Open Access

Salivary microbiota analysis of patients with membranous nephropathy

  • Authors:
    • Shaodong Luan
    • Shuyuan Zhang
    • Litao Pan
    • Wenjun Hu
    • Haihong Cui
    • Xing Wei
    • Renyong Lin
    • Chundi Li
    • Ping Zeng
    • Xi Wang
    • Weilong Li
    • Zigan Xu
    • Yingwei Zhang
    • Bo Hu
    • Hanchao Gao
  • View Affiliations

  • Published online on: March 31, 2022     https://doi.org/10.3892/mmr.2022.12706
  • Article Number: 190
  • Copyright: © Luan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The oral microbiota are closely related to human health. Nonetheless, to the best of our knowledge, their relationship with membranous nephropathy (MN) remains unstudied. The saliva microbiota collected from 22 patients with MN and 15 healthy controls were analyzed by next‑generation sequencing, and bioinformatics analysis of the 16S ribosomal RNA gene was subsequently carried out. The Chao1 and Shannon indices in patients with MN were higher than those in healthy controls. Analysis of similarities revealed that the oral microbiota in the patient group were significantly different from those in the healthy controls. At the genus level, the abundance of Alloprevotella, Granulicatella, Prevotella, Streptococcus and Prevotella_7 was markedly higher in patients with MN than in healthy controls. Six operational taxonomic units (OTUs; OTU5, OTU28, OTU9, OTU15, OTU33 and OTU38) were found to be markedly correlated with the clinical factors creatinine, proteinuria in 24 h, estimated glomerular filtration rate and systolic blood pressure. A total of 28 Kyoto Encyclopedia of Genes and Genomes pathways were obtained from the significant OTUs. The oral microbiota of patients with MN were investigated and it was found that OTU5, OTU28, OTU9, OTU15, OTU33 and OTU38 may be used as biomarkers. The present findings may assist in the diagnosis of patients with MN.
View Figures
View References

Related Articles

Journal Cover

May-2022
Volume 25 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Luan S, Zhang S, Pan L, Hu W, Cui H, Wei X, Lin R, Li C, Zeng P, Wang X, Wang X, et al: Salivary microbiota analysis of patients with membranous nephropathy. Mol Med Rep 25: 190, 2022
APA
Luan, S., Zhang, S., Pan, L., Hu, W., Cui, H., Wei, X. ... Gao, H. (2022). Salivary microbiota analysis of patients with membranous nephropathy. Molecular Medicine Reports, 25, 190. https://doi.org/10.3892/mmr.2022.12706
MLA
Luan, S., Zhang, S., Pan, L., Hu, W., Cui, H., Wei, X., Lin, R., Li, C., Zeng, P., Wang, X., Li, W., Xu, Z., Zhang, Y., Hu, B., Gao, H."Salivary microbiota analysis of patients with membranous nephropathy". Molecular Medicine Reports 25.5 (2022): 190.
Chicago
Luan, S., Zhang, S., Pan, L., Hu, W., Cui, H., Wei, X., Lin, R., Li, C., Zeng, P., Wang, X., Li, W., Xu, Z., Zhang, Y., Hu, B., Gao, H."Salivary microbiota analysis of patients with membranous nephropathy". Molecular Medicine Reports 25, no. 5 (2022): 190. https://doi.org/10.3892/mmr.2022.12706