Phytochemical‑rich herbal formula ATG‑125 protects against sucrose‑induced gastrocnemius muscle atrophy by rescuing Akt signaling and improving mitochondrial dysfunction in young adult mice
- Authors:
- Ching-Chuan Yeh
- Hsuan-Miao Liu
- Ming-Chung Lee
- Yann-Lii Leu
- Wei-Han Chiang
- Hen-Hong Chang
- Tzung-Yan Lee
-
Affiliations: Graduate Institute of Traditional Chinese Medicine, School of Chinese Medicine, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan, R.O.C., Brion Research Institute of Taiwan, New Taipei City 23143, Taiwan, R.O.C., Graduate Institute of Nature Products, College of Medicine, Chang Gung University, Taoyuan 33302, Taiwan, R.O.C., Department of Rehabilitation, Cheng‑Hsin General Hospital, Taipei 11283, Taiwan, R.O.C., Graduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan, R.O.C. - Published online on: December 15, 2021 https://doi.org/10.3892/mmr.2021.12572
- Article Number: 57
-
Copyright: © Yeh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Lynch GS, Schertzer JD and Ryall JG: Therapeutic approaches for muscle wasting disorders. Pharmacol Ther. 113:461–487. 2007. View Article : Google Scholar : PubMed/NCBI | |
Bonaldo P and Sandri M: Cellular and molecular mechanisms of muscle atrophy. Dis Model Mech. 6:25–39. 2013. View Article : Google Scholar : PubMed/NCBI | |
Ferrucci L and Guralnik JM: Inflammation, hormones, and body composition at a crossroad. Am J Med. 115:501–502. 2003. View Article : Google Scholar : PubMed/NCBI | |
Pedersen BK and Bruunsgaard H: Possible beneficial role of exercise in modulating low-grade inflammation in the elderly. Scand J Med Sci Sports. 13:56–62. 2003. View Article : Google Scholar : PubMed/NCBI | |
Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E and De Benedictis G: Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci. 908:244–254. 2000. View Article : Google Scholar : PubMed/NCBI | |
Ali S and Garcia JM: Sarcopenia, cachexia and aging: Diagnosis, mechanisms and therapeutic options-a mini-review. Gerontology. 60:294–305. 2014. View Article : Google Scholar : PubMed/NCBI | |
Costamagna D, Costelli P, Sampaolesi M and Penna F: Role of Inflammation in muscle homeostasis and myogenesis. Mediators Inflamm. 2015:8051722015. View Article : Google Scholar : PubMed/NCBI | |
Milan G, Romanello V, Pescatore F, Armani A, Paik JH, Frasson L, Seydel A, Zhao J, Abraham R, Goldberg AL, et al: Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy. Nat Commun. 6:66702015. View Article : Google Scholar : PubMed/NCBI | |
Gregor MF and Hotamisligil GS: Inflammatory mechanisms in obesity. Annu Rev Immunol. 29:415–445. 2011. View Article : Google Scholar : PubMed/NCBI | |
Glass CK and Olefsky JM: Inflammation and lipid signaling in the etiology of insulin resistance. Cell Metab. 15:635–645. 2012. View Article : Google Scholar : PubMed/NCBI | |
Olefsky JM and Glass CK: Macrophages, inflammation, and insulin resistance. Annu Rev Physiol. 72:219–246. 2010. View Article : Google Scholar : PubMed/NCBI | |
Perry BD, Caldow MK, Brennan-Speranza TC, Sbaraglia M, Jerums G, Garnham A, Wong C, Levinger P, Asrar Ul Haq M, Hare DL, et al: Muscle atrophy in patients with Type 2 Diabetes Mellitus: Roles of inflammatory pathways, physical activity and exercise. Exerc Immunol Rev. 22:94–109. 2016.PubMed/NCBI | |
Maliszewska K, Adamska-Patruno E and Krętowski A: The interplay between muscle mass decline, obesity, and type 2 diabetes. Pol Arch Intern Med. 129:809–816. 2019.PubMed/NCBI | |
Monier S, Le Cam A and Le Marchand-Brustel Y: Insulin and insulin-like growth factor I. Effects on protein synthesis in isolated muscles from lean and goldthioglucose-obese mice. Diabetes. 32:392–397. 1983. View Article : Google Scholar : PubMed/NCBI | |
