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Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells

  • Authors:
    • Liuxie Yang
    • Zhenhuan Li
    • Yueping Ouyang
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    Affiliations: Department of Orthopedics, Shanghai Jing'an District Zhabei Central Hospital, Shanghai 200040, P.R. China, Department of Orthopedics, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai 200003, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 172
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    Published online on: March 18, 2022
       https://doi.org/10.3892/mmr.2022.12688
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Abstract

Nucleus pulposus (NP) apoptosis and subsequent excessive degradation of the extracellular matrix (ECM) are key pathological characteristics of intervertebral disc degeneration (IDD). The present study aims to examine the signaling processes underlying the effects of taurine on IDD, with specific focus on endoplasmic reticulum (ER) stress‑mediated apoptosis and ECM degradation, in NP cells. To clarify the role of taurine in IDD, NP cells were treated with various concentrations of taurine and IL‑1β or thapsigargin (TG). Cell Counting Kit‑8, western blotting, TUNEL, immunofluorescence assays and reverse transcription‑quantitative PCR were applied to measure cell viability, the expression of ER stress‑associated proteins (GRP78, CHOP and caspase‑12), apoptosis and the levels of metabolic factors associated with ECM (MMP‑1, 3, 9, ADAMTS‑4, 5 and collagen II), respectively. Taurine was found to attenuate ER stress and prevent apoptosis in NP cells induced by IL‑1β treatment. Additionally, taurine significantly decreased the expression of ER stress‑activated glucose regulatory protein 78, C/EBP homologous protein and caspase‑12. TUNEL results revealed that taurine decreased the number of apoptotic TG‑treated NP cells. TG‑treated NP cells also exhibited characteristics of increased ECM degradation, supported by observations of increased MMP‑1, MMP‑3, MMP‑9 and A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)‑4 and ADAMTS‑5 expression in addition to decreased collagen‑II expression. However, taurine treatment significantly reversed all indicators of excessive ECM catabolism aforementioned. These data suggest that taurine can mediate protection against apoptosis and ECM degradation in NP cells by inhibiting ER stress, implicating therapeutic potential for the treatment of IDD.
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View References

1 

Wang F, Cai F, Shi R, Wang XH and Wu XT: Aging and age related stresses: A senescence mechanism of intervertebral disc degeneration. Osteoarthritis Cartilage. 24:398–408. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Simon J, McAuliffe M, Shamim F, Vuong N and Tahaei A: Discogenic low back pain. Phys Med Rehabil Clin N Am. 25:305–317. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Petersen T, Laslett M and Juhl C: Clinical classification in low back pain: Best-evidence diagnostic rules based on systematic reviews. BMC Musculoskelet Disord. 18:1882017. View Article : Google Scholar : PubMed/NCBI

4 

Barrey CY and Le Huec JC; French Society for Spine Surgery, : Chronic low back pain: Relevance of a new classification based on the injury pattern. Orthop Traumatol Surg Res. 105:339–346. 2019. View Article : Google Scholar : PubMed/NCBI

5 

Liang D, Hong D, Tang F, Wang Y, Li J, Li L and Chen H: Upregulated lnc-HRK-2:1 prompts nucleus pulposus cell senescence in intervertebral disc degeneration. Mol Med Rep. 22:5251–5261. 2020. View Article : Google Scholar : PubMed/NCBI

6 

Pattappa G, Li Z, Peroglio M, Wismer N, Alini M and Grad S: Diversity of intervertebral disc cells: Phenotype and function. J Anat. 221:480–496. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Sakai D and Grad S: Advancing the cellular and molecular therapy for intervertebral disc disease. Adv Drug Deliv Rev. 84:159–171. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Ding F, Shao ZW and Xiong LM: Cell death in intervertebral disc degeneration. Apoptosis. 18:777–785. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Xu S, Liang T and Li S: Correlation between polymorphism of TRAIL gene and condition of intervertebral disc degeneration. Med Sci Monit. 21:2282–2287. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Zhao Z, Zheng J, Ye Y, Zhao K and Wang R and Wang R: MicroRNA-25-3p regulates human nucleus pulposus cell proliferation and apoptosis in intervertebral disc degeneration by targeting Bim. Mol Med Rep. 22:3621–3628. 2020.PubMed/NCBI

