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Article

Role of Thrombospondin‑1 in sepsis‑induced myocardial injury

Corrigendum in: /10.3892/mmr.2023.13000
  • Authors:
    • Yun Xie
    • Jiaxiang Zhang
    • Wei Jin
    • Rui Tian
    • Ruilan Wang
  • View Affiliations / Copyright

    Affiliations: Department of Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, P.R. China
  • Article Number: 869
    |
    Published online on: October 25, 2021
       https://doi.org/10.3892/mmr.2021.12509
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Abstract

Sepsis often causes myocardial injury with a high mortality. The aim of the present study was to investigate the effects of thrombospondin‑1 (THBS1) on myocardial cell injury, oxi‑dative stress and apoptosis in sepsis. The expression of THBS1 mRNA in lipopolysaccharide (LPS)‑induced mouse primary cardiomyocytes was detected by reverse transcription‑quantitative PCR (RT‑qPCR). A eukaryotic small interfering (si)RNA expression vector was constructed and transfected into myocardial cells to knockdown THBS1 mRNA expression, which was confirmed by RT‑qPCR. Four in vitro experimental groups were used: i) Control, ii) LPS, iii) THBS1 siRNA (siTHBS1) and iv) siTHBS + LPS. ELISA was used to detect cardiac troponin I (cTnI), pro‑brain natriuretic peptide (proBNP), reactive oxygen species (ROS), caspase‑3, IL‑6 and TNF‑α. In vivo mouse sepsis models were also established, and H&E, TUNEL and caspase‑3 staining were used to evaluate myocardial cell injury and apoptosis. Clinical samples were collected to analyze the serum THBS1 levels and to associate this with the prognosis of patients with sepsis‑induced myocardial injury. The expression level of THBS1 mRNA in myocardial cells induced by LPS was increased, and the serum THBS1 level in patients with myocardial injury in sepsis was also significantly increased compared with patients without sepsis‑induced myocardial injury. In the siTHBS1‑treated mice with myocardial injury, the levels of cTnI and proBNP were significantly decreased, the levels of the inflammatory cytokines IL‑6 and TNF‑α were significantly decreased, ROS were significantly decreased, caspase‑3 was significantly decreased, and myocardial cell apoptosis was also reduced, compared with the LPS group. Data from the present study suggested that THBS1 may be closely related to the biological behavior of myocardial cells and may be a therapeutic target for myocardial injury in sepsis.
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1 

Rhodes A, Evans LE, Alhazzani W, Levy MM, Antonelli M, Ferrer R, Kumar A, Sevransky JE, Sprung CL, Nunnally ME, et al: Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Crit Care Med. 45:486–552. 2017. View Article : Google Scholar : PubMed/NCBI

2 

Frencken JF, Donker DW, Spitoni C, Koster-Brouwer ME, Soliman IW, Ong DSY, Horn J, van der Poll T, van Klei WA, Bonten MJM, et al: Myocardial Injury in Patients With Sepsis and Its Association With Long-Term Outcome. Circ Cardiovasc Qual Outcomes. 11:e0040402018. View Article : Google Scholar : PubMed/NCBI

3 

Aneman A and Vieillard-Baron A: Cardiac dysfunction in sepsis. Intensive Care Med. 42:2073–2076. 2016. View Article : Google Scholar : PubMed/NCBI

4 

Xie Y, Tian R, Jin W, Xie H, Du J, Zhou Z and Wang R: Antithrombin III Predicts Acute Kidney Injury in Septic Elderly Patients. Exp Ther Med. 19:1024–1032. 2020.PubMed/NCBI

5 

Liu YC, Yu MM, Shou ST and Chai YF: Sepsis-induced cardiomyopathy: Mechanisms and treatments. Front Immunol. 8:10212017. View Article : Google Scholar : PubMed/NCBI

6 

Buerke U, Carter JM, Schlitt A, Russ M, Schmidt H, Sibelius U, Grandel U, Grimminger F, Seeger W, Mueller-Werdan U, et al: Apoptosis contributes to septic cardiomyopathy and is improved by simvastatin therapy. Shock. 29:497–503. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Peng S, Xu J, Ruan W, Li S and Xiao F: PPAR- γ activation prevents septic cardiac dysfunction via inhibition of apoptosis and necroptosis. Oxid Med Cell Longev. 2017:1–11. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Lopez-Dee Z, Pidcock K and Gutierrez LS: Thrombospondin-1: Multiple paths to inflammation. Mediators Inflamm. 2011:2960692011. View Article : Google Scholar : PubMed/NCBI

9 

Bornstein P: Thrombospondins function as regulators of angiogenesis. J Cell Commun Signal. 3:189–200. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Stenina-Adognravi O: Thrombospondins: Old players, new games. Curr Opin Lipidol. 24:401–409. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Bigé N, Boffa JJ, Lepeytre F and Shweke N: Rôle de la thrombospondine-1 dans le développement des maladies rénales [Role of thrombospondin-1 in the development of kidney diseases. Med Sci (Paris). 29:1131–1137. 2013.(In French). View Article : Google Scholar : PubMed/NCBI

