Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
May-2022 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2022 Volume 25 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Review Open Access

The role of galectins‑1, 3, 7, 8 and 9 as potential diagnostic and therapeutic markers in ovarian cancer (Review)

  • Authors:
    • Aleksandra Mielczarek‑Palacz
    • Zdzisława Kondera‑Anasz
    • Marta Smycz‑Kubańska
    • Aleksandra Englisz
    • Aleksandra Janusz
    • Patrycja Królewska‑Daszczyńska
    • Dominika Wendlocha
  • View Affiliations / Copyright

    Affiliations: Department of Immunology and Serology, School of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, 40‑055 Katowice, Poland
    Copyright: © Mielczarek‑Palacz et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 166
    |
    Published online on: March 15, 2022
       https://doi.org/10.3892/mmr.2022.12682
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The incidence of ovarian cancer is increasing, particularly throughout the highly developed countries, while this cancer type remains a major diagnostic and therapeutic challenge. The currently poorly recognized lectins called galectins have various roles in interactions occurring in the tumor microenvironment. Galectins are involved in tumor‑associated processes, including the promotion of growth, adhesion, angiogenesis and survival of tumor cells. Results of research studies performed so far point to a complex role of galectins‑1, 3, ‑7, ‑8 and ‑9 in carcinogenesis of ovarian cancer and elucidation of the mechanisms may contribute to novel forms of therapies targeting the proteins. In particular, it appears important to recognize the reasons for changes in expression of galectins. Galectins also appear to be a useful diagnostic and prognostic tool to evaluate tumor progression or the efficacy of therapies in patients with ovarian cancer, which requires further study.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Kossai M, Leary A, Scoazec JY and Genestie C: Ovarian cancer: A heterogeneous disease. Pathobiology. 85:41–49. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Kroeger PT and Drapkin R: Pathogenesis and heterogeneity in ovarian cancer. Curr Opin Obstet Gynecol. 29:26–34. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Labrie M, De Araujo LOF, Communal L, Mes-Masson AM and St-Pierre Y: Tissue and plasma levels of galectins in patients with high grade serous ovarian carcinoma as new predictive biomarkers. Sci Rep. 7:13242017. View Article : Google Scholar : PubMed/NCBI

4 

Dubé-Delarosbil C and St-Pierre Y: The emerging role of galectins in high-fatality cancers. Cell Mol Life Sci. 75:1215–1226. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Compagno D, Gentilini LD, Jaworski FM, Pérez IG, Contrufo G and Laderach DJ: Glycans and galectins in prostate cancer biology, angiogenesis and metastasis. Glycobiology. 24:899–906. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Thijssen VL, Rabinovich GA and Griffioen AW: Vascular galectins: Regulators of tumor progression and targets for cancer therapy. Cytokine Growth Factor Rev. 24:547–558. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Dings RP, Miller MC, Griffin RJ and Mayo KH: Galectins as molecular targets for therapeutic intervention. Int J Mol Sci. 19:905–927. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Wdowiak K, Francuz T, Gallego-Colon E, Ruiz-Agamez N, Kubeczko M, Grochoła I and Wojnar J: Galectin targeted therapy in oncology: Current knowledge and perspectives. Int J Mol Sci. 19:210–231. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Balan V, Nangia-Makker P and Raz A: Galectins as cancer biomarkers. Cancers (Basel). 2:592–610. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Rabinovich GA, Baum LG, Tinari N, Paganelli R, Natoli C, Liu FT and Iacobelli S: Galectins and their ligands: Amplifiers, silencers or tuners of the inflammatory response? Trends Immunol. 23:313–320. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Camby I, Le Mercier M, Lefranc F and Kiss R: Galectin-1: A small protein with major functions. Glycobiology. 16:137R–157R. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Wu MH, Hong TM, Cheng HW, Pan SH, Liang YR, Hong HC, Chiang WF, Wong TY, Shieh DB, Shiau AL, et al: Galectin-1-mediated tumor invasion and metastasis, up-regulated matrix metalloproteinase expression, and reorganized actin cytoskeletons. Mol Cancer Res. 7:311–318. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Anginot A, Espeli M, Chasson L, Mancini SJ and Schiff C: Galectin1 modulates plasma cell homeostasis and regulates the humoral immune response. J Immunol. 190:5526–5533. 2013. View Article : Google Scholar : PubMed/NCBI