11 

Tsingas M, Ottone OK, Haseeb A, Barve RA, Shapiro IM, Lefebvre V and Risbud MV: Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes. Matrix Biol. 94:110–133. 2020. View Article : Google Scholar : PubMed/NCBI

12 

Borrelli C and Buckley CT: Injectable disc-derived ECM hydrogel functionalised with chondroitin sulfate for intervertebral disc regeneration. Acta Biomater. 117:142–155. 2020. View Article : Google Scholar : PubMed/NCBI

13 

Ohnishi T, Novais EJ and Risbud MV: Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degeneration. Matrix Biol Plus. 6–7, 100036. 2020.PubMed/NCBI

14 

Le Maitre CL, Pockert A, Buttle DJ, Freemont AJ and Hoyland JA: Matrix synthesis and degradation in human intervertebral disc degeneration. Biochem Soc Trans. 35:652–655. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Wang WJ, Yu XH, Wang C, Yang W, He WS, Zhang SJ, Yan YG and Zhang J: MMPs and ADAMTSs in intervertebral disc degeneration. Clin Chim Acta. 448:238–246. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Ding F and Li X: Apigenin mitigates intervertebral disc degeneration through the amelioration of tumor necrosis factor α (TNF-α) signaling pathway. Med Sci Monit. 26:e9245872020. View Article : Google Scholar : PubMed/NCBI

17 

Roberts S, Caterson B, Menage J, Evans EH, Jaffray DC and Eisenstein SM: Matrix metalloproteinases and aggrecanase: Their role in disorders of the human intervertebral disc. Spine (Phila Pa 1976). 25:3005–3013. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Pockert AJ, Richardson SM, Le Maitre CL, Lyon M, Deakin JA, Buttle DJ, Freemont AJ and Hoyland JA: Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration. Arthritis Rheum. 60:482–491. 2009. View Article : Google Scholar : PubMed/NCBI

19 

Yamori Y, Nara Y, Ikeda K and Mizushima S: Is taurine a preventive nutritional factor of cardiovascular diseases or just a biological marker of nutrition? Adv Exp Med Biol. 403:623–629. 1996. View Article : Google Scholar : PubMed/NCBI

20 

Wallace DR and Dawson R Jr: Decreased plasma taurine in aged rats. Gerontology. 36:19–27. 1990. View Article : Google Scholar : PubMed/NCBI

21 

Pacholczyk-Sienicka B, Radek M, Radek A and Jankowski S: Characterization of metabolites determined by means of 1H HR MAS NMR in intervertebral disc degeneration. MAGMA. 28:173–183. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Goodman CA, Horvath D, Stathis C, Mori T, Croft K, Murphy RM and Hayes A: Taurine supplementation increases skeletal muscle force production and protects muscle function during and after high-frequency in vitro stimulation. J Appl Physiol (1985). 107:144–154. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Ghosh S, Chowdhury S, Das AK and Sil PC: Taurine ameliorates oxidative stress induced inflammation and ER stress mediated testicular damage in STZ-induced diabetic Wistar rats. Food Chem Toxicol. 124:64–80. 2019. View Article : Google Scholar : PubMed/NCBI

24 

Rainesalo S, Keränen T, Palmio J, Peltola J, Oja SS and Saransaari P: Plasma and cerebrospinal fluid amino acids in epileptic patients. Neurochem Res. 29:319–324. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Engelborghs S, Marescau B and De Deyn PP: Amino acids and biogenic amines in cerebrospinal fluid of patients with Parkinson's disease. Neurochem Res. 28:1145–1150. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Gao Z, Lin Y, Zhang P, Cheng Q, Ye L, Wu F, Chen Y, Fu M, Cheng C and Gao Y: Sinomenine ameliorates intervertebral disc degeneration via inhibition of apoptosis and autophagy in vitro and in vivo. Am J Transl Res. 11:5956–5966. 2019.PubMed/NCBI

