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Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury

  • Authors:
    • Wang Deng
    • Jing He
    • Xu-Mao Tang
    • Chang-Yi Li
    • Jin Tong
    • Di Qi
    • Dao-Xin Wang
  • View Affiliations / Copyright

    Affiliations: Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China
    Copyright: © Deng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 725
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    Published online on: August 11, 2021
       https://doi.org/10.3892/mmr.2021.12364
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Abstract

Chronic alcohol abuse increases the risk of mortality and poor outcomes in patients with acute respiratory distress syndrome. However, the underlying mechanisms remain to be elucidated. The present study aimed to investigate the effects of chronic alcohol consumption on lung injury and clarify the signaling pathways involved in the inhibition of alveolar fluid clearance (AFC). In order to produce rodent models with chronic alcohol consumption, wild‑type C57BL/6 mice were treated with alcohol. A2a adenosine receptor (AR) small interfering (si)RNA or A2bAR siRNA were transfected into the lung tissue of mice and primary rat alveolar type II (ATII) cells. The rate of AFC in lung tissue was measured during exposure to lipopolysaccharide (LPS). Epithelial sodium channel (ENaC) expression was determined to investigate the mechanisms underlying alcohol‑induced regulation of AFC. In the present study, exposure to alcohol reduced AFC, exacerbated pulmonary edema and worsened LPS‑induced lung injury. Alcohol caused a decrease in cyclic adenosine monophosphate (cAMP) levels and inhibited α‑ENaC, β‑ENaC and γ‑ENaC expression levels in the lung tissue of mice and ATII cells. Furthermore, alcohol decreased α‑ENaC, β‑ENaC and γ‑ENaC expression levels via the A2aAR or A2bAR‑cAMP signaling pathways in vitro. In conclusion, the results of the present study demonstrated that chronic alcohol consumption worsened lung injury by aggravating pulmonary edema and impairing AFC. An alcohol‑induced decrease of α‑ENaC, β‑ENaC and γ‑ENaC expression levels by the A2AR‑mediated cAMP pathway may be responsible for the exacerbated effects of chronic alcohol consumption in lung injury.
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1 

Manthey J, Shield KD, Rylett M, Hasan OSM, Probst C and Rehm J: Global alcohol exposure between 1990 and 2017 and forecasts until 2030: A modelling study. Lancet. 393:2493–2502. 2019. View Article : Google Scholar : PubMed/NCBI

2 

GBD 2016 Alcohol Collaborators, . Alcohol use and burden for 195 countries and territories, 1990–2016: A systematic analysis for the global burden of disease study 2016. Lancet. 392:1015–1035. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Clark BJ, Williams A, Feemster LM, Bradley KA, Macht M, Moss M and Burnham EL; NHLBI ARDS Network Investigators, : Alcohol screening scores and 90-day outcomes in patients with acute lung injury. Crit Care Med. 41:1518–1525. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Sarmiento X, Guardiola JJ and Soler M: Alcohol and acute respiratory distress syndrome: Casuality or causality? Med Clin (Barc). 140:546–553. 2013.(In Spanish). View Article : Google Scholar : PubMed/NCBI

5 

Yeligar SM, Chen MM, Kovacs EJ, Sisson JH, Burnham EL and Brown LA: Alcohol and lung injury and immunity. Alcohol. 55:51–59. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Ramalho R: Alcohol consumption and alcohol-related problems during the COVID-19 pandemic: A narrative review. Australas Psychiatry. 28:524–526. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Chick J: Alcohol and COVID-19. Alcohol Alcohol. 55:341–342. 2020. View Article : Google Scholar : PubMed/NCBI

8 

Máca J, Jor O, Holub M, Sklienka P, Burša F, Burda M, Janout V and Ševčík P: Past and present ARDS mortality rates: A systematic review. Respir Care. 62:113–122. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Huppert LA, Matthay MA and Ware LB: Pathogenesis of acute respiratory distress syndrome. Semin Respir Crit Care Med. 40:31–39. 2019. View Article : Google Scholar : PubMed/NCBI

10 

Azzam ZS and Sznajder JI: Lung edema clearance: Relevance to patients with lung injury. Rambam Maimonides Med J. 6:e00252015. View Article : Google Scholar : PubMed/NCBI

11 

Berthiaume Y and Matthay MA: Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol. 159:350–359. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Matalon S, Bartoszewski R and Collawn JF: Role of epithelial sodium channels (ENaC) in the regulation of lung fluid homeostasis. Am J Physiol Lung Cell Mol Physiol. 309:L1229–L1238. 2015. View Article : Google Scholar : PubMed/NCBI

