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Dichloromethane fractions of Calystegia soldanella induce S‑phase arrest and apoptosis in HT‑29 human colorectal cancer cells

  • Authors:
    • In-Hye Kim
    • Taekil Eom
    • Joon-Young Park
    • Hyung-Joo Kim
    • Taek-Jeong Nam
  • View Affiliations / Copyright

    Affiliations: Future Fisheries Food Research Center, Institute of Fisheries Sciences, Pukyong National University, Busan 46041, Republic of Korea, Department of Food Science and Nutrition, Pukyong National University, Busan 48513, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 60
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    Published online on: December 17, 2021
       https://doi.org/10.3892/mmr.2021.12576
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Abstract

Calystegia soldanella is a halophyte and a perennial herb that grows on coastal sand dunes worldwide. Extracts from this plant have been previously revealed to have a variety of bioactive properties in humans. However, their effects on colorectal cancer cells remain poorly understood. In the present study, the potential biological activity of C. soldanella extracts in the colorectal cancer cell line HT‑29 was examined. First, five solvent fractions [n‑hexane, dichloromethane (DCM), ethyl acetate, n‑butanol and water] were obtained from the crude extracts of C. soldanella through an organic solvent extraction method. In particular, the DCM fraction was demonstrated to exert marked dose‑ and time‑dependent inhibitory effects according to results from the cell viability assay. Data obtained from the apoptosis assay suggested that the inhibition of HT‑29 cell viability induced by DCM treatment was attributed to increased apoptosis. The apoptotic rate was markedly increased in a dose‑dependent manner, which was associated with the protein expression levels of apoptosis‑related proteins, including increased Fas, Bad and Bax, and decreased pro‑caspase‑8, Bcl‑2, Bcl‑xL, pro‑caspase‑9, pro‑caspase‑7 and pro‑caspase‑3. A mitochondrial membrane potential assay demonstrated that more cells became depolarized and the extent of cytochrome c release was markedly increased in a dose‑dependent manner in HT‑29 cells treated with DCM. In addition, cell cycle analysis confirmed S‑phase arrest following DCM fraction treatment, which was associated with decreased protein expression levels of cell cycle‑related proteins, such as cyclin A, CDK2, cell division cycle 25 A and cyclin dependent kinase inhibitor 1. Based on these results, the present study suggested that the DCM fraction of the C. soldanella extract can inhibit HT‑29 cell viability whilst inducing apoptosis through mitochondrial membrane potential regulation and S‑phase arrest. These results also suggested that the DCM fraction has potential anticancer activity in HT‑29 colorectal cells. Further research on the composition of the DCM fraction is warranted.
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View References

1 

Rawla P, Sunkara T and Barsouk A: Epidemiology of colorectal cancer: Incidence, mortality, survival, and risk factors. Prz Gastroenterol. 14:89–103. 2019.PubMed/NCBI

2 

Cancer Trends Progress Report; Colorectal Cancer Treatment. National Cancer Institute; 2020

3 

Xie YH, Chen YX and Fang JY: Comprehensive review of targeted therapy for colorectal cancer. Signal Transduct Target Ther. 5:222020. View Article : Google Scholar : PubMed/NCBI

4 

Pandey R, Singh PK and Shrivastava AK: Seaweeds: Potential candidates in human colon cancer therapy. Colon Cancer Diagnosis Ther. Jun 5–2021.(Epub ahead of print). doi: 10.1007/978-3-030-64668-4_13. View Article : Google Scholar

5 

Zhao Y and Jiang Q: Roles of the polyphenol-gut microbiota interaction in alleviating colitis and preventing colitis-associated colorectal cancer. Adv Nutr. 12:546–565. 2021. View Article : Google Scholar : PubMed/NCBI

6 

García-Lafuente A, Guillamón E, Villares A, Rostagno MA and Martínez JA: Flavonoids as anti-inflammatory agents: Implications in cancer and cardiovascular disease. Inflamm Res. 58:537–552. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Akiyama Y, Kimura Y, Enatsu R, Mikami T, Wanibuchi M and Mikuni N: Advantages and disadvantages of combined chemotherapy with carmustine wafer and bevacizumab in patients with newly diagnosed glioblastoma: A single-institutional experience. World Neurosurg. 113:e508–e514. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Bar-Shalom R, Bergman M, Graossman S, Azzam N, Sharvit L and Fares F: Inula viscosa extract inhibits growth of colorectal cancer cells in vitro and in vivo through induction of apoptosis. Front Oncol. 9:2272019. View Article : Google Scholar : PubMed/NCBI