14 

Sandberg TP, Oosting J, van Pelt G, Mesker WE, Tollenaar RAEM and Morreau H: Molecular profiling of colorectal tumors stratified by the histological tumor-stroma ratio-increased expression of galectin-1 in tumors with high stromal content. Oncotarget. 9:31502–31515. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Satelli A, Rao PS, Gupta PK, Lockman PR, Srivenugopal KS and Rao US: Varied expression and localization of multiple galectins in different cancer cell lines. Oncol Rep. 19:587–594. 2008.PubMed/NCBI

16 

Hughes RC: Secretion of the galectin family of mammalian carbohydrate-binding proteins. Biochim Biophys Acta. 1473:172–185. 1999. View Article : Google Scholar : PubMed/NCBI

17 

Sundblad V, Morosi LG, Geffner JR and Rabinovich GA: Galectin-1: A Jack-of-All-Trades in the resolution of acute and chronic inflammation. J Immunol. 199:3721–3730. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Perillo NL, Pace KE, Seilhamer JJ and Baum LG: Apoptosis of T cells mediated by galectin-1. Nature. 378:736–739. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Rabinovich GA, Iglesias MM, Modesti NM, Castagna LF, Wolfenstein-Todel C, Riera CM and Sotomayor CE: Activated rat macrophages produce a galectin-1-like protein that induces apoptosis of T cells: Biochemical and functional characterization. J Immunol. 160:4831–4840. 1998.PubMed/NCBI

20 

Matarrese P, Tinari A, Mormone E, Bianco GA, Toscano MA, Ascione B, Rabinovich GA and Malorni W: Galectin-1 sensitizes resting human T lymphocytes to Fas (CD95)-mediated cell death via mitochondrial hyperpolarization, budding, and fission. J Biol Chem. 280:6969–6985. 2005. View Article : Google Scholar : PubMed/NCBI

21 

Dias-Baruffi M, Zhu H, Cho M, Karmakar S, McEver RP and Cummings RD: Dimeric galectin-1 induces surface exposure of phosphatidylserine and phagocytic recognition of leukocytes without inducing apoptosis. J Biol Chem. 278:41282–41293. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Stowell SR, Karmakar S, Stowell CJ, Dias-Baruffi M, McEver RP and Cummings RD: Human galectins-1, −2, and −4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells. Blood. 109:219–227. 2007. View Article : Google Scholar : PubMed/NCBI

23 

Hernandez JD and Baum LG: Ah, sweet mystery of death! Galectins and control of cell fate. Glycobiology. 12:127–136. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Sturm A, Lensch M and Andre S: Human galectin-2: Novel inducer of T cell apoptosis with distinct profile of caspase activation. J Immunol. 173:3825–3837. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Fuertes MB, Molinero LL, Toscano MA, Ilarregui JM, Rubinstein N, Fainboim L, Zwirner NW and Rabinovich GA: Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase. Mol Cell Biochem. 267:177–185. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Rubinstein N, Alvarez M, Zwirner NW, Toscano MA, Ilarregui JM, Bravo A, Mordoh J, Fainboim L, Podhajcer OL and Rabinovich GA: Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection: A potential mechanism of tumor-immune privilege. Cancer Cell. 5:241–251. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Toscano MA, Commodaro AG, Ilarregui JM, Bianco GA, Liberman A, Serra HM, Hirabayashi J, Rizzo LV and Rabinovich GA: Galectin-1 suppresses autoimmune retinal disease by promoting concomitant Th2- and T regulatory-mediated anti-inflammatory responses. J Immunol. 176:6323–6332. 2006. View Article : Google Scholar : PubMed/NCBI