Rommel C, Bodine SC, Clarke BA, Rossman R, Nunez L, Stitt TN, Yancopoulos GD and Glass DJ: Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways. Nat Cell Biol. 3:1009–1013. 2001. View Article : Google Scholar : PubMed/NCBI | |
Sacheck JM, Ohtsuka A, McLary SC and Goldberg AL: IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am J Physiol Endocrinol Metab. 287:E591–E601. 2004. View Article : Google Scholar : PubMed/NCBI | |
de Alvaro C, Teruel T, Hernandez R and Lorenzo M: Tumor necrosis factor alpha produces insulin resistance in skeletal muscle by activation of inhibitor kappaB kinase in a p38 MAPK-dependent manner. J Biol Chem. 279:17070–17078. 2004. View Article : Google Scholar : PubMed/NCBI | |
Dogra C, Changotra H, Wedhas N, Qin X, Wergedal JE and Kumar A: TNF-related weak inducer of apoptosis (TWEAK) is a potent skeletal muscle-wasting cytokine. FASEB J. 21:1857–1869. 2007. View Article : Google Scholar : PubMed/NCBI | |
Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M and Hotamisligil GS: A central role for JNK in obesity and insulin resistance. Nature. 420:333–336. 2002. View Article : Google Scholar : PubMed/NCBI | |
Peterson JM, Bakkar N and Guttridge DC: NF-κB signaling in skeletal muscle health and disease. Curr Top Dev Biol. 96:85–119. 2011. View Article : Google Scholar : PubMed/NCBI | |
Törrönen R, Kolehmainen M, Sarkkinen E, Mykkänen H and Niskanen L: Postprandial glucose, insulin, and free fatty acid responses to sucrose consumed with blackcurrants and lingonberries in healthy women. Am J Clin Nutr. 96:527–533. 2012. View Article : Google Scholar : PubMed/NCBI | |
Abdullah A, Peeters A, de Courten M and Stoelwinder J: The magnitude of association between overweight and obesity and the risk of diabetes: A meta-analysis of prospective cohort studies. Diabetes Res Clin Pract. 89:309–319. 2010. View Article : Google Scholar : PubMed/NCBI | |
Boden G: Obesity and free fatty acids. Endocrinol Metab Clin North Am. 37:635–646, viii-ix. 2008. View Article : Google Scholar : PubMed/NCBI | |
K S, Senthilkumar GP, Sankar P and Bobby Z: Attenuation of oxidative stress, inflammation and insulin resistance by allium sativum in fructose-fed male rats. J Clin Diagn Res. 7:1860–1862. 2013.PubMed/NCBI | |
Hwang IS, Ho H, Hoffman BB and Reaven GM: Fructose-induced insulin resistance and hypertension in rats. Hypertension. 10:512–516. 1987. View Article : Google Scholar : PubMed/NCBI | |
Gatineau E, Savary-Auzeloux I, Migné C, Polakof S, Dardevet D and Mosoni L: Chronic intake of sucrose accelerates sarcopenia in older male rats through alterations in insulin sensitivity and muscle protein synthesis. J Nutr. 145:923–930. 2015. View Article : Google Scholar : PubMed/NCBI | |
Shin MS, Lee J, Lee JW, Park SH, Lee IK, Choi JA, Lee JS and Kang KS: Anti-Inflammatory effect of Artemisia argyi on Ethanol-Induced gastric ulcer: Analytical in vitro and in vivo studies for the identification of action mechanism and active compounds. Plants (Basel). 10:3322021. View Article : Google Scholar : PubMed/NCBI | |
Gao XH, Zhang SD, Wang LT, Yu L, Zhao XL, Ni HY, Wang YQ, Wang JD, Shan CH and Fu YJ: Anti-Inflammatory effects of neochlorogenic acid extract from mulberry leaf (Morus alba L.) against LPS-Stimulated inflammatory response through mediating the AMPK/Nrf2 signaling pathway in A549 Cells. Molecules. 25:13852020. View Article : Google Scholar : PubMed/NCBI | |
