Open Access

Ferroptosis‑related long non‑coding RNAs and the roles of LASTR in stomach adenocarcinoma

  • Authors:
    • Gongjun Wang
    • Libin Sun
    • Shasha Wang
    • Jing Guo
    • Ruoxi Xiao
    • Wenqian Li
    • Weiwei Qi
    • Wensheng Qiu
  • View Affiliations

  • Published online on: February 8, 2022     https://doi.org/10.3892/mmr.2022.12634
  • Article Number: 118
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ferroptosis is a form of programmed cell death that participates in diverse physiological processes. Increasing evidence suggests that long noncoding RNAs (lncRNAs) regulate ferroptosis in tumors, including stomach adenocarcinoma (STAD). In the present study, RNA‑sequencing data from The Cancer Genome Atlas database and ferroptosis‑related markers from the FerrDb data resource were analyzed to select differentially expressed lncRNAs. Univariate and multivariate Cox regression analyses were performed on these differentially expressed lncRNAs to screen 12 lncRNAs linked with overall survival (OS) and 13 associated with progression‑free survival (PFS). Subsequently, two signatures for predicting OS and PFS were established based on these lncRNAs. Kaplan‑Meier analyses indicated that the high‑risk group of patients with STAD had relatively poor prognosis. The areas under the receiver operating characteristic curves of the two signatures indicated their excellent efficacy in predicting STAD prognosis. In addition, the effect of the lncRNA LASTR on proliferation and migration in gastric cancer was confirmed and the relationship between LASTR and ferroptosis was initially explored through experiments. These results provide potential novel targets for tumor treatment and promote personalized medicine.
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April-2022
Volume 25 Issue 4

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Wang G, Sun L, Wang S, Guo J, Xiao R, Li W, Qi W and Qiu W: Ferroptosis‑related long non‑coding RNAs and the roles of LASTR in stomach adenocarcinoma. Mol Med Rep 25: 118, 2022
APA
Wang, G., Sun, L., Wang, S., Guo, J., Xiao, R., Li, W. ... Qiu, W. (2022). Ferroptosis‑related long non‑coding RNAs and the roles of LASTR in stomach adenocarcinoma. Molecular Medicine Reports, 25, 118. https://doi.org/10.3892/mmr.2022.12634
MLA
Wang, G., Sun, L., Wang, S., Guo, J., Xiao, R., Li, W., Qi, W., Qiu, W."Ferroptosis‑related long non‑coding RNAs and the roles of LASTR in stomach adenocarcinoma". Molecular Medicine Reports 25.4 (2022): 118.
Chicago
Wang, G., Sun, L., Wang, S., Guo, J., Xiao, R., Li, W., Qi, W., Qiu, W."Ferroptosis‑related long non‑coding RNAs and the roles of LASTR in stomach adenocarcinoma". Molecular Medicine Reports 25, no. 4 (2022): 118. https://doi.org/10.3892/mmr.2022.12634