28 

Toscano MA, Bianco GA, Ilarregui JM, Croci DO, Correale J, Hernandez JD, Zwirner NW, Poirier F, Riley EM, Baum LG and Rabinovich GA: Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death. Nat Immunol. 8:825–834. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Kuo PL, Huang MS, Cheng DE, Hung JY, Yang CJ and Chou SH: Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor. J Biol Chem. 287:9753–9764. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Soldati R, Berger E, Zenclussen AC, Jorch G, Lode HN, Salatino M, Rabinovich GA and Fest S: Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments. Int J Cancer. 131:1131–1141. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Ilarregui JM, Croci DO, Bianco GA, Toscano MA, Salatino M, Vermeulen ME, Geffner JR and Rabinovich GA: Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10. Nat Immunol. 10:981–991. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Cedeno-Laurent F, Opperman M, Barthel SR, Kuchroo VK and Dimitroff CJ: Galectin-1 triggers an immunoregulatory signature in Th cells functionally defined by IL-10 expression. J Immunol. 188:3127–3137. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Baatar D, Olkhanud PB, Wells V, Indig FE, Mallucci L and Biragyn A: Tregs utilize beta-galactoside-binding protein to transiently inhibit PI3K/p21ras activity of human CD8+ T cells to block their TCR-mediated ERK activity and proliferation. Brain Behav Immun. 23:1028–1037. 2009. View Article : Google Scholar : PubMed/NCBI

34 

Garín MI, Chu CC, Golshayan D, Cernuda-Morollón E, Wait R and Lechler RI: Galectin-1: A key effector of regulation mediated by CD4+CD25+ T cells. Blood. 109:2058–2065. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Espeli M, Mancini SJ, Breton C, Poirier F and Schiff C: Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions. Blood. 113:5878–5886. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Mourcin F, Breton C, Tellier J, Narang P, Chasson L, Jorquera A, Coles M, Schiff C and Mancini SJ: Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow. Blood. 117:6552–6561. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Tsai CM, Chiu YK, Hsu TL, Lin IY, Hsieh SL and Lin KI: Galectin-1 promotes immunoglobulin production during plasma cell differentiation. J Immunol. 181:4570–4579. 2008. View Article : Google Scholar : PubMed/NCBI

38 

Chen L, Yao Y, Sun L and Tang J: Galectin-1 promotes tumor progression via NF-κB signaling pathway in epithelial ovarian cancer. J Cancer. 8:3733–3741. 2017. View Article : Google Scholar : PubMed/NCBI

39 

Zhang P, Shi B, Zhou M, Jiang H, Zhang H, Pan X, Gao H, Sun H and Li Z: Galectin-1 overexpression promotes progression and chemoresistance to cisplatin in epithelial ovarian cancer. Cell Death Dis. 5:e9912014. View Article : Google Scholar : PubMed/NCBI

40 

Kim HJ, Jeon HK, Cho YJ, Park YA, Choi JJ, Do IG, Song SY, Lee YY, Choi CH, Kim TJ, et al: High galectin-1 expression correlates with poor prognosis and is involved in epithelial ovarian cancer proliferation and invasion. Eur J Cancer. 48:1914–1921. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Schulz H, Schmoeckel E, Kuhn C, Hofmann S, Mayr D, Mahner S and Jeschke U: Galectins-1, −3, and −7 are prognostic markers for survival of ovarian cancer patients. Int J Mol Sci. 18:12302017. View Article : Google Scholar : PubMed/NCBI

42 

Chen L, Yao Y, Sun L, Zhou J, Liu J, Wang J, Li J and Tang J: Clinical implication of the serum galectin-1 expression in epithelial ovarian cancer patients. J Ovarian Res. 8:782015. View Article : Google Scholar : PubMed/NCBI

43 

Abdelwahab M, Ebian H, Ibrahim T, Badr M, Lashin M, Yassin M, Ismail A and Obaya A: Clinical significance of serum galectin-1 and its tissue immunohistochemical expression in serous ovarian carcinoma patients. J Obstet Gynecol. 9:937–953. 2019.

44 

Argüeso P and Panjwani N: Focus on molecules: Galectin-3. Exp Eye Res. 9:2–3. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Pinnelli V, Sirsiker M and Silvia WD: Galectin-3: A novel biomarker. Int J Chem Pharm Res. 2:81–94. 2013.

46 

Lityńska A and Pokrywka M: Structure and biological functions of galectin-3 Część Part I. Post Biol Kom. 37:677–684. 2010.

