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Opioids in cancer: The κ‑opioid receptor (Review)

  • Authors:
    • Qier Zhou
    • Zhiwei Zhang
    • Songkai Long
    • Wanjun Li
    • Baiyun Wang
    • Na Liang
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, The Affiliated Nanhua Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan 421001, P.R. China, Key Laboratory of Cancer Cellular and Molecular Pathology, Cancer Research Institute of Hengyang Medical College, University of South China, Hengyang, Hunan 421001, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 44
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    Published online on: December 8, 2021
       https://doi.org/10.3892/mmr.2021.12560
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Abstract

The κ‑opioid receptor (KOR) is one of the primary receptors of opioids and serves a vital role in the regulation of pain, anesthesia, addiction and other pathological and physiological processes. KOR is associated with several types of cancer and may influence cancer progression. It has been proposed that KOR may represent a new tumor molecular marker and provide a novel basis for molecular targeted therapies for cancer. However, the association between KOR and cancer remains to be explored comprehensively. The present review introduces KOR and its association with different types of cancer. Improved understanding of KOR may facilitate development of novel antitumor therapies.
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1 

Ferlay J, Colombet M, Soerjomataram I, Parkin DM, Piñeros M, Znaor A and Bray F: Cancer statistics for the year 2020: An overview. Int J Cancer. April 5–2021.(Epub ahead of print). View Article : Google Scholar

2 

Rogers TJ: Kappa opioid receptor expression and function in cells of the immune system. Handb Exp Pharmacol. 271:419–433. 2022. View Article : Google Scholar : PubMed/NCBI

3 

Trescot AM: Review of the role of opioids in cancer pain. J Natl Compr Cancer Netw. 8:1087–1094. 2010. View Article : Google Scholar : PubMed/NCBI

4 

Lohse I and Brothers SP: Pathogenesis and treatment of pancreatic cancer related pain. Anticancer Res. 40:1789–1796. 2020. View Article : Google Scholar : PubMed/NCBI

5 

Mercadante S and Vitrano V: Pain in patients with lung cancer: Pathophysiology and treatment. Lung Cancer. 68:10–15. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Szczepaniak A, Fichna J and Zielińska M: Opioids in cancer development, progression and metastasis: Focus on colorectal cancer. Curr Treat Options Oncol. 21:62020. View Article : Google Scholar : PubMed/NCBI

7 

Satija A, Ahmed SM, Gupta R, Ahmed A, Rana SPS, Singh SP, Mishra S and Bhatnagar S: Breast cancer pain management-a review of current & novel therapies. Indian J Med Res. 139:216–225. 2014.PubMed/NCBI

8 

Ing JW: Head and neck cancer pain. Otolaryngol Clin North Am. 50:793–806. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Lu H, Zhang H, Weng ML, Zhang J, Jiang N, Cata JP, Ma D, Chen WK and Miao CH: Morphine promotes tumorigenesis and cetuximab resistance via EGFR signaling activation in human colorectal cancer. J Cell Physiol. 236:4445–4454. 2021. View Article : Google Scholar : PubMed/NCBI

10 

Ma Y, Ren Z, Ma S, Yan W, He M, Wang D and Ding P: Morphine enhances renal cell carcinoma aggressiveness through promotes survivin level. Ren Fail. 39:258–264. 2017. View Article : Google Scholar : PubMed/NCBI

11 

Ustun F, Durmus-Altun G, Altaner S, Tuncbilek N, Uzal C and Berkarda S: Evaluation of morphine effect on tumour angiogenesis in mouse breast tumour model, EATC. Med Oncol. 28:1264–1272. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Guerrero Orriach JL, Raigon Ponferrada A, Malo Manso A, Herrera Imbroda B, Escalona Belmonte JJ, Ramirez Aliaga M, Ramirez Fernandez A, Crespo JD, Soriano Perez AM, Fontaneda Heredia A, et al: Anesthesia in combination with propofol increases disease-free survival in bladder cancer patients who undergo radical tumor cystectomy as compared to inhalational anesthetics and opiate-based analgesia. Oncology. 98:161–167. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Hasegawa T, Oguri T, Osawa T, Sawa T, Osaga S, Okuyama T, Uchida M, Maeno K, Fukuda S, Nishie H, et al: Opioid dose and survival of patients with incurable nonsmall cell lung cancer: A prospective cohort study. J Palliat Med. 21:1436–1441. 2018. View Article : Google Scholar : PubMed/NCBI

14 

Gong S, Ying L, Fan Y and Sun Z: Fentanyl inhibits lung cancer viability and invasion via upregulation of miR-331-3p and repression of HDAC5. Onco Targets Ther. 13:13131–13141. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Li C, Qin Y, Zhong Y, Qin Y, Wei Y, Li L and Xie Y: Fentanyl inhibits the progression of gastric cancer through the suppression of MMP-9 via the PI3K/Akt signaling pathway. Ann Transl Med. 8:1182020. View Article : Google Scholar : PubMed/NCBI

16 

Zhang XL, Chen ML and Zhou SL: Fentanyl inhibits proliferation and invasion of colorectal cancer via β-catenin. Int J Clin Exp Pathol. 8:227–235. 2015.PubMed/NCBI

17 

Sasamura T, Nakamura S, Iida Y, Fujii H, Murata J, Saiki I, Nojima H and Kuraishi Y: Morphine analgesia suppresses tumor growth and metastasis in a mouse model of cancer pain produced by orthotopic tumor inoculation. Eur J Pharmacol. 441:185–191. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Fichna J and Janecka A: Opioid peptides in cancer. Cancer Metastasis Rev. 23:351–366. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Chatikhine VA, Chevrier A, Chauzy C, Duval C, d'Anjou J, Girard N and Delpech B: Expression of opioid peptides in cells and stroma of human breast cancer and adenofibromas. Cancer Lett. 77:51–56. 1994. View Article : Google Scholar : PubMed/NCBI

20 

Zagon IS, Hytrek SD and McLaughlin PJ: Opioid growth factor tonically inhibits human colon cancer cell proliferation in tissue culture. Am J Physiol. 271:R511–R518. 1996.PubMed/NCBI

21 

Hatzoglou A, Gravanis A, Margioris AN, Zoumakis E and Castanas E: Identification and characterization of opioid-binding sites present in the Ishikawa human endometrial adenocarcinoma cell line. J Clin Endocrinol Metab. 80:418–423. 1995. View Article : Google Scholar : PubMed/NCBI

22 

Roth KA and Barchas JD: Small cell carcinoma cell lines contain opioid peptides and receptors. Cancer. 57:769–773. 1986. View Article : Google Scholar : PubMed/NCBI