13 

Qadri YJ, Rooj AK and Fuller CM: ENaCs and ASICs as therapeutic targets. Am J Physiol Cell Physiol. 302:C943–C965. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Hummler E, Barker P, Gatzy J, Beermann F, Verdumo C, Schmidt A, Boucher R and Rossier BC: Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet. 12:325–328. 1996. View Article : Google Scholar : PubMed/NCBI

15 

Randrianarison N, Clerici C, Ferreira C, Fontayne A, Pradervand S, Fowler-Jaeger N, Hummler E, Rossier BC and Planès C: Low expression of the beta-ENaC subunit impairs lung fluid clearance in the mouse. Am J Physiol Lung Cell Mol Physiol. 294:L409–L416. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Elias N, Rafii B, Rahman M, Otulakowski G, Cutz E and O'Brodovich H: The role of alpha-, beta-, and gamma-ENaC subunits in distal lung epithelial fluid absorption induced by pulmonary edema fluid. Am J Physiol Lung Cell Mol Physiol. 293:L537–L545. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Nagy LE, Diamond I, Casso DJ, Franklin C and Gordon AS: Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter. J Biol Chem. 265:1946–1951. 1990. View Article : Google Scholar : PubMed/NCBI

18 

Nagy LE, Diamond I, Collier K, Lopez L, Ullman B and Gordon AS: Adenosine is required for ethanol-induced heterologous desensitization. Mol Pharmacol. 36:744–748. 1989.PubMed/NCBI

19 

Deng W, Wang DX, Zhang W and Li CY: Regulation of epithelial sodium channel α-subunit expression by adenosine receptor A2a in alveolar epithelial cells. Chin Med J (Engl). 124:1551–1555. 2011.PubMed/NCBI

20 

Jerrells TR, Pavlik JA, DeVasure J, Vidlak D, Costello A, Strachota JM and Wyatt TA: Association of chronic alcohol consumption and increased susceptibility to and pathogenic effects of pulmonary infection with respiratory syncytial virus in mice. Alcohol. 41:357–369. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Song K, Coleman RA, Zhu X, Alber C, Ballas ZK, Waldschmidt TJ and Cook RT: Chronic ethanol consumption by mice resuls in activated splenic T cells. J Leukoc Biol. 72:1109–1116. 2002.PubMed/NCBI

22 

Downs CA, Trac D, Brewer EM, Brown LA and Helms MN: Chronic alcohol ingestion changes the landscape of the alveolar epithelium. Biomed Res Int. 2013:4702172013. View Article : Google Scholar : PubMed/NCBI

23 

Dobbs L, Gonzales G and Williams M: An improved method for isolating type II cells in high yield and purity. Am Rev Respir Dis. 134:141–145. 1986.PubMed/NCBI

24 

Dobbs LG: Isolation and culture of alveolar type II cells. Am J Physiol. 258:L134–L147. 1990.PubMed/NCBI

25 

Goodson P, Kumar A, Jain L, Kundu K, Murthy N, Koval M and Helms MN: Nadph oxidase regulates alveolar epithelial sodium channel activity and lung fluid balance in vivo via O2− signaling. Am J Physiol Lung Cell Mol Physiol. 302:L410–L419. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Lomas-Neira JL, Chung CS, Wesche DE, Perl M and Ayala A: In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury. J Leukoc Biol. 77:846–853. 2005. View Article : Google Scholar : PubMed/NCBI

27 

You K, Xu X, Fu J, Xu S, Yue X, Yu Z and Xue X: Hyperoxia disrupts pulmonary epithelial barrier in newborn rats via the deterioration of occludin and ZO-1. Respir Res. 13:362012. View Article : Google Scholar : PubMed/NCBI

28 

Matute-Bello G, Downey G, Moore BB, Groshong SD, Matthay MA, Slutsky AS and Kuebler WM; Acute Lung Injury In Animals Study Group, : An official American thoracic society workshop report: Features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol. 44:725–738. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Mutlu GM, Adir Y, Jameel M, Akhmedov AT, Welch L, Dumasius V, Meng FJ, Zabner J, Koenig C, Lewis ER, et al: Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport. Circ Res. 96:999–1005. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Mutlu GM, Dumasius V, Burhop J, McShane PJ, Meng FJ, Welch L, Dumasius A, Mohebahmadi N, Thakuria G, Hardiman K, et al: Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling. Circ Res. 94:1091–1100. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