47 

Pokrywka M and Lityńska A: Structure and biological functions of galectin-3 Part II. Post Biol Kom. 37:685–697. 2010.

48 

Ruvolo P: Galectin-3 as a guardian of the tumor microenvironment. Biochim Biophys Acta. 1863:427–437. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Gudowska M and Chrostek L: Diagnostic role of galectin-3. Pol Merkur Lekarski. 222:408–412. 2014.(In Polish). PubMed/NCBI

50 

Li M, Feng YM and Fang SQ: Overexpression of ezrin and galectin-3 as predictors of poor prognosis of cervical cancer. Braz J Med Biol Res. 50:5356–5365. 2017. View Article : Google Scholar

51 

Wdowiak K, Spychałowicz W, Fajkis M and Wojnar J: Galectins in hematological malignancies-role, functions and potential therapeutic targets. Postepy Hig Med Dosw (Online. 70:95–103. 2016.(In Polish). View Article : Google Scholar : PubMed/NCBI

52 

Punt S, Thijssen VL, Vrolijk J, de Kroon CD, Gorter A and Jordanova E: Galectin-1, −3 and −9 expression and clinical significance in squamous cervical cancer. PLoS One. 10:e01291192015. View Article : Google Scholar : PubMed/NCBI

53 

Vladoiu MC, Labrie M and St-Pierre Y: Intracellular galectins in cancer cells: Potential new targets for therapy (Review). Int J Oncol. 44:1001–10014. 2014. View Article : Google Scholar : PubMed/NCBI

54 

Chetry M, Thapa S, Hu X, Song Y, Zhang J, Zhu H and Zhu X: The role of galectins in tumor progression, treatment and prognosis of gynecological cancers. J Cancer. 9:4742–4755. 2018. View Article : Google Scholar : PubMed/NCBI

55 

Wang L, Zhao Y, Wang Y and Wu X: The role of galectins in cervical cancer biology and progression. Biomed Res Int. 2018:21759272018.PubMed/NCBI

56 

Farhad M, Rolig A and Redmond W: The role of Galectin-3 in modulating tumor growth and immunosuppression within the tumor microenvironment. Oncoimmunology. 7:e14344672018. View Article : Google Scholar : PubMed/NCBI

57 

Lee JH, Zhang X, Shin BK, Lee ES and Kim I: Mac-2 binding protein and galectin-3 expression in mucinous tumors of the ovary: An annealing control primer system and immunohistochemical study. Pathology. 41:229–233. 2009. View Article : Google Scholar : PubMed/NCBI

58 

Kim MK, Sung CO, Do IG, Jeon HK, Song TJ, Park HS, Lee YY, Kim BG, Lee JW and Bae DS: Overexpression of galectin-3 and its clinical significance in ovarian carcinoma. Int J Clin Oncol. 16:352–358. 2011. View Article : Google Scholar : PubMed/NCBI

59 

Brustmann H: Epidermal growth factor receptor expression in serous ovarian carcinoma: An immunohistochemical study with galectin-3 and cyclin D1 and outcome. Int J Gynecol Pathol. 27:380–389. 2008. View Article : Google Scholar : PubMed/NCBI

60 

Lu H, Liu Y, Wang D, Wang L, Zhou H, Xu G, Xie L, Wu M, Lin Z and Yu Y: Galectin-3 regulates metastatic capabilities and chemotherapy sensitivity in epithelial ovarian carcinoma via NF-κB pathway. Tumour Biol. 37:11469–11477. 2016. View Article : Google Scholar : PubMed/NCBI

61 

Kang HG, Kim DH, Kim SJ, Cho Y, Jung J, Jang W and Chun KH: Galectin-3 supports stemness in ovarian cancer stem cells by activation of the Notch1 intracellular domain. Oncotarget. 7:68229–68241. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Mirandola L, Yu Y, Cannon MJ, Jenkins MR, Rahman RL and Nguyen DD: Galectin-3 inhibition suppresses drug resistance, motility, invasion and angiogenic potential in ovarian cancer. Gynecol Oncol. 135:573–579. 2014. View Article : Google Scholar : PubMed/NCBI

