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Weilan gum oligosaccharide ameliorates dextran sulfate sodium‑induced experimental ulcerative colitis

  • Authors:
    • Ping Zhang
    • Le Su
    • Feifan Ma
    • Xiuyu Ji
    • Yue Su
    • Qiulin Yue
    • Chen Zhao
    • Song Zhang
    • Xin Sun
    • Lin Zhao
  • View Affiliations / Copyright

    Affiliations: State Key Laboratory of Biobased Material and Green Papermaking, School of Bioengineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan, Shandong 250353, P.R. China, Shandong Provincial Key Laboratory of Food and Fermentation Engineering, Shandong Food Ferment Industry Research and Design Institute, Qilu University of Technology, Shandong Academy of Sciences, Jinan, Shandong 250013, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 52
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    Published online on: December 13, 2021
       https://doi.org/10.3892/mmr.2021.12568
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Abstract

Ulcerative colitis (UC) is a global disease, characterized by periods of relapse that seriously affects the quality of life of patients. Oligosaccharides are considered to be a prospective strategy to alleviate the symptoms of UC. The present study aimed to evaluate the effect of weilan gum oligosaccharide (WLGO) on a mouse UC model induced by dextran sulfate sodium (DSS). WLGO structural physical properties were characterized by electrospray mass spectrometry and fourier tansform infrared spectroscopy. MTT assays were performed to evaluate the non‑toxic concentration of WLGO. RT‑qPCR and ELISAs were conducted to determine the levels of inflammatory factors. The clinical symptoms and mucosal integrity of the DSS‑induced UC model were assessed by DAI and histological assessment. LPS‑induced Caco‑2 cells and DSS‑induced UC mice were used to explore the effects of WLGO on UC. Treatment of the mice with 4.48 g/kg/day WLGO via gavage for 7 days significantly relieved the symptoms of DSS‑induced UC model mice, whereas significant effects were not observed for all symptoms of DSS‑induced UC in the WLGO‑low group. The disease activity index score was decreased and the loss of body weight was reduced in DSS‑induced UC model mice treated with WLGO. Moreover, colonic damage and abnormally short colon length shortenings were relieved following WLGO treatment. WLGO treatment also reduced the concentration and mRNA expression levels of proinflammatory cytokines, including interleukin‑1β, interleukin‑6 and tumor necrosis factor α, in DSS‑induced UC model mice and lipopolysaccharide‑treated Caco‑2 cells. These results indicated that WLGO may be an effective strategy for UC treatment.
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Copy and paste a formatted citation
Spandidos Publications style
Zhang P, Su L, Ma F, Ji X, Su Y, Yue Q, Zhao C, Zhang S, Sun X, Zhao L, Zhao L, et al: Weilan gum oligosaccharide ameliorates dextran sulfate sodium‑induced experimental ulcerative colitis. Mol Med Rep 25: 52, 2022.
APA
Zhang, P., Su, L., Ma, F., Ji, X., Su, Y., Yue, Q. ... Zhao, L. (2022). Weilan gum oligosaccharide ameliorates dextran sulfate sodium‑induced experimental ulcerative colitis. Molecular Medicine Reports, 25, 52. https://doi.org/10.3892/mmr.2021.12568
MLA
Zhang, P., Su, L., Ma, F., Ji, X., Su, Y., Yue, Q., Zhao, C., Zhang, S., Sun, X., Zhao, L."Weilan gum oligosaccharide ameliorates dextran sulfate sodium‑induced experimental ulcerative colitis". Molecular Medicine Reports 25.2 (2022): 52.
Chicago
Zhang, P., Su, L., Ma, F., Ji, X., Su, Y., Yue, Q., Zhao, C., Zhang, S., Sun, X., Zhao, L."Weilan gum oligosaccharide ameliorates dextran sulfate sodium‑induced experimental ulcerative colitis". Molecular Medicine Reports 25, no. 2 (2022): 52. https://doi.org/10.3892/mmr.2021.12568
Copy and paste a formatted citation
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Spandidos Publications style
Zhang P, Su L, Ma F, Ji X, Su Y, Yue Q, Zhao C, Zhang S, Sun X, Zhao L, Zhao L, et al: Weilan gum oligosaccharide ameliorates dextran sulfate sodium‑induced experimental ulcerative colitis. Mol Med Rep 25: 52, 2022.
APA
Zhang, P., Su, L., Ma, F., Ji, X., Su, Y., Yue, Q. ... Zhao, L. (2022). Weilan gum oligosaccharide ameliorates dextran sulfate sodium‑induced experimental ulcerative colitis. Molecular Medicine Reports, 25, 52. https://doi.org/10.3892/mmr.2021.12568
MLA
Zhang, P., Su, L., Ma, F., Ji, X., Su, Y., Yue, Q., Zhao, C., Zhang, S., Sun, X., Zhao, L."Weilan gum oligosaccharide ameliorates dextran sulfate sodium‑induced experimental ulcerative colitis". Molecular Medicine Reports 25.2 (2022): 52.
Chicago
Zhang, P., Su, L., Ma, F., Ji, X., Su, Y., Yue, Q., Zhao, C., Zhang, S., Sun, X., Zhao, L."Weilan gum oligosaccharide ameliorates dextran sulfate sodium‑induced experimental ulcerative colitis". Molecular Medicine Reports 25, no. 2 (2022): 52. https://doi.org/10.3892/mmr.2021.12568
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