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Review Open Access

Association between HO‑1 gene promoter polymorphisms and diseases (Review)

  • Authors:
    • Lin-Lin Ma
    • Lei Sun
    • Yu-Xi Wang
    • Bai-He Sun
    • Yan-Fei Li
    • Yue-Ling Jin
  • View Affiliations / Copyright

    Affiliations: School of Medical Technology, Shanghai University of Medicine & Health Sciences, Shanghai 201318, P.R. China, Management Department of Scientific Research, Shanghai Science and Technology Museum, Shanghai 200127, P.R. China
    Copyright: © Ma et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 29
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    Published online on: November 25, 2021
       https://doi.org/10.3892/mmr.2021.12545
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Abstract

Heme oxygenase‑1 (HO‑1) is an inducible cytoprotective enzyme that degrades heme into free iron, carbon monoxide and biliverdin, which is then rapidly converted into bilirubin. These degradation products serve an important role in the regulation of inflammation, oxidative stress and apoptosis. While the expression level of HO‑1 is typically low in most cells, it may be highly expressed when induced by a variety of stimulating factors, a process that contributes to the regulation of cell homeostasis. In the 5'‑non‑coding region of the HO‑1 gene, there are two polymorphic sites, namely the (GT)n dinucleotide and T(‑413)A single nucleotide polymorphism sites, which regulate the transcriptional activity of HO‑1. These polymorphisms have been shown to be closely associated with the occurrence and progression of numerous diseases, including cardiovascular, pulmonary, liver and kidney, various types of cancer and viral diseases. The present article reviews the progress that has been made in research on the association between the two types of polymorphisms and these diseases, which is expected to provide novel strategies for the diagnosis, treatment and prognosis of various diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Ma L, Sun L, Wang Y, Sun B, Li Y and Jin Y: Association between HO‑1 gene promoter polymorphisms and diseases (Review). Mol Med Rep 25: 29, 2022.
APA
Ma, L., Sun, L., Wang, Y., Sun, B., Li, Y., & Jin, Y. (2022). Association between HO‑1 gene promoter polymorphisms and diseases (Review). Molecular Medicine Reports, 25, 29. https://doi.org/10.3892/mmr.2021.12545
MLA
Ma, L., Sun, L., Wang, Y., Sun, B., Li, Y., Jin, Y."Association between HO‑1 gene promoter polymorphisms and diseases (Review)". Molecular Medicine Reports 25.1 (2022): 29.
Chicago
Ma, L., Sun, L., Wang, Y., Sun, B., Li, Y., Jin, Y."Association between HO‑1 gene promoter polymorphisms and diseases (Review)". Molecular Medicine Reports 25, no. 1 (2022): 29. https://doi.org/10.3892/mmr.2021.12545
Copy and paste a formatted citation
x
Spandidos Publications style
Ma L, Sun L, Wang Y, Sun B, Li Y and Jin Y: Association between HO‑1 gene promoter polymorphisms and diseases (Review). Mol Med Rep 25: 29, 2022.
APA
Ma, L., Sun, L., Wang, Y., Sun, B., Li, Y., & Jin, Y. (2022). Association between HO‑1 gene promoter polymorphisms and diseases (Review). Molecular Medicine Reports, 25, 29. https://doi.org/10.3892/mmr.2021.12545
MLA
Ma, L., Sun, L., Wang, Y., Sun, B., Li, Y., Jin, Y."Association between HO‑1 gene promoter polymorphisms and diseases (Review)". Molecular Medicine Reports 25.1 (2022): 29.
Chicago
Ma, L., Sun, L., Wang, Y., Sun, B., Li, Y., Jin, Y."Association between HO‑1 gene promoter polymorphisms and diseases (Review)". Molecular Medicine Reports 25, no. 1 (2022): 29. https://doi.org/10.3892/mmr.2021.12545
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