12 

Kuzmanov A, Wielockx B, Rezaei M, Kettelhake A and Breier G: Overexpression of factor inhibiting HIF-1 enhances vessel maturation and tumor growth via platelet-derived growth factor-C. Int J Cancer. 131:E603–E613. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Weng TY, Wang CY, Hung YH, Chen WC, Chen YL and Lai MD: Differential Expression Pattern of THBS1 and THBS2 in Lung Cancer: Clinical Outcome and a Systematic-Analysis of Microarray Databases. PLoS One. 11:e01610072016. View Article : Google Scholar : PubMed/NCBI

14 

Larche J, Lancel S, Hassoun SM, Favory R, Decoster B, Marchetti P, Chopin C and Neviere R: Inhibition of mitochondrial permeability transition prevents sepsis-induced myocardial dysfunction and mortality. J Am Coll Cardiol. 48:377–385. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Takehara K, Murakami T, Kuwahara-Arai K, Iba T, Nagaoka I and Sakamoto K: Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model. Exp Ther Med. 13:2969–2974. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Lu J, Wei Z, Jiang H, Cheng L, Chen Q, Chen M, Yan J and Sun Z: Lactate dehydrogenase is associated with 28-day mortality in patients with sepsis: A retrospective observational study. J Surg Res. 228:314–321. 2018. View Article : Google Scholar : PubMed/NCBI

18 

Gao JB, Tang WD, Wang HX and Xu Y: Predictive value of thrombospondin-1 for outcomes in patients with acute ischemic stroke. Clin Chim Acta. 450:176–180. 2015. View Article : Google Scholar : PubMed/NCBI

19 

van der Wekken RJ, Kemperman H, Roest M and de Lange DW: Baseline thrombospondin-1 concentrations are not associated with mortality in septic patients: A single-center cohort study on the intensive care unit. Intensive Care Med Exp. 5:72017. View Article : Google Scholar : PubMed/NCBI

20 

McMaken S, Exline MC, Mehta P, Piper MC, Wang Y, Fischer SN, Newland CA, Schrader CA, Basler SR, Sarkar A, et al: Thrombospondin-1 Contributes to Mortality in Murine Sepsis through Effects on Innate Immunity. PLOS ONE. 6:e196542011.https://doi.org/10.1371/journal.pone.0019654 View Article : Google Scholar : PubMed/NCBI

21 

Xing T, Wang Y, Ding WJ, Li YL, Hu XD, Wang C, Ding A and Shen JL: Thrombospondin-1 Production Regulates the Inflammatory Cytokine Secretion in THP-1 Cells Through NF-κB Signaling Pathway. Inflammation. 40:1606–1621. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Chen X, Yang B, Tian J, Hong H, Du Y, Li K, Li X, Wang N, Yu X and Wei X: Dental Follicle Stem Cells Ameliorate Lipopolysaccharide-Induced Inflammation by Secreting TGF-β3 and TSP-1 to Elicit Macrophage M2 Polarization. Cell Physiol Biochem. 51:2290–2308. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Xie Y, Zhang J, Jin W, Tian R and Wang R: Role of Thrombospondin‑1 in sepsis‑induced myocardial injury Corrigendum in /10.3892/mmr.2023.13000. Mol Med Rep 24: 869, 2021.
APA
Xie, Y., Zhang, J., Jin, W., Tian, R., & Wang, R. (2021). Role of Thrombospondin‑1 in sepsis‑induced myocardial injury Corrigendum in /10.3892/mmr.2023.13000. Molecular Medicine Reports, 24, 869. https://doi.org/10.3892/mmr.2021.12509
MLA
Xie, Y., Zhang, J., Jin, W., Tian, R., Wang, R."Role of Thrombospondin‑1 in sepsis‑induced myocardial injury Corrigendum in /10.3892/mmr.2023.13000". Molecular Medicine Reports 24.6 (2021): 869.
Chicago
Xie, Y., Zhang, J., Jin, W., Tian, R., Wang, R."Role of Thrombospondin‑1 in sepsis‑induced myocardial injury Corrigendum in /10.3892/mmr.2023.13000". Molecular Medicine Reports 24, no. 6 (2021): 869. https://doi.org/10.3892/mmr.2021.12509
Copy and paste a formatted citation
x
Spandidos Publications style
Xie Y, Zhang J, Jin W, Tian R and Wang R: Role of Thrombospondin‑1 in sepsis‑induced myocardial injury Corrigendum in /10.3892/mmr.2023.13000. Mol Med Rep 24: 869, 2021.
APA
Xie, Y., Zhang, J., Jin, W., Tian, R., & Wang, R. (2021). Role of Thrombospondin‑1 in sepsis‑induced myocardial injury Corrigendum in /10.3892/mmr.2023.13000. Molecular Medicine Reports, 24, 869. https://doi.org/10.3892/mmr.2021.12509
MLA
Xie, Y., Zhang, J., Jin, W., Tian, R., Wang, R."Role of Thrombospondin‑1 in sepsis‑induced myocardial injury Corrigendum in /10.3892/mmr.2023.13000". Molecular Medicine Reports 24.6 (2021): 869.
Chicago
Xie, Y., Zhang, J., Jin, W., Tian, R., Wang, R."Role of Thrombospondin‑1 in sepsis‑induced myocardial injury Corrigendum in /10.3892/mmr.2023.13000". Molecular Medicine Reports 24, no. 6 (2021): 869. https://doi.org/10.3892/mmr.2021.12509
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