Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
April-2022 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
April-2022 Volume 25 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Expression of SOX2OT, DANCR and TINCR long non‑coding RNAs in papillary thyroid cancer and its effects on clinicopathological features

  • Authors:
    • Fadime Mutlu Icduygu
    • Egemen Akgun
    • Demet Sengul
    • Asuman Ozgoz
    • Ebru Alp
  • View Affiliations / Copyright

    Affiliations: Department of Medical Genetics, Faculty of Medicine, Giresun University, Giresun 28100, Turkey, Department of Medical Biology, Faculty of Medicine, Giresun University, Giresun 28100, Turkey, Department of Pathology, Faculty of Medicine, Giresun University, Giresun 28100, Turkey, Department of Medical Genetics, Faculty of Medicine, Kastamonu University, Kastamonu 37100, Turkey
    Copyright: © Icduygu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 120
    |
    Published online on: February 10, 2022
       https://doi.org/10.3892/mmr.2022.12636
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Long non‑coding RNAs (lncRNAs) are molecules that are >200 base pairs long and do not encode a protein. However, they perform important roles in regulating gene expression. Recent studies have revealed that the changes in the expressions of lncRNAs serve a role in the development and metastases of a number of types of cancer. A number of studies have been published on the association of SOX2 overlapping transcript (SOX2OT), differentiation antagonizing non‑protein coding RNA (DANCR) and tissue differentiation‑induced non‑coding RNA (TINCR) expression with various types of cancer. However, researchers have not yet studied their roles in papillary thyroid cancer or at least, those roles are not clarified. The aim of the present study was to investigate the expression and clinical significance of SOX2OT, DANCR and TINCR in papillary thyroid cancer (PTC). A total of 102 patients with PTC were included in the present study. Reverse transcription‑quantitative PCR method was used to determine the relative gene expression levels of lncRNAs and then the relationship between expressions of lncRNAs and clinical characteristics of the subjects was analyzed in detail. Expression levels of SOX2OT (P=0.016) and DANCR (P=0.017) increased in the tumor samples in contrast to the normal tissues. No significant difference was observed in the expression level of TINCR (P=0.298). In addition, SOX2OT expression was associated with micro carcinoma (P<0.001), tumor size (P=0.010) and primary tumor (P=0.006), while DANCR expression was associated with age (P=0.030) and micro carcinoma (P=0.004). The findings of the present study indicated that DANCR may contribute to the development of PTC while SOX2OT may contribute to both the development and progression of PTC.
View Figures

Figure 1

Figure 2

Figure 3

View References

1 

Deng Y, Li H, Wang M, Li N, Tian T, Wu Y, Xu P, Yang S, Zhai Z, Zhou L, et al: Global burden of thyroid cancer from 1990 to 2017. JAMA Netw Open. 3:e2087592020. View Article : Google Scholar : PubMed/NCBI

2 

Cao J, Zhang M, Zhang L, Lou J, Zhou F and Fang M: Non-coding RNA in thyroid cancer-Functions and mechanisms. Cancer Lett. 496:117–126. 2021. View Article : Google Scholar : PubMed/NCBI

3 

Javed Z, Ahmed Shah F, Rajabi S, Raza Q, Iqbal Z, Ullah M, Ahmad T, Salehi B, Sharifi-Rad M, Pezzani R, et al: LncRNAs as potential therapeutic targets in thyroid cancer. Asian Pac J Cancer Prev. 21:281–287. 2020. View Article : Google Scholar : PubMed/NCBI

4 

Peng X, Zhang K, Ma L, Xu J and Chang W: The Role of long non-coding RNAs in thyroid cancer. Front Oncol. 10:9412020. View Article : Google Scholar : PubMed/NCBI

5 

Liyanarachchi S, Gudmundsson J, Ferkingstad E, He H, Jonasson JG, Tragante V, Asselbergs FW, Xu L, Kiemeney LA, Netea-Maier RT, et al: Assessing thyroid cancer risk using polygenic risk scores. Proc Natl Acad Sci USA. 117:5997–6002. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Zhang Y, Jin T, Shen H, Yan J, Guan M and Jin X: Identification of long non-coding RNA expression profiles and Co-expression genes in thyroid carcinoma based on the cancer genome atlas (TCGA) database. Med Sci Monit. 25:9752–9769. 2019. View Article : Google Scholar : PubMed/NCBI