9 

Bravo L: Polyphenols: Chemistry dietary sources metabolism nutritional significance. Nutr Rev. 56:317–333. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Moreira H, Slezak A, Szyjka A, Oszmianski J and Gasiorowski K: Antioxidant and cancer chemopreventive activities of cistus and pomegranate polyphenols. Acta Pol Pharm. 74:688–698. 2017.PubMed/NCBI

11 

del Mar Blanquer-Rosselló M, Hernández-López R, Roca P, Oliver J and Valle A: Resveratrol induces mitochondrial respiration and apoptosis in SW620 colon cancer cells. Biochim Biophys Acta Gen Sugj. 1861:431–440. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Kim IH and Nam TJ: Fucoidan downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. Oncol Rep. 39:1516–1522. 2018.PubMed/NCBI

13 

Kim IH, Kwon MJ and Nam TJ: Differences in cell death and cell cycle following fucoidan treatment in high-density HT-29 colon cancer cells. Mol Med Rep. 15:4116–4122. 2017. View Article : Google Scholar : PubMed/NCBI

14 

Bae CY, Hwang JS, Bae JJ, Choi SC, Lim SH, Choi DG, Kim JG and Choo YS: Physiological responses of Calystegia soldanella under drought stress. J Ecol Environ. 36:255–265. 2013. View Article : Google Scholar

15 

Bae KH: The Medicinal Plants of Korea. Korea, Kyo-Hak publishing. (Seoul). 2000.

16 

Lee YS, Kwak CG and Kim NW: Nutritional characteristics of Calystegia japonica. Korean J Food Preserv. 19:619–625. 2012. View Article : Google Scholar

17 

Takagi S, Yamaki M, Masuda K and Kubota M: Studies on the purgative drugs. IV. On the constituents of Calystegia japonica Choisy (author's transl). Yakugaku Zasshi. 97:1369–1371. 1977.(In Japanese). View Article : Google Scholar : PubMed/NCBI

18 

Kim Y, Min HY, Park HJ, Lee EJ, Park EJ, Hwang HJ, Jin C, Lee YS and Lee SK: Suppressive effects of nitric oxide production and inducible nitric oxide synthase (iNOS) gene expression by Calystegia soldanella methanol extract on lipopolysaccharide-activated RAW 264.7 cells. Eur J Cancer Prev. 13:419–424. 2004. View Article : Google Scholar : PubMed/NCBI

19 

Huang Z and Feng C: Experimental study on anti-inflammatory and analgesic effects of water extracts of Calystegia soldanella. Chin Arch Tradit Chin Med. 6:72010.

20 

Lee JI, Kim IH, Choi YH, Kim EY and Nam TJ: PTP1B inhibitory effect of alkyl p-coumarates from Calystegia soldanella. Nat Prod Commun. 9:1585–1588. 2014.PubMed/NCBI

21 

Nidiry ES, Ganeshan G and Lokesha AN: Antifungal activity and isomerization of octadecyl p-coumarates from Ipomoea carnea subsp. fistulosa. Nat Prod Commun. 6:1889–1892. 2011.PubMed/NCBI

22 

Ono M, Kanemaru Y, Yasuda S, Okawa M, Kinjo J, Miyashita H, Yokomizo K, Yoshimitsu H and Nohara T: A new resin glycoside from Calystegia soldanella and its antiviral activity towards herpes. Nat Prod Res. 31:2660–2664. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Ono M, Takigawa A, Kanemaru Y, Kawakami G, Kabata K, Okawa M, Kinjo J, Yokomizo K, Yoshimitsu H and Nohara T: Calysolins V–IX, resin glycosides from Calystegia soldanella and their antiviral activity toward herpes. Chem Pharm Bull (Tokyo). 62:97–105. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Ono M, Kawakami G, Takigawa A, Kabata K, Okawa M, Kinjo J, Yokomizo K, Yoshimitsu H and Nohara T: Calysolins X–XIII, resin glycosides from Calystegia soldanella, and their antiviral activity toward herpes simplex virus. Chem Pharm Bull (Tokyo). 62:839–844. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Ono M, Takigawa A, Muto H, Kabata K, Okawa M, Kinjo J, Yokomizo K, Yoshimitsu H and Nohara T: Antiviral activity of four new resin glycosides calysolins XIV–XVII from Calystegia soldanella against Herpes Simplex Virus. Chem Pharm Bull (Tokyo). 63:641–648. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Min HY, Kim Y, Lee EJ, Hwang HJ, Park EJ and Lee SK: Cytotoxic activities of indigenous plant extracts in cultured human cancer cells. Nat Prod Sci. 8:170–172. 2002.

