Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
November-2021 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2021 Volume 24 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells

  • Authors:
    • Baosheng Han
    • Jianzhong Wang
    • Jiawei Wu
    • Fang Yan
    • Yaru Wang
    • Jun Li
  • View Affiliations / Copyright

    Affiliations: Department of Cardiac Surgery, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi 030000, P.R. China, Department of Cardiology, Shanxi Cardiovascular Hospital, Taiyuan, Shanxi 030000, P.R. China
    Copyright: © Han et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 764
    |
    Published online on: September 3, 2021
       https://doi.org/10.3892/mmr.2021.12404
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cardiac inflammation serves an important role in the progression of diabetic cardiomyopathy. CD36 (cluster of differentiation 36) mediates inflammation stress in a variety of disease states. The present study investigated CD36 expression in high glucose (HG)‑induced H9c2 cells, whether CD36 upregulation promotes inflammatory stress, and its potential mechanism. HG induced CD36 expression in a time‑dependent manner in cells, which was blocked following CD36 knockout or treatment with N‑acetylcysteine or MitoTEMPO. CD36 translocation to the cell membrane was increased at 72 h by HG stimulation of H9c2 cells. Moreover, CD36 knockout inhibited HG‑induced reactive oxygen species (ROS) generation, tumor necrosis factor‑α, interleukin (IL)‑6 and IL‑1β expression, and nuclear factor (NF)‑κB pathway activation. Further, CD36 knockout reversed metabolic reprogramming, lipid accumulation and AMP‑activated protein kinase activation caused by HG. The aforementioned data suggest that HG‑induced upregulation of CD36 promotes inflammatory stress via NF‑κB in H9c2 cells, mediated by metabolism reprogramming, lipid accumulation and enhanced ROS generation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

View References

1 

Falcão-Pires I and Leite Moreira AF: Diabetic cardiomyopathy: Understanding the molecular and cellular basis to progress in diagnosis and treatment. Heart Fail Rev. 17:325–344. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Jia G, Hill MA and Sowers JR: Diabetic cardiomyopathy: An update of mechanisms contributing to this clinical entity. Circ Res. 122:624–638. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Kaludercic N and Di Lisa F: Mitochondrial ROS formation in the pathogenesis of diabetic cardiomyopathy. Front Cardiovasc Med. 7:122020. View Article : Google Scholar : PubMed/NCBI

4 

Jia G, DeMarco VG and Sowers JR: Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy. Nat Rev Endocrinol. 12:144–153. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Brinkmann JF, Abumrad NA, Ibrahimi A, vander Vusse GJ and Glatz JF: New insights into long-chain fatty acid uptake by heart muscle: A crucial role for fatty acid translocase/CD36. Biochem J. 367:561–570. 2002. View Article : Google Scholar : PubMed/NCBI

6 

Griffin E, Re A, Hamel N, Fu C, Bush H, McCaffrey T and Asch AS: A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation. Nat Med. 7:840–846. 2001. View Article : Google Scholar : PubMed/NCBI

7 

Hou Y, Wu M, Wei J, Ren Y, Du C, Wu H, Li Y and Shi Y: CD36 is involved in high glucose-induced epithelial to mesenchymal transition in renal tubular epithelial cells. Biochem Biophys Res Commun. 468:281–286. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Lu H, Yao K, Huang D, Sun A, Zou Y, Qian J and Ge J: High glucose induces upregulation of scavenger receptors and promotes maturation of dendritic cells. Cardiovasc Diabetol. 12:802013. View Article : Google Scholar : PubMed/NCBI

9 

Sheedy FJ, Grebe A, RaynerK J, Kalantari P, Ramkhelawon B, Carpenter SB, Becker CE, Ediriweera HN, Mullick AE, Golenbock DT, et al: CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation. Nat Immunol. 14:812–820. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, et al: Mitochondrial metabolic reprogramming by CD36 signaling drives macrophage inflammatory responses. Circ Res. 125:1087–1102. 2019. View Article : Google Scholar : PubMed/NCBI