63 

Eliaz I: The role of galectin-3 as a marker of cancer and inflammation in a stage IV ovarian cancer patient with underlying pro-inflammatory comorbidities. Case Rep Oncol. 6:343–349. 2013. View Article : Google Scholar : PubMed/NCBI

64 

Hossein G, Keshavarz M, Ahmadi S and Naderi N: Synergistic effects of PectaSol-C modified citrus pectin an inhibitor of galectin-3 and paclitaxel on apoptosis of human SKOV-3 ovarian cancer cells. Asian Pac J Cancer Prev. 14:7561–7568. 2013. View Article : Google Scholar : PubMed/NCBI

65 

Hossein G, Halvaei S, Heidarian Y, Dehghani-Ghobadi Z, Hassani M, Hosseini H, Naderi N and Sheikh Hassani S: Pectasol-C modified citrus pectin targets galectin-3-induced STAT3 activation and synergize paclitaxel cytotoxic effect on ovarian cancer spheroids. Cancer Med. 8:4315–4329. 2019. View Article : Google Scholar : PubMed/NCBI

66 

Cai G, Ma X, Chen B, Huang Y, Liu S, Yang H and Zo W: Galectin-3 induces ovarian cancer cell survival and chemoresistance via TLR4 signalingactivation. Tumour Biol. 37:11883–11891. 2016. View Article : Google Scholar : PubMed/NCBI

67 

Wang D, You D and Li L: Galectin-3 regulates chemotherapy sensitivity in epithelial ovarian carcinoma via regulating mitochondrial function. J Toxicol Sci. 44:47–56. 2019. View Article : Google Scholar : PubMed/NCBI

68 

Bieg D, Sypniewski D, Nowak E and Bednarek I: Morin decreases galectin-3 expression and sensitizes ovarian cancer cells to cisplatin. Arch Gynecol Obstet. 298:1181–1194. 2018. View Article : Google Scholar : PubMed/NCBI

69 

Bieg D, Sypniewski D, Nowak E and Bednarek I: MiR-424-3p suppresses galectin-3 expression and sensitizes ovarian cancer cells to cisplatin. Arch Gynecol Obstet. 299:1077–1087. 2019. View Article : Google Scholar : PubMed/NCBI

70 

Kaur M, Kaur T, Kamboj S and Singh J: Roles of galectin-7 in cancer. Asian Pac J Cancer Prev. 17:455–461. 2016. View Article : Google Scholar : PubMed/NCBI

71 

Menkhorst E, Griffiths M, van Sinderen M, Rainczuk K, Niven K and Dimitriadis E: Galectin-7 is elevated in endometrioid (type I) endometrial cancer and promotes cell migration. Oncol Lett. 16:4721–4728. 2018.PubMed/NCBI

72 

Chou F, Chen H, Kuo C and Sytwu H: Role of galectins in tumors and in clinical immunotherapy. Int J Mol Sci. 19:430–441. 2018. View Article : Google Scholar : PubMed/NCBI

73 

Johannes L, Jacob R and Leffler H: Galectins at a glance. J Cell Sci. 131:jcs2088842018. View Article : Google Scholar : PubMed/NCBI

74 

Labrie M, Vladoiu MC, Grosset A, Gaboury L and St-Pierre Y: Expression and functions of galectin-7 in ovarian cancer. Oncotarget. 5:7705–7721. 2014. View Article : Google Scholar : PubMed/NCBI

75 

Higareda-Almaraz JC, Ruiz-Moreno JS, Klimentova J, Barbieri D, Salvador-Gallego R, Ly R, Valtierra-Gutierrez IA, Dinsart C, Rabinovich GA, Stulik J, et al: Systems-level effects of ectopic galectin-7 reconstitution in cervical cancer and its microenvironment. BMC Cancer. 16:680–692. 2016. View Article : Google Scholar : PubMed/NCBI

76 

St-Pierre Y: Towards a better understanding of the relationships between Galectin-7, p53 and MMP-9 during cancer progression. Biomolecules. 11:8792021. View Article : Google Scholar : PubMed/NCBI