23 

Singleton PA, Mirzapoiazova T, Hasina R, Salgia R and Moss J: Increased µ-opioid receptor expression in metastatic lung cancer. Br J Anaesth. 113 (Suppl 1):i103–i108. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Lennon FE, Mirzapoiazova T, Mambetsariev B, Salgia R, Moss J and Singleton PA: Overexpression of the µ-opioid receptor in human non-small cell lung cancer promotes Akt and mTOR activation, tumor growth, and metastasis. Anesthesiology. 116:857–867. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Wolff RF, Aune D, Truyers C, Hernandez AV, Misso K, Riemsma R and Kleijnen J: Systematic review of efficacy and safety of buprenorphine versus fentanyl or morphine in patients with chronic moderate to severe pain. Curr Med Res Opin. 28:833–845. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Cieślińska A, Sienkiewicz-Szłapka E, Kostyra E, Fiedorowicz E, Snarska J, Wroński K, Tenderenda M, Jarmołowska B and Matysiewicz M: µ-Opioid receptor gene (OPRM1) polymorphism in patients with breast cancer. Tumour Biol. 36:4655–4660. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Singleton PA, Moss J, Karp DD, Atkins JT and Janku F: The mu opioid receptor: A new target for cancer therapy? Cancer. 121:2681–2688. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Steele GL, Dudek AZ, Gilmore GE, Richter SA, Olson DA, Eklund JP and Zylla DM: Impact of pain, opioids, and the mu-opioid receptor on progression and survival in patients with newly diagnosed stage IV pancreatic cancer. Am J Clin Oncol. 43:591–597. 2020. View Article : Google Scholar : PubMed/NCBI

29 

Kim J, Ham S, Hong H, Moon C and Im HI: Brain reward circuits in morphine addiction. Mol Cells. 39:645–653. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Benyamin R, Trescot AM, Datta S, Buenaventura R, Adlaka R, Sehgal N, Glaser SE and Vallejo R: Opioid complications and side effects. Pain Physician. 11 (Suppl 2):S105–S120. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Bodnar RJ: Endogenous opioid modulation of food intake and body weight: Implications for opioid influences upon motivation and addiction. Peptides. 116:42–62. 2019. View Article : Google Scholar : PubMed/NCBI

32 

Bagley EE and Ingram SL: Endogenous opioid peptides in the descending pain modulatory circuit. Neuropharmacology. 173:1081312020. View Article : Google Scholar : PubMed/NCBI

33 

Barron BA: Opioid peptides and the heart. Cardiovasc Res. 43:13–16. 1999. View Article : Google Scholar : PubMed/NCBI

34 

Gein SV and Baeva TA: Endogenous opioid peptides in regulation of innate immunity cell functions. Biochemistry (Mosc). 76:309–319. 2011. View Article : Google Scholar : PubMed/NCBI

35 

Mercadante S and Romualdi P: The therapeutic potential of novel kappa opioid receptor-based treatments. Curr Med Chem. 27:2012–2020. 2020. View Article : Google Scholar : PubMed/NCBI

36 

Waldhoer M, Bartlett SE and Whistler JL: Opioid receptors. Annu Rev Biochem. 73:953–990. 2004. View Article : Google Scholar : PubMed/NCBI

37 

Minami M, Toya T, Katao Y, Maekawa K, Nakamura S, Onogi T, Kaneko S and Satoh M: Cloning and expression of a cDNA for the rat kappa-opioid receptor. FEBS Lett. 329:291–295. 1993. View Article : Google Scholar : PubMed/NCBI

38 

Schoffelmeer AN, Hogenboom F and Mulder AH: Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum. Br J Pharmacol. 122:520–524. 1997. View Article : Google Scholar : PubMed/NCBI

39 

Brooks AI, Standifer KM, Rossi GC, Mathis JP and Pasternak GW: Characterizing kappa3 opioid receptors with a selective monoclonal antibody. Synapse. 22:247–252. 1996. View Article : Google Scholar : PubMed/NCBI

40 

Cahill CM, Taylor AM, Cook C, Ong E, Morón JA and Evans CJ: Does the kappa opioid receptor system contribute to pain aversion? Front Pharmacol. 5:2532014. View Article : Google Scholar : PubMed/NCBI

41 

Crowley NA and Kash TL: Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment. Prog Neuropsychopharmacol Biol Psychiatry. 62:51–60. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Ruan X, Mancuso KF and Kaye AD: Revisiting oxycodone analgesia: A review and hypothesis. Anesthesiol Clin. 35:e163–e174. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Schmidt-Hansen M, Bennett MI, Arnold S, Bromham N and Hilgart JS: Oxycodone for cancer-related pain. Cochrane Database Syst Rev. 8:Cd0038702017.PubMed/NCBI

44 

Jin WQ, Tai KK, Chan TK and Wong TM: Further characterization of [3H]U69593 binding sites in the rat heart. J Mol Cell Cardiol. 27:1507–1511. 1995. View Article : Google Scholar : PubMed/NCBI

45 

Simonin F, Gavériaux-Ruff C, Befort K, Matthes H, Lannes B, Micheletti G, Mattéi MG, Charron G, Bloch B and Kieffer B: kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system. Proc Natl Acad Sci USA. 92:7006–7010. 1995. View Article : Google Scholar : PubMed/NCBI

46 

Gavériaux-Ruff C, Peluso J, Befort K, Simonin F, Zilliox C and Kieffer BL: Detection of opioid receptor mRNA by RT-PCR reveals alternative splicing for the delta- and kappa-opioid receptors. Brain Res Mol Brain Res. 48:298–304. 1997. View Article : Google Scholar : PubMed/NCBI

47 

Wang YJ, Rasakham K, Huang P, Chudnovskaya D, Cowan A and Liu-Chen LY: Sex difference in κ-opioid receptor (KOPR)-mediated behaviors, brain region KOPR level and KOPR-mediated guanosine 5′-O-(3-[35S]thiotriphosphate) binding in the guinea pig. J Pharmacol Exp Ther. 339:438–450. 2011. View Article : Google Scholar : PubMed/NCBI

48 

Machelska H and Celik M: Opioid receptors in immune and glial cells-implications for pain control. Front Immunol. 11:3002020. View Article : Google Scholar : PubMed/NCBI

49 

Spasov AA, Grechko O and Shtareva DM: Kappa-opioid receptor: Molecular structure and function. Eksp klin Farmakol. 77:27–35. 2014.(In Russian).