27 

Lee JI, Kim IH and Nam TJ: Crude extract and solvent fractions of Calystegia soldanella induce G1 and S phase arrest of the cell cycle in HepG2 cells. Int J Oncol. 50:414–420. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Ly JD, Grubb DR and Lawen A: The mitochondrial membrane potential (deltapsi(m)) in apoptosis; an update. Apoptosis. 8:115–128. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Gottlieb E, Armour SM, Harris MH and Thompson CB: Mitochondrial membrane potential regulates matrix configuration and cytochrome c release during apoptosis. Cell Death Differ. 10:709–717. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Yang J, Cao L, Li Y, Liu H, Zhang M, Ma H, Wang B, Yuan X and Li Q: Gracillin isolated from Reineckia carnea induces apoptosis of A549 cells via the mitochondrial pathway. Drug Des Devel Ther. 15:233–243. 2021. View Article : Google Scholar : PubMed/NCBI

31 

Christensen ME, Jansen ES, Sanchez W and Waterhouse NJ: Flow cytometry-based assays for the measurement of apoptosis-associated mitochondrial membrane depolarisation and cytochrome c release. Methods. 61:138–145. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Mosca L, Pagano M, Pecoraro A, Borzacchiello L, Mele L, Cacciapuoti G, Porcelli M, Russo G and Russo A: S-Adenosyl-L-methionine overcomes uL3-mediated drug resistance in p53 deleted colon cancer cells. Int J Mol Sci. 22:1032020. View Article : Google Scholar : PubMed/NCBI

33 

Lu SC and Mato JM: S-Adenosylmethionine in cell growth, apoptosis and liver cancer. J Gastroenterol Hepatol. 23 (Suppl 1):S73–S77. 2008. View Article : Google Scholar : PubMed/NCBI

34 

Cave DD, Desiderio V, Mosca L, Ilisso CP, Mele L, Caraglia M, Cacciapuoti G and Porcelli M: S-Adenosylmethionine-mediated apoptosis is potentiated by autophagy inhibition induced by chloroquine in human breast cancer cells. J Cell Physiol. 233:1370–1383. 2018. View Article : Google Scholar : PubMed/NCBI

35 

Ilisso CP, Delle Cave D, Mosca L, Pagano M, Coppola A, Mele L, Caraglia M, Cacciapuoti G and Porcelli M: S-Adenosylmethionine regulates apoptosis and autophagy in MCF-7 breast cancer cells through the modulation of specific microRNAs. Cancer Cell Int. 18:1972018. View Article : Google Scholar : PubMed/NCBI

36 

Mosca L, Minopoli M, Pagano M, Vitiello F, Carriero MV, Cacciapuoti G and Porcelli M: Effects of S-adenosyl-L-methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 56:1212–1224. 2020.PubMed/NCBI

37 

D'Arcy MS: Cell death: A review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 43:582–592. 2019. View Article : Google Scholar : PubMed/NCBI

38 

Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI

39 

Pistritto G, Trisciuoglio D, Ceci C, Garufi A and D'Orazi G: Apoptosis as anticancer mechanism: Function and dysfunction of its modulators and targeted therapeutic strategies. Aging (Albany NY). 8:603–619. 2016. View Article : Google Scholar : PubMed/NCBI

40 

Goldar S, Khaniani MS, Derakhshan SM and Baradaran B: Molecular mechanisms of apoptosis and roles in cancer development and treatment. Asian Pac J Cancer Prev. 16:2129–2144. 2015. View Article : Google Scholar : PubMed/NCBI

41 

Pan Y, Ye C, Tian Q, Yan S, Zeng X, Xiao C, Wang L and Wang H: miR-145 suppresses the proliferation, invasion and migration of NSCLC cells by regulating the BAX/BCL-2 ratio and the caspase-3 cascade. Oncol Lett. 15:4337–4343. 2018.PubMed/NCBI

42 

Knight T, Luedtke D, Edwards H, Taub JW and Ge Y: A delicate balance-The Bcl-2 family and its role in apoptosis, oncogenesis, and cancer therapeutics. Biochem Pharmacol. 162:250–261. 2019. View Article : Google Scholar : PubMed/NCBI

43 

Orrenius S: Mitochondrial regulation of apoptotic cell death. Toxicol Lett. 149:19–23. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Scorrano L and Korsmeyer SJ: Mechanisms of cytochrome c release by proapoptotic BCL-2 family members. Biochem Biophys Res Commun. 304:437–444. 2003. View Article : Google Scholar : PubMed/NCBI

