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Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice

  • Authors:
    • Caishun Zhang
    • Di Zhang
    • Haidan Wang
    • Qian Lin
    • Manwen Li
    • Junhua Yuan
    • Guangkai Gao
    • Jing Dong
  • View Affiliations / Copyright

    Affiliations: Special Medicine Department, College of Basic Medicine, Qingdao University, Qingdao, Shandong 266071, P.R. China, Shandong Provincial Engineering Laboratory of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Medicine and Nursing, Dezhou University, Dezhou, Shandong 253023, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 90
    |
    Published online on: January 17, 2022
       https://doi.org/10.3892/mmr.2022.12606
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Abstract

Type‑2 diabetes mellitus (T2DM) causes several complications that affect the quality of life and life span of patients. Hyperbaric oxygen therapy (HBOT) has been used to successfully treat several diseases, including carbon monoxide poisoning, ischemia, infections and diabetic foot ulcer, and increases insulin sensitivity in T2DM. The present study aimed to determine the effect of HBOT on β‑cell function and hepatic gluconeogenesis in streptozotocin (STZ)‑induced type‑2 diabetic mice. To establish a T2DM model, 7‑week‑old male C57BL/6J mice were fed a high‑fat diet (HFD) and injected once daily with low‑dose STZ for 3 days after 1‑week HFD feeding. At the 14th week, HFD+HBOT and T2DM+HBOT groups received 1‑h HBOT (2 ATA; 100% pure O2) daily from 5:00 to 6:00 p.m. for 7 days. The HFD and T2DM groups were maintained under normobaric oxygen conditions and used as controls. During HBOT, the 12‑h nocturnal food intake and body weight were measured daily. Moreover, blood glucose was measured by using a tail vein prick and a glucometer. After the final HBO treatment, all mice were sacrificed to conduct molecular biology experiments. Fasting insulin levels of blood samples of sacrificed mice were measured by an ultrasensitive ELISA kit. Pancreas and liver tissues were stained with hematoxylin and eosin, while immunohistochemistry was performed to determine the effects of HBOT on insulin resistance. TUNEL was used to determine the effects of HBOT on β‑cell apoptosis, and immunoblotting was conducted to determine the β‑cell apoptosis pathway. HBOT notably reduced fasting blood glucose and improved insulin sensitivity in T2DM mice. After HBOT, β‑cell area and β‑cell mass in T2DM mice were significantly increased. HBOT significantly decreased the β‑cell apoptotic rate in T2DM mice via the pancreatic Bcl‑2/caspase‑3/poly(ADP‑ribose) polymerase (PARP) apoptosis pathway. Moreover, HBOT improved the morphology of the liver tissue and increased hepatic glycogen storage in T2DM mice. These findings suggested that HBOT ameliorated the insulin sensitivity of T2DM mice by decreasing the β‑cell apoptotic rate via the pancreatic Bcl‑2/caspase‑3/PARP apoptosis pathway.
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1 

Cho NH, Shaw JE, Karuranga S, Huang Y, da Rocha Fernandes JD, Ohlrogge AW and Malanda B: IDF diabetes atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 138:271–281. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Lu Y, Li Y, Li G and Lu H: Identification of potential markers for type 2 diabetes mellitus via bioinformatics analysis. Mol Med Rep. 22:1868–1882. 2020. View Article : Google Scholar : PubMed/NCBI

3 

Ichise M and Harris PE: Imaging of beta-cell mass and function. J Nucl Med. 51:1001–1004. 2010. View Article : Google Scholar : PubMed/NCBI

4 

DeFronzo RA, Eldor R and Abdul-Ghani M: Pathophysiologic approach to therapy in patients with newly diagnosed type 2 diabetes. Diabetes Care. 36 (Suppl 2):S127–S138. 2013. View Article : Google Scholar : PubMed/NCBI

5 

Weir GC and Bonner-Weir S: Islet β cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci. 1281:92–105. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Butler AE, Janson J, Bonner-Weir S, Ritzel R, Rizza RA and Butler PC: Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes. 52:102–110. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Germonpre P, Levie P, Dehalleux C and Caers D: ENT indications for Hyperbaric Oxygen Therapy. B-ENT Suppl. 26:S87–S106. 2016.PubMed/NCBI

8 

Karadurmus N, Sahin M, Tasci C, Naharci I, Ozturk C, Ilbasmis S, Dulkadir Z, Sen A and Saglam K: Potential benefits of hyperbaric oxygen therapy on atherosclerosis and glycaemic control in patients with diabetic foot. Endokrynol Pol. 61:275–279. 2010.PubMed/NCBI

9 

Chen CY, Wu RW, Hsu MC, Hsieh CJ and Chou MC: Adjunctive hyperbaric oxygen therapy for healing of chronic diabetic foot ulcers: A randomized controlled trial. J Wound Ostomy Continence Nurs. 44:536–545. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Wilkinson D, Nolting M, Mahadi MK, Chapman I and Heilbronn L: Hyperbaric oxygen therapy increases insulin sensitivity in overweight men with and without type 2 diabetes. Diving Hyperb Med. 45:30–36. 2015.PubMed/NCBI