7 

Ghafouri-Fard S, Mohammad-Rahimi H and Taheri M: The role of long non-coding RNAs in the pathogenesis of thyroid cancer. Exp Mol Pathol. 112:1043322020. View Article : Google Scholar : PubMed/NCBI

8 

Mahmoudian-Sani MR, Jalali A, Jamshidi M, Moridi H, Alghasi A, Shojaeian A and Mobini GR: Long non-coding RNAs in thyroid cancer: Implications for pathogenesis, diagnosis, and therapy. Oncol Res Treat. 42:136–142. 2019. View Article : Google Scholar : PubMed/NCBI

9 

Chang X, Zhang H, Yang Q and Pang L: LncRNA SOX2OT affects cervical cancer cell growth, migration and invasion by regulating SOX2. Cell Cycle. 19:1391–1403. 2020. View Article : Google Scholar : PubMed/NCBI

10 

Wang Y, Wu N, Luo X, Zhang X, Liao Q and Wang J: SOX2OT, a novel tumor-related long non-coding RNA. Biomed Pharmacother. 123:1097252020. View Article : Google Scholar : PubMed/NCBI

11 

Li PY, Wang P, Gao SG and Dong DY: Long Noncoding RNA SOX2-OT: Regulations, functions, and roles on mental Illnesses, cancers, and diabetic complications. Biomed Res Int. 2020:29015892020. View Article : Google Scholar : PubMed/NCBI

12 

Zhan Y, Chen Z, He S, Gong Y, He A, Li Y, Zhang L, Zhang X, Fang D, Li X and Zhou L: Long non-coding RNA SOX2OT promotes the stemness phenotype of bladder cancer cells by modulating SOX2. Mol Cancer. 19:252020. View Article : Google Scholar : PubMed/NCBI

13 

Wei CX, Wong H, Xu F, Liu Z, Ran L and Jiang RD: IRF4-induced upregulation of lncRNA SOX2-OT promotes cell proliferation and metastasis in cholangiocarcinoma by regulating SOX2 and PI3K/AKT signaling. Eur Rev Med Pharmacol Sci. 22:8169–8178. 2018.PubMed/NCBI

14 

Li Z, Jiang P, Li J, Peng M, Zhao X, Zhang X, Chen K, Zhang Y, Liu H, Gan L, et al: Tumor-derived exosomal lnc-Sox2ot promotes EMT and stemness by acting as a ceRNA in pancreatic ductal adenocarcinoma. Oncogene. 37:3822–3838. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Kretz M, Webster DE, Flockhart RJ, Lee CS, Zehnder A, Lopez-Pajares V, Qu K, Zheng GX, Chow J, Kim GE, et al: Suppression of progenitor differentiation requires the long noncoding RNA ANCR. Genes Dev. 26:338–343. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Pan L, Xiao X, Zhao Y, Yin L, Fu M, Zhang X and Jiang P: The functional roles of long noncoding RNA DANCR in Human Cancers. J Cancer. 11:6970–6981. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Hao YP, Qiu JH, Zhang DB and Yu CG: Long non-coding RNA DANCR, a prognostic indicator, promotes cell growth and tumorigenicity in gastric cancer. Tumour Biol. Jun 15–2017.(Epub ahead of print). doi: 10.1177/1010428317699798. View Article : Google Scholar

18 

Ma X, Wang X, Yang C, Wang Z, Han B, Wu L and Zhuang L: DANCR Acts as a diagnostic biomarker and promotes tumor growth and metastasis in hepatocellular carcinoma. Anticancer Res. 36:6389–6398. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Liu Y, Zhang M, Liang L, Li J and Chen YX: Over-expression of lncRNA DANCR is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer. Int J Clin Exp Pathol. 8:114802015.PubMed/NCBI

20 

Tao W, Wang C, Zhu B, Zhang G and Pang D: LncRNA DANCR contributes to tumor progression via targetting miR-216a-5p in breast cancer: LncRNA DANCR contributes to tumor progression. Biosci Rep. 39:BSR201816182019. View Article : Google Scholar : PubMed/NCBI

21 

Yan Y, Shi Q, Yuan X, Xue C, Shen S and He Y: DANCR: An emerging therapeutic target for cancer. Am J Transl Res. 12:4031–4042. 2020.PubMed/NCBI

22 

Li Z, Hou P, Fan D, Dong M, Ma M, Li H, Yao R, Li Y, Wang G, Geng P, et al: The degradation of EZH2 mediated by lncRNA ANCR attenuated the invasion and metastasis of breast cancer. Cell Death Differ. 24:59–71. 2017. View Article : Google Scholar : PubMed/NCBI

23 

Zhang K, Lv J, Peng X, Liu J, Li C, Li J, Yin N, Li H and Li Z: Down-regulation of DANCR acts as a potential biomarker for papillary thyroid cancer diagnosis. Biosci Rep. Apr 23–2019.(Epub ahead of print). doi: 10.1042/BSR20181618.