77 

Guo JP and Li XG: Galectin-7 promotes the invasiveness of human oral squamous cell carcinoma cells via activation of ERK and JNK signaling. Oncol Lett. 13:1919–1924. 2017. View Article : Google Scholar : PubMed/NCBI

78 

Krześlak A: Akt kinase: A key regulator of metabolism and progression of tumors. Postepy Hig Med Dosw (Online). 64:490–503. 2010.(In Polish). PubMed/NCBI

79 

Kim HJ, Jeon HK, Lee JK, Sung CO, Do IG, Choi CH, Kim TJ, Kim BG, Bae DS and Lee JW: Clinical significance of galectin-7 in epithelial ovarian cancer. Anticancer Res. 33:1555–1561. 2013.PubMed/NCBI

80 

Bibens-Laulan N and St-Pierre Y: Intracellular galectin-7 expression in cancer cells results from an autocrine transcriptional mechanism and endocytosis of extracellular galectin-7. PLoS One. 12:e01871942017. View Article : Google Scholar : PubMed/NCBI

81 

Elola MT, Ferragut F, Cárdenas Delgado VM, Nugnes LG, Gentilini L, Laderach D, Troncoso MF, Compagno D, Wolfenstein-Todel C and Rabinovich GA: Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors. Histol Histopathol. 29:1093–1105. 2014.PubMed/NCBI

82 

Zick Y, Eisenstein M, Goren RA, Hadari YR, Levy Y and Ronen D: Role of galectin-8 as a modulator of cell adhesion and cell growth. Glycoconj J. 19:517–526. 2002. View Article : Google Scholar : PubMed/NCBI

83 

Troncoso MF, Ferragut F, Bacigalupo ML, Cárdenas Delgado VM, Nugnes LG, Gentilini L, Laderach D, Wolfenstein-Todel C, Compagno D, Rabinovich GA and Elola MT: Galectin-8: A matricellular lectin with key roles in angiogenesis. Glycobiology. 10:907–914. 2014. View Article : Google Scholar : PubMed/NCBI

84 

Elola MT, Wolfenstein-Todel C, Troncoso MF, Vasta GR and Rabinovich GA: Galectins: Matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Cell Mol Life Sci. 64:1679–1700. 2007. View Article : Google Scholar : PubMed/NCBI

85 

Levy Y, Arbel-Goren R, Hadari YR, Eshhar S, Ronen D, Elhanany E, Geiger B and Zick Y: Galectin-8 functions as a matricellular modulator of cell adhesion. J Biol Chem. 276:31285–31295. 2001. View Article : Google Scholar : PubMed/NCBI

86 

Troncoso MF, Elola MT, Croci DO and Rabinovich GA: Integrating structure and function of ‘tandem-repeat’ galectins. Front Biosci (Schol Ed). 4:864–887. 2012.PubMed/NCBI

87 

Tribulatti MV, Carabelli J, Prato CA and Campetella O: Galectin-8 in the onset of the immune response and inflammation. Glycobiology. 30:134–142. 2020. View Article : Google Scholar : PubMed/NCBI

88 

Ferragut F, Cagnoni AJ, Colombo LL, Sánchez Terrero C, Wolfenstein-Todel C, Troncoso MF, Vanzulli SI, Rabinovich GA, Mariño KV and Elola MT: Dual knockdown of Galectin-8 and its glycosylated ligand, the activated leukocyte cell adhesion molecule (ALCAM/CD166), synergistically delays in vivo breast cancer growth. Biochim Biophys Acta Mol Cell Res. 1866:1338–1352. 2019. View Article : Google Scholar : PubMed/NCBI

89 

Fan J, Tang X, Wang Q, Zhang Z, Wu S, Li W, Liu S, Yao G, Chen H and Sun L: Mesenchymal stem cells alleviate experimental autoimmune cholangitis through immunosuppression and cytoprotective function mediated by galectin-9. Stem Cell Res Ther. 9:237–349. 2018. View Article : Google Scholar : PubMed/NCBI