11 

Bhat A, Das S, Yadav G, Chaudhary S, Vyas A, Islam M, Gupta AC, Bajpai M, Maiwall R, Maras JS and Sarin SK: Hyperoxidized albumin modulates platelets and promotes inflammation through CD36 receptor in severe alcoholic hepatitis. Hepatol Commun. 4:50–65. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Yang X, Okamura DM, Lu X, Chen Y, Moorhead J, Varghese Z and Ruan XZ: CD36 in chronic kidney disease: Novel insights and therapeutic opportunities. Nat Rev Nephrol. 13:769–781. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Kunz A, Abe T, Hochrainer K, Shimamura M, Anrather J, Racchumi G, Zhou P and Iadecola C: Nuclear factor-kappaB activation and postischemic inflammation are suppressed in CD36-null mice after middle cerebral artery occlusion. J Neurosci. 28:1649–1658. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Cao D, Luo J, Zang W, Chen D, Xu H, Shi H and Jing X: Gamma-linolenic acid suppresses NF-κΒ signaling via CD36 in the lipopolysaccharide-induced inflammatory response in primary goat mammary gland epithelial cells. Inflammation. 39:1225–1237. 2016.PubMed/NCBI

15 

Sp N, Kang DK, Kim DH, Park JH, Lee HG, Kim HJ, Darvin P, Park YM and Yang YM: Inhibits CD36-dependent tumor angiogenesis, migration, invasion, and sphere formation through the Cd36/Stat3/Nf-Κb signaling axis. Nutrients. 10:7722018. View Article : Google Scholar : PubMed/NCBI

16 

Zhao L, Zhang C, Luo X, Wang P, Zhou W, Zhong S, Xie Y, Jiang Y, Yang P, Tang R, et al: CD36 palmitoylation disrupts free fatty acid metabolism and promotes tissue inflammation in non-alcoholic steatohepatitis. J Hepatol. 69:705–717. 2018. View Article : Google Scholar : PubMed/NCBI

17 

Hou Y, Shi Y, Han B, Liu X, Qiao X, Qi Y and Wang L: The antioxidant peptide SS31 prevents oxidative stress, downregulates CD36 and improves renal function in diabetic nephropathy. Nephrol Dial Transplant. 33:1908–1918. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PcR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Ruderman N, Carling D, Prentki M and Cacicedo J: AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 123:2764–2772. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Ramírez E, Picatoste B, González-Bris A, Oteo M, Cruz F, Caro-Vadillo A, Egido J, Tuñón J, Morcillo MA and Lorenzo Ó: Sitagliptin improved glucose assimilation in detriment of fatty-acid utilization in experimental type-II diabetes: Role of GLP-1 isoforms in Glut4 receptor trafficking. Cardiovasc Diabetol. 17:122018. View Article : Google Scholar : PubMed/NCBI

21 

Palomer X, Salvadó L, Barroso E and Vázquez-Carrera M: An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy. Int J Cardiol. 168:3160–3172. 2013. View Article : Google Scholar : PubMed/NCBI

22 

Koonen DP, Sung MM, Kao CK, Dolinsky VW, Koves TR, Ilkayeva O, Jacobs RL, Vance DE, Light PE, Muoio DM, et al: Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance. Diabetes. 59:1366–1375. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Abumrad NA and Goldberg IJ: CD36 actions in the heart: Lipids, calcium, inflammation, repair and more? Biochim Biophys Acta. 1861:1442–1449. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Han L, Yang Q, Li J, Cheng F, Zhang Y, Li Y and Wang M: Protocatechuic acid-ameliorated endothelial oxidative stress through regulating acetylation level via CD36/AMPK pathway. J Agric Food Chem. 67:7060–7072. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Li W, Febbraio M, Reddy SP, Yu DY, Yamamoto M and Silverstein RL: CD36 participates in a signaling pathway that regulates ROS formation in murine VSMCs. J Clin Invest. 120:3996–4006. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Liang E, Liu X, Du Z, Yang R and Zhao Y: Andrographolide ameliorates diabetic cardiomyopathy in mice by blockage of oxidative damage and NF-κB-mediated inflammation. Oxid Med Cell Longev. 2018:90867472018. View Article : Google Scholar : PubMed/NCBI

27 

Morgan M and Liu Z: Crosstalk of reactive oxygen species and NF-κB signaling. Cell Res. 21:103–115. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Frati G, Schirone L, Chimenti I, Yee D, Biondi-Zoccai G, Volpe M and Sciarretta S: An overview of the inflammatory signalling mechanisms in the myocardium underlying the development of diabetic cardiomyopathy. Cardiovasc Res. 113:378–388. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Febbraio M, Hajjar DP and Silverstein RL: CD36: A class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation and lipid metabolism. J Clin Invest. 108:785–791. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Lisa S, Winer P and Wu M: Rapid analysis of glycolytic and oxidative substrate flux of cancer cells in a microplate. PLoS One. 9:e1099162014. View Article : Google Scholar : PubMed/NCBI