24 

Ghafouri-Fard S, Dashti S, Taheri M and Omrani MD: TINCR: An lncRNA with dual functions in the carcinogenesis process. Non-coding RNA Res. 5:109–115. 2020. View Article : Google Scholar : PubMed/NCBI

25 

Sharma U, Barwal TS, Malhotra A, Pant N, Vive K, Dey D, Gautam A, Tuli HS, Vasquez KM and Jain A: Long non-coding RNA TINCR as potential biomarker and therapeutic target for cancer. Life Sci. 257:1180352020. View Article : Google Scholar : PubMed/NCBI

26 

You X, Zhao Y, Sui J, Shi X, Sun Y, Xu J, Liang G, Xu Q and Yao Y: Integrated analysis of long noncoding RNA interactions reveals the potential role in progression of human papillary thyroid cancer. Cancer Med. 7:5394–5410. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

28 

Fu XM, Guo W, Li N, Liu HZ, Liu J, Qiu SQ, Zhang Q, Wang LC, Li F and Li CL: The expression and function of long noncoding RNA lncRNA-ATB in papillary thyroid cancer. Eur Rev Med Pharmacol Sci. 21:3239–3246. 2017.PubMed/NCBI

29 

Han CG, Huang Y and Qin L: Long Non-Coding RNA ZFAS1 as a novel potential biomarker for predicting the prognosis of thyroid cancer. Med Sci Monit. 25:2984–2992. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Bolha L, Ravnik-Glavač M and Glavač D: Long noncoding RNAs as biomarkers in cancer. Dis Markers. 2017:72439682017. View Article : Google Scholar : PubMed/NCBI

31 

Huarte M: The emerging role of lncRNAs in cancer. Nat Med. 21:1253–1261. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Amaral PP, Neyt C, Wilkins SJ, Askarian-Amiri ME, Sunkin SM, Perkins AC and Mattick JS: Complex architecture and regulated expression of the Sox2ot locus during vertebrate development. RNA. 15:2013–2027. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Zhang E and Li X: LncRNA SOX2-OT regulates proliferation and metastasis of nasopharyngeal carcinoma cells through miR-146b-5p/HNRNPA2B1 pathway. J Cell Biochem. 120:16575–16588. 2019. View Article : Google Scholar : PubMed/NCBI

34 

Santiago K, Chen Wongworawat Y and Khan S: Differential MicroRNA-signatures in thyroid cancer subtypes. J Oncol. 2020:20523962020. View Article : Google Scholar : PubMed/NCBI

35 

Hu N, Tian Y, Song Y and Zang L: miR-122-5p suppresses the oncogenesis of PTC by inhibiting DUSP4 expression. Mol Med Rep. 23:3682021. View Article : Google Scholar : PubMed/NCBI

36 

Chen X, Li M, Zhou H and Zhang L: miR-132 Targets FOXA1 and exerts tumor-suppressing functions in thyroid cancer. Oncol Res. 27:4312019. View Article : Google Scholar : PubMed/NCBI

37 

Xue L, Yan H, Chen Y, Zhang Q, Xie X, Ding X, Wang X, Qian Z, Xiao F, Song Z, et al: EZH2 upregulation by ERα induces proliferation and migration of papillary thyroid carcinoma. BMC Cancer. 19:10942019. View Article : Google Scholar : PubMed/NCBI

38 

Teng Y, Kang H and Chu Y: Identification of an exosomal long noncoding RNA SOX2-OT in plasma as a promising biomarker for lung squamous cell carcinoma. Genet Test Mol Biomarkers. 23:235–240. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Shi XM and Teng F: Up-regulation of long non-coding RNA Sox2ot promotes hepatocellular carcinoma cell metastasis and correlates with poor prognosis. Int J Clin Exp Pathol. 8:4008–4014. 2015.PubMed/NCBI