11 

Wilkinson D, Chapman IM and Heilbronn LK: Hyperbaric oxygen therapy improves peripheral insulin sensitivity in humans. Diabet Med. 29:986–989. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Nagatomo F, Takemura A, Roy RR, Fujino H, Kondo H and Ishihara A: Mild hyperbaric oxygen inhibits the growth-related decline in skeletal muscle oxidative capacity and prevents hyperglycemia in rats with type 2 diabetes mellitus. J Diabetes. 10:753–763. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Liu Y, Zhang D, Yuan J, Song L, Zhang C, Lin Q, Li M, Sheng Z, Ma Z, Lv F, et al: Hyperbaric oxygen ameliorates insulin sensitivity by increasing GLUT4 expression in skeletal muscle and stimulating UCP1 in brown adipose tissue in T2DM mice. Front Endocrinol (Lausanne). 11:322020. View Article : Google Scholar : PubMed/NCBI

14 

Jansson L and Hellerström C: Stimulation by glucose of the blood flow to the pancreatic islets of the rat. Diabetologia. 25:45–50. 1983. View Article : Google Scholar : PubMed/NCBI

15 

Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, et al: Animal models of obesity and diabetes mellitus. Nat Rev Endocrinol. 14:140–162. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Yu T, Sungelo MJ, Goldberg IJ, Wang H and Eckel RH: Streptozotocin-treated high fat fed mice: A new type 2 diabetes model used to study canagliflozin-induced alterations in lipids and lipoproteins. Horm Metab Res. 49:400–406. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Yuan J, Jiang Q, Song L, Liu Y, Li M, Lin Q, Li Y, Su K, Ma Z, Wang Y, et al: L-Carnitine is involved in hyperbaric oxygen-mediated therapeutic effects in high fat diet-induced lipid metabolism dysfunction. Molecules. 25:1762020. View Article : Google Scholar : PubMed/NCBI

18 

Zhang D, Yu YJ, Xu FS, Yuan JH, Wang R, Zhang CS, Wang LX, Liu Y, Song LM, Liu JL and Dong J: Recombinant betatrophin (Angptl-8/lipasin) ameliorates streptozotocin-induced hyperglycemia and β-cell destruction in neonatal rats. Mol Med Rep. 20:4523–4532. 2019.PubMed/NCBI

19 

Song L, Yuan J, Liu Y, Zhang D, Zhang C, Lin Q, Li M, Su K, Li Y, Gao G, et al: Ghrelin system is involved in improvements in glucose metabolism mediated by hyperbaric oxygen treatment in a streptozotocin-induced type 1 diabetes mouse model. Mol Med Rep. 22:3767–3776. 2020.PubMed/NCBI

20 

Jensen TL, Kiersgaard MK, Sørensen DB and Mikkelsen LF: Fasting of mice: A review. Lab Anim. 47:225–240. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Wei X, Gu N, Feng N, Guo X and Ma X: Inhibition of p38 mitogen-activated protein kinase exerts a hypoglycemic effect by improving β cell function via inhibition of β cell apoptosis in db/db mice. J Enzyme Inhib Med Chem. 33:1494–1500. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Cui X, Wang B, Wu Y, Xie L, Xun P, Tang Q, Cai W and Shen X: Vegetarians have a lower fasting insulin level and higher insulin sensitivity than matched omnivores: A cross-sectional study. Nutr Metab Cardiovasc Dis. 29:467–473. 2019. View Article : Google Scholar : PubMed/NCBI

23 

Kou K, Saisho Y, Satoh S, Yamada T and Itoh H: Change in β-cell mass in Japanese nondiabetic obese individuals. J Clin Endocrinol Metab. 98:3724–3730. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Lautenbach A, Wernecke M, Riedel N, Veigel J, Yamamura J, Keller S, Jung R, Busch P, Mann O, Knop FK, et al: Adaptive changes in pancreas post Roux-en-Y gastric bypass induced weight loss. Diabetes Metab Res Rev. 34:e30252018. View Article : Google Scholar : PubMed/NCBI

25 

Poret JM, Souza-Smith F, Marcell SJ, Gaudet DA, Tzeng TH, Braymer HD, Harrison-Bernard LM and Primeaux SD: High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity-resistant rats. Int J Obes (Lond). 42:535–541. 2018. View Article : Google Scholar : PubMed/NCBI

26 

Siersbæk MS, Ditzel N, Hejbøl EK, Præstholm SM, Markussen LK, Avolio F, Li L, Lehtonen L, Hansen AK, Schrøder HD, et al: C57BL/6J substrain differences in response to high-fat diet intervention. Sci Rep. 10:140522020. View Article : Google Scholar : PubMed/NCBI

