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Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling

  • Authors:
    • Ruihong Yuan
    • Xiaoming Dai
    • Yisong Li
    • Chunshan Li
    • Liu Liu
  • View Affiliations / Copyright

    Affiliations: Department of Plastic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China
    Copyright: © Yuan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 758
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    Published online on: September 2, 2021
       https://doi.org/10.3892/mmr.2021.12398
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Abstract

Pathological scars mainly refer to hypertrophic scars and keloids, and have a high incidence. Moreover, these scars seriously affect the patient's appearance and are associated with significant pain. The present study aimed to investigate the inhibitory effect of microRNA (miR)‑29a from human adipose‑derived mesenchymal stem cells (hADSCs) exosomes on scar formation. Firstly, the expression of miR‑29a in thermal skin tissues of mice and human hypertrophic scar fibroblasts (HSFBs) was detected via reverse transcription‑quantitative PCR. Exosomes derived from miR‑29a‑modified hADSCs were extracted and the influence of miR‑29a‑modified hADSCs‑exo on the proliferation and function of HSFBs was determined. Lastly, the effect of miR‑29a‑modified hADSCs‑exo on scar formation was determined using a thermal mouse model. The results demonstrated that miR‑29a was downregulated in scar tissues after scalding and in HSFBs. After treating HSFBs with miR‑29a‑modified hADSC exosomes, miR‑29a‑overexpressing hADSC exosomes inhibited the proliferation and migration of HSFBs. Moreover, it was found that TGF‑β2 was the target of miR‑29a, and that hADSC exosome‑derived miR‑29a inhibited the fibrosis of HSFBs and scar hyperplasia after scalding in mice by targeting the TGF‑β2/Smad3 signaling pathway. In summary, the current data indicated that miR‑29a‑modified hADSC exosome therapy can decrease scar formation by inhibiting the TGF‑β2/Smad3 signaling pathway via its derived exogenous miR‑29a, and this may be useful for the future treatment of pathological scars by providing a potential molecular basis.
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View References

1 

Schultz G, Davidson J, Kirsner R, Bornstein P and Herman I: Dynamic reciprocity in the wound microenvironment. Wound Repair Regen. 19:134–148. 2011. View Article : Google Scholar : PubMed/NCBI

2 

Karppinen S, Heljasvaara R, Gullberg D, Tasanen K and Pihlajaniemi T: Toward understanding scarless skin wound healing and pathological scarring. F1000Res. 8:F10002019. View Article : Google Scholar : PubMed/NCBI

3 

Brown BC, Moss TP, McGrouther DA and Bayat A: Skin scar preconceptions must be challenged: Importance of self-perception in skin scarring. J Plast Reconstr Aesthet Surg. 63:1022–1029. 2010. View Article : Google Scholar : PubMed/NCBI

4 

van den Broek LJ, Limandjaja GC, Niessen FB and Gibbs S: Human hypertrophic and keloid scar models: Principles, limitations and future challenges from a tissue engineering perspective. Exp Dermatol. 23:382–386. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Yu J, Wang MY, Tai HC and Cheng NC: Cell sheet composed of adipose-derived stem cells demonstrates enhanced skin wound healing with reduced scar formation. Acta Biomater. 77:191–200. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Liu SC, Bamodu OA, Kuo KT, Fong IH, Lin CC, Yeh CT and Chen SG: Adipose-derived stem cell induced-tissue repair or wound healing is mediated by the concomitant upregulation of miR-21 and miR-29b expression and activation of the AKT signaling pathway. Arch Biochem Biophys. 705:1088952021. View Article : Google Scholar : PubMed/NCBI

7 

Ni X, Shan X, Xu L, Yu W, Zhang M, Lei C, Xu N, Lin J and Wang B: Adipose-derived stem cells combined with platelet-rich plasma enhance wound healing in a rat model of full-thickness skin defects. Stem Cell Res Ther. 12:2262021. View Article : Google Scholar : PubMed/NCBI

8 

Cai Y, Li J, Jia C, He Y and Deng C: Therapeutic applications of adipose cell-free derivatives: A review. Stem Cell Res Ther. 11:3122020. View Article : Google Scholar : PubMed/NCBI