Hu PF, Sun FF and Qian J: Leonurine exerts Anti-Catabolic and Anti-apoptotic effects via nuclear factor kappa B (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways in chondrocytes. Med Sci Monit. 25:6271–6280. 2019. View Article : Google Scholar : PubMed/NCBI | |
Cho SY, Kim HW, Lee MK, Kim HJ, Kim JB, Choe JS, Lee YM and Jang HH: Antioxidant and Anti-Inflammatory activities in relation to the flavonoids composition of pepper (Capsicum annuum L.). Antioxidants (Basel). 9:9862020. View Article : Google Scholar : PubMed/NCBI | |
Hernández-Ortega M, Ortiz-Moreno A, Hernández-Navarro MD, Chamorro-Cevallos G, Dorantes-Alvarez L and Necoechea-Mondragón H: Antioxidant, antinociceptive, and anti-inflammatory effects of carotenoids extracted from dried pepper (Capsicum annuum L.). J Biomed Biotechnol. 2012:5240192012. View Article : Google Scholar : PubMed/NCBI | |
Lai KH, Chen PJ, Chen CC, Yang SH, El-Shazly M, Chang YC, Wu YH, Wu YH, Wang YH, Hsieh HL and Hwang TL: Lophatherum gracile Brongn. attenuates neutrophilic inflammation through inhibition of JNK and calcium. J Ethnopharmacol. 264:1132242021. View Article : Google Scholar : PubMed/NCBI | |
Ti H, Mai Z, Wang Z, Zhang W, Xiao M, Yang Z and Shaw P: Bisabolane-type sesquiterpenoids from Curcuma longa L. exert anti-influenza and anti-inflammatory activities through NF-κB/MAPK and RIG-1/STAT1/2 signaling pathways. Food Funct. 12:6697–6711. 2021. View Article : Google Scholar : PubMed/NCBI | |
Memarzia A, Khazdair MR, Behrouz S, Gholamnezhad Z, Jafarnezhad M, Saadat S and Boskabady MH: Experimental and clinical reports on anti-inflammatory, antioxidant, and immunomodulatory effects of Curcuma longa and curcumin, an updated and comprehensive review. Biofactors. 47:311–350. 2021. View Article : Google Scholar : PubMed/NCBI | |
Yue SJ, Qin YF, Kang A, Tao HJ, Zhou GS, Chen YY, Jiang JQ, Tang YP and Duan JA: Total Flavonoids of Glycyrrhiza uralensis Alleviates irinotecan-induced colitis via modification of gut microbiota and fecal metabolism. Front Immunol. 12:6283582021. View Article : Google Scholar : PubMed/NCBI | |
Li M, Chai X, Wang L, Yang J and Wang Y: Study of the variation of phenolic acid and flavonoid content from fresh artemisiae argyi folium to moxa wool. Molecules. 24:46032019. View Article : Google Scholar : PubMed/NCBI | |
Zhao L, Wang D, Liu J, Yu X, Wang R, Wei Y, Wen C and Ouyang Z: Transcriptomic analysis of key genes involved in chlorogenic acid biosynthetic pathway and characterization of MaHCT from Morus alba L. Protein Expr Purif. 156:25–35. 2019. View Article : Google Scholar : PubMed/NCBI | |
Chang Y, Zhang D, Yang G, Zheng Y and Guo L: Screening of Anti-Lipase components of Artemisia argyi leaves based on Spectrum-Effect relationships and HPLC-MS/MS. Front Pharmacol. 12:6753962021. View Article : Google Scholar : PubMed/NCBI | |
Wen YQ, Gong LY, Wang L, Zhao N, Sun Q, Kamara MO, Ma HY and Meng FH: Comparative pharmacokinetics study of leonurine and stachydrine in normal rats and rats with Cold-Stagnation and Blood-Stasis primary dysmenorrhoea after the administration of Leonurus japonicus houtt electuary. J Sep Sci. 42:1725–1732. 2019. View Article : Google Scholar : PubMed/NCBI | |
Dan-Dan L, Hua-Sheng P, Yuan Z, Xian-Zhang H, Zhi-Lai Z, Da-Hui L, Li-Ping K and Lu-Qi H: Comparison of chemical components between Artemisia stolonifera and Artemisia argyi using UPLC-Q-TOF-MS. Zhongguo Zhong Yao Za Zhi. 45:4057–4064. 2020.(In Chinese). PubMed/NCBI | |
Wang ZL, Gao HM, Wang S, Zhang M, Chen K, Zhang YQ, Wang HD, Han BY, Xu LL, Song TQ, et al: Dissection of the general two-step di-C-glycosylation pathway for the biosynthesis of (iso)schaftosides in higher plants. Proc Natl Acad Sci USA. 117:30816–30823. 2020. View Article : Google Scholar : PubMed/NCBI | |