32 

Moss M, Bucher B, Moore FA, Moore EE and Parsons PE: The role of chronic alcohol abuse in the development of acute respiratory distress syndrome in adults. JAMA. 275:50–54. 1996. View Article : Google Scholar : PubMed/NCBI

33 

Moss M, Parsons PE, Steinberg KP, Hudson LD, Guidot DM, Burnham EL, Eaton S and Cotsonis GA: Chronic alcohol abuse is associated with an increased incidence of acute respiratory distress syndrome and severity of multiple organ dysfunction in patients with septic shock. Crit Care Med. 31:869–877. 2003. View Article : Google Scholar : PubMed/NCBI

34 

Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H III, Hoth JJ, Mikkelsen ME, Gentile NT, et al: Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 183:462–470. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, et al: Transfusion-related acute lung injury: Incidence and risk factors. Blood. 119:1757–1767. 2012. View Article : Google Scholar : PubMed/NCBI

36 

Moazed F and Calfee CS: Environmental risk factors for acute respiratory distress syndrome. Clin Chest Med. 35:625–637. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Wang R, Ramos C, Joshi I, Zagariya A, Pardo A, Selman M and Uhal BD: Human lung myofibroblast-derived inducers of alveolar epithelial apoptosis identified as angiotensin peptides. Am J Physiol. 277:L1158–L1164. 1999.PubMed/NCBI

38 

Dubowski KM: Absorption, distribution and elimination of alcohol: Highway safety aspects. J Stud Alcohol Suppl. 10:98–108. 1985. View Article : Google Scholar : PubMed/NCBI

39 

Guidot DM and Hart CM: Alcohol abuse and acute lung injury: Epidemiology and pathophysiology of a recently recognized association. J Investig Med. 53:235–245. 2005. View Article : Google Scholar : PubMed/NCBI

40 

Deitch EA: Role of the gut lymphatic system in multiple organ failure. Curr Opin Crit Care. 7:92–98. 2001. View Article : Google Scholar : PubMed/NCBI

41 

Hassoun HT, Kone BC, Mercer DW, Moody FG, Weisbrodt NW and Moore FA: Post-injury multiple organ failure: The role of the gut. Shock. 15:1–10. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Kavanaugh MJ, Clark C, Goto M, Kovacs EJ, Gamelli RL, Sayeed MM and Choudhry MA: Effect of acute alcohol ingestion prior to burn injury on intestinal bacterial growth and barrier function. Burns. 31:290–296. 2005. View Article : Google Scholar : PubMed/NCBI

43 

Zahs A, Bird MD, Ramirez L, Choudhry MA and Kovacs EJ: Anti-IL-6 antibody treatment but not IL-6 knockout improves intestinal barrier function and reduces inflammation after binge ethanol exposure and burn injury. Shock. 39:373–379. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Toews GB: Cytokines and the lung. Eur Respir J Suppl. 34:3s–17s. 2001. View Article : Google Scholar : PubMed/NCBI

45 

Idell S: Anticoagulants for acute respiratory distress syndrome: Can they work? Am J Respir Crit Care Med. 164:517–520. 2001. View Article : Google Scholar : PubMed/NCBI

46 

Fialkow L, Wang Y and Downey GP: Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function. Free Radic Biol Med. 42:153–164. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Dada L, Gonzalez AR, Urich D, Soberanes S, Manghi TS, Chiarella SE, Chandel NS, Budinger GR and Mutlu GM: Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor. PLoS One. 7:e304482012. View Article : Google Scholar : PubMed/NCBI

48 

Eaton DC, Helms MN, Koval M, Bao HF and Jain L: The contribution of epithelial sodium channels to alveolar function in health and disease. Annu Rev Physiol. 71:403–423. 2009. View Article : Google Scholar : PubMed/NCBI

49 

Fan M, Qin W and Mustafa SJ: Characterization of adenosine receptor(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model. Am J Physiol Lung Cell Mol Physiol. 284:L1012–L1019. 2003. View Article : Google Scholar : PubMed/NCBI

50 

Eckle T, Grenz A, Laucher S and Eltzschig HK: A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest. 118:3301–3315. 2008.PubMed/NCBI

51 

Factor P, Mutlu GM, Chen L, Mohameed J, Akhmedov AT, Meng FJ, Jilling T, Lewis ER, Johnson MD, Xu A, et al: Adenosine regulation of alveolar fluid clearance. Proc Natl Acad Sci USA. 104:4083–4088. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Kleinboelting S, van den Heuvel J and Steegborn C: Structural analysis of human soluble adenylyl cyclase and crystal structures of its nucleotide complexes-implications for cyclase catalysis and evolution. FEBS J. 281:4151–4164. 2014. View Article : Google Scholar : PubMed/NCBI