50 

Carroll FI and Carlezon WA Jr: Development of κ opioid receptor antagonists. J Med Chem. 56:2178–2195. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Yamamizu K, Hamada Y and Narita M: κ Opioid receptor ligands regulate angiogenesis in development and in tumours. Br J Pharmacol. 172:268–276. 2015. View Article : Google Scholar : PubMed/NCBI

52 

Shi Y, Luo J, Tian J, Zou Q and Wang X: The kappa opioid receptor may be a potential tumor suppressor by regulating angiogenesis in breast cancer. Med Hypotheses. 150:1105682021. View Article : Google Scholar : PubMed/NCBI

53 

Wigmore T and Farquhar-Smith P: Opioids and cancer: Friend or foe? Curr Opin Support Palliat Care. 10:109–118. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Strang P: Cancer pain-a provoker of emotional, social and existential distress. Acta Oncol. 37:641–644. 1998. View Article : Google Scholar : PubMed/NCBI

55 

Reiche EM, Nunes SO and Morimoto HK: Stress, depression, the immune system, and cancer. Lancet Oncol. 5:617–625. 2004. View Article : Google Scholar : PubMed/NCBI

56 

Edwards KA, Havelin JJ, McIntosh MI, Ciccone HA, Pangilinan K, Imbert I, Largent-Milnes TM, King T, Vanderah TW and Streicher JM: A kappa opioid receptor agonist blocks bone cancer pain without altering bone loss, tumor size, or cancer cell proliferation in a mouse model of cancer-induced bone pain. J Pain. 19:612–625. 2018. View Article : Google Scholar : PubMed/NCBI

57 

Zhang YF, Xu QX, Liao LD, Xu XE, Wu JY, Shen J, Wu ZY, Shen JH, Li EM and Xu LY: κ-Opioid receptor in the nucleus is a novel prognostic factor of esophageal squamous cell carcinoma. Hum Pathol. 44:1756–1765. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Diao CT, Li L, Lau SY, Wong TM and Wong NS: kappa-Opioid receptor potentiates apoptosis via a phospholipase C pathway in the CNE2 human epithelial tumor cell line. Biochim Biophys Acta. 1499:49–62. 2000. View Article : Google Scholar : PubMed/NCBI

59 

Li H, Ma Z and Lei Y: The expression of kappa-opioid receptor promotes the migration of breast cancer cells in vitro. BMC Anesthesiol. 21:2102021. View Article : Google Scholar : PubMed/NCBI

60 

Chen D, Chen Y, Yan Y, Pan J, Xing W, Li Q and Zeng W: Down-regulation of the tumour suppressor κ-opioid receptor predicts poor prognosis in hepatocellular carcinoma patients. BMC Cancer. 17:5532017. View Article : Google Scholar : PubMed/NCBI

61 

Tripolt S, Neubauer HA, Knab VM, Elmer DP, Aberger F, Moriggl R and Fux DA: Opioids drive breast cancer metastasis through the δ-opioid receptor and oncogenic STAT3. Neoplasia. 23:270–279. 2021. View Article : Google Scholar : PubMed/NCBI

62 

Brejchova J, Holan V and Svoboda P: Expression of opioid receptors in cells of the immune system. Int J Mol Sci. 22:3152020. View Article : Google Scholar : PubMed/NCBI

63 

Pert CB and Snyder SH: Opiate receptor: Demonstration in nervous tissue. Science. 179:1011–1014. 1973. View Article : Google Scholar : PubMed/NCBI

64 

Kiguchi N, Ding H, Kishioka S and Ko MC: Nociceptin/orphanin FQ peptide receptor-related ligands as novel analgesics. Curr Top Med Chem. 20:2878–2888. 2020. View Article : Google Scholar : PubMed/NCBI

65 

Dhaliwal A and Gupta M: Physiology, opioid receptor. StatPearls (Internet). StatPearls Publishing; Treasure Island, FL: 2021

66 

Valentino RJ and Volkow ND: Untangling the complexity of opioid receptor function. Neuropsychopharmacology. 43:2514–2520. 2018. View Article : Google Scholar : PubMed/NCBI

67 

Chavkin C, James IF and Goldstein A: Dynorphin is a specific endogenous ligand of the kappa opioid receptor. Science. 215:413–415. 1982. View Article : Google Scholar : PubMed/NCBI

68 

Bruchas MR, Land BB and Chavkin C: The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors. Brain Res. 1314:44–55. 2010. View Article : Google Scholar : PubMed/NCBI

69 

Terenius L: From opiate pharmacology to opioid peptide physiology. Ups J Med Sci. 105:1–15. 2000. View Article : Google Scholar : PubMed/NCBI

70 

Goldstein A and Naidu A: Multiple opioid receptors: Ligand selectivity profiles and binding site signatures. Mol Pharmacol. 36:265–272. 1989.PubMed/NCBI

71 

Giros B, Pohl M, Rochelle JM and Seldin MF: Chromosomal localization of opioid peptide and receptor genes in the mouse. Life Sci. 56:PL369–PL375. 1995. View Article : Google Scholar : PubMed/NCBI

72 

Wei LN and Loh HH: Transcriptional and epigenetic regulation of opioid receptor genes: Present and future. Annu Rev Pharmacol Toxicol. 51:75–97. 2011. View Article : Google Scholar : PubMed/NCBI

73 

Xie GX, Meng F, Mansour A, Thompson RC, Hoversten MT, Goldstein A, Watson SJ and Akil H: Primary structure and functional expression of a guinea pig kappa opioid (dynorphin) receptor. Proc Natl Acad Sci USA. 91:3779–3783. 1994. View Article : Google Scholar : PubMed/NCBI

74 

Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI, et al: Structure of the human κ-opioid receptor in complex with JDTic. Nature. 485:327–332. 2012. View Article : Google Scholar : PubMed/NCBI

75 

Akil H and Watson SJ: Cloning of kappa opioid receptors: Functional significance and future directions. Prog Brain Res. 100:81–86. 1994. View Article : Google Scholar : PubMed/NCBI

76 

Law PY, Loh HH and Wei LN: Insights into the receptor transcription and signaling: Implications in opioid tolerance and dependence. Neuropharmacology. 47 (Suppl 1):S300–S311. 2004. View Article : Google Scholar : PubMed/NCBI

77 

Al-Hasani R and Bruchas MR: Molecular mechanisms of opioid receptor-dependent signaling and behavior. Anesthesiology. 115:1363–1381. 2011. View Article : Google Scholar : PubMed/NCBI

78 

Bruchas MR, Xu M and Chavkin C: Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2. Neuroreport. 19:1417–1422. 2008. View Article : Google Scholar : PubMed/NCBI