Suntornsuk L, Kasemsook S and Wongyai S: Quantitative analysis of aglycone quercetin in mulberry leaves (Morus alba L.) by capillary zone electrophoresis. Electrophoresis. 24:1236–1241. 2003. View Article : Google Scholar : PubMed/NCBI | |
Kim GD, Lee YS, Cho JY, Lee YH, Choi KJ, Lee Y, Han TH, Lee SH, Park KH and Moon JH: Comparison of the content of bioactive substances and the inhibitory effects against rat plasma oxidation of conventional and organic hot peppers (Capsicum annuum L.). J Agric Food Chem. 58:12300–12306. 2010. View Article : Google Scholar : PubMed/NCBI | |
Li S, Zhou S, Yang W and Meng D: Gastro-protective effect of edible plant Artemisia argyi in ethanol-induced rats via normalizing inflammatory responses and oxidative stress. J Ethnopharmacol. 214:207–217. 2018. View Article : Google Scholar : PubMed/NCBI | |
Chuang TY, Lien CY, Tsai YC, Lin KF, Hsu CH, Wu WJ, Su LY, Lu CW and Wu CH: Oral treatment with the Chinese herbal supplements B307 enhances muscle endurance of ICR mice after exhaustive swimming via suppressing fatigue, oxidative stress, and inflammation. Food Sci Nutr. 8:3682–3691. 2020. View Article : Google Scholar : PubMed/NCBI | |
Lien CY, Lu CW, Lin YH, Wu WJ, Hsu CH, Chuang TY, Lin KF, Chuang WC, Lee MC and Wu CH: Chinese herbal medicine, guilu erxian glue, as alternative medicine for adverse side effects of chemotherapy in Doxorubicin-Treated cell and mouse models. Evid Based Complement Alternat Med. 2021:55489682021. View Article : Google Scholar : PubMed/NCBI | |
Kato T, Iizuka K, Takao K, Horikawa Y, Kitamura T and Takeda J: ChREBP-Knockout mice show sucrose intolerance and fructose malabsorption. Nutrients. 10:3402018. View Article : Google Scholar : PubMed/NCBI | |
Burke SJ, Batdorf HM, Martin TM, Burk DH, Noland RC, Cooley CR, Karlstad MD, Johnson WD and Collier JJ: Liquid sucrose consumption promotes obesity and impairs glucose tolerance without altering circulating insulin levels. Obesity (Silver Spring). 26:1188–1196. 2018. View Article : Google Scholar : PubMed/NCBI | |
Chen YS, Liu HM and Lee TY: Ursodeoxycholic acid regulates hepatic energy homeostasis and white adipose tissue macrophages polarization in Leptin-Deficiency obese mice. Cells. 8:2532019. View Article : Google Scholar : PubMed/NCBI | |
Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI | |
Moylan JS, Smith JD, Chambers MA, McLoughlin TJ and Reid MB: TNF induction of atrogin-1/MAFbx mRNA depends on Foxo4 expression but not AKT-Foxo1/3 signaling. Am J Physiol Cell Physiol. 295:C986–C993. 2008. View Article : Google Scholar : PubMed/NCBI | |
Qian Y, Guo X, Che L, Guan X, Wu B, Lu R, Zhu M, Pang H, Yan Y, Ni Z and Gu L: Klotho reduces necroptosis by targeting oxidative stress involved in renal Ischemic-Reperfusion injury. Cell Physiol Biochem. 45:2268–2282. 2018. View Article : Google Scholar : PubMed/NCBI | |
Omede F, Zhang S, Johnson C, Daniel E, Zhang Y, Fields TA, Boulanger J, Liu S, Ahmed I, Umar S, et al: Dietary phosphate restriction attenuates polycystic kidney disease in mice. Am J Physiol Renal Physiol. 318:F35–F42. 2020. View Article : Google Scholar : PubMed/NCBI | |
Murdoch CE, Alom-Ruiz SP, Wang M, Zhang M, Walker S, Yu B, Brewer A and Shah AM: Role of endothelial Nox2 NADPH oxidase in angiotensin II-induced hypertension and vasomotor dysfunction. Basic Res Cardiol. 106:527–538. 2011. View Article : Google Scholar : PubMed/NCBI | |
Sag CM, Schnelle M, Zhang J, Murdoch CE, Kossmann S, Protti A, Santos CXC, Sawyer G, Zhang X, Mongue-Din H, et al: Distinct regulatory effects of myeloid cell and endothelial cell NAPDH oxidase 2 on blood pressure. Circulation. 135:2163–2177. 2017. View Article : Google Scholar : PubMed/NCBI | |