9 

Basu J and Ludlow JW: Exosomes for repair, regeneration and rejuvenation. Expert Opin Biol Ther. 16:489–506. 2016. View Article : Google Scholar : PubMed/NCBI

10 

Merino-González C, Zuñiga FA, Escudero C, Ormazabal V, Reyes C, Nova-Lamperti E, Salomón C and Aguayo C: Mesenchymal stem cell-derived extracellular vesicles promote angiogenesis: Potencial clinical application. Front Physiol. 7:242016. View Article : Google Scholar : PubMed/NCBI

11 

Konala VB, Mamidi MK, Bhonde R, Das AK, Pochampally R and Pal R: The current landscape of the mesenchymal stromal cell secretome: A new paradigm for cell-free regeneration. Cytotherapy. 18:13–24. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Casado-Díaz A, Quesada-Gómez JM and Dorado G: Extracellular vesicles derived from mesenchymal stem cells (MSC) in regenerative medicine: Applications in skin wound Healing. Front Bioeng Biotechnol. 8:1462020. View Article : Google Scholar : PubMed/NCBI

13 

Rani S and Ritter T: The exosome - A naturally secreted nanoparticle and its application to wound healing. Advanced materials (Deerfield Beach Fla.). 28:5542–5552. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Rani S, Ryan A, Griffin M and Ritter T: Mesenchymal stem cell-derived extracellular vesicles: Toward cell-free therapeutic applications. Molecular therapy : the journal of the American Society of Gene Therapy. 23:812–823. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Shabbir A, Cox A, Rodriguez-Menocal L, Salgado M and Van Badiavas E: Mesenchymal stem cell exosomes induce proliferation and migration of normal and chronic wound fibroblasts, and enhance angiogenesis in vitro. Stem Cells Dev. 24:1635–1647. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Diegelmann R and Evans M: Wound healing: an overview of acute, fibrotic and delayed healing. Front Biosci. 9:283–289. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Yuan H, Guan J, Zhang J, Zhang R and Li M: Exosomes secreted by human urine-derived stem cells accelerate skin wound healing by promoting angiogenesis in rat. Cell Biol Int. 41:9332017. View Article : Google Scholar : PubMed/NCBI

18 

Hu L, Wang J, Zhou X, Xiong Z, Zhao J, Yu R, Huang F, Zhang H and Chen L: Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts. Sci Rep. 6:329932016. View Article : Google Scholar : PubMed/NCBI

19 

Li X, Liu L, Yang J, Yu Y, Chai J, Wang L, Ma L and Yin H: Exosome derived from human umbilical cord mesenchymal stem cell mediates MiR-181c attenuating burn-induced excessive inflammation. EBioMedicine. 8:72–82. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Tafrihi M and Hasheminasab E: MiRNAs: Biology, biogenesis, their Web-based tools, and databases. MicroRNA. 8:4–27. 2019. View Article : Google Scholar : PubMed/NCBI

21 

Ha M and Kim VN: Regulation of microRNA biogenesis. Nat Rev Mol Cell Biol. 15:509–524. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Dietrich C, Singh M, Kumar N and Singh SR: The emerging roles of microRNAs in stem cell aging. Adv Exp Med Biol. 1056:11–26. 2018. View Article : Google Scholar : PubMed/NCBI

23 

Cheng J, Wang Y, Wang D and Wu Y: Identification of collagen 1 as a post-transcriptional target of miR-29b in skin fibroblasts: Therapeutic implication for scar reduction. Am J Med Sci. 346:98–103. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Murali VP and Holmes CA: Mesenchymal stromal cell-derived extracellular vesicles for bone regeneration therapy. Bone Rep. 14:1010932021. View Article : Google Scholar : PubMed/NCBI

25 

Ichinohe N, Ishii M, Tanimizu N, Mizuguchi T, Yoshioka Y, Ochiya T, Suzuki H and Mitaka T: Extracellular vesicles containing miR-146a-5p secreted by bone marrow mesenchymal cells activate hepatocytic progenitors in regenerating rat livers. Stem Cell Res Ther. 12:3122021. View Article : Google Scholar : PubMed/NCBI