27 

Liu D, Gu Y, Wang W and Chen W: Astragalin alleviates ischemia/reperfusion-induced brain injury via suppression of endoplasmic reticulum stress. Mol Med Rep. 22:4070–4078. 2020.PubMed/NCBI

28 

Chen J, Xuan J, Gu YT, Shi KS, Xie JJ, Chen JX, Zheng ZM, Chen Y, Chen XB, Wu YS, et al: Celastrol reduces IL-1β induced matrix catabolism, oxidative stress and inflammation in human nucleus pulposus cells and attenuates rat intervertebral disc degeneration in vivo. Biomed Pharmacother. 91:208–219. 2017. View Article : Google Scholar : PubMed/NCBI

29 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Pfaffl MW: A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:e452001. View Article : Google Scholar : PubMed/NCBI

31 

Martirosyan NL, Patel AA, Carotenuto A, Kalani MY, Belykh E, Walker CT, Preul MC and Theodore N: Genetic alterations in intervertebral disc disease. Front Surg. 3:592016. View Article : Google Scholar : PubMed/NCBI

32 

Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, Kurosaka M and Nishida K: Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Arthritis Res Ther. 14:R512012. View Article : Google Scholar : PubMed/NCBI

33 

Ekşi MŞ, Özcan-Ekşi EE, Özmen BB, Turgut VU, Huet SE, Dinç T, Kara M, Özgen S, Özek MM and Pamir MN: Lumbar intervertebral disc degeneration, end-plates and paraspinal muscle changes in children and adolescents with low-back pain. J Pediatr Orthop B. 31:93–102. 2022. View Article : Google Scholar : PubMed/NCBI

34 

Khan AN, Jacobsen HE, Khan J, Filippi CG, Levine M, Lehman RA Jr, Riew KD, Lenke LG and Chahine NO: Inflammatory biomarkers of low back pain and disc degeneration: A review. Ann N Y Acad Sci. 1410:68–84. 2017. View Article : Google Scholar : PubMed/NCBI

35 

Zhang B, Xu H, Wang J, Liu B and Sun G: A narrative review of non-operative treatment, especially traditional Chinese medicine therapy, for lumbar intervertebral disc herniation. Biosci Trends. 11:406–417. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Jacobs WC, van der Gaag NA, Kruyt MC, Tuschel A, de Kleuver M, Peul WC, Verbout AJ and Oner FC: Total disc replacement for chronic discogenic low back pain: A Cochrane review. Spine (Phila Pa 1976). 38:24–36. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Ogon I, Takashima H, Morita T, Oshigiri T, Terashima Y, Yoshimoto M, Fukushi R, Fujimoto S, Emori M, Teramoto A, et al: Relevance between schmorl's node and lumbar intervertebral disc degeneration quantified with magnetic resonance imaging T2 mapping in chronic low back pain. Asian Spine J. 14:621–628. 2020. View Article : Google Scholar : PubMed/NCBI

38 

Cherif H, Bisson DG, Mannarino M, Rabau O, Ouellet JA and Haglund L: Senotherapeutic drugs for human intervertebral disc degeneration and low back pain. Elife. 9:e546932020. View Article : Google Scholar : PubMed/NCBI

39 

Wang D, Chen Y, Cao S, Ren P, Shi H, Li H, Xie L, Huang W, Shi B and Han J: Cyclic mechanical stretch ameliorates the degeneration of nucleus pulposus cells through promoting the ITGA2/PI3K/AKT signaling pathway. Oxid Med Cell Longev. 2021:66993262021.PubMed/NCBI

40 

Mobasheri A, Csaki C, Clutterbuck AL, Rahmanzadeh M and Shakibaei M: Mesenchymal stem cells in connective tissue engineering and regenerative medicine: Applications in cartilage repair and osteoarthritis therapy. Histol Histopathol. 24:347–366. 2009.PubMed/NCBI