Yates Z, Tarling EJ, Langley-Evans SC and Salter AM: Maternal undernutrition programmes atherosclerosis in the ApoE*3-Leiden mouse. Br J Nutr. 101:1185–1194. 2009. View Article : Google Scholar : PubMed/NCBI | |
Wang CH, Liu HM, Chang ZY, Huang TH and Lee TY: Losartan prevents hepatic steatosis and macrophage polarization by inhibiting HIF-1α in a murine model of NAFLD. Int J Mol Sci. 22:78412021. View Article : Google Scholar : PubMed/NCBI | |
Huang Y, Wang J, Qua G, Wang X, Yang L and Zhong L: Lactobacillus acidophilus ATCC 4356 prevents atherosclerosis via inhibition of intestinal cholesterol absorption in apolipoprotein E-knockout mice. Appl Environ Microbiol. 80:7496–7504. 2014. View Article : Google Scholar : PubMed/NCBI | |
Jin YN, Hwang WY, Jo C and Johnson GV: Metabolic state determines sensitivity to cellular stress in Huntington disease: Normalization by activation of PPARγ. PLoS One. 7:e304062012. View Article : Google Scholar : PubMed/NCBI | |
Shimano H, Yahagi N, Amemiya-Kudo M, Hasty AH, Osuga J, Tamura Y, Shionoiri F, Iizuka Y, Ohashi K, Harada K, et al: Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes. J Biol Chem. 274:35832–35839. 1999. View Article : Google Scholar : PubMed/NCBI | |
Sung YY, Yoon T, Jang S and Kim HK: Forsythia suspensa suppresses house dust mite Extract-Induced atopic dermatitis in NC/Nga Mice. PLoS One. 11:e01676872016. View Article : Google Scholar : PubMed/NCBI | |
Saba E, Lee YS, Yang WK, Lee YY, Kim M, Woo SM, Kim K, Kwon YS, Kim TH, Kwak D, et al: Effects of a herbal formulation, KGC3P, and its individual component, nepetin, on coal fly dust-induced airway inflammation. Sci Rep. 10:140362020. View Article : Google Scholar : PubMed/NCBI | |
Kagari T, Doi H and Shimozato T: The importance of IL-1 beta and TNF-alpha, and the noninvolvement of IL-6, in the development of monoclonal antibody-induced arthritis. J Immunol. 169:1459–1466. 2002. View Article : Google Scholar : PubMed/NCBI | |
Choi BH, Ahn IS, Kim YH, Park JW, Lee SY, Hyun CK and Do MS: Berberine reduces the expression of adipogenic enzymes and inflammatory molecules of 3T3-L1 adipocyte. Exp Mol Med. 38:599–605. 2006. View Article : Google Scholar : PubMed/NCBI | |
Yang H, Liao D, Tong L, Zhong L and Wu K: MiR-373 exacerbates renal injury and fibrosis via NF-κB/MatrixMetalloproteinase-9 signaling by targeting Sirtuin1. Genomics. 111:786–792. 2019. View Article : Google Scholar : PubMed/NCBI | |
Shin H, Ma Y, Chanturiya T, Cao Q, Wang Y, Kadegowda AKG, Jackson R, Rumore D, Xue B, Shi H, et al: Lipolysis in brown adipocytes is not essential for Cold-Induced thermogenesis in mice. Cell Metab. 26:764–777.e5. 2017. View Article : Google Scholar : PubMed/NCBI | |
Thornton SM, Krolopp JE and Abbott MJ: IL-15 mediates mitochondrial activity through a PPAR δ-Dependent-PPAR α-Independent mechanism in skeletal muscle cells. PPAR Res. 2016:54658042016. View Article : Google Scholar : PubMed/NCBI | |
Luan G, Li G, Ma X, Jin Y, Hu N, Li J, Wang Z and Wang H: Dexamethasone-Induced mitochondrial dysfunction and insulin Resistance-Study in 3T3-L1 adipocytes and mitochondria isolated from mouse liver. Molecules. 24:19822019. View Article : Google Scholar : PubMed/NCBI | |
Dusaulcy R, Rancoule C, Grès S, Wanecq E, Colom A, Guigné C, van Meeteren LA, Moolenaar WH, Valet P and Saulnier-Blache JS: Adipose-specific disruption of autotaxin enhances nutritional fattening and reduces plasma lysophosphatidic acid. J Lipid Res. 52:1247–1255. 2011. View Article : Google Scholar : PubMed/NCBI | |