31 

Day EA, Ford RJ and Steinberg GR: AMPK as a therapeutic target for treating metabolic diseases. Trends Endocrinol Metab. 28:545–560. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Samovski D, Sun J, Pietka T, Gross RM, Eckel RH, Su X, Stahl PD and Abumrad NA: Regulation of AMPK activation by CD36 links fatty acid uptake to β-oxidation. Diabetes. 64:353–359. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Shrikanth CB and Nandini CD: AMPK in microvascular complications of diabetes and the beneficial effects of AMPK activators from plants. Phytomedicine. 24:1528082018.PubMed/NCBI

34 

Glatz JFC, Luiken JJFP and Nabben M: CD36 (SR-B2) as a target to treat lipid overload-induced cardiac dysfunction. J Lipid Atheroscler. 9:66–78. 2020. View Article : Google Scholar : PubMed/NCBI

35 

Li Y, Yang P, Zhao L, Chen Y, Zhang X, Zeng S, Wei L, Varghese Z, Moorhead JF, Chen Y and Ruan XZ: CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway. J Lipid Res. 60:844–855. 2019. View Article : Google Scholar : PubMed/NCBI

36 

Zhu Y, Qian X, Li J, Lin X, Luo J, Huang J and Jin Z: Astragaloside-IV protects H9C2(2-1) cardiomyocytes from high glucose-induced injury via miR-34a-mediated autophagy pathway. Artif Cells Nanomed Biotechnol. 47:4172–4181. 2019. View Article : Google Scholar : PubMed/NCBI

37 

Ma L, Cao Y, Zhang L, Li K, Pan Y and Zhu J: Celastrol mitigates high glucose-induced inflammation and apoptosis in rat H9c2 cardiomyocytes via miR-345-5p/growth arrest-specific 6. J Gene Med. 22:e32012020. View Article : Google Scholar : PubMed/NCBI

38 

Huang Z, Dong X, Zhuang X, Hu X, Wang L and Liao X: Exogenous hydrogen sulfide protects against high glucose-induced inflammation and cytotoxicity in H9c2 cardiac cells. Mol Med Rep. 14:4911–4917. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Zhao MX, Zhou B, Ling L, Xiong XQ, Zhang F, Chen Q, Li YH, Kang YM and Zhu GQ: Salusin-β contributes to oxidative stress and inflammation in diabetic cardiomyopathy. Cell Death Dis. 8:e26902017. View Article : Google Scholar : PubMed/NCBI

40 

Kotla S and Rao GN: Reactive oxygen species (ROS) mediate p300-dependent STAT1 protein interaction with peroxisome proliferator-activated receptor (PPAR)-γ in CD36 protein expression and foam cell formation. J Biol Chem. 290:30306–30320. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Han B, Wang J, Wu J, Yan F, Wang Y and Li J: High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells. Mol Med Rep 24: 764, 2021.
APA
Han, B., Wang, J., Wu, J., Yan, F., Wang, Y., & Li, J. (2021). High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells. Molecular Medicine Reports, 24, 764. https://doi.org/10.3892/mmr.2021.12404
MLA
Han, B., Wang, J., Wu, J., Yan, F., Wang, Y., Li, J."High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells". Molecular Medicine Reports 24.5 (2021): 764.
Chicago
Han, B., Wang, J., Wu, J., Yan, F., Wang, Y., Li, J."High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells". Molecular Medicine Reports 24, no. 5 (2021): 764. https://doi.org/10.3892/mmr.2021.12404
Copy and paste a formatted citation
x
Spandidos Publications style
Han B, Wang J, Wu J, Yan F, Wang Y and Li J: High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells. Mol Med Rep 24: 764, 2021.
APA
Han, B., Wang, J., Wu, J., Yan, F., Wang, Y., & Li, J. (2021). High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells. Molecular Medicine Reports, 24, 764. https://doi.org/10.3892/mmr.2021.12404
MLA
Han, B., Wang, J., Wu, J., Yan, F., Wang, Y., Li, J."High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells". Molecular Medicine Reports 24.5 (2021): 764.
Chicago
Han, B., Wang, J., Wu, J., Yan, F., Wang, Y., Li, J."High glucose‑induced upregulation of CD36 promotes inflammation stress via NF‑κB in H9c2 cells". Molecular Medicine Reports 24, no. 5 (2021): 764. https://doi.org/10.3892/mmr.2021.12404
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team