40 

Wang S and Jiang M: The long non-coding RNA-DANCR exerts oncogenic functions in non-small cell lung cancer via miR-758-3p. Biomed Pharmacother. 103:94–100. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Pan Z, Wu C, Li Y, Li H, An Y, Wang G, Dai J and Wang Q: LncRNA DANCR silence inhibits SOX5-medicated progression and autophagy in osteosarcoma via regulating miR-216a-5p. Biomed Pharmacother. 122:1097072020. View Article : Google Scholar : PubMed/NCBI

42 

Li Q, Jiang Y, Zhong G, Lu Y, Song T, Zhang Y, Wu J, Zhang M, Liang X, Zhou L, et al: Long noncoding RNA DANCR regulates cell proliferation by stabilizing SOX2 mRNA in nasopharyngeal carcinoma. Am J Pathol. 190:2343–2354. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Li J and Zhou L: Overexpression of lncRNA DANCR positively affects progression of glioma via activating Wnt/β-catenin signaling. Biomed Pharmacother. 102:602–607. 2018. View Article : Google Scholar : PubMed/NCBI

44 

Hitu L, Gabora K, Bonci EA, Piciu A, Hitu AC, Ștefan PA and Piciu D: MicroRNA in papillary thyroid carcinoma: A systematic review from 2018 to June 2020. Cancers (Basel). 12:31182020. View Article : Google Scholar : PubMed/NCBI

45 

Lu HW and Liu XD: UCA1 promotes papillary thyroid carcinoma development by stimulating cell proliferation via Wnt pathway. Eur Rev Med Pharmacol Sci. 22:5576–5582. 2018.PubMed/NCBI

46 

Pan L, Liang W, Gu J, Zang X, Huang Z, Shi H, Chen J, Fu M, Zhang P, Xiao X, et al: Long noncoding RNA DANCR is activated by SALL4 and promotes the proliferation and invasion of gastric cancer cells. Oncotarget. 9:1915–1930. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Vouri M and Hafizi S: TAM Receptor tyrosine kinases in cancer drug resistance. Cancer Res. 77:2775–2778. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Collina F, La Sala L, Liotti F, Prevete N, La Mantia E, Chiofalo MG, Aquino G, Arenare L, Cantile M, Liguori G, et al: AXL Is a novel predictive factor and therapeutic target for radioactive iodine refractory thyroid cancer. Cancers (Basel). 11:7852019. View Article : Google Scholar : PubMed/NCBI

49 

Liu XF, Hao JL, Xie T, Pant OP, Lu CB, Lu CW and Zhou DD: The BRAF activated non-coding RNA: A pivotal long non-coding RNA in human malignancies. Cell Prolif. 51:e124492018. View Article : Google Scholar : PubMed/NCBI

50 

Pahlevan Kakhki M, Rakhshi N, Emami Aleagha MS, Abdari M, Alikhah A, Safarian G, Behmanesh M and Nikravesh A: Differential expression of STAT3 gene and its regulatory long non-coding RNAs, namely lnc-DC and THRIL, in two eastern Iranian ethnicities with multiple sclerosis. Neurol Sci. 41:561–568. 2020. View Article : Google Scholar : PubMed/NCBI

51 

Chen F, Qi S, Zhang X, Wu J, Yang X and Wang R: lncRNA PLAC2 activated by H3K27 acetylation promotes cell proliferation and invasion via the activation of Wnt/β-catenin pathway in oral squamous cell carcinoma. Int J Oncol. 54:1183–1194. 2019.PubMed/NCBI

52 

Chen Z, Liu H, Yang H, Gao Y, Zhang G and Hu J: The long noncoding RNA, TINCR, functions as a competing endogenous RNA to regulate PDK1 expression by sponging miR-375 in gastric cancer. Onco Targets Ther. 10:3353–3362. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Tian F, Xu J, Xue F, Guan E and Xu X: TINCR expression is associated with unfavorable prognosis in patients with hepatocellular carcinoma. Biosci Rep. 37:BSR201703012017. View Article : Google Scholar : PubMed/NCBI

54 

Zhu ZJ and He JK: TINCR facilitates non-small cell lung cancer progression through BRAF-activated MAPK pathway. Biochem Biophys Res Commun. 497:971–977. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Kretz M, Siprashvili Z, Chu C, Webster DE, Zehnder A, Qu K, Lee CS, Flockhart RJ, Groff AF, Chow J, et al: Control of somatic tissue differentiation by the long non-coding RNA TINCR. Nature. 493:231–235. 2013. View Article : Google Scholar : PubMed/NCBI