41 

Zhao CQ, Wang LM, Jiang LS and Dai LY: The cell biology of intervertebral disc aging and degeneration. Ageing Res Rev. 6:247–261. 2007. View Article : Google Scholar : PubMed/NCBI

42 

Xu H, Ji L, Yu C, Chen Q, Ge Q and Lu Y: MiR-423-5p regulates cells apoptosis and extracellular matrix degradation via nucleotide-binding, leucine-rich repeat containing X1 (NLRX1) in interleukin 1 beta (IL-1β)-induced human nucleus pulposus cells. Med Sci Monit. 26:e9224972020.PubMed/NCBI

43 

Guo HT, Yang SD, Zhang F, Liu S, Yang DL, Ma L, Wang H and Ding WY: 17β-Estradiol protects against interleukin-1β-induced apoptosis in rat nucleus pulposus cells via the mTOR/caspase-3 pathway. Mol Med Rep. 20:1523–1530. 2019.PubMed/NCBI

44 

Horiuchi K, Tohmonda T and Morioka H: The unfolded protein response in skeletal development and homeostasis. Cell Mol Life Sci. 73:2851–2869. 2016. View Article : Google Scholar : PubMed/NCBI

45 

Uehara Y, Hirose J, Yamabe S, Okamoto N, Okada T, Oyadomari S and Mizuta H: Endoplasmic reticulum stress-induced apoptosis contributes to articular cartilage degeneration via C/EBP homologous protein. Osteoarthritis Cartilage. 22:1007–1017. 2014. View Article : Google Scholar : PubMed/NCBI

46 

Shimizu A, Kaira K, Yasuda M, Asao T and Ishikawa O: Clinical and pathological significance of ER stress marker (BiP/GRP78 and PERK) expression in malignant melanoma. Pathol Oncol Res. 23:111–116. 2017. View Article : Google Scholar : PubMed/NCBI

47 

Chern YJ, Wong JCT, Cheng GSW, Yu A, Yin Y, Schaeffer DF, Kennecke HF, Morin G and Tai IT: The interaction between SPARC and GRP78 interferes with ER stress signaling and potentiates apoptosis via PERK/eIF2α and IRE1α/XBP-1 in colorectal cancer. Cell Death Dis. 10:5042019. View Article : Google Scholar : PubMed/NCBI

48 

Fu YF, Liu X, Gao M, Zhang YN and Liu J: Endoplasmic reticulum stress induces autophagy and apoptosis while inhibiting proliferation and drug resistance in multiple myeloma through the PI3K/Akt/mTOR signaling pathway. Oncotarget. 8:61093–61106. 2017. View Article : Google Scholar : PubMed/NCBI

49 

Lee W, Kim DH, Boo JH, Kim YH, Park IS and Mook-Jung I: ER stress-induced caspase-12 activation is inhibited by PKC in neuronal cells. Apoptosis. 10:407–415. 2005. View Article : Google Scholar : PubMed/NCBI

50 

Yang Y, Zhang Y, Liu X, Zuo J, Wang K, Liu W and Ge J: Exogenous taurine attenuates mitochondrial oxidative stress and endoplasmic reticulum stress in rat cardiomyocytes. Acta Biochim Biophys Sin (Shanghai). 45:359–367. 2013. View Article : Google Scholar : PubMed/NCBI

51 

Yang YJ, Han YY, Chen K, Zhang Y, Liu X, Li S, Wang KQ, Ge JB, Liu W and Zuo J: TonEBP modulates the protective effect of taurine in ischemia-induced cytotoxicity in cardiomyocytes. Cell Death Dis. 6:e20252015. View Article : Google Scholar : PubMed/NCBI

52 

Nonaka H, Tsujino T, Watari Y, Emoto N and Yokoyama M: Taurine prevents the decrease in expression and secretion of extracellular superoxide dismutase induced by homocysteine: Amelioration of homocysteine-induced endoplasmic reticulum stress by taurine. Circulation. 104:1165–1170. 2001. View Article : Google Scholar : PubMed/NCBI

