor to atherosclerosis: An animal study. Molecular Medicine Reports, 24, 716. https://doi.org/10.3892/mmr.2021.12355
MLA
Zhao, J., Yang, M., Wu, J."CXCL16 may be a predisposing factor to atherosclerosis: An animal study". Molecular Medicine Reports 24.4 (2021): 716.
Chicago
Zhao, J., Yang, M., Wu, J."CXCL16 may be a predisposing factor to atherosclerosis: An animal study". Molecular Medicine Reports 24, no. 4 (2021): 716. https://doi.org/10.3892/mmr.2021.12355
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Yang M and Wu J: CXCL16 may be a predisposing factor to atherosclerosis: An animal study. Mol Med Rep 24: 716, 2021.
APA
Zhao, J., Yang, M., & Wu, J. (2021). CXCL16 may be a predisposing factor to atherosclerosis: An animal study. Molecular Medicine Reports, 24, 716. https://doi.org/10.3892/mmr.2021.12355
MLA
Zhao, J., Yang, M., Wu, J."CXCL16 may be a predisposing factor to atherosclerosis: An animal study". Molecular Medicine Reports 24.4 (2021): 716.
Chicago
Zhao, J., Yang, M., Wu, J."CXCL16 may be a predisposing factor to atherosclerosis: An animal study". Molecular Medicine Reports 24, no. 4 (2021): 716. https://doi.org/10.3892/mmr.2021.12355
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