45 

Meeran SM and Katiyar SK: Grape seed proanthocyanidins promote apoptosis in human epidermoid carcinoma A431 cells through alterations in Cdki-Cdk-cyclin cascade, and caspase-3 activation via loss of mitochondrial membrane potential. Exp Dermatol. 16:405–415. 2007. View Article : Google Scholar : PubMed/NCBI

46 

Siu WP, Pun PB, Latchoumycandane C and Boelsterli UA: Bax-mediated mitochondrial outer membrane permeabilization (MOMP), distinct from the mitochondrial permeability transition, is a key mechanism in diclofenac-induced hepatocyte injury: Multiple protective roles of cyclosporin A. Toxicol Appl Pharmacol. 227:451–461. 2008. View Article : Google Scholar : PubMed/NCBI

47 

Ohtsuka T, Buchsbaum D, Oliver P, Makhija S, Kimberly R and Zhou T: Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway. Oncogene. 22:2034–2044. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Wang X, Lu X, Zhu R, Zhang K, Li S, Chen Z and Li L: Betulinic acid induces apoptosis in differentiated PC12 cells via ROS-mediated mitochondrial pathway. Neurochem Res. 42:1130–1140. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Estaquier J, Vallette F, Vayssiere JL and Mignotte B: The mitochondrial pathways of apoptosis. Adv Exp Med Biol. 942:157–183. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Pucci B, Kasten M and Giordano A: Cell cycle and apoptosis. Neoplasia. 2:291–299. 2000. View Article : Google Scholar : PubMed/NCBI

51 

Canavese M, Santo L and Raje N: Cyclin dependent kinases in cancer: Potential for therapeutic intervention. Cancer Biol Ther. 13:451–457. 2012. View Article : Google Scholar : PubMed/NCBI

52 

Sperka T, Wang J and Rudolph KL: DNA damage checkpoints in stem cells, ageing and cancer. Nat Rev Mol Cell Biol. 13:579–590. 2012. View Article : Google Scholar : PubMed/NCBI

53 

George Rosenker KM, Paquette WD, Johnston PA, Sharlow ER, Vogt A, Bakan A, Lazo JS and Wipf P: Synthesis and biological evaluation of 3-aminoisoquinolin-1(2H)-one based inhibitors of the dual-specificity phosphatase Cdc25B. Bioorg Med Chem. 23:2810–2818. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Tilaoui M, Mouse HA, Jaafari A and Zyad A: Differential effect of artemisinin against cancer cell lines. Nat Prod Bioprospect. 4:189–196. 2014. View Article : Google Scholar : PubMed/NCBI

55 

Zhu H, Zhang L, Wu S, Teraishi F, Davis JJ, Jacob D and Fang B: Induction of S-phase arrest and p21 overexpression by a small molecule 2-[[3-(2,3-dichlorophenoxy) propyl]amino]ethanol in correlation with activation of ERK. Oncogene. 23:4984–4992. 2004. View Article : Google Scholar : PubMed/NCBI

56 

Ahn NR, Ko JM and Cha HC: Comparison of flavonoid profiles between leaves and stems of Calystegia soldanella and Calystegia japonica. Am J Plant Sci. 3:1073–1076. 2012. View Article : Google Scholar

57 

Al Aaraj L, Hayar B, Jaber Z, Saad W, Saliba NA, Darwiche N and Ghaddar T: The effect of different ester chain modifications of two guaianolides for inhibition of colorectal cancer cell growth. Molecules. 26:54812021. View Article : Google Scholar : PubMed/NCBI

58 

Takayama T, Miyanishi K, Hayashi T, Sato Y and Niitsu Y: Colorectal cancer: Genetics of development and metastasis. J Gastroenterol. 41:185–192. 2006. View Article : Google Scholar : PubMed/NCBI

59 

Nakayama M and Oshima M: Mutant p53 in colon cancer. J Mol Cell Biol. 11:267–276. 2019. View Article : Google Scholar : PubMed/NCBI

60 

Li XL, Zhou J, Chen ZR and Chng WJ: p53 mutations in colorectal cancer-molecular pathogenesis and pharmacological reactivation. World J Gastroenterol. 21:84–93. 2015. View Article : Google Scholar : PubMed/NCBI

61 

Murai Y, Setoguchi H, Ono E and Iwashina T: Flavonoids and their qualitative variation in Calystegia soldanella and related species (Convolvulaceae). Nat Prod Commun. 10:429–432. 2015.PubMed/NCBI

62 

Abotaleb M, Liskova A, Kubatka P and Busselberg D: Therapeutic potential of plant phenolic acids in the treatment of cancer. Biomolecules. 10:2212020. View Article : Google Scholar : PubMed/NCBI