27 

Faselis C, Katsimardou A, Imprialos K, Deligkaris P, Kallistratos M and Dimitriadis K: Microvascular complications of type 2 diabetes mellitus. Curr Vasc Pharmacol. 18:117–124. 2020. View Article : Google Scholar : PubMed/NCBI

28 

Stumvoll M and Gerich J: Clinical features of insulin resistance and beta cell dysfunction and the relationship to type 2 diabetes. Clin Lab Med. 21:31–51. 2001.PubMed/NCBI

29 

Elosta A, Ghous T and Ahmed N: Natural products as anti-glycation agents: possible therapeutic potential for diabetic complications. Curr Diabetes Rev. 8:92–108. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Guo S: Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms. J Endocrinol. 220:T1–T23. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Utumatwishima JN, Chung ST, Bentley AR, Udahogora M and Sumner AE: Reversing the tide-diagnosis and prevention of T2DM in populations of African descent. Nat Rev Endocrinol. 14:45–56. 2018. View Article : Google Scholar : PubMed/NCBI

32 

DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, et al: Type 2 diabetes mellitus. Nat Rev Dis Primers. 1:150192015. View Article : Google Scholar : PubMed/NCBI

33 

Kitamura T: The role of FOXO1 in β-cell failure and type 2 diabetes mellitus. Nat Rev Endocrinol. 9:615–623. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Freeman AM and Pennings N: Insulin Resistance. StatPearls (Internet); Treasure Island, FL: 2021 https://www.ncbi.nlm.nih.gov/books/NBK507839July 10–2021

35 

Hjermann I: The metabolic cardiovascular syndrome: Syndrome X, Reaven's syndrome, insulin resistance syndrome, atherothrombogenic syndrome. J Cardiovasc Pharmacol. 20 (Suppl 8):S5–S10. 1992. View Article : Google Scholar : PubMed/NCBI

36 

Stumvoll M and Häring H: Insulin resistance and insulin sensitizers. Horm Res. 55 (Suppl 2):3–13. 2001.PubMed/NCBI

37 

Klip A and Pâquet MR: Glucose transport and glucose transporters in muscle and their metabolic regulation. Diabetes Care. 13:228–243. 1990. View Article : Google Scholar : PubMed/NCBI

38 

Rui L: Energy metabolism in the liver. Compr Physiol. 4:177–197. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Faleo G, Fotino C, Bocca N, Molano RD, Zahr-Akrawi E, Molina J, Villate S, Umland O, Skyler JS, Bayer AL, et al: Prevention of autoimmune diabetes and induction of β-cell proliferation in NOD mice by hyperbaric oxygen therapy. Diabetes. 61:1769–1778. 2012. View Article : Google Scholar : PubMed/NCBI

40 

Matsunami T, Sato Y, Hasegawa Y, Ariga S, Kashimura H, Sato T and Yukawa M: Enhancement of reactive oxygen species and induction of apoptosis in streptozotocin-induced diabetic rats under hyperbaric oxygen exposure. Int J Clin Exp Pathol. 4:255–266. 2011.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang C, Zhang D, Wang H, Lin Q, Li M, Yuan J, Gao G and Dong J: Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice. Mol Med Rep 25: 90, 2022.
APA
Zhang, C., Zhang, D., Wang, H., Lin, Q., Li, M., Yuan, J. ... Dong, J. (2022). Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice. Molecular Medicine Reports, 25, 90. https://doi.org/10.3892/mmr.2022.12606
MLA
Zhang, C., Zhang, D., Wang, H., Lin, Q., Li, M., Yuan, J., Gao, G., Dong, J."Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice". Molecular Medicine Reports 25.3 (2022): 90.
Chicago
Zhang, C., Zhang, D., Wang, H., Lin, Q., Li, M., Yuan, J., Gao, G., Dong, J."Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice". Molecular Medicine Reports 25, no. 3 (2022): 90. https://doi.org/10.3892/mmr.2022.12606
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang C, Zhang D, Wang H, Lin Q, Li M, Yuan J, Gao G and Dong J: Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice. Mol Med Rep 25: 90, 2022.
APA
Zhang, C., Zhang, D., Wang, H., Lin, Q., Li, M., Yuan, J. ... Dong, J. (2022). Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice. Molecular Medicine Reports, 25, 90. https://doi.org/10.3892/mmr.2022.12606
MLA
Zhang, C., Zhang, D., Wang, H., Lin, Q., Li, M., Yuan, J., Gao, G., Dong, J."Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice". Molecular Medicine Reports 25.3 (2022): 90.
Chicago
Zhang, C., Zhang, D., Wang, H., Lin, Q., Li, M., Yuan, J., Gao, G., Dong, J."Hyperbaric oxygen treatment improves pancreatic β‑cell function and hepatic gluconeogenesis in STZ‑induced type‑2 diabetes mellitus model mice". Molecular Medicine Reports 25, no. 3 (2022): 90. https://doi.org/10.3892/mmr.2022.12606
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