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Review Open Access

Systemic inflammatory response syndrome is triggered by mitochondrial damage (Review)

  • Authors:
    • Can Kong
    • Wei Song
    • Tao Fu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery II, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China
    Copyright: © Kong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 147
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    Published online on: March 1, 2022
       https://doi.org/10.3892/mmr.2022.12663
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Abstract

Mitochondria are key organelles of cellular energy metabolism; both mitochondrial function and metabolism determine the physiological function of cells and serve an essential role in immune responses. Key damage‑associated molecular patterns (DAMPs), such as mitochondrial DNA and N‑formyl peptides, released following severe trauma‑induced mitochondrial damage may affect the respiratory chain, enhance oxidative stress and activate systemic inflammatory responses via a variety of inflammation‑associated signaling pathways. Severe trauma can lead to sepsis, multiple organ dysfunction syndrome and death. The present review aimed to summarize the pathophysiological mechanisms underlying the effects of human mitochondrial injury‑released DAMPs on triggering systemic inflammatory responses and to determine their potential future clinical applications in preventing and treating sepsis.
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Copy and paste a formatted citation
Spandidos Publications style
Kong C, Song W and Fu T: Systemic inflammatory response syndrome is triggered by mitochondrial damage (Review). Mol Med Rep 25: 147, 2022.
APA
Kong, C., Song, W., & Fu, T. (2022). Systemic inflammatory response syndrome is triggered by mitochondrial damage (Review). Molecular Medicine Reports, 25, 147. https://doi.org/10.3892/mmr.2022.12663
MLA
Kong, C., Song, W., Fu, T."Systemic inflammatory response syndrome is triggered by mitochondrial damage (Review)". Molecular Medicine Reports 25.4 (2022): 147.
Chicago
Kong, C., Song, W., Fu, T."Systemic inflammatory response syndrome is triggered by mitochondrial damage (Review)". Molecular Medicine Reports 25, no. 4 (2022): 147. https://doi.org/10.3892/mmr.2022.12663
Copy and paste a formatted citation
x
Spandidos Publications style
Kong C, Song W and Fu T: Systemic inflammatory response syndrome is triggered by mitochondrial damage (Review). Mol Med Rep 25: 147, 2022.
APA
Kong, C., Song, W., & Fu, T. (2022). Systemic inflammatory response syndrome is triggered by mitochondrial damage (Review). Molecular Medicine Reports, 25, 147. https://doi.org/10.3892/mmr.2022.12663
MLA
Kong, C., Song, W., Fu, T."Systemic inflammatory response syndrome is triggered by mitochondrial damage (Review)". Molecular Medicine Reports 25.4 (2022): 147.
Chicago
Kong, C., Song, W., Fu, T."Systemic inflammatory response syndrome is triggered by mitochondrial damage (Review)". Molecular Medicine Reports 25, no. 4 (2022): 147. https://doi.org/10.3892/mmr.2022.12663
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