53 

Li Z, Guo J, Bian Y and Zhang M: Intermedin protects thapsigargin-induced endoplasmic reticulum stress in cardiomyocytes by modulating protein kinase A and sarco/endoplasmic reticulum Ca2+-ATPase. Mol Med Rep. 23:1072021. View Article : Google Scholar : PubMed/NCBI

54 

Luo R, Song Y, Liao Z, Yin H, Zhan S, Wang K, Li S, Li G, Ma L, Lu S, et al: Impaired calcium homeostasis via advanced glycation end products promotes apoptosis through endoplasmic reticulum stress in human nucleus pulposus cells and exacerbates intervertebral disc degeneration in rats. FEBS J. 286:4356–4373. 2019. View Article : Google Scholar : PubMed/NCBI

55 

Canová NK, Kmonícková E, Martínek J, Zídek Z and Farghali H: Thapsigargin, a selective inhibitor of sarco-endoplasmic reticulum Ca2+-ATPases, modulates nitric oxide production and cell death of primary rat hepatocytes in culture. Cell Biol Toxicol. 23:337–354. 2007. View Article : Google Scholar : PubMed/NCBI

56 

Mao HZ, Ehrhardt N, Bedoya C, Gomez JA, DeZwaan-McCabe D, Mungrue IN, Kaufman RJ, Rutkowski DT and Péterfy M: Lipase maturation factor 1 (lmf1) is induced by endoplasmic reticulum stress through activating transcription factor 6α (Atf6α) signaling. J Biol Chem. 289:24417–24427. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Finger F and Hoppe T: MicroRNAs meet calcium: Joint venture in ER proteostasis. Sci Signal. 7:re112014. View Article : Google Scholar : PubMed/NCBI

58 

Groenendyk J, Peng Z, Dudek E, Fan X, Mizianty MJ, Dufey E, Urra H, Sepulveda D, Rojas-Rivera D, Lim Y, et al: Interplay between the oxidoreductase PDIA6 and microRNA-322 controls the response to disrupted endoplasmic reticulum calcium homeostasis. Sci Signal. 7:ra542014. View Article : Google Scholar : PubMed/NCBI

59 

Lama P, Zehra U, Balkovec C, Claireaux HA, Flower L, Harding IJ, Dolan P and Adams MA: Significance of cartilage endplate within herniated disc tissue. Eur Spine J. 23:1869–1877. 2014. View Article : Google Scholar : PubMed/NCBI

60 

Novais EJ, Choi H, Madhu V, Suyama K, Anjo SI, Manadas B, Shapiro IM, Salgado AJ and Risbud MV: Hypoxia and hypoxia-inducible factor-1α regulate endoplasmic reticulum stress in nucleus pulposus cells: Implications of endoplasmic reticulum stress for extracellular matrix secretion. Am J Pathol. 191:487–502. 2021. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang L, Li Z and Ouyang Y: Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells. Mol Med Rep 25: 172, 2022.
APA
Yang, L., Li, Z., & Ouyang, Y. (2022). Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells. Molecular Medicine Reports, 25, 172. https://doi.org/10.3892/mmr.2022.12688
MLA
Yang, L., Li, Z., Ouyang, Y."Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells". Molecular Medicine Reports 25.5 (2022): 172.
Chicago
Yang, L., Li, Z., Ouyang, Y."Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells". Molecular Medicine Reports 25, no. 5 (2022): 172. https://doi.org/10.3892/mmr.2022.12688
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Spandidos Publications style
Yang L, Li Z and Ouyang Y: Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells. Mol Med Rep 25: 172, 2022.
APA
Yang, L., Li, Z., & Ouyang, Y. (2022). Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells. Molecular Medicine Reports, 25, 172. https://doi.org/10.3892/mmr.2022.12688
MLA
Yang, L., Li, Z., Ouyang, Y."Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells". Molecular Medicine Reports 25.5 (2022): 172.
Chicago
Yang, L., Li, Z., Ouyang, Y."Taurine attenuates ER stress‑associated apoptosis and catabolism in nucleus pulposus cells". Molecular Medicine Reports 25, no. 5 (2022): 172. https://doi.org/10.3892/mmr.2022.12688
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