79 

Kam AY, Chan AS and Wong YH: Kappa-opioid receptor signals through Src and focal adhesion kinase to stimulate c-Jun N-terminal kinases in transfected COS-7 cells and human monocytic THP-1 cells. J Pharmacol Exp Ther. 310:301–310. 2004. View Article : Google Scholar : PubMed/NCBI

80 

Finley MJ, Steele A, Cornwell WD and Rogers TJ: Transcriptional regulation of the major HIV-1 coreceptor, CXCR4, by the kappa opioid receptor. J Leukoc Biol. 90:111–121. 2011. View Article : Google Scholar : PubMed/NCBI

81 

Georgoussi Z, Georganta EM and Milligan G: The other side of opioid receptor signalling: Regulation by protein-protein interaction. Curr Drug Targets. 13:80–102. 2012. View Article : Google Scholar : PubMed/NCBI

82 

Fink RM and Gallagher E: Cancer pain assessment and measurement. Semin Oncol Nurs. 35:229–234. 2019. View Article : Google Scholar : PubMed/NCBI

83 

Wiffen PJ, Cooper TE, Anderson AK, Gray AL, Grégoire MC, Ljungman G and Zernikow B: Opioids for cancer-related pain in children and adolescents. Cochrane Database Syst Rev. 7:Cd0125642017.PubMed/NCBI

84 

Wiffen PJ, Wee B, Derry S, Bell RF and Moore RA: Opioids for cancer pain-an overview of cochrane reviews. Cochrane Database Syst Rev. 7:Cd0125922017.PubMed/NCBI

85 

Paton KF, Atigari DV, Kaska S, Prisinzano T and Kivell BM: Strategies for developing κ opioid receptor agonists for the treatment of pain with fewer side effects. J Pharmacol Exp Ther. 375:332–348. 2020. View Article : Google Scholar : PubMed/NCBI

86 

Escobar ADP, Casanova JP, Andrés ME and Fuentealba JA: Crosstalk between kappa opioid and dopamine systems in compulsive behaviors. Front Pharmacol. 11:572020. View Article : Google Scholar : PubMed/NCBI

87 

McLaughlin JP, Li S, Valdez J, Chavkin TA and Chavkin C: Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system. Neuropsychopharmacology. 31:1241–1248. 2006. View Article : Google Scholar : PubMed/NCBI

88 

Knoll AT and Carlezon WA Jr: Dynorphin, stress, and depression. Brain Res. 1314:56–73. 2010. View Article : Google Scholar : PubMed/NCBI

89 

Carlezon WA Jr and Krystal AD: Kappa-Opioid antagonists for psychiatric disorders: From bench to clinical trials. Depress Anxiety. 33:895–906. 2016. View Article : Google Scholar : PubMed/NCBI

90 

Falcon E, Maier K, Robinson SA, Hill-Smith TE and Lucki I: Effects of buprenorphine on behavioral tests for antidepressant and anxiolytic drugs in mice. Psychopharmacology (Berl). 232:907–915. 2015. View Article : Google Scholar : PubMed/NCBI

91 

Ahmadi J, Jahromi MS and Ehsaei Z: The effectiveness of different singly administered high doses of buprenorphine in reducing suicidal ideation in acutely depressed people with co-morbid opiate dependence: A randomized, double-blind, clinical trial. Trials. 19:4622018. View Article : Google Scholar : PubMed/NCBI

92 

Serafini G, Adavastro G, Canepa G, De Berardis D, Valchera A, Pompili M, Nasrallah H and Amore M: The efficacy of buprenorphine in major depression, treatment-resistant depression and suicidal behavior: A systematic review. Int J Mol Sci. 19:24102018. View Article : Google Scholar : PubMed/NCBI

93 

Wang Q, Long Y, Hang A, Zan GY, Shu XH, Wang YJ and Liu JG: The anxiolytic- and antidepressant-like effects of ATPM-ET, a novel κ agonist and µ partial agonist, in mice. Psychopharmacology (Berl). 233:2411–2418. 2016. View Article : Google Scholar : PubMed/NCBI

94 

Kovalska M, Kovalska L, Tothova B, Mahmood S, Adamkov M and Lehotsky J: Combination of hyperhomocysteinemia and ischemic tolerance in experimental model of global ischemia in rats. J Physiol Pharmacol. 66:887–897. 2015.PubMed/NCBI

95 

Dennis TS, Beck KD, Cominski TP, Bobzean SAM, Kuzhikandathil EV, Servatius RJ and Perrotti LI: Exposure to morphine-associated cues increases mu opioid receptor mRNA expression in the nucleus accumbens of Wistar Kyoto rats. Behav Brain Res. 313:208–213. 2016. View Article : Google Scholar : PubMed/NCBI

96 

Menyhárt Á, Makra P, Szepes BE, Tóth OM, Hertelendy P, Bari F and Farkas E: High incidence of adverse cerebral blood flow responses to spreading depolarization in the aged ischemic rat brain. Neurobiol Aging. 36:3269–3277. 2015. View Article : Google Scholar : PubMed/NCBI

97 

Chen C, Xi C, Liang X, Ma J, Su D, Abel T and Liu R: The role of κ opioid receptor in brain ischemia. Crit Care Med. 44:e1219–e1225. 2016. View Article : Google Scholar : PubMed/NCBI

98 

Sobanski P, Krajnik M, Shaqura M, Bloch-Boguslawska E, Schäfer M and Mousa SA: The presence of mu-, delta-, and kappa-opioid receptors in human heart tissue. Heart Vessels. 29:855–863. 2014. View Article : Google Scholar : PubMed/NCBI

99 

Jaiswal A, Kumar S, Seth S, Dinda AK and Maulik SK: Effect of U50,488H, a κ-opioid receptor agonist on myocardial α-and β-myosin heavy chain expression and oxidative stress associated with isoproterenol-induced cardiac hypertrophy in rat. Mol Cell Biochem. 345:231–240. 2010. View Article : Google Scholar : PubMed/NCBI

100 

Komaba H, Moriwaki K, Goto S, Yamada S, Taniguchi M, Kakuta T, Kamae I and Fukagawa M: Cost-effectiveness of cinacalcet hydrochloride for hemodialysis patients with severe secondary hyperparathyroidism in Japan. Am J Kidney Dis. 60:262–271. 2012. View Article : Google Scholar : PubMed/NCBI

101 

Wang H, Wang JL, Ren HW, He WF and Sun M: Butorphanol protects on myocardial ischemia/reperfusion injury in rats through MAPK signaling pathway. Eur Rev Med Pharmacol Sci. 23:10541–10548. 2019.PubMed/NCBI