63 

Anantharaju PG, Gowda PC, Vimalambike MG and Madhunapantula SV: An overview on the role of dietary phenolics for the treatment of cancers. Nutr J. 15:992016. View Article : Google Scholar : PubMed/NCBI

64 

Jaganathan SK, Supriyanto E and Mandal M: Events associated with apoptotic effect of p-coumaric acid in HCT-15 colon cancer cells. World J Gastroenterol. 19:7726–7734. 2013. View Article : Google Scholar : PubMed/NCBI

65 

Janicke B, Hegardt C, Korgh M, Onning G, Akesson B, Cirenajwis HM and Oredsson SM: The antiproliferative effect of dietary fiber phenolic compounds ferulic acid and p-coumaric acid on the cell cycle of Caco-2 cells. Nutr Cancer. 63:611–622. 2011. View Article : Google Scholar : PubMed/NCBI

66 

Janicke B, Onning G and Oredsson SM: Differential effects of ferulic acid and p-coumaric acid on S phase distribution and length of S phase in the human colonic cell line Caco-2. J Agric Food Chem. 53:6658–6665. 2005. View Article : Google Scholar : PubMed/NCBI

67 

García-Gutiérrez N, Maldonado-Celis ME, Rojas-López M, Loarca-Piñaa GF and Campos-Vega R: The fermented non-digestible fraction of spent coffee grounds induces apoptosis in human colon cancer cells (SW480). J Funct Foods. 30:237–246. 2017. View Article : Google Scholar

68 

Ekbatan SS, Li XQ, Ghorbani M, Azadi B and Kubow S: Chlorogenic acid and its microbial metabolites exert anti-proliferative effects, S-phase cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells. Int J Mol Sci. 19:7232018. View Article : Google Scholar

69 

Hernández-Arriaga AM, Oomah BD and Campos-Vega R: Microbiota source impact in vitro metabolite colonic production and anti-proliferative effect of spent coffee grounds on human colon cancer cells (HT-29). Food Res Int. 97:191–198. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kim I, Eom T, Park J, Kim H and Nam T: Dichloromethane fractions of <em>Calystegia soldanella</em> induce S‑phase arrest and apoptosis in HT‑29 human colorectal cancer cells. Mol Med Rep 25: 60, 2022.
APA
Kim, I., Eom, T., Park, J., Kim, H., & Nam, T. (2022). Dichloromethane fractions of <em>Calystegia soldanella</em> induce S‑phase arrest and apoptosis in HT‑29 human colorectal cancer cells. Molecular Medicine Reports, 25, 60. https://doi.org/10.3892/mmr.2021.12576
MLA
Kim, I., Eom, T., Park, J., Kim, H., Nam, T."Dichloromethane fractions of <em>Calystegia soldanella</em> induce S‑phase arrest and apoptosis in HT‑29 human colorectal cancer cells". Molecular Medicine Reports 25.2 (2022): 60.
Chicago
Kim, I., Eom, T., Park, J., Kim, H., Nam, T."Dichloromethane fractions of <em>Calystegia soldanella</em> induce S‑phase arrest and apoptosis in HT‑29 human colorectal cancer cells". Molecular Medicine Reports 25, no. 2 (2022): 60. https://doi.org/10.3892/mmr.2021.12576
Copy and paste a formatted citation
x
Spandidos Publications style
Kim I, Eom T, Park J, Kim H and Nam T: Dichloromethane fractions of <em>Calystegia soldanella</em> induce S‑phase arrest and apoptosis in HT‑29 human colorectal cancer cells. Mol Med Rep 25: 60, 2022.
APA
Kim, I., Eom, T., Park, J., Kim, H., & Nam, T. (2022). Dichloromethane fractions of <em>Calystegia soldanella</em> induce S‑phase arrest and apoptosis in HT‑29 human colorectal cancer cells. Molecular Medicine Reports, 25, 60. https://doi.org/10.3892/mmr.2021.12576
MLA
Kim, I., Eom, T., Park, J., Kim, H., Nam, T."Dichloromethane fractions of <em>Calystegia soldanella</em> induce S‑phase arrest and apoptosis in HT‑29 human colorectal cancer cells". Molecular Medicine Reports 25.2 (2022): 60.
Chicago
Kim, I., Eom, T., Park, J., Kim, H., Nam, T."Dichloromethane fractions of <em>Calystegia soldanella</em> induce S‑phase arrest and apoptosis in HT‑29 human colorectal cancer cells". Molecular Medicine Reports 25, no. 2 (2022): 60. https://doi.org/10.3892/mmr.2021.12576
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