53 

Tabakoff B and Hoffman PL: Adenylyl cyclases and alcohol. Adv Second Messenger Phosphoprotein Res. 32:173–193. 1998. View Article : Google Scholar : PubMed/NCBI

54 

Gupta R, Qualls-Creekmore E and Yoshimura M: Real-time monitoring of intracellular cAMP during acute ethanol exposure. Alcohol Clin Exp Res. 37:1456–1465. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Liu Z, Liu Y, Gao R, Li H, Dunn T, Wu P, Smith RG, Sarkar PS and Fang X: Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells. PLoS One. 9:e1042472014. View Article : Google Scholar : PubMed/NCBI

56 

Ohta A and Sitkovsky M: Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature. 414:916–920. 2001. View Article : Google Scholar : PubMed/NCBI

57 

Greenberg SS, Zhao X, Hua L, Wang JF, Nelson S and Ouyang J: Ethanol inhibits lung clearance of pseudomonas aeruginosa by a neutrophil and nitric oxide-dependent mechanism, in vivo. Alcohol Clin Exp Res. 23:735–744. 1999. View Article : Google Scholar : PubMed/NCBI

58 

Burnham EL, Kovacs EJ and Davis CS: Pulmonary cytokine composition differs in the setting of alcohol use disorders and cigarette smoking. Am J Physiol Lung Cell Mol Physiol. 304:L873–L882. 2013. View Article : Google Scholar : PubMed/NCBI

59 

Brown LA, Harris FL, Bechara R and Guidot DM: Effect of chronic ethanol ingestion on alveolar type II cell: Glutathione and inflammatory mediator-induced apoptosis. Alcohol Clin Exp Res. 25:1078–1085. 2001. View Article : Google Scholar : PubMed/NCBI

60 

Downs CA, Trac DQ, Kreiner LH, Eaton AF, Johnson NM, Brown LA and Helms MN: Ethanol alters alveolar fluid balance via Nadph oxidase (NOX) signaling to epithelial sodium channels (ENaC) in the lung. PLoS One. 8:e547502013. View Article : Google Scholar : PubMed/NCBI

61 

Bao HF, Song JZ, Duke BJ, Ma HP, Denson DD and Eaton DC: Ethanol stimulates epithelial sodium channels by elevating reactive oxygen species. Am J Physiol Cell Physiol. 303:C1129–C1138. 2012. View Article : Google Scholar : PubMed/NCBI

62 

Snyder PM: Intoxicated Na(+) channels. Focus on ‘ethanol stimulates epithelial sodium channels by elevating reactive oxygen species’. Am J Physiol Cell Physiol. 303:C1125–C1126. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Deng W, He J, Tang X, Li C, Tong J, Qi D and Wang D: Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury. Mol Med Rep 24: 725, 2021.
APA
Deng, W., He, J., Tang, X., Li, C., Tong, J., Qi, D., & Wang, D. (2021). Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury. Molecular Medicine Reports, 24, 725. https://doi.org/10.3892/mmr.2021.12364
MLA
Deng, W., He, J., Tang, X., Li, C., Tong, J., Qi, D., Wang, D."Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury". Molecular Medicine Reports 24.4 (2021): 725.
Chicago
Deng, W., He, J., Tang, X., Li, C., Tong, J., Qi, D., Wang, D."Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury". Molecular Medicine Reports 24, no. 4 (2021): 725. https://doi.org/10.3892/mmr.2021.12364
Copy and paste a formatted citation
x
Spandidos Publications style
Deng W, He J, Tang X, Li C, Tong J, Qi D and Wang D: Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury. Mol Med Rep 24: 725, 2021.
APA
Deng, W., He, J., Tang, X., Li, C., Tong, J., Qi, D., & Wang, D. (2021). Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury. Molecular Medicine Reports, 24, 725. https://doi.org/10.3892/mmr.2021.12364
MLA
Deng, W., He, J., Tang, X., Li, C., Tong, J., Qi, D., Wang, D."Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury". Molecular Medicine Reports 24.4 (2021): 725.
Chicago
Deng, W., He, J., Tang, X., Li, C., Tong, J., Qi, D., Wang, D."Alcohol inhibits alveolar fluid clearance through the epithelial sodium channel via the A2 adenosine receptor in acute lung injury". Molecular Medicine Reports 24, no. 4 (2021): 725. https://doi.org/10.3892/mmr.2021.12364
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