102 

Brust TF, Morgenweck J, Kim SA, Rose JH, Locke JL, Schmid CL, Zhou L, Stahl EL, Cameron MD, Scarry SM, et al: Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria. Sci Signal. 9:ra1172016. View Article : Google Scholar : PubMed/NCBI

103 

Feng Y, He X, Yang Y, Chao D, Lazarus LH and Xia Y: Current research on opioid receptor function. Curr Drug Targets. 13:230–246. 2012. View Article : Google Scholar : PubMed/NCBI

104 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

105 

Llovet JM, Zucman-Rossi J, Pikarsky E, Sangro B, Schwartz M, Sherman M and Gores G: Hepatocellular carcinoma. Nat Rev Dis Primers. 2:160182016. View Article : Google Scholar : PubMed/NCBI

106 

DeSantis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS and Jemal A: Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 64:252–271. 2014. View Article : Google Scholar : PubMed/NCBI

107 

Maneckjee R and Minna JD: Opioid and nicotine receptors affect growth regulation of human lung cancer cell lines. Proc Natl Acad Sci USA. 87:3294–3298. 1990. View Article : Google Scholar : PubMed/NCBI

108 

Kuzumaki N, Suzuki A, Narita M, Hosoya T, Nagasawa A, Imai S, Yamamizu K, Morita H, Nagase H, Okada Y, et al: Effect of κ-opioid receptor agonist on the growth of non-small cell lung cancer (NSCLC) cells. Br J Cancer. 106:1148–1152. 2012. View Article : Google Scholar : PubMed/NCBI

109 

Sim EH, Yang IA, Wood-Baker R, Bowman RV and Fong KM: Gefitinib for advanced non-small cell lung cancer. Cochrane Database Syst Rev. 1:CD0068472018.PubMed/NCBI

110 

Bareschino MA, Schettino C, Troiani T, Martinelli E, Morgillo F and Ciardiello F: Erlotinib in cancer treatment. Ann Oncol. 18 (Suppl 6):vi35–vi41. 2007. View Article : Google Scholar : PubMed/NCBI

111 

Rho JK, Choi YJ, Ryoo BY, Na III, Yang SH, Kim CH and Lee JC: p53 enhances gefitinib-induced growth inhibition and apoptosis by regulation of Fas in non-small cell lung cancer. Cancer Res. 67:1163–1169. 2007. View Article : Google Scholar : PubMed/NCBI

112 

An WF, Germain AR, Bishop JA, Nag PP, Metkar S, Ketterman J, Walk M, Weiwer M, Liu X, Patnaik D, et al: Discovery of potent and highly selective inhibitors of GSK3b. Probe Reports from the NIH Molecular Libraries Program. National Center for Biotechnology Information (US); Bethesda (MD): 2010, PubMed/NCBI

113 

Tian D, Zhu M, Chen WS, Li JS, Wu RL and Wang X: Role of glycogen synthase kinase 3 in squamous differentiation induced by cigarette smoke in porcine tracheobronchial epithelial cells. Food Chem Toxicol. 44:1590–1596. 2006. View Article : Google Scholar : PubMed/NCBI

114 

Zheng H, Saito H, Masuda S, Yang X and Takano Y: Phosphorylated GSK3beta-ser9 and EGFR are good prognostic factors for lung carcinomas. Anticancer Res. 27:3561–3569. 2007.PubMed/NCBI

115 

Oren M: Decision making by p53: Life, death and cancer. Cell Death Differ. 10:431–442. 2003. View Article : Google Scholar : PubMed/NCBI

116 

Gao S, Brown J, Wang H and Feng X: The role of glycogen synthase kinase 3-β in immunity and cell cycle: Implications in esophageal cancer. Arch Immunol Ther Exp (Warsz). 62:131–144. 2014. View Article : Google Scholar : PubMed/NCBI

117 

Maneckjee R, Biswas R and Vonderhaar BK: Binding of opioids to human MCF-7 breast cancer cells and their effects on growth. Cancer Res. 50:2234–2238. 1990.PubMed/NCBI

118 

Hatzoglou A, Bakogeorgou E and Castanas E: The antiproliferative effect of opioid receptor agonists on the T47D human breast cancer cell line, is partially mediated through opioid receptors. Eur J Pharmacol. 296:199–207. 1996. View Article : Google Scholar : PubMed/NCBI

119 

Montagna G, Gupta HV, Hannum M, Tan KS, Lee J, Scarpa JR, Plitas G, Irie T, McCormick PJ, Fischer GW, et al: Intraoperative opioids are associated with improved recurrence-free survival in triple-negative breast cancer. Br J Anaesth. 126:367–376. 2021. View Article : Google Scholar : PubMed/NCBI

120 

Abnet CC, Arnold M and Wei WQ: Epidemiology of esophageal squamous cell carcinoma. Gastroenterology. 154:360–373. 2018. View Article : Google Scholar : PubMed/NCBI

121 

Zylla D, Gourley BL, Vang D, Jackson S, Boatman S, Lindgren B, Kuskowski MA, Le C, Gupta K and Gupta P: Opioid requirement, opioid receptor expression, and clinical outcomes in patients with advanced prostate cancer. Cancer. 119:4103–4110. 2013. View Article : Google Scholar : PubMed/NCBI

122 

Harper P, Hald O, Lwaleed BA, Kyyaly A, Johnston D, Cooper AJ and Birch B: The impact of morphine treatment on bladder cancer cell proliferation and apoptosis: In vitro studies. Exp Oncol. 40:190–193. 2018. View Article : Google Scholar : PubMed/NCBI

123 

Moon TD: The effect of opiates upon prostatic carcinoma cell growth. Biochem Biophys Res Commun. 153:722–727. 1988. View Article : Google Scholar : PubMed/NCBI

124 

Kampa M, Bakogeorgou E, Hatzoglou A, Damianaki A, Martin PM and Castanas E: Opioid alkaloids and casomorphin peptides decrease the proliferation of prostatic cancer cell lines (LNCaP, PC3 and DU145) through a partial interaction with opioid receptors. Eur J Pharmacol. 335:255–265. 1997. View Article : Google Scholar : PubMed/NCBI

125 

Kampa M, Loukas S, Tsapis A and Castanas E: Receptorphin: A conserved peptide derived from the sequence of the opioid receptor, with opioid displacement activity and potent antiproliferative actions in tumor cells. BMC Pharmacol. 1:92001. View Article : Google Scholar : PubMed/NCBI