26 

Du Y and Ning JZ: MiR-182 Promotes ischemia/reperfusion-induced acute kidney injury in rat by targeting FoxO3. Urol Int. 105:687–696. 2021. View Article : Google Scholar : PubMed/NCBI

27 

Ouyang Z and Wei K: miRNA in cardiac development and regeneration. Cell Regen (Lond). 10:142021.PubMed/NCBI

28 

Zhou J, Zhang X, Liang P, Ren L, Zeng J, Zhang M, Zhang P and Huang X: Protective role of microRNA-29a in denatured dermis and skin fibroblast cells after thermal injury. Biol Open. 5:211–219. 2016. View Article : Google Scholar : PubMed/NCBI

29 

Guo L and Huang X, Liang P, Zhang P, Zhang M, Ren L, Zeng J, Cui X and Huang X: Role of XIST/miR-29a/LIN28A pathway in denatured dermis and human skin fibroblasts (HSFs) after thermal injury. J Cell Biochem. 119:1463–1474. 2018. View Article : Google Scholar : PubMed/NCBI

30 

Zgheib C, Hodges M, Hu J, Beason DP, Soslowsky LJ, Liechty KW and Xu J: Mechanisms of mesenchymal stem cell correction of the impaired biomechanical properties of diabetic skin: The role of miR-29a. Wound Repair Regen. 24:237–246. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Wang Z, Feng C, Song K, Qi Z, Huang W and Wang Y: lncRNA-H19/miR-29a axis affected the viability and apoptosis of keloid fibroblasts through acting upon COL1A1 signaling. J Cell Biochem. 121:4364–4376. 2020. View Article : Google Scholar : PubMed/NCBI

32 

Zhang T, Wang X, Wang Z, Lou D, Fang QQ, Hu YY, Zhao WY, Zhang LY, Wu LH and Tan WQ: Current potential therapeutic strategies targeting the TGF-β/Smad signaling pathway to attenuate keloid and hypertrophic scar formation. Biomed Pharmacother. 129:1102872020. View Article : Google Scholar : PubMed/NCBI

33 

Guo J, Lin Q, Shao Y, Rong L and Zhang D: miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of the TGF-β1/Smad/CTGF signaling pathway. Can J Physiol Pharmacol. 95:437–442. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Zhu Y, Li Z, Wang Y, Li L, Wang D, Zhang W, Liu L, Jiang H, Yang J and Cheng J: Overexpression of miR-29b reduces collagen biosynthesis by inhibiting heat shock protein 47 during skin wound healing. Transl Res. 178:38–53.e6. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Zhang SJ, Yun CJ, Liu J, Yao SY, Li Y, Wang M, Wang C, Bai YY and Xue H: MicroRNA-29a attenuates angiotensin-II induced-left ventricular remodeling by inhibiting collagen, TGF-β and SMAD2/3 expression. J Geriatr Cardiol. 17:96–104. 2020.PubMed/NCBI

36 

Ragni E, Perucca Orfei C, De Luca P, Viganò M, Colombini A, Lugano G, Bollati V and de Girolamo L: miR-22-5p and miR-29a-5p are reliable reference genes for analyzing extracellular vesicle-associated miRNAs in adipose-derived mesenchymal stem cells and are stable under inflammatory priming mimicking osteoarthritis condition. Stem Cell Rev Rep. 15:743–754. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Wang X, Li Z, Cui Y, Cui X, Chen C and Wang Z: Exosomes isolated from bone marrow mesenchymal stem cells exert a protective effect on osteoarthritis via lncRNA LYRM4-AS1-GRPR-miR-6515-5p. Front Cell Dev Biol. 9:6443802021. View Article : Google Scholar : PubMed/NCBI

38 

Bian W, Meng B, Li X, Wang S, Cao X, Liu N, Yang M, Tang J, Wang Y and Yang X: OA-GL21, a novel bioactive peptide from Odorrana andersonii, accelerated the healing of skin wounds. Biosci Rep. Jun 21–2018.(Epub ahead of print). doi: 10.1042/BSR20180215. View Article : Google Scholar : PubMed/NCBI