90 

Zhou X, Sun L, Jing D, Xu G, Zhang J, Lin L, Zhao J, Yao Z and Lin H: Galectin-9 expression predicts favorable clinical outcome in solid tumors: A systematic review and meta-analysis. Front Physiol. 9:4522018. View Article : Google Scholar : PubMed/NCBI

91 

Fujihara S, Mori H, Kobara H, Rafiq K, Niki T, Hirashima M and Masaki T: Galectin-9 in cancer therapy. Recent Pat Endocr Metab Immune Drug Discov. 7:130–137. 2013. View Article : Google Scholar : PubMed/NCBI

92 

Lahm H, André S, Hoeflich A, Fischer JR, Sordat B, Kaltner H, Wolf E and Gabius HJ: Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures. J Cancer Res Clin Oncol. 127:375–386. 2001. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Mielczarek‑Palacz A, Kondera‑Anasz Z, Smycz‑Kubańska M, Englisz A, Janusz A, Królewska‑Daszczyńska P and Wendlocha D: The role of galectins‑1, 3, 7, 8 and 9 as potential diagnostic and therapeutic markers in ovarian cancer (Review). Mol Med Rep 25: 166, 2022.
APA
Mielczarek‑Palacz, A., Kondera‑Anasz, Z., Smycz‑Kubańska, M., Englisz, A., Janusz, A., Królewska‑Daszczyńska, P., & Wendlocha, D. (2022). The role of galectins‑1, 3, 7, 8 and 9 as potential diagnostic and therapeutic markers in ovarian cancer (Review). Molecular Medicine Reports, 25, 166. https://doi.org/10.3892/mmr.2022.12682
MLA
Mielczarek‑Palacz, A., Kondera‑Anasz, Z., Smycz‑Kubańska, M., Englisz, A., Janusz, A., Królewska‑Daszczyńska, P., Wendlocha, D."The role of galectins‑1, 3, 7, 8 and 9 as potential diagnostic and therapeutic markers in ovarian cancer (Review)". Molecular Medicine Reports 25.5 (2022): 166.
Chicago
Mielczarek‑Palacz, A., Kondera‑Anasz, Z., Smycz‑Kubańska, M., Englisz, A., Janusz, A., Królewska‑Daszczyńska, P., Wendlocha, D."The role of galectins‑1, 3, 7, 8 and 9 as potential diagnostic and therapeutic markers in ovarian cancer (Review)". Molecular Medicine Reports 25, no. 5 (2022): 166. https://doi.org/10.3892/mmr.2022.12682
Copy and paste a formatted citation
x
Spandidos Publications style
Mielczarek‑Palacz A, Kondera‑Anasz Z, Smycz‑Kubańska M, Englisz A, Janusz A, Królewska‑Daszczyńska P and Wendlocha D: The role of galectins‑1, 3, 7, 8 and 9 as potential diagnostic and therapeutic markers in ovarian cancer (Review). Mol Med Rep 25: 166, 2022.
APA
Mielczarek‑Palacz, A., Kondera‑Anasz, Z., Smycz‑Kubańska, M., Englisz, A., Janusz, A., Królewska‑Daszczyńska, P., & Wendlocha, D. (2022). The role of galectins‑1, 3, 7, 8 and 9 as potential diagnostic and therapeutic markers in ovarian cancer (Review). Molecular Medicine Reports, 25, 166. https://doi.org/10.3892/mmr.2022.12682
MLA
Mielczarek‑Palacz, A., Kondera‑Anasz, Z., Smycz‑Kubańska, M., Englisz, A., Janusz, A., Królewska‑Daszczyńska, P., Wendlocha, D."The role of galectins‑1, 3, 7, 8 and 9 as potential diagnostic and therapeutic markers in ovarian cancer (Review)". Molecular Medicine Reports 25.5 (2022): 166.
Chicago
Mielczarek‑Palacz, A., Kondera‑Anasz, Z., Smycz‑Kubańska, M., Englisz, A., Janusz, A., Królewska‑Daszczyńska, P., Wendlocha, D."The role of galectins‑1, 3, 7, 8 and 9 as potential diagnostic and therapeutic markers in ovarian cancer (Review)". Molecular Medicine Reports 25, no. 5 (2022): 166. https://doi.org/10.3892/mmr.2022.12682
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team