126 

Yamashita H, Shuman L, Warrick JI, Raman JD and Degraff DJ: Androgen represses opioid growth factor receptor (OGFR) in human prostate cancer LNCaP cells and OGFR expression in human prostate cancer tissue. Am J Clin Exp Urol. 6:164–171. 2018.PubMed/NCBI

127 

Lec PM, Lenis AT, Golla V, Brisbane W, Shuch, Garraway IP, Reiter RE and Chamie K: The role of opioids and their receptors in urological malignancy: A review. J Urol. 204:1150–1159. 2020. View Article : Google Scholar : PubMed/NCBI

128 

Goodenberger ML and Jenkins RB: Genetics of adult glioma. Cancer Genet. 205:613–621. 2012. View Article : Google Scholar : PubMed/NCBI

129 

Bohn LM, Belcheva MM and Coscia CJ: Evidence for kappa- and mu-opioid receptor expression in C6 glioma cells. J Neurochem. 70:1819–1825. 1998. View Article : Google Scholar : PubMed/NCBI

130 

Remmers AE, Clark MJ, Mansour A, Akil H, Woods JH and Medzihradsky F: Opioid efficacy in a C6 glioma cell line stably expressing the human kappa opioid receptor. J Pharmacol Exp Ther. 288:827–833. 1999.PubMed/NCBI

131 

Giakoumettis D, Kritis A and Foroglou N: C6 cell line: The gold standard in glioma research. Hippokratia. 22:105–112. 2018.PubMed/NCBI

132 

Bohn LM, Belcheva MM and Coscia CJ: Mitogenic signaling via endogenous kappa-opioid receptors in C6 glioma cells: Evidence for the involvement of protein kinase C and the mitogen-activated protein kinase signaling cascade. J Neurochem. 74:564–573. 2000. View Article : Google Scholar : PubMed/NCBI

133 

Bohn LM, Belcheva MM and Coscia CJ: Mu-opioid agonist inhibition of kappa-opioid receptor-stimulated extracellular signal-regulated kinase phosphorylation is dynamin-dependent in C6 glioma cells. J Neurochem. 74:574–581. 2000. View Article : Google Scholar : PubMed/NCBI

134 

Kampa M, Margioris AN, Hatzoglou A, Dermitzaki I, Denizot A, Henry JF, Oliver C, Gravanis A and Castanas E: Kappa1-opioid binding sites are the dominant opioid binding sites in surgical specimens of human pheochromocytomas and in a human pheochromocytoma (KAT45) cell line. Eur J Pharmacol. 364:255–262. 1999. View Article : Google Scholar : PubMed/NCBI

135 

Venihaki M, Gravanis A and Margioris AN: Kappa opioids exert a strong antiproliferative effect on PC12 rat pheochromocytoma cells. Peptides. 17:413–419. 1996. View Article : Google Scholar : PubMed/NCBI

136 

Takekoshi K, Ishii K, Kawakami Y, Isobe K and Nakai T: kappa-Opioid inhibits catecholamine biosynthesis in PC12 rat pheochromocytoma cell. FEBS Lett. 477:273–277. 2000. View Article : Google Scholar : PubMed/NCBI

137 

Chatzaki E, Margioris AN, Makrigiannakis A, Castanas E, Georgoulias V and Gravanis A: Kappa opioids and TGFbeta1 interact in human endometrial cells. Mol Hum Reprod. 6:602–609. 2000. View Article : Google Scholar : PubMed/NCBI

138 

Li WW, Zhao WJ, Yang Y and Yang YM: Effects of TGF-β1 on the expression of endometrial stromal cell-related protein and mRNA. Eur Rev Med Pharmacol Sci. 24:11475–11480. 2020.PubMed/NCBI

139 

Chatzaki E, Kouimtzoglou E, Margioris AN and Gravanis A: Transforming growth factor beta1 exerts an autocrine regulatory effect on human endometrial stromal cell apoptosis, involving the FasL and Bcl-2 apoptotic pathways. Mol Hum Reprod. 9:91–95. 2003. View Article : Google Scholar : PubMed/NCBI

140 

Chamouard P, Klein A, Martin E, Adloff M and Angel F: Regulatory role of enteric kappa opioid receptors in human colonic motility. Life Sci. 53:1149–1156. 1993. View Article : Google Scholar : PubMed/NCBI

141 

Sherman SK, Maxwell JE, Carr JC, Wang D, Bellizzi AM, O'Dorisio MS, O'Dorisio TM and Howe JR: Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors. Clin Exp Metastasis. 31:935–944. 2014. View Article : Google Scholar : PubMed/NCBI

142 

Li T, Kang G, Wang T and Huang H: Tumor angiogenesis and anti-angiogenic gene therapy for cancer. Oncol Lett. 16:687–702. 2018.PubMed/NCBI

143 

Mody K, Baldeo C and Bekaii-Saab T: Antiangiogenic therapy in colorectal cancer. Cancer J. 24:165–170. 2018. View Article : Google Scholar : PubMed/NCBI

144 

Al-Husein B, Abdalla M, Trepte M, Deremer DL and Somanath PR: Antiangiogenic therapy for cancer: An update. Pharmacotherapy. 32:1095–1111. 2012. View Article : Google Scholar : PubMed/NCBI

145 

Carmeliet P: VEGF as a key mediator of angiogenesis in cancer. Oncology. 69 (Suppl 3):S4–S10. 2005. View Article : Google Scholar

146 

Olejarz W, Kubiak-Tomaszewska G, Chrzanowska A and Lorenc T: Exosomes in angiogenesis and anti-angiogenic therapy in cancers. Int J Mol Sci. 21:58402020. View Article : Google Scholar : PubMed/NCBI

147 

Pujade-Lauraine E, Hilpert F, Weber B, Reuss A, Poveda A, Kristensen G, Sorio R, Vergote I, Witteveen P, Bamias A, et al: Bevacizumab combined with chemotherapy for platinum-resistant recurrent ovarian cancer: The AURELIA open-label randomized phase III trial. J Clin Oncol. 32:1302–1308. 2014. View Article : Google Scholar : PubMed/NCBI

148 

Heinemann V, von Weikersthal LF, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran SE, Heintges T, Lerchenmüller C, Kahl C, Seipelt G, et al: FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): A randomised, open-label, phase 3 trial. Lancet Oncol. 15:1065–1075. 2014. View Article : Google Scholar : PubMed/NCBI

149 

Rini BI, Bellmunt J, Clancy J, Wang K, Niethammer AG, Hariharan S and Escudier B: Randomized phase III trial of temsirolimus and bevacizumab versus interferon alfa and bevacizumab in metastatic renal cell carcinoma: INTORACT trial. J Clin Oncol. 32:752–759. 2014. View Article : Google Scholar : PubMed/NCBI