56 

Song L, Qi Y and Lin M: Long noncoding RNA PLAC2 regulates PTEN in retinoblastoma and participates in the regulation of cancer cell apoptosis. Oncol Lett. 19:2489–2494. 2020.PubMed/NCBI

57 

Xia H, Xiu M, Gao J and Jing H: LncRNA PLAC 2 downregulated miR-21 in non-small cell lung cancer and predicted survival. BMC Pulm Med. 19:1722019. View Article : Google Scholar : PubMed/NCBI

58 

Xu Y, Qiu M, Chen Y, Wang J, Xia W, Mao Q, Yang L, Li M, Jiang F, Xu L and Yin R: Long noncoding RNA, tissue differentiation-inducing nonprotein coding RNA is upregulated and promotes development of esophageal squamous cell carcinoma. Dis Esophagus. 29:950–958. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Zhang ZY, Lu YX, Zhang ZY, Chang YY, Zheng L, Yuan L, Zhang F, Hu YH, Zhang WJ and Li XN: Loss of TINCR expression promotes proliferation, metastasis through activating EpCAM cleavage in colorectal cancer. Oncotarget. 7:22639–22649. 2016. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Icduygu FM, Akgun E, Sengul D, Ozgoz A and Alp E: Expression of <em>SOX2OT</em>, <em>DANCR</em> and <em>TINCR</em> long non‑coding RNAs in papillary thyroid cancer and its effects on clinicopathological features. Mol Med Rep 25: 120, 2022.
APA
Icduygu, F.M., Akgun, E., Sengul, D., Ozgoz, A., & Alp, E. (2022). Expression of <em>SOX2OT</em>, <em>DANCR</em> and <em>TINCR</em> long non‑coding RNAs in papillary thyroid cancer and its effects on clinicopathological features. Molecular Medicine Reports, 25, 120. https://doi.org/10.3892/mmr.2022.12636
MLA
Icduygu, F. M., Akgun, E., Sengul, D., Ozgoz, A., Alp, E."Expression of <em>SOX2OT</em>, <em>DANCR</em> and <em>TINCR</em> long non‑coding RNAs in papillary thyroid cancer and its effects on clinicopathological features". Molecular Medicine Reports 25.4 (2022): 120.
Chicago
Icduygu, F. M., Akgun, E., Sengul, D., Ozgoz, A., Alp, E."Expression of <em>SOX2OT</em>, <em>DANCR</em> and <em>TINCR</em> long non‑coding RNAs in papillary thyroid cancer and its effects on clinicopathological features". Molecular Medicine Reports 25, no. 4 (2022): 120. https://doi.org/10.3892/mmr.2022.12636
Copy and paste a formatted citation
x
Spandidos Publications style
Icduygu FM, Akgun E, Sengul D, Ozgoz A and Alp E: Expression of <em>SOX2OT</em>, <em>DANCR</em> and <em>TINCR</em> long non‑coding RNAs in papillary thyroid cancer and its effects on clinicopathological features. Mol Med Rep 25: 120, 2022.
APA
Icduygu, F.M., Akgun, E., Sengul, D., Ozgoz, A., & Alp, E. (2022). Expression of <em>SOX2OT</em>, <em>DANCR</em> and <em>TINCR</em> long non‑coding RNAs in papillary thyroid cancer and its effects on clinicopathological features. Molecular Medicine Reports, 25, 120. https://doi.org/10.3892/mmr.2022.12636
MLA
Icduygu, F. M., Akgun, E., Sengul, D., Ozgoz, A., Alp, E."Expression of <em>SOX2OT</em>, <em>DANCR</em> and <em>TINCR</em> long non‑coding RNAs in papillary thyroid cancer and its effects on clinicopathological features". Molecular Medicine Reports 25.4 (2022): 120.
Chicago
Icduygu, F. M., Akgun, E., Sengul, D., Ozgoz, A., Alp, E."Expression of <em>SOX2OT</em>, <em>DANCR</em> and <em>TINCR</em> long non‑coding RNAs in papillary thyroid cancer and its effects on clinicopathological features". Molecular Medicine Reports 25, no. 4 (2022): 120. https://doi.org/10.3892/mmr.2022.12636
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team