Bernardi S, Toffoli B, Tisato V, Bossi F, Biffi S, Lorenzon A, Zauli G, Secchiero P and Fabris B: TRAIL reduces impaired glucose tolerance and NAFLD in the high-fat diet fed mouse. Clin Sci (Lond). 132:69–83. 2018. View Article : Google Scholar : PubMed/NCBI | |
Bermúdez-Muñoz JM, Celaya AM, Hijazo-Pechero S, Wang J, Serrano M and Varela-Nieto I: G6PD overexpression protects from oxidative stress and age-related hearing loss. Aging Cell. 19:e132752020. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Sakata T, Elalieh HZ, Munson SJ, Burghardt A, Majumdar S, Halloran BP and Bikle DD: Gender differences in the response of CD-1 mouse bone to parathyroid hormone: Potential role of IGF-I. J Endocrinol. 189:279–287. 2006. View Article : Google Scholar : PubMed/NCBI | |
Al-Dwairi A, Brown AR, Pabona JM, Van TH, Hamdan H, Mercado CP, Quick CM, Wight PA, Simmen RC and Simmen FA: Enhanced gastrointestinal expression of cytosolic malic enzyme (ME1) induces intestinal and liver lipogenic gene expression and intestinal cell proliferation in mice. PLoS One. 9:e1130582014. View Article : Google Scholar : PubMed/NCBI | |
Zhao L, Li C, Liu F, Zhao Y, Liu J, Hua Y, Liu J, Huang J and Ge C: A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway. Onco Targets Ther. 10:2115–2126. 2017. View Article : Google Scholar : PubMed/NCBI | |
Deng L, Huang L, Sun Y, Heath JM, Wu H and Chen Y: Inhibition of FOXO1/3 promotes vascular calcification. Arterioscler Thromb Vasc Biol. 35:175–183. 2015. View Article : Google Scholar : PubMed/NCBI | |
Choi DH, Yang J and Kim YS: Rapamycin suppresses postnatal muscle hypertrophy induced by myostatin-inhibition accompanied by transcriptional suppression of the Akt/mTOR pathway. Biochem Biophys Rep. 17:182–190. 2019.PubMed/NCBI | |
Roselló-Díez A, Madisen L, Bastide S, Zeng H and Joyner AL: Cell-nonautonomous local and systemic responses to cell arrest enable long-bone catch-up growth in developing mice. PLoS Biol. 16:e20050862018. View Article : Google Scholar : PubMed/NCBI | |
Prieto C and Barrios D: RaNA-Seq: Interactive RNA-Seq analysis from FASTQ files to functional analysis. Bioinformatics. Nov 15–2019.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI | |
Bolger AM, Lohse M and Usadel B: Trimmomatic: A flexible trimmer for Illumina sequence data. Bioinformatics. 30:2114–2120. 2014. View Article : Google Scholar : PubMed/NCBI | |
Sahraeian SME, Mohiyuddin M, Sebra R, Tilgner H, Afshar PT, Au KF, Bani Asadi N, Gerstein MB, Wong WH, Snyder MP, et al: Gaining comprehensive biological insight into the transcriptome by performing a broad-spectrum RNA-seq analysis. Nat Commun. 8:592017. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Wang S and Li W: RSeQC: Quality control of RNA-seq experiments. Bioinformatics. 28:2184–2185. 2012. View Article : Google Scholar : PubMed/NCBI | |
Okonechnikov K, Conesa A and García-Alcalde F: Qualimap 2: Advanced multi-sample quality control for high-throughput sequencing data. Bioinformatics. 32:292–294. 2046.PubMed/NCBI | |
Liao Y, Smyth GK and Shi W: FeatureCounts: An efficient general purpose program for assigning sequence reads to genomic features. Bioinformatics. 30:923–930. 2014. View Article : Google Scholar : PubMed/NCBI | |
Varet H, Brillet-Guéguen L, Coppée JY and Dillies MA: SARTools: A DESeq2- and EdgeR-Based R pipeline for comprehensive differential analysis of RNA-Seq data. PLoS One. 11:e01570222016. View Article : Google Scholar : PubMed/NCBI | |
Holm L and Sander C: Removing near-neighbour redundancy from large protein sequence collections. Bioinformatics. 14:423–429. 1998. View Article : Google Scholar : PubMed/NCBI | |
Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc Ser C Appl Stat. 57:289–300. 1995. | |
Liu S, Cai Y, Changyong E, Sheng J and Zhang X: Screening and validation of independent predictors of poor survival in pancreatic cancer. Pathol Oncol Res. 27:16098682021. View Article : Google Scholar : PubMed/NCBI | |
Gene Ontology Consortium: The Gene Ontology project in 2008. Nucleic Acids Res. 36:D440–D444. 2008. View Article : Google Scholar : PubMed/NCBI | |
Zhu HM, Fei Q, Qian LX, Liu BL, He X and Yin L: Identification of key pathways and genes in nasopharyngeal carcinoma using bioinformatics analysis. Oncol Lett. 17:4683–4694. 2019.PubMed/NCBI | |
Deng YJ, Ren FH, Yuan WH, Zhang GZ, Wu ZL and Xie QQ: GRB10 and E2F3 as diagnostic markers of osteoarthritis and their correlation with immune infiltration. Diagnostics (Basel). 10:1712020. View Article : Google Scholar : PubMed/NCBI | |
Wu T, Hu E, Xu S, Chen M, Guo P, Dai J, Feng T, Zhou L, Tang W, Zhan L, et al: clusterProfiler 4.0: A universal enrichment tool for interpreting omics data. Innovation (N Y). 2:1001412021.PubMed/NCBI | |
Bagul PK, Middela H, Matapally S, Padiya R, Bastia T, Madhusudana K, Reddy BR, Chakravarty S and Banerjee SK: Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats. Pharmacol Res. 66:260–268. 2012. View Article : Google Scholar : PubMed/NCBI | |
Phuwamongkolwiwat P, Suzuki T, Hira T and Hara H: Fructooligosaccharide augments benefits of quercetin-3-O-β-glucoside on insulin sensitivity and plasma total cholesterol with promotion of flavonoid absorption in sucrose-fed rats. Eur J Nutr. 53:457–468. 2014. View Article : Google Scholar : PubMed/NCBI | |
Marzani B, Balage M, Vénien A, Astruc T, Papet I, Dardevet D and Mosoni L: Antioxidant supplementation restores defective leucine stimulation of protein synthesis in skeletal muscle from old rats. J Nutr. 138:2205–2211. 2008. View Article : Google Scholar : PubMed/NCBI | |
Slowik A, Borratynska A, Turaj W, Pera J, Dziedzic T, Figlewicz DA, Betlej M, Krzyszkowski T, Czepko R and Szczudlik A: Alpha1-antichymotrypsin gene (SERPINA3) A/T polymorphism as a risk factor for aneurysmal subarachnoid hemorrhage. Stroke. 36:737–740. 2005. View Article : Google Scholar : PubMed/NCBI | |
O'Brien M: The reciprocal relationship between inflammation and coagulation. Top Companion Anim Med. 27:46–52. 2012. View Article : Google Scholar : PubMed/NCBI | |
Levi M: The coagulant response in sepsis and inflammation. Hamostaseologie. 30:10–12. 14–16. 2010. View Article : Google Scholar : PubMed/NCBI | |
Levi M and van der Poll T: Inflammation and coagulation. Crit Care Med. 38 (Suppl 2):S26–S34. 2010. View Article : Google Scholar : PubMed/NCBI | |
Sohn EH, Khanna A, Tucker BA, Abràmoff MD, Stone EM and Mullins RF: Structural and biochemical analyses of choroidal thickness in human donor eyes. Invest Ophthalmol Vis Sci. 55:1352–1360. 2014. View Article : Google Scholar : PubMed/NCBI | |
Nazir S, Jankowski V, Bender G, Zewinger S, Rye KA and van der Vorst EPC: Interaction between high-density lipoproteins and inflammation: Function matters more than concentration! Adv Drug Deliv Rev. 159:94–119. 2020. View Article : Google Scholar : PubMed/NCBI | |
Maïga SF, Kalopissis AD and Chabert M: Apolipoprotein A-II is a key regulatory factor of HDL metabolism as appears from studies with transgenic animals and clinical outcomes. Biochimie. 96:56–66. 2014. View Article : Google Scholar : PubMed/NCBI | |
da Silva IT, de Almeida-Pititto B and Ferreira SRG: Reassessing lipid metabolism and its potentialities in the prediction of cardiovascular risk. Arch Endocrinol Metab. 59:171–180. 2015. View Article : Google Scholar : PubMed/NCBI | |
Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM and Kelly DP: Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest. 106:847–856. 2000. View Article : Google Scholar : PubMed/NCBI | |
Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L, Ramadori G, Teodoro JS, et al: SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 15:675–690. 2012. View Article : Google Scholar : PubMed/NCBI | |
Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM and Puigserver P: PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell. 23:287–301. 2013. View Article : Google Scholar : PubMed/NCBI | |
Zhang L, Zhou Y, Wu W, Hou L, Chen H, Zuo B, Xiong Y and Yang J: Skeletal muscle-specific overexpression of PGC-1α induces Fiber-type conversion through enhanced mitochondrial respiration and fatty acid oxidation in mice and pigs. Int J Biol Sci. 13:1152–1162. 2017. View Article : Google Scholar : PubMed/NCBI | |
Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, et al: Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 418:797–801. 2002. View Article : Google Scholar : PubMed/NCBI | |
Puigserver P, Wu Z, Park CW, Graves R, Wright M and Spiegelman BM: A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 92:829–839. 1998. View Article : Google Scholar : PubMed/NCBI | |
Eisele PS, Salatino S, Sobek J, Hottiger MO and Handschin C: The peroxisome proliferator-activated receptor γ coactivator 1α/β (PGC-1) coactivators repress the transcriptional activity of NF-κB in skeletal muscle cells. J Biol Chem. 288:2246–2260. 2013. View Article : Google Scholar : PubMed/NCBI | |
Lira VA, Benton CR, Yan Z and Bonen A: PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity. Am J Physiol Endocrinol Metab. 299:E145–E161. 2010. View Article : Google Scholar : PubMed/NCBI | |
Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, Picard A, Walsh K, Schiaffino S, Lecker SH and Goldberg AL: Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell. 117:399–412. 2004. View Article : Google Scholar : PubMed/NCBI | |
Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, Kline WO, Gonzalez M, Yancopoulos GD and Glass DJ: The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell. 14:395–403. 2004. View Article : Google Scholar : PubMed/NCBI | |
Guttridge DC, Mayo MW, Madrid LV, Wang CY and Baldwin AS Jr: NF-kappaB-induced loss of MyoD messenger RNA: possible role in muscle decay and cachexia. Science. 289:2363–2366. 2000. View Article : Google Scholar : PubMed/NCBI | |
Kang C, Shin WS, Yeo D, Lim W, Zhang T and Ji LL: Anti-inflammatory effect of avenanthramides via NF-κB pathways in C2C12 skeletal muscle cells. Free Radic Biol Med. 117:30–36. 2018. View Article : Google Scholar : PubMed/NCBI | |
Solomon V and Goldberg AL: Importance of the ATP-ubiquitin-proteasome pathway in the degradation of soluble and myofibrillar proteins in rabbit muscle extracts. J Biol Chem. 271:26690–26697. 1996. View Article : Google Scholar : PubMed/NCBI | |
Scott SV and Klionsky DJ: Delivery of proteins and organelles to the vacuole from the cytoplasm. Curr Opin Cell Biol. 10:523–529. 1998. View Article : Google Scholar : PubMed/NCBI | |
Lecker SH, Goldberg AL and Mitch WE: Protein degradation by the ubiquitin-proteasome pathway in normal and disease states. J Am Soc Nephrol. 17:1807–1819. 2006. View Article : Google Scholar : PubMed/NCBI | |
Papanicolaou KN, Izumiya Y and Walsh K: Forkhead transcription factors and cardiovascular biology. Circ Res. 102:16–31. 2008. View Article : Google Scholar : PubMed/NCBI |