150 

Bear HD, Tang G, Rastogi P, Geyer CE Jr, Liu Q, Robidoux A, Baez-Diaz L, Brufsky AM, Mehta RS, Fehrenbacher L, et al: Neoadjuvant plus adjuvant bevacizumab in early breast cancer [NSABP B-40 (NRG Oncology)]: Secondary outcomes of a phase 3, randomised controlled trial. Lancet Oncol. 16:1037–1048. 2015. View Article : Google Scholar : PubMed/NCBI

151 

Yamamizu K, Furuta S, Hamada Y, Yamashita A, Kuzumaki N and Narita M, Doi K, Katayama S, Nagase H, Yamashita JK and Narita M: к Opioids inhibit tumor angiogenesis by suppressing VEGF signaling. Sci Rep. 3:32132013. View Article : Google Scholar : PubMed/NCBI

152 

Yamamizu K and Yamashita JK: Roles of cyclic adenosine monophosphate signaling in endothelial cell differentiation and arterial-venous specification during vascular development. Circ J. 75:253–260. 2011. View Article : Google Scholar : PubMed/NCBI

153 

Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS and Pujari VB: Inflammation and cancer. Ann Afr Med. 18:121–126. 2019. View Article : Google Scholar : PubMed/NCBI

154 

Elinav E, Nowarski R, Thaiss CA, Hu B, Jin C and Flavell RA: Inflammation-induced cancer: Crosstalk between tumours, immune cells and microorganisms. Nat Rev Cancer. 13:759–771. 2013. View Article : Google Scholar : PubMed/NCBI

155 

Chuang TK, Killam KF Jr, Chuang LF, Kung HF, Sheng WS, Chao CC, Yu L and Chuang RY: Mu opioid receptor gene expression in immune cells. Biochem Biophys Res Commun. 216:922–930. 1995. View Article : Google Scholar : PubMed/NCBI

156 

Kao TK, Ou YC, Liao SL, Chen WY, Wang CC, Chen SY, Chiang AN and Chen CJ: Opioids modulate post-ischemic progression in a rat model of stroke. Neurochem Int. 52:1256–1265. 2008. View Article : Google Scholar : PubMed/NCBI

157 

Zhang P, Yang M, Chen C, Liu L, Wei X and Zeng S: Toll-Like receptor 4 (TLR4)/opioid receptor pathway crosstalk and impact on opioid analgesia, immune function, and gastrointestinal motility. Front Immunol. 11:14552020. View Article : Google Scholar : PubMed/NCBI

158 

Eisenstein TK: The role of opioid receptors in immune system function. Front Immunol. 10:29042019. View Article : Google Scholar : PubMed/NCBI

159 

Finley MJ, Happel CM, Kaminsky DE and Rogers TJ: Opioid and nociceptin receptors regulate cytokine and cytokine receptor expression. Cell Immunol. 252:146–154. 2008. View Article : Google Scholar : PubMed/NCBI

160 

Multhoff G and Vaupel P: Hypoxia compromises anti-cancer immune responses. Adv Exp Med Biol. 1232:131–143. 2020. View Article : Google Scholar : PubMed/NCBI

161 

Dehne N, Mora J, Namgaladze D, Weigert A and Brüne B: Cancer cell and macrophage cross-talk in the tumor microenvironment. Curr Opin Pharmacol. 35:12–19. 2017. View Article : Google Scholar : PubMed/NCBI

162 

Xi C, Liang X, Chen C, Babazada H, Li T and Liu R: Hypoxia induces internalization of κ-opioid receptor. Anesthesiology. 126:842–854. 2017. View Article : Google Scholar : PubMed/NCBI

163 

Babcock J, Herrera A, Coricor G, Karch C, Liu AH, Rivera-Gines A and Ko JL: Mechanism governing human kappa-opioid receptor expression under desferrioxamine-induced hypoxic mimic condition in neuronal NMB cells. Int J Mol Sci. 18:2112017. View Article : Google Scholar : PubMed/NCBI

164 

Brownstein MJ: A brief history of opiates, opioid peptides, and opioid receptors. Proc Natl Acad Sci USA. 90:5391–5393. 1993. View Article : Google Scholar : PubMed/NCBI

165 

Meuser T, Pietruck C, Radbruch L, Stute P, Lehmann KA and Grond S: Symptoms during cancer pain treatment following WHO-guidelines: A longitudinal follow-up study of symptom prevalence, severity and etiology. Pain. 93:247–257. 2001. View Article : Google Scholar : PubMed/NCBI

166 

Zylla D, Steele G and Gupta P: A systematic review of the impact of pain on overall survival in patients with cancer. Support Care Cancer. 25:1687–1698. 2017. View Article : Google Scholar : PubMed/NCBI

167 

Boland JW and Pockley AG: Influence of opioids on immune function in patients with cancer pain: From bench to bedside. Br J Pharmacol. 175:2726–2736. 2018. View Article : Google Scholar : PubMed/NCBI

168 

Juneja R: Opioids and cancer recurrence. Curr Opin Support Palliat Care. 8:91–101. 2014. View Article : Google Scholar : PubMed/NCBI

169 

Amaram-Davila J, Davis M and Reddy A: Opioids and cancer mortality. Curr Treat Options Oncol. 21:222020. View Article : Google Scholar : PubMed/NCBI

170 

Fujiwara Y, Yamamoto H and Monden M: Molecular biology-based surgery for the future progress of cancer treatment. Nihon Geka Gakkai Zasshi. 103:278–283. 2002.(In Japanese). PubMed/NCBI

171 

Hashizume M and Tsugawa K: Robotic surgery and cancer: The present state, problems and future vision. Jpn J Clin Oncol. 34:227–237. 2004. View Article : Google Scholar : PubMed/NCBI

172 

Baskar R, Lee KA, Yeo R and Yeoh KW: Cancer and radiation therapy: Current advances and future directions. Int J Med Sci. 9:193–199. 2012. View Article : Google Scholar : PubMed/NCBI

173 

Lee YT, Tan YJ and Oon CE: Molecular targeted therapy: Treating cancer with specificity. Eur J Pharmacol. 834:188–196. 2018. View Article : Google Scholar : PubMed/NCBI

174 

Cross D and Burmester JK: Gene therapy for cancer treatment: Past, present and future. Clin Med Res. 4:218–227. 2006. View Article : Google Scholar : PubMed/NCBI

175 

Chen WK and Miao CH: The effect of anesthetic technique on survival in human cancers: A meta-analysis of retrospective and prospective studies. PLoS One. 8:e565402013. View Article : Google Scholar : PubMed/NCBI

