Open Access

Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review)

  • Authors:
    • Yang Zhang
    • Yuan Wu
    • Wenjuan Shen
    • Bingyu Wang
    • Xingxing Yuan
  • View Affiliations

  • Published online on: May 3, 2022     https://doi.org/10.3892/mmr.2022.12724
  • Article Number: 208
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Liver fibrosis is a common pathological process of chronic liver diseases, including viral hepatitis and alcoholic liver disease, and ultimately progresses to irreversible cirrhosis and cancer. Hepatic stellate cells (HSCs) are activated to produce amounts of collagens in response to liver injury, thus triggering the initiation and progression of fibrogenesis. Natural killer (NK) cells serve as the essential component of hepatic innate immunity and are considered to alleviate fibrosis by killing activated HSCs. Current antifibrotic interventions have improved fibrosis, but fail to halt its progression in the advanced stage. Clarifying the interaction between NK cells and HSCs will provide clues to the pathogenesis and potential therapies for advanced liver fibrosis.

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June-2022
Volume 25 Issue 6

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Y, Wu Y, Shen W, Wang B and Yuan X: Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review). Mol Med Rep 25: 208, 2022
APA
Zhang, Y., Wu, Y., Shen, W., Wang, B., & Yuan, X. (2022). Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review). Molecular Medicine Reports, 25, 208. https://doi.org/10.3892/mmr.2022.12724
MLA
Zhang, Y., Wu, Y., Shen, W., Wang, B., Yuan, X."Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review)". Molecular Medicine Reports 25.6 (2022): 208.
Chicago
Zhang, Y., Wu, Y., Shen, W., Wang, B., Yuan, X."Crosstalk between NK cells and hepatic stellate cells in liver fibrosis (Review)". Molecular Medicine Reports 25, no. 6 (2022): 208. https://doi.org/10.3892/mmr.2022.12724