Open Access

Insights into the role of STAT3 in intrahepatic cholangiocarcinoma (Review)

  • Authors:
    • Ranzhiqiang Yang
    • Yinghui Song
    • Kashif Shakoor
    • Weimin Yi
    • Chuang Peng
    • Sulai Liu
  • View Affiliations

  • Published online on: March 17, 2022     https://doi.org/10.3892/mmr.2022.12687
  • Article Number: 171
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Intrahepatic cholangiocarcinoma (ICC) is a primary malignant liver tumour whose incidence is second only to that of hepatocellular carcinoma. ICC is a highly heterogeneous disease arising from neoplastic transformation of intrahepatic biliary epithelial cells (cholangiocytes), and it is characterized by a very poor prognosis. Signal transducer and activator of transcription 3 (STAT3) is an important oncogene that is widely expressed in numerous cancers. STAT3 is a candidate target for the treatment of ICC. However, studies on STAT3 and the occurrence and development of ICC require improvements. Therefore, the present review summarized the mechanism of STAT3 in ICC and provided a theoretical basis for STAT3 to become an effective target for determining the prognosis and treatment of ICC.
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May-2022
Volume 25 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Yang R, Song Y, Shakoor K, Yi W, Peng C and Liu S: Insights into the role of STAT3 in intrahepatic cholangiocarcinoma (Review). Mol Med Rep 25: 171, 2022
APA
Yang, R., Song, Y., Shakoor, K., Yi, W., Peng, C., & Liu, S. (2022). Insights into the role of STAT3 in intrahepatic cholangiocarcinoma (Review). Molecular Medicine Reports, 25, 171. https://doi.org/10.3892/mmr.2022.12687
MLA
Yang, R., Song, Y., Shakoor, K., Yi, W., Peng, C., Liu, S."Insights into the role of STAT3 in intrahepatic cholangiocarcinoma (Review)". Molecular Medicine Reports 25.5 (2022): 171.
Chicago
Yang, R., Song, Y., Shakoor, K., Yi, W., Peng, C., Liu, S."Insights into the role of STAT3 in intrahepatic cholangiocarcinoma (Review)". Molecular Medicine Reports 25, no. 5 (2022): 171. https://doi.org/10.3892/mmr.2022.12687