176 

Gach K, Wyrębska A, Fichna J and Janecka A: The role of morphine in regulation of cancer cell growth. Naunyn Schmiedebergs Arch Pharmacol. 384:221–230. 2011. View Article : Google Scholar : PubMed/NCBI

177 

Forget P, Aguirre JA, Bencic I, Borgeat A, Cama A, Condron C, Eintrei C, Eroles P, Gupta A, Hales TG, et al: How anesthetic, analgesic and other non-surgical techniques during cancer surgery might affect postoperative oncologic outcomes: A summary of current state of evidence. Cancers (Basel). 11:5922019. View Article : Google Scholar : PubMed/NCBI

178 

Liu B, Liu Y, Li N, Zhang J and Zhang X: Oxycodone regulates incision-induced activation of neurotrophic factors and receptors in an acute post-surgery pain rat model. J Pain Res. 11:2663–2674. 2018. View Article : Google Scholar : PubMed/NCBI

179 

Ji J, Lin W, Vrudhula A, Xi J, Yeliseev A, Grothusen JR, Bu W and Liu R: Molecular interaction between butorphanol and κ-opioid receptor. Anesth Analg. 131:935–942. 2020. View Article : Google Scholar : PubMed/NCBI

180 

Tian M, Jin L, Li R, Zhu S, Ji M and Li W: Comparison of oxycodone and morphine on the proliferation, apoptosis and expression of related molecules in the A549 human lung adenocarcinoma cell line. Exp Ther Med. 12:559–566. 2016. View Article : Google Scholar : PubMed/NCBI

181 

Yu Y, Li D, Duan J, Xu H, Li L, Tan D and Yan H: The pro- and anti-cancer effects of oxycodone are associated with epithelial growth factor receptor level in cancer cells. Biosci Rep. 40:BSR201935242020. View Article : Google Scholar : PubMed/NCBI

182 

Gery S, Yin D, Xie D, Black KL and Koeffler HP: TMEFF1 and brain tumors. Oncogene. 22:2723–2727. 2003. View Article : Google Scholar : PubMed/NCBI

183 

Nie X, Gao L, Zheng M, Wang C, Wang S, Li X, Qi Y, Zhu L, Liu J and Lin B: Overexpression of TMEFF1 in endometrial carcinoma and the mechanism underlying its promotion of malignant behavior in cancer cells. J Cancer. 12:5772–5788. 2021. View Article : Google Scholar : PubMed/NCBI

184 

Nie X, Liu C, Guo Q, Zheng MJ, Gao LL, Li X, Liu DW, Zhu LC, Liu JJ and Lin B: TMEFF1 overexpression and its mechanism for tumor promotion in ovarian cancer. Cancer Manag Res. 11:839–855. 2019. View Article : Google Scholar : PubMed/NCBI

185 

Wang B, Li Y, Shen Y, Xu Y and Zhang C: Butorphanol inhibits the malignant biological behaviors of ovarian cancer cells via down-regulating the expression of TMEFF1. Onco Targets Ther. 13:10973–10981. 2020. View Article : Google Scholar : PubMed/NCBI

186 

Ramirez MF, Gorur A and Cata JP: Opioids and cancer prognosis: A summary of the clinical evidence. Neurosci Lett. 746:1356612021. View Article : Google Scholar : PubMed/NCBI

187 

Wang YH, Sun JF, Tao YM, Chi ZQ and Liu JG: The role of kappa-opioid receptor activation in mediating antinociception and addiction. Acta Pharmacol Sin. 31:1065–1070. 2010. View Article : Google Scholar : PubMed/NCBI

188 

Torre LA, Siegel RL, Ward EM and Jemal A: Global cancer incidence and mortality rates and trends-an update. Cancer Epidemiol Biomarkers Prev. 25:16–27. 2016. View Article : Google Scholar : PubMed/NCBI

189 

Ramirez MF, Gorur A and Cata JP: The role of opioids in cancer progression. Int Anesthesiol Clin Spring. 58:57–63. 2020. View Article : Google Scholar : PubMed/NCBI

190 

Rodrigue D, Winkelmann J, Price M, Kalandranis E, Klempner L and Kapoor-Hintzen N: Opioid misuse: An organizational response while managing cancer-related pain. Clin J Oncol Nurs. 24:170–176. 2020. View Article : Google Scholar : PubMed/NCBI

191 

Schmidhammer H, Erli F, Guerrieri E and Spetea M: Development of diphenethylamines as selective kappa opioid receptor ligands and their pharmacological activities. Molecules. 25:50922020. View Article : Google Scholar : PubMed/NCBI

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Zhou Q, Zhang Z, Long S, Li W, Wang B and Liang N: Opioids in cancer: The κ‑opioid receptor (Review). Mol Med Rep 25: 44, 2022.
APA
Zhou, Q., Zhang, Z., Long, S., Li, W., Wang, B., & Liang, N. (2022). Opioids in cancer: The κ‑opioid receptor (Review). Molecular Medicine Reports, 25, 44. https://doi.org/10.3892/mmr.2021.12560
MLA
Zhou, Q., Zhang, Z., Long, S., Li, W., Wang, B., Liang, N."Opioids in cancer: The κ‑opioid receptor (Review)". Molecular Medicine Reports 25.2 (2022): 44.
Chicago
Zhou, Q., Zhang, Z., Long, S., Li, W., Wang, B., Liang, N."Opioids in cancer: The κ‑opioid receptor (Review)". Molecular Medicine Reports 25, no. 2 (2022): 44. https://doi.org/10.3892/mmr.2021.12560
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Spandidos Publications style
Zhou Q, Zhang Z, Long S, Li W, Wang B and Liang N: Opioids in cancer: The κ‑opioid receptor (Review). Mol Med Rep 25: 44, 2022.
APA
Zhou, Q., Zhang, Z., Long, S., Li, W., Wang, B., & Liang, N. (2022). Opioids in cancer: The κ‑opioid receptor (Review). Molecular Medicine Reports, 25, 44. https://doi.org/10.3892/mmr.2021.12560
MLA
Zhou, Q., Zhang, Z., Long, S., Li, W., Wang, B., Liang, N."Opioids in cancer: The κ‑opioid receptor (Review)". Molecular Medicine Reports 25.2 (2022): 44.
Chicago
Zhou, Q., Zhang, Z., Long, S., Li, W., Wang, B., Liang, N."Opioids in cancer: The κ‑opioid receptor (Review)". Molecular Medicine Reports 25, no. 2 (2022): 44. https://doi.org/10.3892/mmr.2021.12560
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