39 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−ΔΔC(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

40 

Bayat A, McGrouther DA and Ferguson MW: Skin scarring. BMJ. 326:88–92. 2003. View Article : Google Scholar : PubMed/NCBI

41 

New SE, Alvarez-Gonzalez C, Vagaska B, Gomez SG, Bulstrode NW, Madrigal A and Ferretti P: A matter of identity - Phenotype and differentiation potential of human somatic stem cells. Stem Cell Res (Amst). 15:1–13. 2015. View Article : Google Scholar

42 

Ren K: Exosomes in perspective: A potential surrogate for stem cell therapy. Odontology. 107:271–284. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Lopez-Verrilli MA, Caviedes A, Cabrera A, Sandoval S, Wyneken U and Khoury M: Mesenchymal stem cell-derived exosomes from different sources selectively promote neuritic outgrowth. Neuroscience. 320:129–139. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Baglio SR, Rooijers K, Koppers-Lalic D, Verweij FJ, Pérez Lanzón M, Zini N, Naaijkens B, Perut F, Niessen HW, Baldini N, et al: Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res Ther. 6:1272015. View Article : Google Scholar : PubMed/NCBI

45 

Kang T, Jones TM, Naddell C, Bacanamwo M, Calvert JW, Thompson WE, Bond VC, Chen YE and Liu D: Adipose-derived stem cells induce angiogenesis via microvesicle transport of miRNA-31. Stem Cells Transl Med. 5:440–450. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Liang X, Zhang L, Wang S, Han Q and Zhao RC: Exosomes secreted by mesenchymal stem cells promote endothelial cell angiogenesis by transferring miR-125a. J Cell Sci. 129:2182–2189. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Fang S, Xu C, Zhang Y, Xue C, Yang C, Bi H, Qian X, Wu M, Ji K, Zhao Y, et al: Umbilical cord-derived mesenchymal stem cell-derived exosomal MicroRNAs suppress myofibroblast differentiation by inhibiting the transforming growth factor-β/SMAD2 pathway during wound healing. Stem Cells Transl Med. 5:1425–1439. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Valluru M, Staton CA, Reed MW and Brown NJ: Transforming growth factor-β and endoglin signaling orchestrate wound healing. Front Physiol. 2:892011. View Article : Google Scholar : PubMed/NCBI

49 

Gras C, Ratuszny D, Hadamitzky C, Zhang H, Blasczyk R and Figueiredo C: miR-145 contributes to hypertrophic scarring of the skin by inducing myofibroblast activity. Mol Med. 21:296–304. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yuan R, Dai X, Li Y, Li C and Liu L: Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling. Mol Med Rep 24: 758, 2021.
APA
Yuan, R., Dai, X., Li, Y., Li, C., & Liu, L. (2021). Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling. Molecular Medicine Reports, 24, 758. https://doi.org/10.3892/mmr.2021.12398
MLA
Yuan, R., Dai, X., Li, Y., Li, C., Liu, L."Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling". Molecular Medicine Reports 24.5 (2021): 758.
Chicago
Yuan, R., Dai, X., Li, Y., Li, C., Liu, L."Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling". Molecular Medicine Reports 24, no. 5 (2021): 758. https://doi.org/10.3892/mmr.2021.12398
Copy and paste a formatted citation
x
Spandidos Publications style
Yuan R, Dai X, Li Y, Li C and Liu L: Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling. Mol Med Rep 24: 758, 2021.
APA
Yuan, R., Dai, X., Li, Y., Li, C., & Liu, L. (2021). Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling. Molecular Medicine Reports, 24, 758. https://doi.org/10.3892/mmr.2021.12398
MLA
Yuan, R., Dai, X., Li, Y., Li, C., Liu, L."Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling". Molecular Medicine Reports 24.5 (2021): 758.
Chicago
Yuan, R., Dai, X., Li, Y., Li, C., Liu, L."Exosomes from miR-29a-modified adipose-derived mesenchymal stem cells reduce excessive scar formation by inhibiting TGF-β2/Smad3 signaling". Molecular Medicine Reports 24, no. 5 (2021): 758. https://doi.org/10.3892/mmr.2021.12398
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